{"id":"https://openalex.org/W197831005","doi":null,"title":"Dietary capsaicin upregulates uncoupling protein 2/3 expression in visceral adipose tissue and enhances acetylcholine-induced hypotensive effect in mice","display_name":"Dietary capsaicin upregulates uncoupling protein 2/3 expression in visceral adipose tissue and enhances acetylcholine-induced hypotensive effect in mice","publication_year":2010,"publication_date":"2010-05-01","ids":{"openalex":"https://openalex.org/W197831005","mag":"197831005"},"language":"en","primary_location":{"id":"pmh:oai:mattioli1885journals.com:article/1006","doi":null,"is_oa":true,"landing_page_url":"https://www.mattioli1885journals.com/index.php/progressinnutrition/article/view/1006","pdf_url":"https://www.mattioli1885journals.com/index.php/progressinnutrition/article/download/1006/715","source":{"id":"https://openalex.org/S108334190","display_name":"Progress in nutrition","issn_l":"1129-8723","issn":["1129-8723"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-20"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1129-8723","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.mattioli1885journals.com/index.php/progressinnutrition/article/download/1006/715","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001610426","display_name":"Per Torp Sangild","orcid":"https://orcid.org/0000-0002-5462-7760","observed_orcids":["https://orcid.org/0000-0002-5462-7760"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Per T. Sangild","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5462-7760","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047152097","display_name":"L. L. Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. L. Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5030372830","display_name":"Dengbao Yang","orcid":"https://orcid.org/0000-0001-7475-0320","observed_orcids":["https://orcid.org/0000-0001-7475-0320"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dengbao Yang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7475-0320","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6862,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.63735021,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"12","issue":"1","first_page":"19","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.7153000235557556,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.7153000235557556,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.1436000019311905,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.05339999869465828,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trpv1","display_name":"TRPV1","score":0.7310000061988831},{"id":"https://openalex.org/keywords/ucp2","display_name":"UCP2","score":0.9570000171661377},{"id":"https://openalex.org/keywords/ucp3","display_name":"UCP3","score":1.0},{"id":"https://openalex.org/keywords/visceral-adipose-tissue","display_name":"visceral adipose tissue","score":0.9620000123977661},{"id":"https://openalex.org/keywords/fat-oxidation","display_name":"fat oxidation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7699999809265137},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9629999995231628},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.9520000219345093},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.6119999885559082},{"id":"https://openalex.org/keywords/plant-based-diet","display_name":"plant-based diet","score":0.7310000061988831},{"id":"https://openalex.org/keywords/cardiometabolic-disease","display_name":"cardiometabolic disease","score":0.6700000166893005},{"id":"https://openalex.org/keywords/blood-pressure-regulation","display_name":"blood pressure regulation","score":0.5929999947547913},{"id":"https://openalex.org/keywords/adipocytes","display_name":"adipocytes","score":0.4399999976158142},{"id":"https://openalex.org/keywords/thermogenesis","display_name":"thermogenesis","score":0.4169999957084656}],"concepts":[{"id":"https://openalex.org/C2780051329","wikidata":"https://www.wikidata.org/wiki/Q273169","display_name":"Capsaicin","level":3,"score":0.9518344402313232},{"id":"https://openalex.org/C160145004","wikidata":"https://www.wikidata.org/wiki/Q413209","display_name":"TRPV1","level":4,"score":0.8798298835754395},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6633782982826233},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6368117928504944},{"id":"https://openalex.org/C2779299233","wikidata":"https://www.wikidata.org/wiki/Q7864100","display_name":"UCP3","level":5,"score":0.6287071108818054},{"id":"https://openalex.org/C2779406938","wikidata":"https://www.wikidata.org/wiki/Q24720289","display_name":"Uncoupling