{"id":"https://openalex.org/W1978322916","doi":"https://doi.org/10.1016/j.jcpa.2009.10.022","title":"Immunity in the Elderly: The Role of the Thymus","display_name":"Immunity in the Elderly: The Role of the Thymus","publication_year":2009,"publication_date":"2009-12-02","ids":{"openalex":"https://openalex.org/W1978322916","doi":"https://doi.org/10.1016/j.jcpa.2009.10.022","mag":"1978322916","pmid":"https://pubmed.ncbi.nlm.nih.gov/19954794"},"language":"en","primary_location":{"id":"doi:10.1016/j.jcpa.2009.10.022","doi":"https://doi.org/10.1016/j.jcpa.2009.10.022","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jcpa.2009.10.022","pdf_url":null,"source":{"id":"https://openalex.org/S177502829","display_name":"Journal of Comparative Pathology","issn_l":"0021-9975","issn":["0021-9975","1532-3129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Comparative Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040054605","display_name":"Richard Aspinall","orcid":"https://orcid.org/0000-0002-1648-1887","observed_orcids":["https://orcid.org/0000-0002-1648-1887"]},"institutions":[{"id":"https://openalex.org/I82284825","display_name":"Cranfield University","ror":"https://ror.org/05cncd958","country_code":"GB","type":"education","lineage":["https://openalex.org/I82284825"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"R. Aspinall","raw_affiliation_strings":["Translational Medicine, Cranfield University, Bedfordshire, UK. r.aspinall@cranfield.ac.uk","Translational Medicine, Cranfield University, Bedfordshire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Medicine, Cranfield University, Bedfordshire, UK. r.aspinall@cranfield.ac.uk","institution_ids":["https://openalex.org/I82284825"]},{"raw_affiliation_string":"Translational Medicine, Cranfield University, Bedfordshire, UK","institution_ids":["https://openalex.org/I82284825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111971779","display_name":"David G. Pitts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I82284825","display_name":"Cranfield University","ror":"https://ror.org/05cncd958","country_code":"GB","type":"education","lineage":["https://openalex.org/I82284825"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D. Pitts","raw_affiliation_strings":["Translational Medicine, Cranfield University, Bedfordshire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Medicine, Cranfield University, Bedfordshire, UK","institution_ids":["https://openalex.org/I82284825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080105712","display_name":"Antonio Lapenna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I82284825","display_name":"Cranfield University","ror":"https://ror.org/05cncd958","country_code":"GB","type":"education","lineage":["https://openalex.org/I82284825"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. Lapenna","raw_affiliation_strings":["Translational Medicine, Cranfield University, Bedfordshire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Medicine, Cranfield University, Bedfordshire, UK","institution_ids":["https://openalex.org/I82284825"]}]},{"author_position":"last","author":{"id":null,"display_name":"W. Mitchell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I82284825","display_name":"Cranfield University","ror":"https://ror.org/05cncd958","country_code":"GB","type":"education","lineage":["https://openalex.org/I82284825"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"W. Mitchell","raw_affiliation_strings":["Translational Medicine, Cranfield University, Bedfordshire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Medicine, Cranfield University, Bedfordshire, UK","institution_ids":["https://openalex.org/I82284825"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5040054605"],"corresponding_institution_ids":["https://openalex.org/I82284825"],"apc_list":{"value":3520,"currency":"USD","value_usd":3520},"apc_paid":null,"fwci":2.7561,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.90071519,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"142","issue":null,"first_page":"S111","last_page":"S115"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11271","display_name":"Myasthenia Gravis and Thymoma","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thymus","display_name":"thymus","score":0.9089999794960022},{"id":"https://openalex.org/keywords/thymic-atrophy","display_name":"thymic atrophy","score":0.8809999823570251},{"id":"https://openalex.org/keywords/immunosenescence","display_name":"immunosenescence","score":0.8230000138282776},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.7570000290870667},{"id":"https://openalex.org/keywords/longevity","display_name":"longevity","score":0.5320000052452087},{"id":"https://openalex.org/keywords/infection-susceptibility","display_name":"infection susceptibility","score":0.6269999742507935},{"id":"https://openalex.org/keywords/indirect-mortality","display_name":"indirect mortality","score":0.953000009059906},{"id":"https://openalex.org/keywords/thymus-regeneration","display_name":"thymus regeneration","score":0.5329999923706055},{"id":"https://openalex.org/keywords/population-aging","display_name":"population aging","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C2776759703","wikidata":"https://www.wikidata.org/wiki/Q1066907","display_name":"Longevity","level":2,"score":0.6715337038040161},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5819751024246216},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5690777897834778},{"id":"https://openalex.org/C133925201","wikidata":"https://www.wikidata.org/wiki/Q188419","display_name":"Life expectancy","level":3,"score":0.49309036135673523},{"id":"https://openalex.org/C2779056147","wikidata":"https://www.wikidata.org/wiki/Q1660191","display_name":"Immunosenescence","level":3,"score":0.481484055519104},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.47366079688072205},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46836957335472107},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.46330147981643677},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.4472167491912842},{"id":"https://openalex.org/C179755657","wikidata":"https://www.wikidata.org/wiki/Q58702","display_name":"Mortality rate","level":2,"score":0.4354773759841919},{"id":"https://openalex.org/C13774568","wikidata":"https://www.wikidata.org/wiki/Q439112","display_name":"Population ageing","level":3,"score":0.429592490196228},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4127238690853119},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.4079005718231201},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.4040473997592926},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.23928964138031006},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10457766056060791},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001284","descriptor_name":"Atrophy","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007109","descriptor_name":"Immunity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jcpa.2009.10.022","doi":"https://doi.org/10.1016/j.jcpa.2009.10.022","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jcpa.2009.10.022","pdf_url":null,"source":{"id":"https://openalex.org/S177502829","display_name":"Journal of Comparative Pathology","issn_l":"0021-9975","issn":["0021-9975","1532-3129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Comparative Pathology","raw_type":"journal-article"},{"id":"pmid:19954794","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19954794","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of comparative pathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W100938499","https://openalex.org/W1502302398","https://openalex.org/W1525438580","https://openalex.org/W1533059496","https://openalex.org/W1552329178","https://openalex.org/W1556334181","https://openalex.org/W1556399965","https://openalex.org/W1856903046","https://openalex.org/W1913220923","https://openalex.org/W1970336503","https://openalex.org/W1984907301","https://openalex.org/W1992455678","https://openalex.org/W1996493196","https://openalex.org/W2019562393","https://openalex.org/W2038915858","https://openalex.org/W2074185181","https://openalex.org/W2074899179","https://openalex.org/W2080181628","https://openalex.org/W2086058693","https://openalex.org/W2086120493","https://openalex.org/W2112981534","https://openalex.org/W2114581239","https://openalex.org/W2114977310","https://openalex.org/W2119483297","https://openalex.org/W2121590486","https://openalex.org/W2148927501","https://openalex.org/W2163955606","https://openalex.org/W4285719527","https://openalex.org/W6631537617"],"related_works":["https://openalex.org/W1992592521","https://openalex.org/W2188894028","https://openalex.org/W4391535481","https://openalex.org/W2080808232","https://openalex.org/W4403530893","https://openalex.org/W2151713210","https://openalex.org/W4406630059","https://openalex.org/W206068192","https://openalex.org/W337095358","https://openalex.org/W2054867287"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}