{"id":"https://openalex.org/W1978251105","doi":"https://doi.org/10.1074/jbc.m113.503714","title":"Novel Structural and Functional Insights into M3 Muscarinic Receptor Dimer/Oligomer Formation","display_name":"Novel Structural and Functional Insights into M3 Muscarinic Receptor Dimer/Oligomer Formation","publication_year":2013,"publication_date":"2013-10-17","ids":{"openalex":"https://openalex.org/W1978251105","doi":"https://doi.org/10.1074/jbc.m113.503714","mag":"1978251105","pmid":"https://pubmed.ncbi.nlm.nih.gov/24133207","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3843091"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m113.503714","doi":"https://doi.org/10.1074/jbc.m113.503714","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m113.503714","pdf_url":"http://www.jbc.org/article/S0021925820554732/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820554732/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101909762","display_name":"Jianxin Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianxin Hu","raw_affiliation_strings":["From the Molecular Signaling Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Molecular Signaling Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kelly Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly Hu","raw_affiliation_strings":["Molecular Signaling Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Signaling Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100392625","display_name":"Tong Liu","orcid":"https://orcid.org/0000-0001-9152-5264","observed_orcids":["https://orcid.org/0000-0001-9152-5264"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tong Liu","raw_affiliation_strings":["Molecular Signaling Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Signaling Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053663320","display_name":"Matthew K. Stern","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew K. Stern","raw_affiliation_strings":["Molecular Signaling Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Signaling Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060543585","display_name":"Rajendra Mistry","orcid":"https://orcid.org/0000-0001-9444-9711","observed_orcids":["https://orcid.org/0000-0001-9444-9711"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rajendra Mistry","raw_affiliation_strings":["Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, LE1 9HN, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, LE1 9HN, United Kingdom","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044018474","display_name":"R. A. John Challiss","orcid":"https://orcid.org/0000-0001-5506-2848","observed_orcids":["https://orcid.org/0000-0001-5506-2848"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R.A.John Challiss","raw_affiliation_strings":["Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, LE1 9HN, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, LE1 9HN, United Kingdom","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021219075","display_name":"Stefano Costanzi","orcid":"https://orcid.org/0000-0003-3183-7332","observed_orcids":["https://orcid.org/0000-0003-3183-7332"]},"institutions":[{"id":"https://openalex.org/I181401687","display_name":"American University","ror":"https://ror.org/052w4zt36","country_code":"US","type":"education","lineage":["https://openalex.org/I181401687"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefano Costanzi","raw_affiliation_strings":["Chemistry Department and Center for Behavioral Neuroscience, American University, Washington, D. C. 20016"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department and Center for Behavioral Neuroscience, American University, Washington, D. C. 20016","institution_ids":["https://openalex.org/I181401687"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015095365","display_name":"J\u00fcrgen Wess","orcid":"https://orcid.org/0000-0003-0818-1232","observed_orcids":["https://orcid.org/0000-0003-0818-1232"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J\u00fcrgen Wess","raw_affiliation_strings":["Molecular Signaling Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Signaling Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5015095365"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.2386,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.87661845,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"288","issue":"48","first_page":"34777","last_page":"34790"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/muscarinic-m3-receptor","display_name":"M3 