{"id":"https://openalex.org/W1978251986","doi":"https://doi.org/10.1097/00000542-199112000-00010","title":"Isoflurane Anesthesia and Circadian Temperature Cycles in Humans","display_name":"Isoflurane Anesthesia and Circadian Temperature Cycles in Humans","publication_year":1991,"publication_date":"1991-12-01","ids":{"openalex":"https://openalex.org/W1978251986","doi":"https://doi.org/10.1097/00000542-199112000-00010","mag":"1978251986","pmid":"https://pubmed.ncbi.nlm.nih.gov/1741520"},"language":"en","primary_location":{"id":"doi:10.1097/00000542-199112000-00010","doi":"https://doi.org/10.1097/00000542-199112000-00010","is_oa":true,"landing_page_url":"https://doi.org/10.1097/00000542-199112000-00010","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/75/6/985/322559/0000542-199112000-00010.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://pubs.asahq.org/anesthesiology/article-pdf/75/6/985/322559/0000542-199112000-00010.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042996287","display_name":"Daniel I. Sessler","orcid":"https://orcid.org/0000-0001-9932-3077","observed_orcids":["https://orcid.org/0000-0001-9932-3077"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel\u00a0I. Sessler","raw_affiliation_strings":["Assistant Professor of Anesthesia, Department of Anesthesia","Department of Anesthesia, University of California San Francisco 94143-0648"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor of Anesthesia, Department of Anesthesia","institution_ids":[]},{"raw_affiliation_string":"Department of Anesthesia, University of California San Francisco 94143-0648","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061309153","display_name":"Kathryn A. Lee","orcid":"https://orcid.org/0000-0001-5331-1740","observed_orcids":["https://orcid.org/0000-0001-5331-1740"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kathryn\u00a0A. Lee","raw_affiliation_strings":["Assistant Professor of Nursing, Department of Family Health Care Nursing"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor of Nursing, Department of Family Health Care Nursing","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063406083","display_name":"Joseph A. McGuire","orcid":"https://orcid.org/0000-0003-3246-5198","observed_orcids":["https://orcid.org/0000-0003-3246-5198"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph McGuire","raw_affiliation_strings":["Staff Research Associate, Department of Anesthesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Staff Research Associate, Department of Anesthesia","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2367,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.36857562,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"75","issue":"6","first_page":"985","last_page":"989"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isoflurane","display_name":"isoflurane","score":0.9580000042915344},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.9150000214576721},{"id":"https://openalex.org/keywords/body-temperature","display_name":"body temperature","score":0.6899999976158142},{"id":"https://openalex.org/keywords/phase-lag","display_name":"phase lag","score":0.593999981880188},{"id":"https://openalex.org/keywords/jet-lag","display_name":"jet lag","score":0.6620000004768372},{"id":"https://openalex.org/keywords/acrophase","display_name":"acrophase","score":0.7110000252723694},{"id":"https://openalex.org/keywords/mesor","display_name":"mesor","score":0.5789999961853027},{"id":"https://openalex.org/keywords/temperature-amplitude","display_name":"temperature amplitude","score":0.4650000035762787},{"id":"https://openalex.org/keywords/internal-biological-clock","display_name":"internal biological clock","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C2776359302","wikidata":"https://www.wikidata.org/wiki/Q413918","display_name":"Isoflurane","level":2,"score":0.9393724203109741},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8435940742492676},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.7784512042999268},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.7597572803497314},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.250876247882843}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000758","descriptor_name":"Anesthesia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001833","descriptor_name":"Body Temperature Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001833","descriptor_name":"Body Temperature Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007530","descriptor_name":"Isoflurane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00000542-199112000-00010","doi":"https://doi.org/10.1097/00000542-199112000-00010","is_oa":true,"landing_page_url":"https://doi.org/10.1097/00000542-199112000-00010","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/75/6/985/322559/0000542-199112000-00010.