{"id":"https://openalex.org/W1978321728","doi":"https://doi.org/10.1084/jem.183.5.2271","title":"Germinal center formation, immunoglobulin class switching, and autoantibody production driven by \"non alpha/beta\" T cells.","display_name":"Germinal center formation, immunoglobulin class switching, and autoantibody production driven by \"non alpha/beta\" T cells.","publication_year":1996,"publication_date":"1996-05-01","ids":{"openalex":"https://openalex.org/W1978321728","doi":"https://doi.org/10.1084/jem.183.5.2271","mag":"1978321728","pmid":"https://pubmed.ncbi.nlm.nih.gov/8642336","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2192585"},"language":"en","primary_location":{"id":"doi:10.1084/jem.183.5.2271","doi":"https://doi.org/10.1084/jem.183.5.2271","is_oa":false,"landing_page_url":"https://doi.org/10.1084/jem.183.5.2271","pdf_url":null,"source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2192585","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100320327","display_name":"Wen Li","orcid":"https://orcid.org/0000-0002-8805-2934","observed_orcids":["https://orcid.org/0000-0002-8805-2934"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L Wen","raw_affiliation_strings":["Department of Biology, Yale University, New Haven, Connecticut 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Yale University, New Haven, Connecticut 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062616992","display_name":"William J. Pao","orcid":"https://orcid.org/0000-0002-9888-0733","observed_orcids":["https://orcid.org/0000-0002-9888-0733"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W Pao","raw_affiliation_strings":["Department of Biology, Yale University, New Haven, Connecticut 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Yale University, New Haven, Connecticut 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026334006","display_name":"Florence Susan Wong","orcid":"https://orcid.org/0000-0002-2812-8845","observed_orcids":["https://orcid.org/0000-0002-2812-8845"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F S Wong","raw_affiliation_strings":["Department of Biology, Yale University, New Haven, Connecticut 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Yale University, New Haven, Connecticut 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Q Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Q Peng","raw_affiliation_strings":["Department of Biology, Yale University, New Haven, Connecticut 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Yale University, New Haven, Connecticut 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013800491","display_name":"Joseph E. Craft","orcid":"https://orcid.org/0000-0002-1368-6756","observed_orcids":["https://orcid.org/0000-0002-1368-6756"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Craft","raw_affiliation_strings":["Department of Biology, Yale University, New Haven, Connecticut 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Yale University, New Haven, Connecticut 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":null,"display_name":"B Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B Zheng","raw_affiliation_strings":["Department of Biology, Yale University, New Haven, Connecticut 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Yale University, New Haven, Connecticut 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065001474","display_name":"Garnett H. Kelsoe","orcid":"https://orcid.org/0000-0002-8770-040X","observed_orcids":["https://orcid.org/0000-0002-8770-040X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G Kelsoe","raw_affiliation_strings":["Department of Biology, Yale University, New Haven, Connecticut 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Yale University, New Haven, Connecticut 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037430768","display_name":"Lee Dianda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L Dianda","raw_affiliation_strings":["Department of Biology, Yale University, New Haven, Connecticut 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Yale University, New Haven, Connecticut 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111688379","display_name":"Michael J. Owen","orcid":"https://orcid.org/0000-0003-4798-0862","observed_orcids":["https://orcid.org/0000-0003-4798-0862"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M J Owen","raw_affiliation_strings":["Department of Biology, Yale University, New Haven, Connecticut 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Yale University, New Haven, Connecticut 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090249459","display_name":"Adrian Hayday","orcid":"https://orcid.org/0000-0002-9495-5793","observed_orcids":["https://orcid.org/0000-0002-9495-5793"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A