{"id":"https://openalex.org/W1978328827","doi":"https://doi.org/10.1111/j.1365-2249.1992.tb05855.x","title":"CD4-independent binding of HIV-1 to the B lymphocyte receptor CR2 (CD21) in the presence of complement and antibody","display_name":"CD4-independent binding of HIV-1 to the B lymphocyte receptor CR2 (CD21) in the presence of complement and antibody","publication_year":1992,"publication_date":"1992-12-01","ids":{"openalex":"https://openalex.org/W1978328827","doi":"https://doi.org/10.1111/j.1365-2249.1992.tb05855.x","mag":"1978328827","pmid":"https://pubmed.ncbi.nlm.nih.gov/1360879","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1554591"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2249.1992.tb05855.x","doi":"https://doi.org/10.1111/j.1365-2249.1992.tb05855.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2249.1992.tb05855.x","pdf_url":"https://academic.oup.com/cei/article-pdf/90/3/383/42212168/j.1365-2249.1992.tb05855.x.pdf","source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/cei/article-pdf/90/3/383/42212168/j.1365-2249.1992.tb05855.x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004036928","display_name":"David C. Montefiori","orcid":"https://orcid.org/0000-0003-0856-6319","observed_orcids":["https://orcid.org/0000-0003-0856-6319"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"D C MONTEFIORI","raw_affiliation_strings":["Department of Pathology, Vanderbilt University Medical School, Nashville, TN, USA","Department of Pathology, Vanderbilt University Medical School, Nashville, TN 37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Vanderbilt University Medical School, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Pathology, Vanderbilt University Medical School, Nashville, TN 37232","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J ZHOU","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J ZHOU","raw_affiliation_strings":["Department of Pathology, Vanderbilt University Medical School, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Vanderbilt University Medical School, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059944945","display_name":"Darryn I. Shaff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D I SHAFF","raw_affiliation_strings":["Department of Pathology, Vanderbilt University Medical School, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Vanderbilt University Medical School, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5004036928"],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":{"value":2894,"currency":"GBP","value_usd":3816},"apc_paid":null,"fwci":0.6044,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.61595848,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"90","issue":"3","first_page":"383","last_page":"389"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cd21","display_name":"CD21","score":0.753000020980835},{"id":"https://openalex.org/keywords/complement-receptor-2","display_name":"CR2","score":0.8309999704360962},{"id":"https://openalex.org/keywords/complement-receptors","display_name":"complement receptors","score":0.6650000214576721},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.5120000243186951},{"id":"https://openalex.org/keywords/immunoglobulins","display_name":"immunoglobulins","score":0.7879999876022339},{"id":"https://openalex.org/keywords/infection-enhancement","display_name":"infection enhancement","score":0.8320000171661377},{"id":"https://openalex.org/keywords/complement-c3","display_name":"complement C3","score":0.6010000109672546},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.875},{"id":"https://openalex.org/keywords/hiv-1-tropism","display_name":"HIV-1 tropism","score":0.6299999952316284},{"id":"https://openalex.org/keywords/immunopathogenesis","display_name":"immunopathogenesis","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7572544813156128},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6308954954147339},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.6227970123291016},{"id":"https://openalex.org/C175773311","wikidata":"https://www.wikidata.org/wiki/Q5156412","display_name":"Complement receptor","level":4,"score":0.6144667267799377},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5476419925689697},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4951590597629547},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.48641371726989746},{"id":"https://openalex.org/C2910041089","wikidata":"https://www.wikidata.org/wiki/Q5156411","display_name":"Complement receptor 1","level":4,"score":0.45261532068252563},{"id":"https://openalex.org/C196594336","wikidata":"https://www.wikidata.org/wiki/Q1662341","display_name":"Antibody-dependent enhancement","level":4,"score":0.44319653511047363},{"id":"https://openalex.org/C189446657","wikidata":"https://www.wikidata.org/wiki/Q4736500","display_name":"Alternative complement pathway","level":4,"score":0.4165518879890442},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.2799263596534729},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.10797625780105591},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000945","descriptor_name":"Antigens, Differentiation, T-Lymphocyte","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002051","descriptor_name":"Burkitt Lymphoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011991","descriptor_name":"Receptors, Virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015728","descriptor_name":"Receptors, HIV","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018801","descriptor_name":"CD2 Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-2249.1992.tb05855.x","doi":"https://doi.org/10.1111/j.1365-2249.1992.tb05855.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2249.1992.tb05855.x","pdf_url":"https://academic.oup.com/cei/article-pdf/90/3/383/42212168/j.1365-2249.1992.tb05855.x.pdf","source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1554591","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1554591","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},{"id":"pmid:1360879","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1360879","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1111/j.1365-2249.1992.tb05855.x","doi":"https://doi.org/10.1111/j.1365-2249.1992.tb05855.