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},{"id":"pmid:1741520","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1741520","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1097/00000542-199112000-00010","doi":"https://doi.org/10.1097/00000542-199112000-00010","is_oa":true,"landing_page_url":"https://doi.org/10.1097/00000542-199112000-00010","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/75/6/985/322559/0000542-199112000-00010.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6849561753","display_name":"FATIGUE AND SLEEP PATTERNS IN CHILDBEARING WOMEN","funder_award_id":"R29NR002247","funder_id":"https://openalex.org/F4320337353","funder_display_name":"National Institute of Nursing Research"},{"id":"https://openalex.org/G8837788875","display_name":"PERIANETHETIC TREMOR AND THERMOREGULATION","funder_award_id":"R29GM039723","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337353","display_name":"National Institute of Nursing Research","ror":"https://ror.org/01y3zfr79"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978251986.pdf","grobid_xml":"https://content.openalex.org/works/W1978251986.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4241484257","https://openalex.org/W2948707312","https://openalex.org/W2921322053","https://openalex.org/W2749145768","https://openalex.org/W2145574698","https://openalex.org/W7145820112","https://openalex.org/W3094507186","https://openalex.org/W2480894326","https://openalex.org/W1978954335","https://openalex.org/W2361436587"],"abstract_inverted_index":{"Cognitive":[0],"performance":[1],"in":[2,36,52,179,226],"postsurgical":[3],"patients":[4],"may":[5],"be":[6],"impaired":[7],"by":[8,18],"disturbances":[9],"of":[10,64,73,100,106,147,154,162,166,187,197,255],"normal":[11,207],"circadian":[12,39,247],"rhythm":[13],"analogous":[14],"to":[15,206,252],"those":[16],"produced":[17],"rapid":[19],"transmeridian":[20],"travel":[21],"(\"jet":[22],"lag\").":[23],"We":[24,42],"therefore":[25],"tested":[26],"the":[27,37,68,101,107,116,180,188,195,209,214,229,243],"hypothesis":[28,239],"that":[29,104,115,242],"isoflurane":[30,75,218],"anesthesia":[31,76,173,198],"alone":[32],"produces":[33],"a":[34,62,124,138,143],"phase-delay":[35],"human":[38],"temperature":[40,46,108,145,164,182,189,248],"rhythm.":[41],"monitored":[43],"central":[44,181],"body":[45],"rhythms":[47],"(using":[48],"an":[49],"ingested":[50],"sensor)":[51],"five":[53],"young,":[54],"healthy,":[55],"male":[56],"volunteers":[57,92,136],"at":[58,80],"3-min":[59],"intervals":[60],"for":[61,130],"total":[63],"5":[65],"days.":[66],"On":[67],"3rd":[69],"day,":[70],"3":[71],"h":[72,113],"1.0%":[74],"was":[77,118,191,221],"administered":[78],"beginning":[79],"approximately":[81],"10:00":[82],"AM.":[83],"Thiopental,":[84],"opioids,":[85],"and":[86,114,127,160,240],"other":[87],"medications":[88],"were":[89,93,121],"not":[90,175,236],"administered;":[91],"kept":[94],"normothermic":[95],"during":[96],"anesthesia.":[97,232],"Visual":[98],"inspection":[99],"data":[102,234],"confirmed":[103],"periodicity":[105],"cycles":[109,249],"remained":[110],"near":[111],"24":[112],"curve":[117],"sinusoidal.":[119],"Data":[120],"fit":[122],"using":[123],"two-step":[125],"sine":[126],"cosine":[128],"regression":[129],"each":[131],"24-h":[132,140],"period.":[133],"Before":[134],"anesthesia,":[135],"demonstrated":[137],"consistent":[139],"cycle,":[141],"with":[142,213],"mean":[144],"(mesor)":[146],"36.8":[148],"+/-":[149,156,169,200],"0.2":[150,157,201],"degrees":[151,158,202],"C,":[152,159],"amplitude":[153],"0.8":[155],"time":[161],"maximum":[163],"(acrophase)":[165],"3:06":[167],"PM":[168],"2.4":[170],"h.":[171],"Isoflurane":[172],"did":[174],"produce":[176],"significant":[177,224],"changes":[178],"mesor.":[183],"Peak-to-trough":[184],"range":[185],"(amplitude)":[186],"cycle":[190],"significantly":[192],"reduced":[193],"on":[194,208,228],"day":[196,230],"(0.5":[199],"C)":[203],"but":[204],"returned":[205],"subsequent":[210],"day.":[211],"Compared":[212],"2":[215],"days":[216],"preceding":[217],"administration,":[219],"there":[220],"no":[222],"statistically":[223],"change":[225],"acrophase":[227],"following":[231],"These":[233],"do":[235],"support":[237],"our":[238],"suggest":[241],"internal":[244],"timer":[245],"controlling":[246],"is":[250],"resistant":[251],"clinical":[253],"concentrations":[254],"isoflurane.":[256]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}