{"id":"https://openalex.org/W1978264115","doi":"https://doi.org/10.1080/02652039509374369","title":"Hydrolysis studies on oleamide in simulated gastrointestinal fluids","display_name":"Hydrolysis studies on oleamide in simulated gastrointestinal fluids","publication_year":1995,"publication_date":"1995-11-01","ids":{"openalex":"https://openalex.org/W1978264115","doi":"https://doi.org/10.1080/02652039509374369","mag":"1978264115","pmid":"https://pubmed.ncbi.nlm.nih.gov/8608851"},"language":"en","primary_location":{"id":"doi:10.1080/02652039509374369","doi":"https://doi.org/10.1080/02652039509374369","is_oa":false,"landing_page_url":"https://doi.org/10.1080/02652039509374369","pdf_url":null,"source":{"id":"https://openalex.org/S4210176327","display_name":"Food Additives & Contaminants","issn_l":"0265-203X","issn":["0265-203X","1464-5122"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food Additives and Contaminants","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070620868","display_name":"Ian Richard Cooper","orcid":"https://orcid.org/0000-0003-1955-5009","observed_orcids":["https://orcid.org/0000-0003-1955-5009"]},"institutions":[{"id":"https://openalex.org/I4210102761","display_name":"Smithers Pira","ror":"https://ror.org/01m484026","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210102761"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ian Cooper","raw_affiliation_strings":["Pira International, Leatherhead, Surrey, UK","Pira International , Randalls Road, Leatherhead, Surrey, KT22 7RU, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pira International, Leatherhead, Surrey, UK","institution_ids":["https://openalex.org/I4210102761"]},{"raw_affiliation_string":"Pira International , Randalls Road, Leatherhead, Surrey, KT22 7RU, UK","institution_ids":["https://openalex.org/I4210102761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084714499","display_name":"Tony Lord","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102761","display_name":"Smithers Pira","ror":"https://ror.org/01m484026","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210102761"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tony Lord","raw_affiliation_strings":["Pira International, Randalls Road, Leatherhead, Surrey, KT22 7RU, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pira International, Randalls Road, Leatherhead, Surrey, KT22 7RU, UK","institution_ids":["https://openalex.org/I4210102761"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034746957","display_name":"Philip A. Tice","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102761","display_name":"Smithers Pira","ror":"https://ror.org/01m484026","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210102761"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Philip A. Tice","raw_affiliation_strings":["Pira International, Randalls Road, Leatherhead, Surrey, KT22 7RU, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pira International, Randalls Road, Leatherhead, Surrey, KT22 7RU, UK","institution_ids":["https://openalex.org/I4210102761"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210102761"],"apc_list":null,"apc_paid":null,"fwci":0.6401,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.66354764,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"12","issue":"6","first_page":"769","last_page":"777"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13165","display_name":"Agricultural safety and regulations","score":0.2515000104904175,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13165","display_name":"Agricultural safety and regulations","score":0.2515000104904175,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13092","display_name":"Environmental Chemistry and Analysis","score":0.11749999970197678,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13171","display_name":"Polymer Science and PVC","score":0.11330000311136246,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oleamide","display_name":"oleamide","score":1.0},{"id":"https://openalex.org/keywords/hydrolysis","display_name":"hydrolysis","score":0.7379999756813049},{"id":"https://openalex.org/keywords/simulated-gastrointestinal-fluids","display_name":"simulated gastrointestinal fluids","score":0.9319999814033508},{"id":"https://openalex.org/keywords/food-packaging-additives","display_name":"food packaging additives","score":0.5519999861717224},{"id":"https://openalex.org/keywords/plastic-food-packaging","display_name":"plastic food packaging","score":0.5849999785423279},{"id":"https://openalex.org/keywords/slip-additives","display_name":"slip additives","score":0.5239999890327454},{"id":"https://openalex.org/keywords/bile-salts","display_name":"bile salts","score":0.5619999766349792},{"id":"https://openalex.org/keywords/oleic-acid","display_name":"oleic