{"id":"https://openalex.org/W1978332330","doi":"https://doi.org/10.1158/1538-7445.am2012-4398","title":"Abstract 4398: Liver is a major primary target for the Toll-like receptor-5 agonist CBLB502 providing radioprotective, antimicrobial and antitumor responses","display_name":"Abstract 4398: Liver is a major primary target for the Toll-like receptor-5 agonist CBLB502 providing radioprotective, antimicrobial and antitumor responses","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W1978332330","doi":"https://doi.org/10.1158/1538-7445.am2012-4398","mag":"1978332330"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2012-4398","doi":"https://doi.org/10.1158/1538-7445.am2012-4398","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-4398","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087204160","display_name":"Lyudmila G. Burdelya","orcid":"https://orcid.org/0000-0001-8632-9154","observed_orcids":["https://orcid.org/0000-0001-8632-9154"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lyudmila Burdelya","raw_affiliation_strings":["1Roswell Rark Cancer Institute, Buffalo, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Roswell Rark Cancer Institute, Buffalo, NY","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027765728","display_name":"Katerina I. Leonova","orcid":"https://orcid.org/0000-0001-5068-5341","observed_orcids":["https://orcid.org/0000-0001-5068-5341"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katerina Leonova","raw_affiliation_strings":["1Roswell Rark Cancer Institute, Buffalo, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Roswell Rark Cancer Institute, Buffalo, NY","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035938490","display_name":"Ilya I. Gitlin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ilya Gitlin","raw_affiliation_strings":["1Roswell Rark Cancer Institute, Buffalo, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Roswell Rark Cancer Institute, Buffalo, NY","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053311556","display_name":"Bojidar Kojouharov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bojidar Kojouharov","raw_affiliation_strings":["1Roswell Rark Cancer Institute, Buffalo, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Roswell Rark Cancer Institute, Buffalo, NY","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091541028","display_name":"Semra Aygun\u2010Sunar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Semra Aygun-Sunar","raw_affiliation_strings":["1Roswell Rark Cancer Institute, Buffalo, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Roswell Rark Cancer Institute, Buffalo, NY","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041420495","display_name":"Jean M. Veith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean Veith","raw_affiliation_strings":["1Roswell Rark Cancer Institute, Buffalo, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Roswell Rark Cancer Institute, Buffalo, NY","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101664946","display_name":"Christopher N. Johnson","orcid":"https://orcid.org/0000-0002-5307-798X","observed_orcids":["https://orcid.org/0000-0002-5307-798X"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Johnson","raw_affiliation_strings":["1Roswell Rark Cancer Institute, Buffalo, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Roswell Rark Cancer Institute, Buffalo, NY","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034188920","display_name":"Anatoli S. Gleiberman","orcid":"https://orcid.org/0000-0001-8491-0826","observed_orcids":["https://orcid.org/0000-0001-8491-0826"]},"institutions":[{"id":"https://openalex.org/I4210113396","display_name":"Cleveland BioLabs (United States)","ror":"https://ror.org/02bxsr265","country_code":"US","type":"company","lineage":["https://openalex.org/I4210113396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anatoli Gleiberman","raw_affiliation_strings":["2Cleveland Biolabs, Inc., Buffalo, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Cleveland Biolabs, Inc., Buffalo, NY","institution_ids":["https://openalex.org/I4210113396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053141762","display_name":"Gary J. Haderski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113396","display_name":"Cleveland BioLabs (United States)","ror":"https://ror.org/02bxsr265","country_code":"US","type":"company","lineage":["https://openalex.org/I4210113396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary Haderski","raw_affiliation_strings":["2Cleveland Biolabs, Inc., Buffalo, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Cleveland Biolabs, Inc., Buffalo, NY","institution_ids":["https://openalex.org/I4210113396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061809726","display_name":"Shyam S.R. Allamaneni","orcid":"https://orcid.org/0000-0002-2779-3296","observed_orcids":["https://orcid.org/0000-0002-2779-3296"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shyam Allamaneni","raw_affiliation_strings":["1Roswell Rark Cancer Institute, Buffalo, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Roswell Rark Cancer Institute, Buffalo, NY","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029079928","display_name":"Joseph J. Skitzki","orcid":"https://orcid.org/0000-0002-3689-2843","observed_orcids":["https://orcid.org/0000-0002-3689-2843"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Skitzki","raw_affiliation_strings":["1Roswell