{"id":"https://openalex.org/W1978287464","doi":"https://doi.org/10.1016/j.freeradbiomed.2014.04.008","title":"Dimerization of visinin-like protein 1 is regulated by oxidative stress and calcium and is a pathological hallmark of amyotrophic lateral sclerosis","display_name":"Dimerization of visinin-like protein 1 is regulated by oxidative stress and calcium and is a pathological hallmark of amyotrophic lateral sclerosis","publication_year":2014,"publication_date":"2014-04-15","ids":{"openalex":"https://openalex.org/W1978287464","doi":"https://doi.org/10.1016/j.freeradbiomed.2014.04.008","mag":"1978287464","pmid":"https://pubmed.ncbi.nlm.nih.gov/24742816"},"language":"en","primary_location":{"id":"doi:10.1016/j.freeradbiomed.2014.04.008","doi":"https://doi.org/10.1016/j.freeradbiomed.2014.04.008","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2014.04.008","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.freeradbiomed.2014.04.008","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057177335","display_name":"Martina P. Liebl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]},{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martina P. Liebl","raw_affiliation_strings":["Institute for Pathobiochemistry, University Medical Center, Johannes Gutenberg University, D-55099 Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Pathobiochemistry, University Medical Center, Johannes Gutenberg University, D-55099 Mainz, Germany","institution_ids":["https://openalex.org/I197323543","https://openalex.org/I4210094062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000906451","display_name":"A Murat Kaya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]},{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ali M. Kaya","raw_affiliation_strings":["Institute for Pathobiochemistry, University Medical Center, Johannes Gutenberg University, D-55099 Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Pathobiochemistry, University Medical Center, Johannes Gutenberg University, D-55099 Mainz, Germany","institution_ids":["https://openalex.org/I197323543","https://openalex.org/I4210094062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055066185","display_name":"Stefan Tenzer","orcid":"https://orcid.org/0000-0003-3034-0017","observed_orcids":["https://orcid.org/0000-0003-3034-0017"]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]},{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Tenzer","raw_affiliation_strings":["Institute for Immunology, University Medical Center, Johannes Gutenberg University, D-55099 Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Immunology, University Medical Center, Johannes Gutenberg University, D-55099 Mainz, Germany","institution_ids":["https://openalex.org/I197323543","https://openalex.org/I4210094062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073437966","display_name":"Romy Mittenzwei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]},{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Romy Mittenzwei","raw_affiliation_strings":["Institute for Pathobiochemistry, University Medical Center, Johannes Gutenberg University, D-55099 Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Pathobiochemistry, University Medical Center, Johannes Gutenberg University, D-55099 Mainz, Germany","institution_ids":["https://openalex.org/I197323543","https://openalex.org/I4210094062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077837422","display_name":"Ingrid Koziollek\u2010Drechsler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]},{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ingrid Koziollek-Drechsler","raw_affiliation_strings":["Institute for Pathobiochemistry, University Medical Center, Johannes Gutenberg University, D-55099 Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Pathobiochemistry, University Medical Center, Johannes Gutenberg University, D-55099 Mainz, Germany","institution_ids":["https://openalex.org/I197323543","https://openalex.org/I4210094062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007309983","display_name":"Hansj\u00f6rg Schild","orcid":"https://orcid.org/0000-0001-9462-3644","observed_orcids":["https://orcid.org/0000-0001-9462-3644"]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]},{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hansj\u00f6rg Schild","raw_affiliation_strings":["Institute for Immunology, University Medical Center, Johannes Gutenberg University, D-55099 Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Immunology, University Medical Center, Johannes Gutenberg University, D-55099 Mainz, Germany","institution_ids":["https://openalex.org/I197323543","https://openalex.org/I4210094062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080397584","display_name":"Bernd Moosmann","orcid":"https://orcid.org/0000-0002-7703-7712","observed_orcids":["https://orcid.org/0000-0002-7703-7712"]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]},{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bernd Moosmann","raw_affiliation_strings":["Institute for Pathobiochemistry, University Medical Center, Johannes Gutenberg University, D-55099 Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Pathobiochemistry, University Medical Center, Johannes Gutenberg University, D-55099 Mainz, Germany","institution_ids":["https://openalex.org/I197323543","https://openalex.org/I4210094062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019893954","display_name":"Christian Behl","orcid":"https://orcid.org/0000-0001-8453-2378","observed_orcids":["https://orcid.org/0000-0001-8453-2378"]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]},{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Behl","raw_affiliation_strings":["Institute