protein","level":4,"score":0.6053118109703064},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.4976818859577179},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4588187336921692},{"id":"https://openalex.org/C122927707","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Adipogenesis","level":3,"score":0.45079994201660156},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4054356515407562},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3774978518486023},{"id":"https://openalex.org/C155164980","wikidata":"https://www.wikidata.org/wiki/Q304043","display_name":"Transient receptor potential channel","level":3,"score":0.3652912974357605},{"id":"https://openalex.org/C2780642333","wikidata":"https://www.wikidata.org/wiki/Q901269","display_name":"Brown adipose tissue","level":3,"score":0.3523695766925812},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2189406454563141}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:mattioli1885journals.com:article/1006","doi":null,"is_oa":true,"landing_page_url":"https://www.mattioli1885journals.com/index.php/progressinnutrition/article/view/1006","pdf_url":"https://www.mattioli1885journals.com/index.php/progressinnutrition/article/download/1006/715","source":{"id":"https://openalex.org/S108334190","display_name":"Progress in nutrition","issn_l":"1129-8723","issn":["1129-8723"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-20"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1129-8723","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:197831005","doi":null,"is_oa":true,"landing_page_url":"https://www.mattioli1885.com/onlinejournals/index.php/progressinnutrition/article/view/1006","pdf_url":null,"source":{"id":"https://openalex.org/S108334190","display_name":"Progress in nutrition","issn_l":"1129-8723","issn":["1129-8723"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-20"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Progress in nutrition","raw_type":null}],"best_oa_location":{"id":"pmh:oai:mattioli1885journals.com:article/1006","doi":null,"is_oa":true,"landing_page_url":"https://www.mattioli1885journals.com/index.php/progressinnutrition/article/view/1006","pdf_url":"https://www.mattioli1885journals.com/index.php/progressinnutrition/article/download/1006/715","source":{"id":"https://openalex.org/S108334190","display_name":"Progress in nutrition","issn_l":"1129-8723","issn":["1129-8723"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-20"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1129-8723","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W197831005.pdf","grobid_xml":"https://content.openalex.org/works/W197831005.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2017171873","https://openalex.org/W2087521735","https://openalex.org/W2037066816","https://openalex.org/W2089927459","https://openalex.org/W2122778205","https://openalex.org/W2584382825","https://openalex.org/W2234894172","https://openalex.org/W28325062","https://openalex.org/W2032631884","https://openalex.org/W2952376991"],"abstract_inverted_index":{"SummaryObesity":[0],"and":[1,18,54,73,101,125,128,142,146,189,205],"hypertension":[2,17],"are":[3],"major":[4,24],"risk":[5],"factors":[6],"for":[7,120,203],"cardiovascular":[8],"events.":[9],"Some":[10],"plant-based":[11],"diets":[12],"lower":[13],"the":[14,63,69,97,112,138,163],"prevalence":[15],"of":[16,46,65,71,75,140,158],"prevent":[19],"weight":[20],"gain.":[21],"Capsaicin,":[22],"a":[23,199,245,338,381,440],"pungent":[25],"ingredient":[26],"in":[27,56,104,131,149,167,174,193,268,365,455,470],"chili":[28],"pepper,":[29],"can":[30],"specifically":[31],"activate":[32],"transient":[33],"receptor":[34],"potential":[35],"vanilloid":[36],"type-1":[37],"(TRPV1)":[38],"channel.":[39],"Our":[40],"previous":[41],"studies":[42],"demonstrated":[43],"that":[44,93,109,180],"activation":[45,67,182],"TRPV1":[47,66,175,181,292,483],"channel":[48],"by":[49,183],"dietary":[50,84,184],"capsaicin":[51,85,94,110,135,159,185,196],"prevents":[52],"adipogenesis":[53,72],"obesity":[55,124,141,204],"mice.":[57,177,194],"However,":[58],"little":[59],"is":[60,79],"known":[61],"about":[62],"mechanism":[64],"mediated":[68],"reduction":[70],"prevention":[74],"obesity.":[76],"Furthermore,":[77],"it":[78],"unclear":[80],"whether":[81],"long":[82],"term":[83],"could":[86],"modulate":[87],"blood":[88],"pressure.":[89],"Here,":[90],"we":[91],"report":[92],"significantly":[95],"increased":[96,126,144,162,186],"uncoupling":[98],"proteins":[99],"(UCP2":[100,362],"UCP3)":[102,364],"expression":[103,130,148],"mature":[105],"adipocytes":[106],"which":[107],"indicated":[108],"promoted":[111,190],"fat":[113,151,187],"oxidation.":[114],"Mice":[115],"on":[116,154],"high-fat":[117],"diet":[118],"(HFD)":[119,388],"4":[121,390],"months":[122],"developed":[123],"UCP2":[127,145,403,430],"UCP3":[129,147,405,432],"visceral":[132,150],"fat.":[133],"Dietary":[134,195],"markedly":[136],"prevented":[137],"development":[139],"further":[143],"from":[152],"mice":[153],"HFD.":[155],"Chronic":[156],"administration":[157],"also":[160],"dose\u2013dependently":[161],"acetylcholine-mediated":[164],"hypotensive":[165,191],"responses":[166],"mice,":[168],"however,":[169],"this":[170],"effect":[171],"was":[172],"absent":[173],"deficient":[176],"We":[178],"conclude":[179],"oxidation":[188],"effects":[192],"may":[197],"become":[198],"novel":[200],"therapeutic":[201],"strategy":[202],"its":[206],"related":[207],"cardiometabolic":[208],"diseases.La":[209],"capsaicina":[210,296,333,353,373,414,451,487,504],"introdotta":[211,297,334,415,488,505],"con":[212,298,416,489,506],"la":[213,249,299,320,324,332,336,343,352,372,413,417,460,490,507],"dieta":[214,300,337,382,418,441,491,508],"up-regola":[215],"l\u2019espressione":[216,357],"di":[217,236,251,256,278,313,315,358,386,400,402,429,445,450],"2/3":[218],"proteine":[219,360],"disaccoppianti":[220,361],"nel":[221,264,406,433,476],"tessuto":[222],"adiposo":[223],"viscerale":[224,435],"e":[225,232,253,303,323,363,395,404,425,431,497,517],"aumenta":[226],"l\u2019effetto":[227],"ipotensivo":[228],"acetilcolina-indotto":[229],"nei":[230,305,458,501],"topiRiassuntoL\u2019obesit\u00e0":[231],"l\u2019ipertensione":[233],"sono":[234],"fattori":[235],"rischio":[237],"maggiore":[238],"per":[239,389,515,518],"gli":[240],"eventi":[241],"cardiovascolari.":[242],"Alcune":[243],"diete":[244],"base":[246],"vegetale":[247],"riducono":[248],"prevalenza":[250],"ipertensione":[252],"prevengono":[254],"l\u2019aumento":[255],"peso.":[257],"La":[258,447,503],"capsaicina,":[259],"il":[260,368],"\u201cpungente\u201d":[261],"componente":[262],"principale":[263],"peperoncino,":[265],"pu\u00f2":[266,509],"attivare":[267],"modo":[269,456],"specifico":[270],"i":[271,398],"canali":[272],"del":[273,290,311,482],"recettore":[274],"vanilloide":[275],"potenziale":[276],"transiente":[277],"tipo":[279],"1":[280],"(TRPV1).":[281],"I":[282],"nostri":[283],"precedenti":[284],"studi":[285],"hanno":[286,392,396],"dimostrato":[287],"che":[288,318,351,369,371,412,472,480],"l\u2019attivazione":[289,481],"canale":[291,317],"da":[293,437,484],"parte":[294,485],"della":[295,486],"impedisce":[301],"l\u2019adipogenesi":[302],"l\u2019obesit\u00e0":[304,516],"topi.":[306,502],"Tuttavia":[307],"si":[308,349],"sa":[309],"poco":[310],"meccanismo":[312],"attivazione":[314],"questo":[316,347,465],"media":[319],"riduzione":[321],"dell\u2019adipogenesi":[322],"prevenzione":[325],"dell\u2019obesit\u00e0.":[326],"Inoltre":[327],"non":[328],"\u00e8":[329,410,467],"chiaro":[330],"se":[331],"attraverso":[335],"lungo":[339],"termine":[340],"possa":[341],"modulare":[342],"pressione":[344],"arteriosa.":[345],"In":[346],"studio":[348],"segnala":[350],"ha":[354,374,419,452,492],"notevolmente":[355],"aumentato":[356,397,454,493],"alcune":[359],"adipociti":[366],"maturi":[367],"indica":[370],"promosso":[375,498],"l\u2019ossidazione":[376,494],"dei":[377,495],"grassi.":[378,446],"Topi":[379],"sottoposti":[380,439],"ad":[383,442],"alto":[384,443],"contenuto":[385,444],"grassi":[387,496],"mesi":[391],"sviluppato":[393],"obesit\u00e0":[394],"livelli":[399],"espressione":[401],"grasso":[407,434],"viscerale.":[408],"Si":[409],"visto":[411],"marcatamente":[420],"impedito":[421],"lo":[422],"sviluppo":[423],"dell\u2019obesit\u00e0":[424],"l\u2019ulteriore":[426],"aumento":[427],"dell\u2019espressione":[428],"prelevato":[436],"topi":[438,459,471],"somministrazione":[448],"cronica":[449],"anche":[453],"dose-dipendente":[457],"risposta":[461],"ipotensiva":[462],"acetilcolina-mediata,":[463],"tuttavia,":[464],"effetto":[466],"stato":[468],"assente":[469],"presentavano":[473],"una":[474,511],"deficienza":[475],"TRPV1.":[477],"Possiamo":[478],"concludere":[479],"effetti":[499],"ipotensivi":[500],"diventare":[510],"nuova":[512],"strategia":[513],"terapeutica":[514],"le":[519],"patologie":[520],"cardiometaboliche":[521],"correlate.":[522]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
