{"id":"https://openalex.org/W1978337405","doi":"https://doi.org/10.1046/j.1365-2362.1997.1730718.x","title":"Effects of low\u2010dose l \u2010arginine on insulin\u2010mediated vasodilatation and insulin sensitivity","display_name":"Effects of low\u2010dose l \u2010arginine on insulin\u2010mediated vasodilatation and insulin sensitivity","publication_year":1997,"publication_date":"1997-08-01","ids":{"openalex":"https://openalex.org/W1978337405","doi":"https://doi.org/10.1046/j.1365-2362.1997.1730718.x","mag":"1978337405","pmid":"https://pubmed.ncbi.nlm.nih.gov/9279534"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2362.1997.1730718.x","doi":"https://doi.org/10.1046/j.1365-2362.1997.1730718.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2362.1997.1730718.x","pdf_url":null,"source":{"id":"https://openalex.org/S153084679","display_name":"European Journal of Clinical Investigation","issn_l":"0014-2972","issn":["0014-2972","1365-2362"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110028723","display_name":"Thomas C. Wascher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"T. C. WASCHER","raw_affiliation_strings":["Department of Internal Medicine, Karl-Franzens University of Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Karl-Franzens University of Graz, Austria","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053111848","display_name":"Wolfgang F. Graier","orcid":"https://orcid.org/0000-0003-1871-3298","observed_orcids":["https://orcid.org/0000-0003-1871-3298"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. F. GRAIER","raw_affiliation_strings":["Institute of Medical Biochemistry,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Biochemistry,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113592309","display_name":"P. Dittrich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"P. DITTRICH","raw_affiliation_strings":["Institute of Pharmacology and Toxicology, Karl-Franzens University of Graz, Austria;,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacology and Toxicology, Karl-Franzens University of Graz, Austria;,","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111445728","display_name":"Mehboob Ali Hussain","orcid":"https://orcid.org/0000-0003-2536-732X","observed_orcids":["https://orcid.org/0000-0003-2536-732X"]},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"M. A. HUSSAIN","raw_affiliation_strings":["Department of Internal Medicine, University Hospital of Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University Hospital of Zurich, Switzerland","institution_ids":["https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":null,"display_name":"B. BAHADORI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. BAHADORI","raw_affiliation_strings":["Department of Internal Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021681760","display_name":"Stefan Wallner","orcid":"https://orcid.org/0000-0002-3365-9579","observed_orcids":["https://orcid.org/0000-0002-3365-9579"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. WALLNER","raw_affiliation_strings":["Department of Internal Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036073749","display_name":"Hermann Toplak","orcid":"https://orcid.org/0000-0002-7513-5167","observed_orcids":["https://orcid.org/0000-0002-7513-5167"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. TOPLAK","raw_affiliation_strings":["Department of Internal Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110028723"],"corresponding_institution_ids":["https://openalex.org/I15766117"],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":null,"fwci":2.3071,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.87076632,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"27","issue":"8","first_page":"690","last_page":"695"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.03449999913573265,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":0.9950000047683716},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.9959999918937683},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9210000038146973},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9509999752044678},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.5979999899864197},{"id":"https://openalex.org/keywords/intravenous-supplementation","display_name":"intravenous supplementation","score":0.7009999752044678},{"id":"https://openalex.org/keywords/insulin-suppression-test","display_name":"insulin suppression test","score":0.8500000238418579},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.8159999847412109},{"id":"https://openalex.org/keywords/free-fatty-acids","display_name":"free fatty