muscarinic receptor","score":0.9959999918937683},{"id":"https://openalex.org/keywords/receptor-oligomerization","display_name":"receptor oligomerization","score":0.9570000171661377},{"id":"https://openalex.org/keywords/disulfide-cross-linking","display_name":"disulfide cross-linking","score":0.9520000219345093},{"id":"https://openalex.org/keywords/second-intracellular-loop","display_name":"second intracellular loop","score":0.7170000076293945},{"id":"https://openalex.org/keywords/dimer-interface","display_name":"dimer interface","score":0.6110000014305115},{"id":"https://openalex.org/keywords/receptor-g-protein-coupling","display_name":"receptor-G protein coupling","score":0.8579999804496765},{"id":"https://openalex.org/keywords/class-a-gpcrs","display_name":"class A GPCRs","score":0.7860000133514404},{"id":"https://openalex.org/keywords/cysteine-mutants","display_name":"cysteine mutants","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.7881416082382202},{"id":"https://openalex.org/C2780642029","wikidata":"https://www.wikidata.org/wiki/Q726004","display_name":"Oligomer","level":2,"score":0.5462538599967957},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5326375961303711},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.49012860655784607},{"id":"https://openalex.org/C2778530040","wikidata":"https://www.wikidata.org/wiki/Q1937315","display_name":"Helix (gastropod)","level":3,"score":0.4395427107810974},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.4244280755519867},{"id":"https://openalex.org/C202033177","wikidata":"https://www.wikidata.org/wiki/Q423107","display_name":"Rhodopsin","level":3,"score":0.41228657960891724},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.394281804561615},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3718527555465698},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3381349742412567},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30433395504951477},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23923718929290771},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2779965526","wikidata":"https://www.wikidata.org/wiki/Q308841","display_name":"Snail","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010716","descriptor_name":"Phosphatidylinositols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010716","descriptor_name":"Phosphatidylinositols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043587","descriptor_name":"Receptor, Muscarinic M3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043587","descriptor_name":"Receptor, Muscarinic M3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D043587","descriptor_name":"Receptor, Muscarinic M3","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m113.503714","doi":"https://doi.org/10.1074/jbc.m113.503714","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m113.503714","pdf_url":"http://www.jbc.org/article/S0021925820554732/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3212624","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3843091","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3843091","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3843091","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:24133207","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24133207","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m113.503714","doi":"https://doi.org/10.1074/jbc.m113.503714","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m113.503714","pdf_url":"http://www.jbc.org/article/S0021925820554732/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/7","score":0.800000011920929,"display_name":"Affordable and clean energy"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978251105.pdf","grobid_xml":"https://content.openalex.org/works/W1978251105.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1603274157","https://openalex.org/W1867117224","https://openalex.org/W1969937437","https://openalex.org/W1973245565","https://openalex.org/W1980823970","https://openalex.org/W1983819790","https://openalex.org/W1994019984","https://openalex.org/W1994113226","https://openalex.org/W1995089537","https://openalex.org/W2000510012","https://openalex.org/W2003465469","https://openalex.org/W2010544588","https://openalex.org/W2012822294","https://openalex.org/W2014055152","https://openalex.org/W2017713787","https://openalex.org/W2025951927","https://openalex.org/W2027354448","https://openalex.org/W2027693921","https://openalex.org/W2028645925","https://openalex.org/W2038