{"id":"https://openalex.org/W1978299813","doi":"https://doi.org/10.2332/allergolint.o-08-543","title":"A Clinical Study of Japanese Cedar (Cryptomeria japonica) Pollen-Induced Asthma","display_name":"A Clinical Study of Japanese Cedar (Cryptomeria japonica) Pollen-Induced Asthma","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W1978299813","doi":"https://doi.org/10.2332/allergolint.o-08-543","mag":"1978299813","pmid":"https://pubmed.ncbi.nlm.nih.gov/18946237"},"language":"en","primary_location":{"id":"doi:10.2332/allergolint.o-08-543","doi":"https://doi.org/10.2332/allergolint.o-08-543","is_oa":true,"landing_page_url":"https://doi.org/10.2332/allergolint.o-08-543","pdf_url":null,"source":{"id":"https://openalex.org/S116585092","display_name":"Allergology International","issn_l":"1323-8930","issn":["1323-8930","1440-1592"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergology International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.2332/allergolint.o-08-543","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113617022","display_name":"Yuji Maeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115833","display_name":"National Sagamihara Hospital","ror":"https://ror.org/01gvfxs59","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115833","https://openalex.org/I4210137409"]},{"id":"https://openalex.org/I4210137409","display_name":"National Hospital Organization","ror":"https://ror.org/03ntccx93","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yuji Maeda","raw_affiliation_strings":["Clinical Center of National Hospital Organization Sagamihara Hospital, Kanagawa, Japan. y-maeda@sagamihara-hosp.gr.jp","Clinical Center of National Hospital Organization Sagamihara Hospital, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Center of National Hospital Organization Sagamihara Hospital, Kanagawa, Japan. y-maeda@sagamihara-hosp.gr.jp","institution_ids":["https://openalex.org/I4210115833","https://openalex.org/I4210137409"]},{"raw_affiliation_string":"Clinical Center of National Hospital Organization Sagamihara Hospital, Kanagawa, Japan","institution_ids":["https://openalex.org/I4210115833"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102191698","display_name":"Kazuo Akiyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115833","display_name":"National Sagamihara Hospital","ror":"https://ror.org/01gvfxs59","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115833","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuo Akiyama","raw_affiliation_strings":["Clinical Center of National Hospital Organization Sagamihara Hospital, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Center of National Hospital Organization Sagamihara Hospital, Kanagawa, Japan","institution_ids":["https://openalex.org/I4210115833"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010557270","display_name":"Takao Shida","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takao Shida","raw_affiliation_strings":["Shinbashi Allergy Clinic, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shinbashi Allergy Clinic, Tokyo, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113617022"],"corresponding_institution_ids":["https://openalex.org/I4210115833","https://openalex.org/I4210137409"],"apc_list":{"value":2280,"currency":"USD","value_usd":2280},"apc_paid":{"value":2280,"currency":"USD","value_usd":2280},"fwci":0.8135,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.71976679,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"57","issue":"4","first_page":"413","last_page":"417"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.7675999999046326,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.7675999999046326,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.22550000250339508,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12208","display_name":"Occupational exposure and asthma","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/japanese-cedar-pollen","display_name":"Japanese cedar pollen","score":0.8080000281333923},{"id":"https://openalex.org/keywords/cryptomeria-japonica","display_name":"Cryptomeria japonica","score":0.996999979019165},{"id":"https://openalex.org/keywords/cedar-pollinosis","display_name":"cedar pollinosis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/allergen-sensitization","display_name":"allergen sensitization","score":0.7149999737739563},{"id":"https://openalex.org/keywords/allergen-provocation-test","display_name":"allergen provocation test","score":0.8550000190734863},{"id":"https://openalex.org/keywords/ige","display_name":"IgE","score":0.6669999957084656},{"id":"https://openalex.org/keywords/adult-asthma","display_name":"adult asthma","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.8984558582305908},{"id":"https://openalex.org/C2780319752","wikidata":"https://www.wikidata.org/wiki/Q147388","display_name":"Cryptomeria","level":3,"score":0.8812344074249268},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.845312237739563},{"id":"https://openalex.org/C110586980","wikidata":"https://www.wikidata.org/wiki/Q4168588","display_name":"Provocation test","level":3,"score":0.6654177904129028},{"id":"https://openalex.org/C2780510475","wikidata":"https://www.wikidata.org/wiki/Q186752","display_name":"Allergen","level":3,"score":0.5676482915878296},{"id":"https://openalex.org/C2780618852","wikidata":"https://www.wikidata.org/wiki/Q79932","display_name":"Pollen","level":2,"score":0.4753011167049408},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.41988605260849},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38851720094680786},{"id":"https://openalex.org/C2779409272","wikidata":"https://www.wikidata.org/wiki/Q1757789","display_name":"Japonica","level":2,"score":0.21774077415466309},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.06875711679458618},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.06065702438354492},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001985","descriptor_name":"Bronchial