{"id":"https://openalex.org/W1978338923","doi":"https://doi.org/10.1016/j.cyto.2006.04.002","title":"Relationship of thrombopoietin and interleukin-11 levels to thrombocytopenia associated with dengue disease","display_name":"Relationship of thrombopoietin and interleukin-11 levels to thrombocytopenia associated with dengue disease","publication_year":2006,"publication_date":"2006-05-01","ids":{"openalex":"https://openalex.org/W1978338923","doi":"https://doi.org/10.1016/j.cyto.2006.04.002","mag":"1978338923","pmid":"https://pubmed.ncbi.nlm.nih.gov/16759877"},"language":"en","primary_location":{"id":"doi:10.1016/j.cyto.2006.04.002","doi":"https://doi.org/10.1016/j.cyto.2006.04.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cyto.2006.04.002","pdf_url":null,"source":{"id":"https://openalex.org/S70396342","display_name":"Cytokine","issn_l":"1043-4666","issn":["1043-4666","1096-0023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytokine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039331923","display_name":"Jos\u00e9 E. Cardier","orcid":"https://orcid.org/0000-0002-5597-5505","observed_orcids":["https://orcid.org/0000-0002-5597-5505"]},"institutions":[{"id":"https://openalex.org/I191242182","display_name":"Instituto Venezolano de Investigaciones Cient\u00edficas","ror":"https://ror.org/02ntheh91","country_code":"VE","type":"facility","lineage":["https://openalex.org/I191242182"]}],"countries":["VE"],"is_corresponding":true,"raw_author_name":"Jose E. Cardier","raw_affiliation_strings":["Laboratorio de Patolog\u00eda Celular y Molecular, Centro de Medicina Experimental, Instituto Venezolano de Investigaciones Cient\u00edficas, IVIC, Apartado 21827, Caracas 1020-A, Venezuela. jcardier@ivic.ve","Laboratorio de Patolog\u00eda Celular y Molecular, Centro de Medicina Experimental, Instituto Venezolano de Investigaciones Cient\u00edficas, IVIC, Apartado 21827, Caracas 1020-A, Venezuela"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Patolog\u00eda Celular y Molecular, Centro de Medicina Experimental, Instituto Venezolano de Investigaciones Cient\u00edficas, IVIC, Apartado 21827, Caracas 1020-A, Venezuela. jcardier@ivic.ve","institution_ids":["https://openalex.org/I191242182"]},{"raw_affiliation_string":"Laboratorio de Patolog\u00eda Celular y Molecular, Centro de Medicina Experimental, Instituto Venezolano de Investigaciones Cient\u00edficas, IVIC, Apartado 21827, Caracas 1020-A, Venezuela","institution_ids":["https://openalex.org/I191242182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029536185","display_name":"Valeria Balogh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Valeria Balogh","raw_affiliation_strings":["Departamento de Pediatr\u00eda, Hospital General del Oeste, Caracas, Venezuela"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Pediatr\u00eda, Hospital General del Oeste, Caracas, Venezuela","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025803393","display_name":"Carlos Perez-Silva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191242182","display_name":"Instituto Venezolano de Investigaciones Cient\u00edficas","ror":"https://ror.org/02ntheh91","country_code":"VE","type":"facility","lineage":["https://openalex.org/I191242182"]}],"countries":["VE"],"is_corresponding":false,"raw_author_name":"Carlos Perez-Silva","raw_affiliation_strings":["Laboratorio de Patolog\u00eda Celular y Molecular, Centro de Medicina Experimental, Instituto Venezolano de Investigaciones Cient\u00edficas, IVIC, Apartado 21827, Caracas 1020-A, Venezuela"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Patolog\u00eda Celular y Molecular, Centro de Medicina Experimental, Instituto Venezolano de Investigaciones Cient\u00edficas, IVIC, Apartado 21827, Caracas 1020-A, Venezuela","institution_ids":["https://openalex.org/I191242182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111989613","display_name":"Egidio L Romano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191242182","display_name":"Instituto Venezolano de Investigaciones Cient\u00edficas","ror":"https://ror.org/02ntheh91","country_code":"VE","type":"facility","lineage":["https://openalex.org/I191242182"]}],"countries":["VE"],"is_corresponding":false,"raw_author_name":"Egidio Romano","raw_affiliation_strings":["Laboratorio de Patolog\u00eda Celular y Molecular, Centro de Medicina Experimental, Instituto Venezolano de Investigaciones Cient\u00edficas, IVIC, Apartado 21827, Caracas 1020-A, Venezuela"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Patolog\u00eda Celular y Molecular, Centro de Medicina Experimental, Instituto Venezolano de Investigaciones Cient\u00edficas, IVIC, Apartado 21827, Caracas 1020-A, Venezuela","institution_ids":["https://openalex.org/I191242182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112692851","display_name":"Betty Rivas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191242182","display_name":"Instituto Venezolano de Investigaciones Cient\u00edficas","ror":"https://ror.org/02ntheh91","country_code":"VE","type":"facility","lineage":["https://openalex.org/I191242182"]}],"countries":["VE"],"is_corresponding":false,"raw_author_name":"Betty Rivas","raw_affiliation_strings":["Laboratorio de Patolog\u00eda Celular y Molecular, Centro de Medicina Experimental, Instituto Venezolano de Investigaciones Cient\u00edficas, IVIC, Apartado 21827, Caracas 1020-A, Venezuela"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Patolog\u00eda Celular y Molecular, Centro de Medicina Experimental, Instituto Venezolano de Investigaciones Cient\u00edficas, IVIC, Apartado 21827, Caracas 1020-A, Venezuela","institution_ids":["https://openalex.org/I191242182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091283123","display_name":"Norma de Bosch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Norma Bosch","raw_affiliation_strings":["Banco Municipal de Sangre, Caracas, Venezuela"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Banco Municipal de Sangre, Caracas, Venezuela","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042897977","display_name":"Alan L. Rothman","orcid":"https://orcid.org/0000-0002-4064-6848","observed_orcids":["https://orcid.org/0000-0002-4064-6848"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan L. Rothman","raw_affiliation_strings":["Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA","institution_ids":["https://openalex.org/I166722992"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039331923"],"corresponding_institution_ids":["https://openalex.org/I191242182"],"apc_list":{"value":3220,"currency":"USD","value_usd":3220},"apc_paid":null,"fwci":0.6029,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.70851917,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"34","issue":"3-4","first_page":"155","last_page":"160"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.5644999742507935,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.5644999742507935,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.42410001158714294,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thrombopoietin","display_name":"thrombopoietin","score":0.9900000095367432},{"id":"https://openalex.org/keywords/interleukin-11","display_name":"interleukin-11","score":1.0},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.9610000252723694},{"id":"https://openalex.org/keywords/dengue","display_name":"dengue","score":0.9729999899864197},{"id":"https://openalex.org/keywords/dengue-hemorrhagic-fever","display_name":"dengue hemorrhagic fever","score":1.0},{"id":"https://openalex.org/keywords/megakaryopoiesis","display_name":"megakaryopoiesis","score":0.8560000061988831},{"id":"https://openalex.org/keywords/serum-cytokine-levels","display_name":"serum cytokine levels","score":0.7490000128746033},{"id":"https://openalex.org/keywords/disease-severity-markers","display_name":"disease severity markers","score":0.6579999923706055},{"id":"https://openalex.org/keywords/platelet-count","display_name":"platelet count","score":0.9610000252723694}],"concepts":[{"id":"https://openalex.org/C2777863708","wikidata":"https://www.wikidata.org/wiki/Q424519","display_name":"Thrombopoietin","level":4,"score":0.9414211511611938},{"id":"https://openalex.org/C533803919","wikidata":"https://www.wikidata.org/wiki/Q30953","display_name":"Dengue fever","level":2,"score":0.9396666288375854},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6723766326904297},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.6149412989616394},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5765224099159241},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4621357023715973},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4262327551841736},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4131471514701843},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.34328693151474},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11586669087409973},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003715","descriptor_name":"Dengue","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003715","descriptor_name":"Dengue","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013921","descriptor_name":"Thrombocytopenia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013921","descriptor_name":"Thrombocytopenia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013926","descriptor_name":"Thrombopoietin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013926","descriptor_name":"Thrombopoietin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017370","descriptor_name":"Interleukin-11","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D017370","descriptor_name":"Interleukin-11","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019595","descriptor_name":"Severe Dengue","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019595","descriptor_name":"Severe Dengue","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cyto.2006.04.002","doi":"https://doi.org/10.1016/j.cyto.2006.04.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cyto.2006.04.002","pdf_url":null,"source":{"id":"https://openalex.org/S70396342","display_name":"Cytokine","issn_l":"1043-4666","issn":["1043-4666","1096-0023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytokine","raw_type":"journal-article"},{"id":"pmid:16759877","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16759877","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytokine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G7838405263","display_name":"PATHOGENESIS OF SEVERE DENGUE INFECTIONS IN VENEZUELA","funder_award_id":"U01AI045440","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320324661","display_name":"Instituto Venezolano de Investigaciones Cient\u00edficas","ror":"https://ror.org/02ntheh91"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W6030807","https://openalex.org/W30608508","https://openalex.org/W36327546","https://openalex.org/W38660889","https://openalex.org/W117742811","https://openalex.org/W131887615","https://openalex.org/W175685950","https://openalex.org/W187398516","https://openalex.org/W203870649","https://openalex.org/W244034654","https://openalex.org/W1591506260","https://openalex.org/W1693659057","https://openalex.org/W1773048998","https://openalex.org/W1876401430","https://openalex.org/W1890881866","https://openalex.org/W1965375035","https://openalex.org/W1971987125","https://openalex.org/W1978546125","https://openalex.org/W1981566497","https://openalex.org/W1983612778","https://openalex.org/W1986497454","https://openalex.org/W1991205890","https://openalex.org/W2000583684","https://openalex.org/W2015868748","https://openalex.org/W2018750823","https://openalex.org/W2038818733","https://openalex.org/W2046997318","https://openalex.org/W2059439339","https://openalex.org/W2078616156","https://openalex.org/W2081185151","https://openalex.org/W2093758335","https://openalex.org/W2097875686","https://openalex.org/W2099883895","https://openalex.org/W2143531841","https://openalex.org/W2144628854","https://openalex.org/W2151286459","https://openalex.org/W2211902599","https://openalex.org/W2260183312","https://openalex.org/W2260760629","https://openalex.org/W2342394157","https://openalex.org/W2416394440","https://openalex.org/W2417492903","https://openalex.org/W2594348894","https://openalex.org/W2983070422","https://openalex.org/W4238628831","https://openalex.org/W6841362215"],"related_works":["https://openalex.org/W2409883261","https://openalex.org/W4289125449","https://openalex.org/W2443681805","https://openalex.org/W2182567865","https://openalex.org/W4403195924","https://openalex.org/W2298570529","https://openalex.org/W4411962704","https://openalex.org/W2000578660","https://openalex.org/W6940665488","https://openalex.org/W7134915637"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}