Rark Cancer Institute, Buffalo, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Roswell Rark Cancer Institute, Buffalo, NY","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082732378","display_name":"Patricia Stanhope-Baker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113396","display_name":"Cleveland BioLabs (United States)","ror":"https://ror.org/02bxsr265","country_code":"US","type":"company","lineage":["https://openalex.org/I4210113396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia Stanhope-Baker","raw_affiliation_strings":["2Cleveland Biolabs, Inc., Buffalo, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Cleveland Biolabs, Inc., Buffalo, NY","institution_ids":["https://openalex.org/I4210113396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113324192","display_name":"D. V. Scheblyakov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099524","display_name":"Gamalei Institute of Epidemiology and Microbiology","ror":"https://ror.org/01616eq90","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210099524"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Dmitry Scheblyakov","raw_affiliation_strings":["3Gamaleya Research Institute for Epidemiology and Microbiology, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Gamaleya Research Institute for Epidemiology and Microbiology, Moscow, Russian Federation","institution_ids":["https://openalex.org/I4210099524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005313486","display_name":"Denis Y. Logunov","orcid":"https://orcid.org/0000-0003-4035-6581","observed_orcids":["https://orcid.org/0000-0003-4035-6581"]},"institutions":[{"id":"https://openalex.org/I4210099524","display_name":"Gamalei Institute of Epidemiology and Microbiology","ror":"https://ror.org/01616eq90","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210099524"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Denis Logunov","raw_affiliation_strings":["3Gamaleya Research Institute for Epidemiology and Microbiology, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Gamaleya Research Institute for Epidemiology and Microbiology, Moscow, Russian Federation","institution_ids":["https://openalex.org/I4210099524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063921601","display_name":"Boris Narodisky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099524","display_name":"Gamalei Institute of Epidemiology and Microbiology","ror":"https://ror.org/01616eq90","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210099524"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Boris Narodisky","raw_affiliation_strings":["3Gamaleya Research Institute for Epidemiology and Microbiology, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Gamaleya Research Institute for Epidemiology and Microbiology, Moscow, Russian Federation","institution_ids":["https://openalex.org/I4210099524"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069808553","display_name":"Andrei V. Gudkov","orcid":"https://orcid.org/0000-0003-2548-0154","observed_orcids":["https://orcid.org/0000-0003-2548-0154"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrei Gudkov","raw_affiliation_strings":["1Roswell Rark Cancer Institute, Buffalo, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Roswell Rark Cancer Institute, Buffalo, NY","institution_ids":["https://openalex.org/I1292894508"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"8_Supplement","first_page":"4398","last_page":"4398"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.019300000742077827,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr5","display_name":"TLR5","score":0.7950000166893005},{"id":"https://openalex.org/keywords/flagellin","display_name":"flagellin","score":0.7870000004768372},{"id":"https://openalex.org/keywords/radiation-protection","display_name":"radiation protection","score":0.9319999814033508},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.5249999761581421},{"id":"https://openalex.org/keywords/nf-kb","display_name":"NF-kB","score":0.6919999718666077},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.9860000014305115},{"id":"https://openalex.org/keywords/salmonella-typhimurium-infection","display_name":"Salmonella typhimurium infection","score":0.7839999794960022},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7549999952316284},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.7699999809265137},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.7480000257492065}],"concepts":[{"id":"https://openalex.org/C2777338127","wikidata":"https://www.wikidata.org/wiki/Q14914085","display_name":"TLR5","level":5,"score":0.9085972309112549},{"id":"https://openalex.org/C38117629","wikidata":"https://www.wikidata.org/wiki/Q24788421","display_name":"Flagellin","level":3,"score":0.6514414548873901},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.5943247675895691},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5847744345664978},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5717101097106934},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.5587469935417175},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.4918990135192871},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4764048159122467},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4751149117946625},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46370819211006165},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