acids","score":0.906000018119812},{"id":"https://openalex.org/keywords/c-peptide","display_name":"C-peptide","score":0.9380000233650208}],"concepts":[{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.774597704410553},{"id":"https://openalex.org/C3017594256","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin sensitivity","level":4,"score":0.7087237238883972},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.6334974765777588},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.6326091289520264},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5374823808670044},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5284338593482971},{"id":"https://openalex.org/C2780352109","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic hormone","level":4,"score":0.45814958214759827},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44467073678970337},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40808555483818054},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3542022705078125},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.33036863803863525},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1713758111000061},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.10655659437179565}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002096","descriptor_name":"C-Peptide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1365-2362.1997.1730718.x","doi":"https://doi.org/10.1046/j.1365-2362.1997.1730718.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2362.1997.1730718.x","pdf_url":null,"source":{"id":"https://openalex.org/S153084679","display_name":"European Journal of Clinical Investigation","issn_l":"0014-2972","issn":["0014-2972","1365-2362"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmid:9279534","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9279534","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of clinical investigation","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322325","display_name":"Oesterreichische Nationalbank","ror":"https://ror.org/00nkcmy90"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2169456011","https://openalex.org/W2080287320","https://openalex.org/W3175819129","https://openalex.org/W2396569693","https://openalex.org/W2438446568","https://openalex.org/W1979511150","https://openalex.org/W2154528603","https://openalex.org/W2009719117","https://openalex.org/W2412185523","https://openalex.org/W1982288629"],"abstract_inverted_index":{"The":[0,23],"present":[1],"study":[2,24],"was":[3,25,50,123,134,152],"carried":[4],"out":[5],"to":[6],"evaluate":[7],"the":[8,57,72,88,169,215],"effect":[9,119,149],"of":[10,15,76,80,146,150,217],"a":[11,77,208],"low-dose":[12],"intravenous":[13,188],"supplementation":[14],"L-arginine":[16,81,151,191],"on":[17,120,154],"insulin-mediated":[18,90,178,218],"vasodilatation":[19,49,91,179],"and":[20,33,40,104,182,198],"insulin":[21,58,62,121,170,193],"sensitivity.":[22,63],"performed":[26,66],"in":[27,68,71,93,140,180,195,204],"healthy":[28,116,205],"subjects":[29],"(n":[30,37,45],"=":[31,38,46],"7)":[32],"patients":[34,197,200],"with":[35],"obesity":[36,94,181],"9)":[39],"non-insulin-dependent":[41],"diabetes":[42],"mellitus":[43],"(NIDDM)":[44],"9).":[47],"Insulin-mediated":[48],"measured":[51],"by":[52,144,187],"venous":[53],"occlusion":[54],"plethysmography":[55],"during":[56,168],"suppression":[59,171],"test,":[60],"evaluating":[61],"Experiments":[64],"were":[65],"twice":[67],"each":[69],"subject":[70],"presence":[73],"or":[74,165],"absence":[75],"concomitant":[78],"infusion":[79,145],"(0.52":[82],"mg":[83],"kg-1":[84],"min-1).":[85],"L-Arginine":[86],"restored":[87],"imparied":[89],"observed":[92,124,153],"(22.4":[95],"+/-":[96,107,126,130],"4.1%,":[97],"P":[98,109],"<":[99,110,138],"0.01":[100,111],"vs.":[101,112,128],"without":[102,113],"L-arginine)":[103],"NIDDM":[105,183,199],"(20.3":[106],"3.2%,":[108],"L-arginine).":[114],"In":[115],"subjects,":[117,206],"no":[118],"mediated-vasodilatation":[122],"(24.8":[125],"3.1%":[127],"21.4":[129],"3.1%).":[131],"Insulin":[132],"sensitivity":[133,194],"improved":[135],"significantly":[136],"(P":[137],"0.001)":[139],"all":[141],"three":[142],"groups":[143],"L-arginine.":[147,189],"No":[148],"insulin,":[155],"insulin-like":[156],"growth":[157],"factor":[158],"I":[159],"(IGF-I),":[160],"free":[161],"fatty":[162],"acids":[163],"(FFAs)":[164],"C-peptide":[166],"levels":[167],"test.":[172],"Our":[173],"data":[174],"indicate":[175],"that":[176,211],"defective":[177],"can":[184],"be":[185],"normalized":[186],"Furthermore,":[190],"improves":[192],"obese":[196],"as":[201,203],"well":[202],"indicating":[207],"possible":[209],"mechanism":[210],"is":[212],"different":[213],"from":[214],"restoration":[216],"vasodilatation.":[219]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}