{"id":"https://openalex.org/W1978340855","doi":"https://doi.org/10.1097/00007890-199905150-00265","title":"MYCOPHENOLATE MOFETIL ALLOWS OVERALL REDUCTION OF IMMUNOSUPPRESSION IN LIVER TRANSPLANTS WITHOUT ADVERSE EFFECTS","display_name":"MYCOPHENOLATE MOFETIL ALLOWS OVERALL REDUCTION OF IMMUNOSUPPRESSION IN LIVER TRANSPLANTS WITHOUT ADVERSE EFFECTS","publication_year":1999,"publication_date":"1999-05-01","ids":{"openalex":"https://openalex.org/W1978340855","doi":"https://doi.org/10.1097/00007890-199905150-00265","mag":"1978340855"},"language":"en","primary_location":{"id":"doi:10.1097/00007890-199905150-00265","doi":"https://doi.org/10.1097/00007890-199905150-00265","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199905150-00265","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101704879","display_name":"Shu Cao","orcid":"https://orcid.org/0000-0002-2992-8588","observed_orcids":["https://orcid.org/0000-0002-2992-8588"]},"institutions":[{"id":"https://openalex.org/I1293502524","display_name":"Loma Linda University Medical Center","ror":"https://ror.org/03et1qs84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293502524"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Cao","raw_affiliation_strings":["Loma Linda University Medical Center, Transplantation Institute, Loma Linda, CA 92354"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loma Linda University Medical Center, Transplantation Institute, Loma Linda, CA 92354","institution_ids":["https://openalex.org/I1293502524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086200709","display_name":"R. S.-H. TAN","orcid":"https://orcid.org/0000-0002-8367-9172","observed_orcids":["https://orcid.org/0000-0002-8367-9172"]},"institutions":[{"id":"https://openalex.org/I1293502524","display_name":"Loma Linda University Medical Center","ror":"https://ror.org/03et1qs84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293502524"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Tan","raw_affiliation_strings":["Loma Linda University Medical Center, Transplantation Institute, Loma Linda, CA 92354"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loma Linda University Medical Center, Transplantation Institute, Loma Linda, CA 92354","institution_ids":["https://openalex.org/I1293502524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085550599","display_name":"Bruce Allen Runyon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1293502524","display_name":"Loma Linda University Medical Center","ror":"https://ror.org/03et1qs84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293502524"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B Runyon","raw_affiliation_strings":["Loma Linda University Medical Center, Transplantation Institute, Loma Linda, CA 92354"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loma Linda University Medical Center, Transplantation Institute, Loma Linda, CA 92354","institution_ids":["https://openalex.org/I1293502524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091214679","display_name":"Donald J. Hillebrand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1293502524","display_name":"Loma Linda University Medical Center","ror":"https://ror.org/03et1qs84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293502524"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Hillebrand","raw_affiliation_strings":["Loma Linda University Medical Center, Transplantation Institute, Loma Linda, CA 92354"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loma Linda University Medical Center, Transplantation Institute, Loma Linda, CA 92354","institution_ids":["https://openalex.org/I1293502524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110185266","display_name":"Okechukwu N. Ojogho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1293502524","display_name":"Loma Linda University Medical Center","ror":"https://ror.org/03et1qs84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293502524"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"O Ojogho","raw_affiliation_strings":["Loma Linda University Medical Center, Transplantation Institute, Loma Linda, CA 92354"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loma Linda University Medical Center, Transplantation Institute, Loma Linda, CA 92354","institution_ids":["https://openalex.org/I1293502524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112377726","display_name":"Jill Weissman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1293502524","display_name":"Loma Linda University Medical Center","ror":"https://ror.org/03et1qs84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293502524"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Weissman","raw_affiliation_strings":["Loma Linda University Medical Center, Transplantation Institute, Loma Linda, CA 92354"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loma Linda University Medical Center, Transplantation Institute, Loma