422963","https://openalex.org/W2041211150","https://openalex.org/W2044872071","https://openalex.org/W2046161078","https://openalex.org/W2047144511","https://openalex.org/W2047567287","https://openalex.org/W2050175789","https://openalex.org/W2056312165","https://openalex.org/W2057148477","https://openalex.org/W2063231928","https://openalex.org/W2066142633","https://openalex.org/W2071327910","https://openalex.org/W2073690777","https://openalex.org/W2083725367","https://openalex.org/W2086647710","https://openalex.org/W2089468762","https://openalex.org/W2093127088","https://openalex.org/W2094454635","https://openalex.org/W2094592079","https://openalex.org/W2095302288","https://openalex.org/W2104477830","https://openalex.org/W2105192362","https://openalex.org/W2118950099","https://openalex.org/W2124233079","https://openalex.org/W2136547072","https://openalex.org/W2143879590","https://openalex.org/W2152853006","https://openalex.org/W2158207659","https://openalex.org/W2165345221","https://openalex.org/W2165357853","https://openalex.org/W2167857702","https://openalex.org/W2169664022"],"related_works":["https://openalex.org/W2143879590","https://openalex.org/W2086647710","https://openalex.org/W2308910585","https://openalex.org/W2071527250","https://openalex.org/W2084413946","https://openalex.org/W2030175837","https://openalex.org/W2095302288","https://openalex.org/W2291782253","https://openalex.org/W2056410410","https://openalex.org/W100736639"],"abstract_inverted_index":{"Class":[0],"A":[1,33,236],"G":[2,185],"protein-coupled":[3],"receptors":[4],"(GPCRs)":[5],"are":[6,47,199],"able":[7,39],"to":[8,40,85,180],"form":[9,41],"homodimers":[10],"and/or":[11],"oligomeric":[12],"arrays.":[13],"We":[14],"recently":[15],"proposed,":[16],"based":[17],"on":[18],"bioluminescence":[19],"resonance":[20],"energy":[21],"transfer":[22],"studies":[23,102],"with":[24,106,143,149,232],"the":[25,36,121,125,150,166,192,215,223],"M3":[26],"muscarinic":[27],"receptor":[28],"(M3R),":[29],"a":[30,81,93,226],"prototypic":[31],"class":[32,235],"GPCR,":[34],"that":[35,46,138,189],"M3R":[37,88,119,156,219,224],"is":[38],"multiple,":[42],"structurally":[43,154],"distinct":[44,117,155],"dimers":[45],"probably":[48],"transient":[49],"in":[50,92,141,183,191,218],"nature":[51],"(McMillin,":[52],"S.":[53],"M.,":[54,56],"Heusel,":[55],"Liu,":[57],"T.,":[58],"Costanzi,":[59],"S.,":[60],"and":[61,130,165,211],"Wess,":[62],"J.":[63,65],"(2011)":[64],"Biol.":[66],"Chem.":[67],"286,":[68],"28584-28598).":[69],"To":[70],"provide":[71,208],"more":[72],"direct":[73],"experimental":[74],"support":[75],"for":[76,201],"this":[77],"concept,":[78],"we":[79,139],"employed":[80],"disulfide":[82,177],"cross-linking":[83,101],"strategy":[84],"trap":[86],"various":[87],"dimeric":[89],"species":[90],"present":[91],"native":[94],"lipid":[95],"environment":[96],"(transfected":[97],"COS-7":[98],"cells).":[99],"Disulfide":[100],"were":[103],"carried":[104],"out":[105],"many":[107,233],"mutant":[108],"M3Rs":[109],"containing":[110],"single":[111],"cysteine":[112],"(Cys)":[113],"substitutions":[114],"within":[115],"two":[116,153],"cytoplasmic":[118],"regions,":[120],"C-terminal":[122],"portion":[123],"of":[124,136,152,197,229,242],"second":[126],"intracellular":[127],"loop":[128],"(i2)":[129],"helix":[131],"H8":[132,198],"(H8).":[133],"The":[134],"pattern":[135],"cross-links":[137,178],"obtained,":[140],"combination":[142],"molecular":[144],"modeling":[145],"studies,":[146],"was":[147],"consistent":[148],"existence":[151],"dimer":[157],"interfaces,":[158],"one":[159,168],"involving":[160],"i2/i2":[161],"contacts":[162],"(TM4-TM5-i2":[163],"interface)":[164],"other":[167,234],"characterized":[169],"by":[170],"H8-H8":[171,176],"interactions":[172],"(TM1-TM2-H8":[173],"interface).":[174],"Specific":[175],"led":[179],"significant":[181],"impairments":[182],"M3R-mediated":[184],"protein":[186,204],"activation,":[187],"suggesting":[188],"changes":[190],"structural":[193,210],"orientation":[194],"or":[195],"mobility":[196],"critical":[200],"efficient":[202],"receptor-G":[203],"coupling.":[205],"Our":[206],"findings":[207,239],"novel":[209],"functional":[212],"insights":[213],"into":[214],"mechanisms":[216],"involved":[217],"dimerization":[220],"(oligomerization).":[221],"Because":[222],"shows":[225],"high":[227],"degree":[228],"sequence":[230],"similarity":[231],"GPCRs,":[237],"our":[238],"should":[240],"be":[241],"considerable":[243],"general":[244],"interest.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