for Pathobiochemistry, University Medical Center, Johannes Gutenberg University, D-55099 Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Pathobiochemistry, University Medical Center, Johannes Gutenberg University, D-55099 Mainz, Germany","institution_ids":["https://openalex.org/I197323543","https://openalex.org/I4210094062"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026143073","display_name":"Albrecht Martin Clement","orcid":"https://orcid.org/0000-0002-6058-7507","observed_orcids":["https://orcid.org/0000-0002-6058-7507"]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]},{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Albrecht M. Clement","raw_affiliation_strings":["Institute for Pathobiochemistry, University Medical Center, Johannes Gutenberg University, D-55099 Mainz, Germany. Electronic address: clement@uni-mainz.de","Institute for Pathobiochemistry, University Medical Center, Johannes Gutenberg University, D-55099 Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Pathobiochemistry, University Medical Center, Johannes Gutenberg University, D-55099 Mainz, Germany. Electronic address: clement@uni-mainz.de","institution_ids":["https://openalex.org/I197323543","https://openalex.org/I4210094062"]},{"raw_affiliation_string":"Institute for Pathobiochemistry, University Medical Center, Johannes Gutenberg University, D-55099 Mainz, Germany","institution_ids":["https://openalex.org/I197323543","https://openalex.org/I4210094062"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026143073"],"corresponding_institution_ids":["https://openalex.org/I197323543","https://openalex.org/I4210094062"],"apc_list":{"value":4240,"currency":"USD","value_usd":4240},"apc_paid":{"value":4240,"currency":"USD","value_usd":4240},"fwci":2.1726,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.8581443,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"72","issue":null,"first_page":"41","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.5839999914169312,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.5839999914169312,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.39989998936653137,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vilip-1","display_name":"VILIP-1","score":0.9789999723434448},{"id":"https://openalex.org/keywords/protein-dimerization","display_name":"protein dimerization","score":0.9580000042915344},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8790000081062317},{"id":"https://openalex.org/keywords/redox-regulation","display_name":"redox regulation","score":0.7390000224113464},{"id":"https://openalex.org/keywords/thioredoxin-reductase","display_name":"thioredoxin reductase","score":0.9559999704360962},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.7450000047683716},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.7730000019073486},{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/disulfide-bonds","display_name":"disulfide bonds","score":0.7279999852180481},{"id":"https://openalex.org/keywords/protein-myristoylation","display_name":"myristoylation","score":0.7919999957084656},{"id":"https://openalex.org/keywords/spinal-cord","display_name":"spinal cord","score":0.6079999804496765},{"id":"https://openalex.org/keywords/neuronal-calcium-sensor","display_name":"neuronal calcium sensor","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7655392289161682},{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.6639177799224854},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.594214677810669},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5721609592437744},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5147290229797363},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.5095174908638},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.5056779384613037},{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.49737098813056946},{"id":"https://openalex.org/C3623737","wikidata":"https://www.wikidata.org/wiki/Q421219","display_name":"Thioredoxin","level":3,"score":0.4962390065193176},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.49197718501091003},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4839616119861603},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4275195002555847},{"id":"https://openalex.org/C122229402","wikidata":"https://www.wikidata.org/wiki/Q5018802","display_name":"Calcium-binding protein","level":3,"score":0.4210865795612335},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31340110301971436},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11584311723709106},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.10676410794258118},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10547280311584473},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072105","descriptor_name":"Superoxide Dismutase-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051596","descriptor_name":"Neurocalcin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.freeradbiomed.2014.04.008","doi":"https://doi.org/10.1016/j.freeradbiomed.2014.04.008","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2014.04.008","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"},{"id":"pmid:24742816","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24742816","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free radical biology & medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.freeradbiomed.2014.04.008","doi":"https://doi.org/10.1016/j.freeradbiomed.2014.04.008","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2014.04.008","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332603","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":78,"referenced_works":["https://openalex.org/W7362354","https://openalex.org/W1521569676","https://openalex.org/W1538683380","https://openalex.org/W1560299838","https://openalex.org/W1562947759","https://openalex.org/W1638297412","https://openalex.org/W1670420367","https://openalex.org/W1782273871","https://openalex.org/W1964377967","https://openalex.org/W1967938128","https://openalex.org/W1969942104","https://openalex.org/W1970155315","https://openalex.org/W1970965314","https://openalex.org/W1971639674","https://openalex.org/W1972523592","https://openalex.org/W1974795836","https://openalex.org/W1975038690","https://openalex.org/W1975442641","https://openalex.org/W1975449325","https://openalex.org/W1977493393","https://openalex.org/W1978312362","https://openalex.org/W1983025747","https://openalex.org/W1988931872","https://openalex.org/W1992033043","https://openalex.org/W1996162600","https://openalex.org/W1997313112","https://openalex.org/W2005350874","https://openalex.org/W2013128012","https://openalex.org/W2014856221","https://openalex.org/W2017033865","https://openalex.org/W2017962609","https://openalex.org/W2018998887","https://openalex.org/W2022425508","https://openalex.org/W2022933182","https://openalex.org/W2028592029","https://openalex.org/W2032276337","https://openalex.org/W2036146475","https://openalex.org/W2036258428","https://openalex.org/W2037107864","https://openalex.org/W2038154629","https://openalex.org/W2038835746","https://openalex.org/W2040111890","https://openalex.org/W2040678584","https://openalex.org/W2040754808","https://openalex.org/W2042889317","https://openalex.org/W2043448850","https://openalex.org/W2044136163","https://openalex.org/W2049774048","https://openalex.org/W2057495929","https://openalex.org/W2062431951","https://openalex.org/W2065606007","https://openalex.org/W2072730564","https://openalex.org/W2073168240","https://openalex.org/W2075686585","https://openalex.org/W2076190864","https://openalex.org/W2080574078","https://openalex.org/W2082118556","https://openalex.org/W2087146463","https://openalex.org/W2089804237","https://openalex.org/W2090044366","https://openalex.org/W2094572278","https://openalex.org/W2097198685","https://openalex.org/W2100385096","https://openalex.org/W2101188587","https://openalex.org/W2105733226","https://openalex.org/W2113456839","https://openalex.org/W2115827933","https://openalex.org/W2122317831","https://openalex.org/W2124989053","https://openalex.org/W2130435783","https://openalex.org/W2133066848","https://openalex.org/W2149497936","https://openalex.org/W2150095505","https://openalex.org/W2155955938","https://openalex.org/W2160690724","https://openalex.org/W2169493549","https://openalex.org/W2170593168","https://openalex.org/W6678304903"],"related_works":["https://openalex.org/W7134235476","https://openalex.org/W2792636890","https://openalex.org/W1995562965","https://openalex.org/W2415489310","https://openalex.org/W7101246867","https://openalex.org/W2097228496","https://openalex.org/W4200001211","https://openalex.org/W2091902711","https://openalex.org/W3016628656","https://openalex.org/W4413309358"],"abstract_inverted_index":{"Redox":[0],"control":[1],"of":[2,21,29,56,72,87,111,122,130,157,171,189,210,216,231],"proteins":[3],"that":[4,95,168,182,193],"form":[5],"disulfide":[6],"bonds":[7],"upon":[8],"oxidative":[9,51,115,208],"challenge":[10],"is":[11,77,97,155],"an":[12,114],"emerging":[13],"topic":[14],"in":[15,44,125,144,200,223,228],"the":[16,27,30,70,73,85,109,145,158,165,169,202,207,211,229,232],"physiological":[17],"and":[18,62,81,135,181,185,206],"pathophysiological":[19],"regulation":[20],"protein":[22,34,36,160,221],"function.":[23],"We":[24,48,117,162],"have":[25,49,118],"investigated":[26,119],"role":[28,199],"neuronal":[31],"calcium":[32,80,204],"sensor":[33,43],"visinin-like":[35],"1":[37],"(VILIP-1)":[38],"as":[39,66],"a":[40,45,59,103,177,197,214],"novel":[41,178],"redox":[42],"cellular":[46,60],"system.":[47],"found":[50],"stress":[52],"to":[53,113,140,220],"trigger":[54],"dimerization":[55,96,107,121,184],"VILIP-1":[57,106,123,138,154,183,194,217],"within":[58],"environment":[61],"identified":[63],"thioredoxin":[64],"reductase":[65],"responsible":[67],"for":[68,164],"facilitating":[69],"remonomerization":[71],"dimeric":[74],"protein.":[75],"Dimerization":[76],"modulated":[78],"by":[79,92,100],"not":[82],"dependent":[83],"on":[84],"myristoylation":[86],"VILIP-1.":[88],"Furthermore,":[89,213],"we":[90],"show":[91,163],"site-directed":[93],"mutagenesis":[94],"exclusively":[98],"mediated":[99],"Cys187.":[101],"As":[102],"functional":[104,198],"consequence,":[105],"modulates":[108],"sensitivity":[110],"cells":[112],"challenge.":[116],"whether":[120],"occurs":[124],"two":[126],"different":[127],"animal":[128],"models":[129],"amyotrophic":[131],"lateral":[132],"sclerosis":[133],"(ALS)":[134],"detected":[136],"soluble":[137],"dimers":[139,195],"be":[141,226],"significantly":[142],"enriched":[143],"spinal":[146],"cord":[147],"from":[148],"phenotypic":[149],"disease":[150],"onset":[151],"onwards.":[152],"Moreover,":[153],"part":[156],"ALS-specific":[159],"aggregates.":[161],"first":[166],"time":[167],"C-terminus":[170],"VILIP-1,":[172],"containing":[173],"Cys187,":[174],"might":[175],"represent":[176],"redox-sensitive":[179],"motif":[180],"aggregation":[186,222],"are":[187],"hallmarks":[188],"ALS.":[190],"This":[191],"suggests":[192],"play":[196],"integrating":[201],"cytosolic":[203],"concentration":[205],"status":[209],"cell.":[212],"loss":[215],"function":[218],"owing":[219],"ALS":[224],"could":[225],"relevant":[227],"pathophysiology":[230],"disease.":[233]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}