4336608052253723},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4052181839942932},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2900640368461609},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.27243155241012573},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.2157997190952301},{"id":"https://openalex.org/C2781236682","wikidata":"https://www.wikidata.org/wiki/Q410015","display_name":"TLR2","level":4,"score":0.20297616720199585},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08379164338111877},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2012-4398","doi":"https://doi.org/10.1158/1538-7445.am2012-4398","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-4398","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1996726345","https://openalex.org/W2330558320","https://openalex.org/W2057858743","https://openalex.org/W2607012424","https://openalex.org/W2076603535","https://openalex.org/W3146679204","https://openalex.org/W2802814283","https://openalex.org/W4313351546","https://openalex.org/W1186717816","https://openalex.org/W2886067522"],"abstract_inverted_index":{"Abstract":[0],"We":[1],"have":[2,114],"previously":[3],"shown":[4],"that":[5,39,187,245],"activation":[6,267],"of":[7,68,104,120,131,141,179,204,213,223,226,232,235,249,268,303,345,350],"Toll-like":[8],"receptor":[9],"5":[10],"(TLR5)":[11],"by":[12,16,128,262],"bacterial":[13],"flagellin":[14,19],"and":[15,24,33,56,59,74,80,98,165,256,287,317,335],"pharmacologically":[17],"optimized":[18],"derivative":[20],"CBLB502":[21,46,123,142,150,173,214,227,276,304],"protects":[22],"mice":[23,65],"monkeys":[25],"from":[26,63,333],"lethal":[27,160],"radiation":[28,177,334],"injury":[29],"to":[30,91,95,159,166,194,329],"the":[31,40,84,88,138,224,246,250,272,346,351],"hematopoietic":[32,144],"gastrointestinal":[34],"systems.":[35],"Here,":[36],"we":[37,185,299],"report":[38],"liver":[41,89,121,132,153,163,293,311],"is":[42,110,253,257],"a":[43],"major":[44],"primary":[45],"target":[47],"organ":[48],"in":[49,147,174,183,202,218,229,240,271,281,320],"mice,":[50],"with":[51,77,176,197,259],"hepatocytes":[52],"specifically":[53],"showing":[54],"rapid":[55],"strong":[57,115],"NF-kB":[58],"STAT3":[60],"activation.":[61],"Livers":[62],"CBLB502-treated":[64],"showed":[66,244],"up-regulation":[67],"numerous":[69,205],"downstream":[70],"genes":[71],"encoding":[72],"intracellular":[73],"secreted":[75],"proteins":[76],"anti-apoptotic,":[78],"anti-microbial":[79],"immunomodulatory":[81],"activities.":[82],"Unlike":[83],"TLR4":[85],"agonist":[86,252],"LPS,":[87],"response":[90],"TLR5":[92,112,242,251,254,269,315],"agonists":[93,113],"appears":[94],"be":[96],"direct":[97,210],"does":[99],"not":[100],"involve":[101],"high":[102],"levels":[103],"proinflammatory":[105],"cytokines.":[106],"Thus,":[107],"while":[108],"LPS":[109],"toxic,":[111],"clinical":[116,301],"potential.":[117],"The":[118],"importance":[119],"for":[122,354],"radioprotective":[124],"activity":[125],"was":[126,216],"confirmed":[127],"temporary":[129],"occlusion":[130],"blood":[133],"circulation":[134],"which":[135],"completely":[136],"abrogated":[137],"protective":[139],"effect":[140,225,248,280],"on":[143,228,296,314],"precursor":[145],"cells":[146],"irradiated":[148],"mice.":[149],"also":[151],"protected":[152],"tissue":[154,189],"itself,":[155],"increasing":[156],"mouse":[157,181,206],"resistance":[158],"Salmonella":[161],"tiphymurium":[162],"infection":[164],"hepatotoxic":[167],"Fas":[168],"agonistic":[169],"antibodies.":[170],"By":[171],"testing":[172],"combination":[175],"treatment":[178,215],"experimental":[180,292],"tumors":[182,283,319],"vivo,":[184],"demonstrated":[186],"its":[188],"protection":[190,200],"properties":[191],"are":[192],"limited":[193],"normal":[195],"tissues":[196],"no":[198],"tumor":[199,207,220,236,260,273],"detected":[201],"any":[203],"models.":[208,221],"Moreover,":[209],"antitumor":[211,247],"effects":[212],"observed":[217],"several":[219],"Comparison":[222],"vivo":[230],"growth":[231],"isogenic":[233],"pairs":[234],"cell":[237],"lines":[238],"differing":[239],"their":[241],"status":[243,316],"dependent":[255],"associated":[258],"infiltration":[261],"immunocytes,":[263],"presumably":[264],"attracted":[265],"following":[266],"signaling":[270],"cells.":[274],"Remarkably,":[275],"caused":[277],"an":[278,306],"immunotherapeutic":[279,308],"TLR5-negative":[282],"(CT26":[284],"colon":[285],"adenocarcinoma":[286],"A20":[288],"lymphoma)":[289],"growing":[290],"as":[291,305,323,325],"metastases.":[294],"Based":[295],"these":[297],"results,":[298],"project":[300],"applications":[302],"anticancer":[307],"drug":[309,328],"against":[310],"metastases":[312],"independently":[313],"TLR5-expressing":[318],"other":[321],"locations":[322],"well":[324],"supporting":[326],"care":[327],"reduce":[330],"adverse":[331],"hepatotoxicity":[332],"chemotherapy.":[336],"Citation":[337],"Format:":[338],"{Authors}.":[339],"{Abstract":[340],"title}":[341],"[abstract].":[342],"In:":[343],"Proceedings":[344],"103rd":[347],"Annual":[348],"Meeting":[349],"American":[352],"Association":[353],"Cancer":[355,366],"Research;":[356],"2012":[357],"Mar":[358],"31-Apr":[359],"4;":[360],"Chicago,":[361],"IL.":[362],"Philadelphia":[363],"(PA):":[364],"AACR;":[365],"Res":[367],"2012;72(8":[368],"Suppl):Abstract":[369],"nr":[370],"4398.":[371],"doi:1538-7445.AM2012-4398":[372]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}