C Hayday","raw_affiliation_strings":["Department of Biology, Yale University, New Haven, Connecticut 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Yale University, New Haven, Connecticut 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":3.5522,"has_fulltext":false,"cited_by_count":119,"citation_normalized_percentile":{"value":0.93191228,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"183","issue":"5","first_page":"2271","last_page":"2282"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gamma-delta-t-cells","display_name":"\u03b3\u03b4 T cells","score":0.9810000061988831},{"id":"https://openalex.org/keywords/germinal-center-formation","display_name":"germinal center formation","score":0.8500000238418579},{"id":"https://openalex.org/keywords/class-switch-recombination","display_name":"class switch recombination","score":0.9860000014305115},{"id":"https://openalex.org/keywords/autoantibody-production","display_name":"autoantibody production","score":0.8510000109672546},{"id":"https://openalex.org/keywords/igg1","display_name":"IgG1","score":0.8029999732971191},{"id":"https://openalex.org/keywords/ige","display_name":"IgE","score":0.9959999918937683},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9160000085830688},{"id":"https://openalex.org/keywords/b-cell-help","display_name":"B cell help","score":0.6790000200271606},{"id":"https://openalex.org/keywords/t-cell-receptor-alpha-chain","display_name":"T cell receptor alpha chain","score":0.5789999961853027},{"id":"https://openalex.org/keywords/scid-mice","display_name":"SCID mice","score":0.6340000033378601},{"id":"https://openalex.org/keywords/t-cell-transfer","display_name":"T cell transfer","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C96926380","wikidata":"https://www.wikidata.org/wiki/Q1737968","display_name":"Germinal center","level":4,"score":0.675039529800415},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5975170731544495},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.536579966545105},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.5156532526016235},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5088710784912109},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.5049999356269836},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4920579791069031},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.47943252325057983},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4791818857192993},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.46967655420303345},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.4589584469795227},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4467219412326813},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39050012826919556},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2215302586555481},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.21477103233337402},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007073","descriptor_name":"Immunoglobulin E","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008212","descriptor_name":"Lymphocyte Depletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016688","descriptor_name":"Mice, Inbred NOD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016693","descriptor_name":"Receptors, Antigen, T-Cell, alpha-beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017578","descriptor_name":"Immunoglobulin Class Switching","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018858","descriptor_name":"Germinal Center","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1084/jem.183.5.2271","doi":"https://doi.org/10.1084/jem.183.5.2271","is_oa":false,"landing_page_url":"https://doi.org/10.1084/jem.183.5.2271","pdf_url":null,"source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2192585","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2192585","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},{"id":"pmid:8642336","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8642336","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.284.2737","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.284.2737","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/ad/49/J_Exp_Med_1996_May_1_183(5)_2271-2282.