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2249.1992.tb05855.x","pdf_url":"https://academic.oup.com/cei/article-pdf/90/3/383/42212168/j.1365-2249.1992.tb05855.x.pdf","source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7900000214576721}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1933291831","display_name":"IMMUNE RESPONSES TO CLYCOSYLATION-MODIFIED SIV VACCINES","funder_award_id":"5r01ai029377-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3603981032","display_name":null,"funder_award_id":"N01-AI-05062","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4908413229","display_name":null,"funder_award_id":"AI29377","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G641027377","display_name":"AIDS VACCINE EVALUATION UNIT","funder_award_id":"n01ai005062-000","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978328827.pdf","grobid_xml":"https://content.openalex.org/works/W1978328827.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W99869050","https://openalex.org/W204100860","https://openalex.org/W333356916","https://openalex.org/W1494539247","https://openalex.org/W1515033630","https://openalex.org/W1520506879","https://openalex.org/W1526624040","https://openalex.org/W1542223441","https://openalex.org/W1587809300","https://openalex.org/W1590702887","https://openalex.org/W1642607010","https://openalex.org/W1778074134","https://openalex.org/W1797770492","https://openalex.org/W1943277847","https://openalex.org/W1950966714","https://openalex.org/W1956759320","https://openalex.org/W1967691505","https://openalex.org/W1971236744","https://openalex.org/W1972624990","https://openalex.org/W1982638287","https://openalex.org/W1991670386","https://openalex.org/W1995513136","https://openalex.org/W2005482754","https://openalex.org/W2012716274","https://openalex.org/W2022687152","https://openalex.org/W2029400685","https://openalex.org/W2038867077","https://openalex.org/W2043015697","https://openalex.org/W2049915467","https://openalex.org/W2060784558","https://openalex.org/W2061433801","https://openalex.org/W2071217466","https://openalex.org/W2076747220","https://openalex.org/W2079999509","https://openalex.org/W2080706877","https://openalex.org/W2083294642","https://openalex.org/W2087646321","https://openalex.org/W2090079821","https://openalex.org/W2109210467","https://openalex.org/W2117689741","https://openalex.org/W2117971086","https://openalex.org/W2121144298","https://openalex.org/W2139316669","https://openalex.org/W2153919911","https://openalex.org/W2163223098","https://openalex.org/W2163715113","https://openalex.org/W2247928159","https://openalex.org/W2395756853","https://openalex.org/W2504749006","https://openalex.org/W6608240031","https://openalex.org/W6629564014"],"related_works":["https://openalex.org/W2153919911","https://openalex.org/W2117971086","https://openalex.org/W2015328849","https://openalex.org/W2049915467","https://openalex.org/W1590702887","https://openalex.org/W2083294642","https://openalex.org/W2408338953","https://openalex.org/W2016043735","https://openalex.org/W2128261004","https://openalex.org/W2413311174"],"abstract_inverted_index":{"Complement":[0],"and":[1,6,42,63,72,85,128,131,149,197,227,250],"antibody":[2,41,84,150,188,228],"contribute":[3],"to":[4,28,46,48,58,98,103,154,160,169,174,229,235],"infection-enhancement":[5,198],"possible":[7],"expanded":[8],"cellular":[9],"tropism":[10],"of":[11,26,92,158,163,167,181,207,216,221,225,233,240,247],"HIV-1":[12,27,45,81,159,168,234],"in":[13,55,75,78,126,152,177,237],"vitro":[14],"through":[15],"a":[16,90,210],"process":[17],"requiring":[18],"complement":[19,30,43,93,148,226],"receptors.":[20],"Until":[21],"now,":[22],"however,":[23],"the":[24,49,136,143,156,214,231,238],"ability":[25,224],"bind":[29,47],"receptors":[31],"has":[32],"not":[33,141,172],"been":[34],"documented":[35],"or":[36],"characterized.":[37],"We":[38],"investigated":[39],"whether":[40],"permitted":[44],"B":[50,69],"lymphocyte":[51],"receptor,":[52],"CR2":[53,66,101,118,161,170,184,217,236],"(CD21),":[54],"an":[56],"effort":[57],"learn":[59],"more":[60],"about":[61],"infection-enhancement,":[62],"also":[64],"because":[65],"can":[67],"mediate":[68],"cell":[70],"proliferation":[71],"antigen":[73],"localization":[74],"lymphoid":[76],"organs":[77],"other":[79],"systems.":[80],"incubated":[82],"with":[83,187,205,213],"fresh":[86],"human":[87],"serum":[88],"as":[89,190],"source":[91],"bound":[94],"approximately":[95],"10-fold":[96],"greater":[97],"cells":[99,105,115],"expressing":[100],"than":[102],"HIV-1-permissive":[104],"lacking":[106],"this":[107],"receptor.":[108],"A":[109],"similar":[110],"effect":[111],"was":[112,124,132,171],"observed":[113],"using":[114],"which":[116],"expressed":[117],"but":[119,140,202],"no":[120],"CD4.":[121,164],"This":[122],"binding":[123,157,166,185,232],"minimal":[125],"heat-inactivated":[127],"C3-deficient":[129],"sera,":[130],"significantly":[133],"reduced":[134],"by":[135,142,192],"anti-CR2":[137],"MoAb,":[138,145],"OKB7,":[139],"anti-CD4":[144],"OKT4a.":[146],"Thus,":[147],"acted":[151],"concert":[153],"facilitate":[155,230],"independently":[162],"CD4-independent":[165],"sufficient":[173],"produce":[175],"infection":[176,220],"Raji-3":[178],"cells.":[179,222],"Titres":[180],"antibodies":[182],"mediating":[183],"correlated":[186],"titres":[189,206],"measured":[191],"immunofluorescence":[193],"(P":[194,199],"<":[195,200],"0.01)":[196],"0.05)":[201],"were":[203],"discordant":[204],"neutralizing":[208],"antibodies,":[209],"result":[211],"consistent":[212],"utilization":[215],"for":[218],"enhanced":[219],"The":[223],"absence":[239],"CD4":[241],"provides":[242],"new":[243],"insights":[244],"into":[245],"mechanisms":[246],"HIV-1-induced":[248],"immunopathogenesis":[249],"infection-enhancement.":[251]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}