{"id":"https://openalex.org/W1978261794","doi":"https://doi.org/10.1021/ja004176c","title":"On the Regiospecificity of Vanadium Bromoperoxidase","display_name":"On the Regiospecificity of Vanadium Bromoperoxidase","publication_year":2001,"publication_date":"2001-03-15","ids":{"openalex":"https://openalex.org/W1978261794","doi":"https://doi.org/10.1021/ja004176c","mag":"1978261794","pmid":"https://pubmed.ncbi.nlm.nih.gov/11457064"},"language":"en","primary_location":{"id":"doi:10.1021/ja004176c","doi":"https://doi.org/10.1021/ja004176c","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja004176c","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065150520","display_name":"Jennifer S. Martinez","orcid":"https://orcid.org/0000-0001-6737-2712","observed_orcids":["https://orcid.org/0000-0001-6737-2712"]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer S. Martinez","raw_affiliation_strings":["Contribution from the Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106-9510"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106-9510","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113872389","display_name":"Georgia Law Carroll","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Georgia L. Carroll","raw_affiliation_strings":["Contribution from the Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106-9510"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106-9510","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041119212","display_name":"Richard A. Tschirret-Guth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard A. Tschirret-Guth","raw_affiliation_strings":["Contribution from the Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106-9510"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106-9510","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076103750","display_name":"Gereon Altenhoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gereon Altenhoff","raw_affiliation_strings":["Contribution from the Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106-9510"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106-9510","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082958504","display_name":"R. Daniel Little","orcid":"https://orcid.org/0000-0001-5836-3814","observed_orcids":["https://orcid.org/0000-0001-5836-3814"]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Daniel Little","raw_affiliation_strings":["Contribution from the Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106-9510"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106-9510","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089184763","display_name":"Alison Butler","orcid":"https://orcid.org/0000-0002-3525-7864","observed_orcids":["https://orcid.org/0000-0002-3525-7864"]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alison Butler","raw_affiliation_strings":["Contribution from the Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106-9510"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106-9510","institution_ids":["https://openalex.org/I154570441"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5089184763"],"corresponding_institution_ids":["https://openalex.org/I154570441"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.1318,"has_fulltext":false,"cited_by_count":99,"citation_normalized_percentile":{"value":0.91071085,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"123","issue":"14","first_page":"3289","last_page":"3294"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12136","display_name":"Vanadium and Halogenation Chemistry","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12136","display_name":"Vanadium and Halogenation Chemistry","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vanadium-bromoperoxidase","display_name":"vanadium bromoperoxidase","score":0.9449999928474426},{"id":"https://openalex.org/keywords/haloperoxidases","display_name":"haloperoxidases","score":0.9150000214576721},{"id":"https://openalex.org/keywords/2-indolinones","display_name":"2-indolinones","score":0.8240000009536743},{"id":"https://openalex.org/keywords/ascophyllum-nodosum","display_name":"Ascophyllum nodosum","score":0.8759999871253967},{"id":"https://openalex.org/keywords/corallina-officinalis","display_name":"Corallina officinalis","score":1.0},{"id":"https://openalex.org/keywords/marine-algae","display_name":"marine algae","score":0.7070000171661377},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.5519999861717224},{"id":"https://openalex.org/keywords/bromide","display_name":"bromide","score":0.6710000038146973},{"id":"https://openalex.org/keywords/halogenated-natural-products","display_name":"halogenated natural products","score":0.7459999918937683}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9468259811401367},{"id":"https://openalex.org/C533411734","wikidata":"https://www.wikidata.org/wiki/Q171877","display_name":"Hydrogen peroxide","level":2,"score":0.7143060564994812},{"id":"https://openalex.org/C65973085","wikidata":"https://www.wikidata.org/wiki/Q888529","display_name":"Halogenation","level":2,"score":0.710332453250885},{"id":"https://openalex.org/C504678139","wikidata":"https://www.wikidata.org/wiki/Q722","display_name":"Vanadium","level":2,"score":0.6369765400886536},{"id":"https://openalex.org/C77176794","wikidata":"https://www.wikidata.org/wiki/Q187689","display_name":"Oxidizing