Provocation Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006255","descriptor_name":"Rhinitis, Allergic, Seasonal","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006255","descriptor_name":"Rhinitis, Allergic, Seasonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006255","descriptor_name":"Rhinitis, Allergic, Seasonal","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007271","descriptor_name":"Injections, Intradermal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011058","descriptor_name":"Pollen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012135","descriptor_name":"Respiratory Sounds","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012135","descriptor_name":"Respiratory Sounds","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012621","descriptor_name":"Seasons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012882","descriptor_name":"Skin Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012912","descriptor_name":"Sneezing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012912","descriptor_name":"Sneezing","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D032485","descriptor_name":"Cryptomeria","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D052179","descriptor_name":"Antigens, Plant","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D052179","descriptor_name":"Antigens, Plant","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2332/allergolint.o-08-543","doi":"https://doi.org/10.2332/allergolint.o-08-543","is_oa":true,"landing_page_url":"https://doi.org/10.2332/allergolint.o-08-543","pdf_url":null,"source":{"id":"https://openalex.org/S116585092","display_name":"Allergology International","issn_l":"1323-8930","issn":["1323-8930","1440-1592"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergology International","raw_type":"journal-article"},{"id":"pmid:18946237","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18946237","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergology international : official journal of the Japanese Society of Allergology","raw_type":"Clinical Trial"},{"id":"pmh:oai:doaj.org/article:e043794dc77e410484e7b20ef11393a5","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/e043794dc77e410484e7b20ef11393a5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Allergology International, Vol 57, Iss 4, Pp 413-417 (2008)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.2332/allergolint.o-08-543","doi":"https://doi.org/10.2332/allergolint.o-08-543","is_oa":true,"landing_page_url":"https://doi.org/10.2332/allergolint.o-08-543","pdf_url":null,"source":{"id":"https://openalex.org/S116585092","display_name":"Allergology International","issn_l":"1323-8930","issn":["1323-8930","1440-1592"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergology International","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W171330389","https://openalex.org/W1979845026","https://openalex.org/W1989795226","https://openalex.org/W2003338152","https://openalex.org/W2004009546","https://openalex.org/W2004667602","https://openalex.org/W2011270821","https://openalex.org/W2019840426","https://openalex.org/W2025678096","https://openalex.org/W2026455004","https://openalex.org/W2050058376","https://openalex.org/W2061853352","https://openalex.org/W2063375892","https://openalex.org/W2069995700","https://openalex.org/W2084468817","https://openalex.org/W2089820399","https://openalex.org/W2104362377","https://openalex.org/W2105773949","https://openalex.org/W2111940863","https://openalex.org/W2133635822","https://openalex.org/W2151071263","https://openalex.org/W2156836597","https://openalex.org/W2401469589","https://openalex.org/W2418252935","https://openalex.org/W2443657546","https://openalex.org/W2464249967"],"related_works":["https://openalex.org/W4236159107","https://openalex.org/W1976611479","https://openalex.org/W2147108889","https://openalex.org/W24085706","https://openalex.org/W2116635791","https://openalex.org/W2316673731","https://openalex.org/W3159763477","https://openalex.org/W2313252831","https://openalex.org/W4298138387","https://openalex.org/W2587694630"],"abstract_inverted_index":{"BACKGROUND:":[0],"Grass":[1],"and":[2,62,107,121,167,186],"birch":[3],"pollens":[4],"are":[5,12],"known":[6],"to":[7,54,105,161],"induce":[8],"asthma.":[9,18,38],"However":[10],"there":[11],"few":[13],"reports":[14],"about":[15],"other":[16,130],"pollen-induced":[17,44],"Japanese":[19,42,56,194],"cedar":[20,43,57,69,73,101,114,195],"is":[21,31],"the":[22,55,68,80,94,125,129,154,176],"most":[23],"common":[24],"allergen":[25,177],"in":[26,28,103,118,128,137,153,205],"rhinitis":[27],"Japan":[29],"but":[30,202],"controversial":[32],"on":[33],"whether":[34],"it":[35],"can":[36],"provoke":[37,198],"METHODS:":[39],"To":[40],"clarify":[41],"asthma,":[45,106],"we":[46],"studied":[47],"adult":[48,89],"patients":[49,91,98],"who":[50,78,92],"were":[51],"sensitized":[52],"only":[53,200],"(CAP-RAST":[58],">":[59],"=":[60],"2)":[61,166],"had":[63,110],"symptoms":[64],"of":[65],"asthma":[66,74,90,117,204],"during":[67],"season.":[70],"We":[71,86,191],"defined":[72],"as":[75],"a":[76,149],"patient":[77,109],"satisfied":[79],"2":[81,131],"criteria":[82],"mentioned":[83],"above.":[84],"RESULTS:":[85],"found":[87],"6":[88],"fulfilled":[93],"two":[95],"criteria.":[96],"Five":[97],"suffered":[99],"from":[100],"pollinosis":[102,115,201],"addition":[104],"1":[108],"no":[111],"pollinosis.":[112],"The":[113],"preceded":[116],"3":[119,180],"cases":[120,139],"occurred":[122],"at":[123],"almost":[124],"same":[126],"time":[127],"cases.":[132],"Pulmonary":[133],"function":[134],"was":[135],"normal":[136],"these":[138],"(FEV":[140],"1%,":[141],"mean":[142],"+/-":[143,146,165,172],"SD,":[144],"76.5":[145],"10%),":[147],"with":[148],"high":[150],"threshold":[151],"value":[152],"non-specific":[155],"airway":[156],"hypersensitivity":[157],"test":[158],"(Ach-PC20,":[159],"2,696":[160],"20,000":[162],"microg/ml,":[163],"9294":[164],"low":[168],"total":[169],"IgE":[170],"(101":[171],"86":[173],"IU/ml).":[174],"In":[175],"provocation":[178],"test,":[179],"subjects":[181],"showed":[182],"both":[183],"an":[184],"immediate":[185],"late":[187],"asthmatic":[188],"reaction.":[189],"CONCLUSIONS:":[190],"concluded":[192],"that":[193],"pollen":[196],"could":[197],"not":[199],"also":[203],"adults.":[206]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}