Linda, CA 92354","institution_ids":["https://openalex.org/I1293502524"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K Thorson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1293502524","display_name":"Loma Linda University Medical Center","ror":"https://ror.org/03et1qs84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293502524"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Thorson","raw_affiliation_strings":["Loma Linda University Medical Center, Transplantation Institute, Loma Linda, CA 92354"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loma Linda University Medical Center, Transplantation Institute, Loma Linda, CA 92354","institution_ids":["https://openalex.org/I1293502524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112445725","display_name":"Patricia Radovich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1293502524","display_name":"Loma Linda University Medical Center","ror":"https://ror.org/03et1qs84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293502524"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P Radovich","raw_affiliation_strings":["Loma Linda University Medical Center, Transplantation Institute, Loma Linda, CA 92354"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loma Linda University Medical Center, Transplantation Institute, Loma Linda, CA 92354","institution_ids":["https://openalex.org/I1293502524"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009748781","display_name":"Waldo Concepcion","orcid":"https://orcid.org/0000-0002-0367-0531","observed_orcids":["https://orcid.org/0000-0002-0367-0531"]},"institutions":[{"id":"https://openalex.org/I1293502524","display_name":"Loma Linda University Medical Center","ror":"https://ror.org/03et1qs84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293502524"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W Concepcion","raw_affiliation_strings":["Loma Linda University Medical Center, Transplantation Institute, Loma Linda, CA 92354"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loma Linda University Medical Center, Transplantation Institute, Loma Linda, CA 92354","institution_ids":["https://openalex.org/I1293502524"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1293502524"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13955498,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"67","issue":"9","first_page":"S603","last_page":"S603"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycophenolate-mofetil","display_name":"mycophenolate mofetil","score":0.9929999709129333},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":0.9559999704360962},{"id":"https://openalex.org/keywords/tacrolimus","display_name":"tacrolimus","score":0.9559999704360962},{"id":"https://openalex.org/keywords/prednisone","display_name":"prednisone","score":0.9520000219345093},{"id":"https://openalex.org/keywords/immunosuppression-reduction","display_name":"immunosuppression reduction","score":0.9409999847412109},{"id":"https://openalex.org/keywords/acute-rejection","display_name":"acute rejection","score":0.878000020980835},{"id":"https://openalex.org/keywords/kidney-failure","display_name":"renal failure","score":0.8859999775886536},{"id":"https://openalex.org/keywords/creatinine-clearance","display_name":"creatinine clearance","score":0.7860000133514404},{"id":"https://openalex.org/keywords/recurrent-hepatitis-c","display_name":"recurrent hepatitis C","score":0.9179999828338623},{"id":"https://openalex.org/keywords/wound-infection","display_name":"wound infection","score":0.7889999747276306},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.527999997138977},{"id":"https://openalex.org/keywords/allograft-function","display_name":"allograft function","score":0.7360000014305115},{"id":"https://openalex.org/keywords/immunosuppressive-side-effects","display_name":"immunosuppressive side effects","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8346995115280151},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.7992005944252014},{"id":"https://openalex.org/C2909675724","wikidata":"https://www.wikidata.org/wiki/Q411648","display_name":"Tacrolimus","level":3,"score":0.7493304014205933},{"id":"https://openalex.org/C2778033501","wikidata":"https://www.wikidata.org/wiki/Q420553","display_name":"Mycophenolic acid","level":3,"score":0.6026865243911743},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5842176675796509},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.5815544128417969},{"id":"https://openalex.org/C2778720950","wikidata":"https://www.wikidata.org/wiki/Q424972","display_name":"Prednisone","level":2,"score":0.5739948749542236},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.5433713793754578},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.532840371131897},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.508150577545166},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5041021108627319},{"id":"https://openalex.org/C2780372218","wikidata":"https://www.wikidata.org/wiki/Q417222","display_name":"Methylprednisolone","level":2,"score":0.49045178294181824},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.4773557186126709},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.4588537812232971},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4506906270980835},{"id":"https://openalex.org/C2992208098","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver function","level":2,"score":0.4420836567878723},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.35526448488235474}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/00007890-199905150-00265","doi":"https://doi.org/10.1097/00007890-199905150-00265","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199905150-00265","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2125901916","https://openalex.org/W2012507870","https://openalex.org/W2077581803","https://openalex.org/W3134128215","https://openalex.org/W2011298598","https://openalex.org/W2068523234","https://openalex.org/W2057674328","https://openalex.org/W2037815991","https://openalex.org/W1978563142","https://openalex.org/W2075913227"],"abstract_inverted_index":{"241":[0],"Despite":[1],"proven":[2],"effectiveness":[3],"in":[4,8,167,172,213,240],"reducing":[5],"acute":[6],"rejection":[7,208,322],"liver":[9,75,235],"transplant":[10,88],"(OLT)":[11],"recipients,":[12],"tacrolimus":[13],"(Prograf\u00ae,":[14],"TAC)":[15],"and":[16,37,184,189,198,234,286,293],"prednisone":[17],"(PRED)":[18],"still":[19],"present":[20],"significant":[21],"side":[22],"effects.":[23],"The":[24,45,205,257],"addition":[25,62,299],"of":[26,35,47,58,63,87,105,138,142,151,207,243,259,267,300,308,321],"mycophenolate":[27],"(Cellcept\u00ae,":[28],"MMF)":[29],"may":[30],"allow":[31],"for":[32,154,177,200,221],"lower":[33],"doses":[34],"TAC":[36,78,162],"PRED,":[38],"especially":[39],"during":[40,247],"the":[41,53,66,71,106,178,222,248],"early":[42],"post-transplant":[43],"period.":[44],"purpose":[46],"this":[48],"study":[49],"is":[50],"to":[51,65,160,195,218,273,302],"evaluate":[52],"impact":[54],"on":[55,77,123,128],"overall":[56,306],"reduction":[57,307],"immunosuppressive":[59],"medications":[60],"via":[61,231],"MMF":[64,82,274,301],"TAC/PRED":[67,303,309],"regimen":[68,79,304],"without":[69,317],"compromising":[70],"allograft":[72],"function.":[73],"35":[74],"recipients":[76,89],"were":[80,108,181,290],"given":[81],"immediately":[83],"post-op.":[84],"Mean":[85,170],"age":[86],"was":[90,100,132,165,210,229,262],"49.3":[91],"years":[92],"(ranges":[93],"25-65":[94],"years).":[95],"1":[96,113,157],"year":[97],"patient":[98],"survival":[99],"91.2%":[101],"(32/35).":[102],"19/35":[103],"(54.3%)":[104],"patients":[107,139,180,215,268],"HCV":[109,226,238,324],"positive.":[110],"All":[111],"received":[112],"gram":[114],"methylprednisolone":[115],"intra-op":[116],"with":[117,146],"rapid":[118],"taper":[119],"(PRED":[120],"100":[121],"mg":[122,127],"POD":[124,129],"1,":[125,187],"20":[126],"5).":[130],"Immunosuppression":[131],"as":[133,193,216],"follows:":[134],"(Table)":[135],"17/35":[136],"(48.6%)":[137],"had":[140,269],"evidence":[141],"renal":[143,202,314],"insufficiency":[144],"(RI)":[145],"creatinine":[147],"clearance":[148],"(Cr":[149],"Cl)":[150],"<60":[152],"cc/min":[153],"at":[155,186,284],"least":[156],"month":[158],"prior":[159],"transplantation.":[161],"immunosuppression":[163],"initiation":[164],"lowered":[166],"these":[168],"patients.":[169,204],"changes":[171],"Cr":[173],"Cl":[174],"following":[175],"OLT":[176],"RI":[179,214],"+45.1%,":[182],"+36.7%,":[183],"+67.9%":[185],"6,":[188],"12":[190,287],"months":[191,251,288],"post-op":[192,289],"compared":[194,217],"\u221225.4%,":[196],"\u221217.4%,":[197],"\u22127.6%":[199],"normal":[201],"function":[203,315],"incidence":[206,320],"episodes":[209],"41.2%":[211],"(7/17)":[212],"27.8%":[219],"(5/18)":[220],"other":[223],"group":[224],"(p=0.32).":[225],"recurrence":[227],"diagnosis":[228],"made":[230],"biochemical,":[232],"HCV-RNA":[233],"biopsy":[236],"studies.":[237],"recurred":[239],"10":[241],"out":[242],"19":[244],"(52.6%),":[245],"mostly":[246],"first":[249],"3":[250,285],"(median:":[252],"2":[253],"months,":[254],"range":[255],"1-12).":[256],"rate":[258],"wound":[260],"infection":[261],"2.9%":[263],"(1/35).":[264],"22.9%":[265],"(8/35)":[266],"side-effects":[270],"directly":[271],"attributable":[272],"(diarrhea,":[275],"abdominal":[276],"cramping,":[277],"nausea,":[278],"vomiting,":[279],"neutropenia).":[280],"Complete":[281],"steroid":[282],"withdrawal":[283],"12%":[291],"(3/25)":[292],"90.9%":[294],"(10/11),":[295],"respectively.":[296],"In":[297],"summary,":[298],"allowed":[305],"doses.":[310],"This":[311],"prevented":[312],"further":[313],"deterioration":[316],"an":[318],"increased":[319],"or":[323],"recurrence.Table":[325]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