agent","level":2,"score":0.5689566135406494},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.5511748194694519},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.5348381400108337},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.520631730556488},{"id":"https://openalex.org/C517835270","wikidata":"https://www.wikidata.org/wiki/Q879","display_name":"Bromine","level":2,"score":0.5095191597938538},{"id":"https://openalex.org/C2777496521","wikidata":"https://www.wikidata.org/wiki/Q7840446","display_name":"Tribromide","level":2,"score":0.43771085143089294},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.4262397289276123},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.3788432478904724},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000459","descriptor_name":"Phaeophyceae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D000461","descriptor_name":"Rhodophyta","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001966","descriptor_name":"Bromine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001966","descriptor_name":"Bromine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010544","descriptor_name":"Peroxidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010544","descriptor_name":"Peroxidases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010637","descriptor_name":"Phenolsulfonphthalein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010637","descriptor_name":"Phenolsulfonphthalein","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ja004176c","doi":"https://doi.org/10.1021/ja004176c","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja004176c","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:11457064","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11457064","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1523040324","https://openalex.org/W1590377765","https://openalex.org/W1965948499","https://openalex.org/W1983226795","https://openalex.org/W1986536974","https://openalex.org/W2007810407","https://openalex.org/W2046015418","https://openalex.org/W2050640768","https://openalex.org/W2069300781","https://openalex.org/W2084140887","https://openalex.org/W4239152447","https://openalex.org/W4254444385","https://openalex.org/W4300630313"],"related_works":["https://openalex.org/W4239152447","https://openalex.org/W243250251","https://openalex.org/W2485543899","https://openalex.org/W4415550619","https://openalex.org/W263724788","https://openalex.org/W2158440192","https://openalex.org/W285337619","https://openalex.org/W4404519042","https://openalex.org/W2045957601","https://openalex.org/W974021876"],"abstract_inverted_index":{"Vanadium":[0],"haloperoxidase":[1,200],"enzymes":[2,99],"catalyze":[3,75,100],"the":[4,41,68,71,81,90,101,119,138,162,181,185,190],"oxidation":[5,84,103],"of":[6,28,43,55,70,85,104,141,158,167,184,193],"halide":[7],"ions":[8],"by":[9,87,197],"hydrogen":[10,29],"peroxide,":[11],"producing":[12],"an":[13,19],"oxidized":[14,60],"intermediate,":[15],"which":[16,56,117,159],"can":[17],"halogenate":[18],"organic":[20],"substrate":[21],"or":[22,61],"react":[23],"with":[24,137,169],"a":[25,107,194,198],"second":[26],"equivalent":[27],"peroxide":[30],"to":[31,37,74],"produce":[32,118,150],"dioxygen.":[33],"Haloperoxidases":[34],"are":[35,58],"thought":[36],"be":[38],"involved":[39],"in":[40,106,124],"biogenesis":[42],"halogenated":[44],"natural":[45],"products":[46],"isolated":[47],"from":[48,89,161],"marine":[49,72,91],"organisms,":[50],"including":[51],"indoles":[52],"and":[53,95,112,153,173,177,201],"terpenes,":[54],"many":[57],"selectively":[59],"halogenated.":[62],"Little":[63],"has":[64],"been":[65],"shown":[66],"concerning":[67],"ability":[69],"haloperoxidases":[73],"regioselective":[76],"reactions.":[77],"Here":[78],"we":[79],"report":[80],"regiospecific":[82,102,195],"bromoperoxidative":[83],"1,3-di-tert-butylindole":[86,105],"V-BrPO":[88,174],"algae":[92],"Ascophyllum":[93],"nodosum":[94],"Corallina":[96],"officinalis.":[97],"Both":[98],"reaction":[108],"requiring":[109],"both":[110,170],"H(2)O(2)":[111,130],"Br(-)":[113],"as":[114,206],"substrates,":[115],"but":[116],"unbrominated":[120],"1,3-di-tert-butyl-2-indolinone":[121,168],"product":[122],"exclusively,":[123],"near":[125],"quantitative":[126],"yield":[127],"(i.e.":[128],"one":[129,154],"consumed":[131],"per":[132],"product).":[133],"By":[134],"contrast,":[135],"reactions":[136],"controlled":[139],"addition":[140],"aqueous":[142,171],"bromine":[143,172],"solution":[144],"(HOBr":[145],"=":[146,148],"Br(2)":[147],"Br(3)(-))":[149],"three":[151],"monobromo":[152],"dibromo-2-indolinone":[155],"products,":[156],"all":[157],"differ":[160,175],"V-BrPO-catalyzed":[163],"product.":[164],"Further,":[165],"reactivities":[166],"significantly":[176],"shed":[178],"light":[179],"onto":[180],"possible":[182],"nature":[183],"oxidizing":[186],"intermediate.":[187],"This":[188],"is":[189],"first":[191],"example":[192],"bromination":[196],"vanadium":[199],"further":[202],"extends":[203],"their":[204],"usefulness":[205],"catalysts.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}