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2192585","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2192585","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1753263254","display_name":null,"funder_award_id":"AI27855","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G485306226","display_name":null,"funder_award_id":"DK-34989","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8875324302","display_name":"SPECIFICITY, DISTRIBUTION AND FUNCTION OF GD T CELLS","funder_award_id":"R01AI027855","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000866473","display_name":"Yale Liver Center","funder_award_id":"P30DK034989","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W813816","https://openalex.org/W41596147","https://openalex.org/W44304614","https://openalex.org/W1533201237","https://openalex.org/W1552738427","https://openalex.org/W1558801857","https://openalex.org/W1591512564","https://openalex.org/W1769351001","https://openalex.org/W1788101322","https://openalex.org/W1895680870","https://openalex.org/W1969293902","https://openalex.org/W1972120590","https://openalex.org/W1975601462","https://openalex.org/W1986945726","https://openalex.org/W1989217948","https://openalex.org/W1989305940","https://openalex.org/W1995634835","https://openalex.org/W1996822762","https://openalex.org/W2005376541","https://openalex.org/W2007802096","https://openalex.org/W2008563327","https://openalex.org/W2013058855","https://openalex.org/W2023517807","https://openalex.org/W2026833579","https://openalex.org/W2030816309","https://openalex.org/W2031551673","https://openalex.org/W2036089151","https://openalex.org/W2037367542","https://openalex.org/W2052820133","https://openalex.org/W2054460972","https://openalex.org/W2062036642","https://openalex.org/W2067707046","https://openalex.org/W2069080743","https://openalex.org/W2071287590","https://openalex.org/W2076747220","https://openalex.org/W2085597255","https://openalex.org/W2091083470","https://openalex.org/W2116537839","https://openalex.org/W2118224103","https://openalex.org/W2131600504","https://openalex.org/W2146175972","https://openalex.org/W2147715156","https://openalex.org/W2158822860","https://openalex.org/W2167184712","https://openalex.org/W2182386412","https://openalex.org/W2411573569","https://openalex.org/W4251633039"],"related_works":["https://openalex.org/W7096700371","https://openalex.org/W2115687523","https://openalex.org/W2007802096","https://openalex.org/W2411024065","https://openalex.org/W1572787868","https://openalex.org/W1521857979","https://openalex.org/W1646508209","https://openalex.org/W1971085945","https://openalex.org/W2559463545","https://openalex.org/W2068064641"],"abstract_inverted_index":{"The":[0,161],"production":[1,167,195],"of":[2,24,35,57,71,101,113,136,139,168,175,190,196,206,228],"class-switched":[3],"antibodies,":[4],"particularly":[5],"immunoglobulin":[6],"(Ig)":[7],"G1":[8],"and":[9,40,51,125,141,220],"IgE,":[10],"occurs":[11],"efficiently":[12],"in":[13,61,103,226],"T":[14,26,53,93,143,148,177,186,213,230],"cell":[15,178,209,214,231],"receptor":[16],"(TCR)":[17],"alpha-/-":[18,63,105,153],"mice":[19,64,106],"that":[20,38,74,164,180,201],"are":[21,43,65,203],"congenitally":[22],"devoid":[23],"alpha/beta":[25,52,92,207,229],"cells.":[27,54,187],"This":[28,188],"finding":[29],"runs":[30],"counter":[31],"to":[32,67,109,117,155],"a":[33,68,118,173],"wealth":[34],"data":[36],"indicating":[37],"IgG1":[39,169],"IgE":[41],"synthesis":[42,219],"largely":[44],"dependent":[45],"on":[46],"the":[47,58,99,129,165,194],"collaboration":[48,122,192],"between":[49,123],"B":[50,114,124,140],"Furthermore,":[55],"many":[56],"antibodies":[59],"synthesized":[60],"TCR":[62,104,152],"reactive":[66],"similar":[69],"spectrum":[70],"self-antigens":[72],"as":[73,90],"targeted":[75],"by":[76,134,184],"autoantibodies":[77,102],"characterizing":[78],"human":[79],"systemic":[80],"lupus":[81],"erythematosus":[82],"(SLE).":[83],"SLE,":[84],"too,":[85],"is":[86,107,172],"most":[87],"commonly":[88],"regarded":[89],"an":[91,110],"cell-mediated":[94],"condition.":[95],"To":[96],"distinguish":[97],"whether":[98],"development":[100],"due":[108],"intrinsic":[111],"de-regulation":[112],"cells,":[115,128],"or":[116],"heretofore":[119],"poorly":[120],"characterized":[121],"\"non-alpha/beta":[126],"T\"":[127],"phenotype":[130],"has":[131],"been":[132],"reconstituted":[133],"transfer":[135],"various":[137,223],"populations":[138],"non-alpha/beta":[142,176,212],"cells":[144,149],"including":[145],"cloned":[146],"gamma/delta":[147,185],"derived":[150],"from":[151],"mice,":[154],"severe":[156],"combined":[157],"immunodeficient":[158],"(SCID)":[159],"mice.":[160],"results":[162],"establish":[163],"reproducible":[166],"(including":[170],"autoantibodies)":[171],"product":[174],"help":[179,215],"can":[181],"be":[182],"provided":[183],"type":[189],"B-T":[191],"sustains":[193],"germinal":[197],"centers,":[198],"lymphoid":[199],"follicles":[200],"ordinarily":[202],"anatomical":[204],"signatures":[205],"T-B":[208],"collaboration.":[210],"Thus,":[211],"may":[216],"drive":[217],"Ig":[218],"autoreactivity":[221],"under":[222],"circumstances,":[224],"especially":[225],"cases":[227],"immunodeficiency.":[232]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}