acid","score":0.8190000057220459},{"id":"https://openalex.org/keywords/migration-into-food","display_name":"food migration","score":0.5220000147819519},{"id":"https://openalex.org/keywords/gastric-juice","display_name":"gastric juice","score":0.6480000019073486},{"id":"https://openalex.org/keywords/intestinal-fluid","display_name":"intestinal fluid","score":0.9300000071525574},{"id":"https://openalex.org/keywords/food-safety","display_name":"food safety","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.4675893485546112},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4000388979911804},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.33437949419021606},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17399799823760986}],"mesh":[{"descriptor_ui":"D001647","descriptor_name":"Bile Acids and Salts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001826","descriptor_name":"Body Fluids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004064","descriptor_name":"Digestive System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005503","descriptor_name":"Food Additives","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005750","descriptor_name":"Gastric Juice","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009829","descriptor_name":"Oleic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010194","descriptor_name":"Pancreatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010434","descriptor_name":"Pepsin A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018857","descriptor_name":"Food Packaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019301","descriptor_name":"Oleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/02652039509374369","doi":"https://doi.org/10.1080/02652039509374369","is_oa":false,"landing_page_url":"https://doi.org/10.1080/02652039509374369","pdf_url":null,"source":{"id":"https://openalex.org/S4210176327","display_name":"Food Additives & Contaminants","issn_l":"0265-203X","issn":["0265-203X","1464-5122"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food Additives and Contaminants","raw_type":"journal-article"},{"id":"pmid:8608851","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8608851","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food additives and contaminants","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308878","display_name":"United States Pharmacopeia","ror":"https://ror.org/03a7bpg58"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W2007708955","https://openalex.org/W2017046958","https://openalex.org/W2060085619","https://openalex.org/W2090077262"],"related_works":["https://openalex.org/W1988771810","https://openalex.org/W2060085619","https://openalex.org/W2007708955","https://openalex.org/W2951558106","https://openalex.org/W2060294059","https://openalex.org/W2091838155","https://openalex.org/W2028755776","https://openalex.org/W2544827160","https://openalex.org/W3023788531","https://openalex.org/W4232485872"],"abstract_inverted_index":{"Hydrolysis":[0],"studies":[1],"using":[2,27],"simulated":[3,29,62,84],"gastrointestinal":[4,30],"fluids":[5,64],"have":[6,24],"been":[7,25,125],"performed":[8],"on":[9],"oleamide,":[10],"an":[11,116],"important":[12],"fatty":[13],"acid":[14],"amide":[15],"slip":[16],"additive":[17],"used":[18],"in":[19,54,61],"plastics":[20],"food":[21,143],"packaging.":[22],"Experiments":[23],"conducted":[26],"the":[28,34,53,92,130,152,155],"fluids,":[31],"specified":[32],"by":[33],"Scientific":[35],"Committee":[36],"for":[37,39,72,104],"Food":[38],"hydrolysis":[40,60,95],"studies,":[41],"and":[42],"with":[43],"slightly":[44],"modified":[45],"preparations":[46],"believed":[47],"to":[48,67,83,89,96,137,147,151],"be":[49,68],"more":[50],"representative":[51],"of":[52,59,80,94,100,113,129,134,154],"vivo":[55],"situation.":[56],"The":[57],"degree":[58,93],"gastric":[63],"was":[65,87,119],"found":[66,88],"negligible":[69],"after":[70,102],"incubation":[71,103],"4":[73,105],"h":[74,106],"at":[75,107],"37":[76,108],"degrees":[77,109],"C.":[78,110],"Addition":[79],"'bile":[81],"salts'":[82],"intestinal":[85],"fluid":[86],"significantly":[90],"increase":[91],"about":[97],"95%":[98],"loss":[99],"oleamide":[101,135],"Stoichiometric":[111],"formation":[112],"oleic":[114],"acid,":[115],"innocuous":[117],"substance,":[118],"also":[120],"demonstrated.":[121],"It":[122],"has":[123],"therefore":[124],"concluded":[126],"that":[127],"ingestion":[128],"very":[131],"low":[132],"levels":[133],"expected":[136],"migrate":[138],"into":[139],"most":[140],"foods":[141],"from":[142],"packaging":[144],"is":[145],"unlikely":[146],"pose":[148],"a":[149],"threat":[150],"health":[153],"consumer.":[156]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
