{"id":"https://openalex.org/W1978249679","doi":"https://doi.org/10.3893/jjaam.21.312","title":"A case of neonatal hyperammonemia and shock resulting from urea cycle disorder","display_name":"A case of neonatal hyperammonemia and shock resulting from urea cycle disorder","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W1978249679","doi":"https://doi.org/10.3893/jjaam.21.312","mag":"1978249679"},"language":"en","primary_location":{"id":"doi:10.3893/jjaam.21.312","doi":"https://doi.org/10.3893/jjaam.21.312","is_oa":true,"landing_page_url":"https://doi.org/10.3893/jjaam.21.312","pdf_url":"https://www.jstage.jst.go.jp/article/jjaam/21/6/21_6_312/_pdf","source":{"id":"https://openalex.org/S182431383","display_name":"Nihon Kyukyu Igakukai Zasshi Journal of Japanese Association for Acute Medicine","issn_l":"0915-924X","issn":["0915-924X","1883-3772"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4363609399","host_organization_name":"Japanese Association for Acute Medicine","host_organization_lineage":["https://openalex.org/P4363609399"],"host_organization_lineage_names":["Japanese Association for Acute Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon Kyukyu Igakukai Zasshi","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/jjaam/21/6/21_6_312/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016264124","display_name":"Atsushi Ujiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099064","display_name":"Osaka City General Hospital","ror":"https://ror.org/00v053551","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210099064","https://openalex.org/I4405284496"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Ujiro","raw_affiliation_strings":["Osaka City General Hospital, Intensive Care Unit"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Osaka City General Hospital, Intensive Care Unit","institution_ids":["https://openalex.org/I4210099064"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085480774","display_name":"Takenori Suga","orcid":"https://orcid.org/0009-0003-8404-2995","observed_orcids":["https://orcid.org/0009-0003-8404-2995"]},"institutions":[{"id":"https://openalex.org/I4210099064","display_name":"Osaka City General Hospital","ror":"https://ror.org/00v053551","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210099064","https://openalex.org/I4405284496"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takenori Suga","raw_affiliation_strings":["Osaka City General Hospital, Intensive Care Unit"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Osaka City General Hospital, Intensive Care Unit","institution_ids":["https://openalex.org/I4210099064"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111598215","display_name":"Yasunori Otsuka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099064","display_name":"Osaka City General Hospital","ror":"https://ror.org/00v053551","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210099064","https://openalex.org/I4405284496"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasunori Otsuka","raw_affiliation_strings":["Osaka City General Hospital, Intensive Care Unit"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Osaka City General Hospital, Intensive Care Unit","institution_ids":["https://openalex.org/I4210099064"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Takashi Matsuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099064","display_name":"Osaka City General Hospital","ror":"https://ror.org/00v053551","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210099064","https://openalex.org/I4405284496"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Matsuo","raw_affiliation_strings":["Osaka City General Hospital, Intensive Care Unit"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Osaka City General Hospital, Intensive Care Unit","institution_ids":["https://openalex.org/I4210099064"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109191371","display_name":"Natsuko Tokuhira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099064","display_name":"Osaka City General Hospital","ror":"https://ror.org/00v053551","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210099064","https://openalex.org/I4405284496"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Natsuko Tokuhira","raw_affiliation_strings":["Osaka City General Hospital, Intensive Care Unit"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Osaka City General Hospital, Intensive Care Unit","institution_ids":["https://openalex.org/I4210099064"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021911156","display_name":"Hideki Shimaoka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099064","display_name":"Osaka City General Hospital","ror":"https://ror.org/00v053551","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210099064","https://openalex.org/I4405284496"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideki Shimaoka","raw_affiliation_strings":["Osaka City General Hospital, Intensive Care Unit"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Osaka City General Hospital, Intensive Care Unit","institution_ids":["https://openalex.org/I4210099064"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210099064"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"6","first_page":"312","last_page":"318"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neonatal-hyperammonemia","display_name":"neonatal hyperammonemia","score":0.9850000143051147},{"id":"https://openalex.org/keywords/shock","display_name":"shock","score":0.5730000138282776},{"id":"https://openalex.org/keywords/continuous-hemofiltration","display_name":"continuous hemofiltration","score":0.8600000143051147},{"id":"https://openalex.org/keywords/continuous-hemodiafiltration","display_name":"continuous hemodiafiltration","score":0.9079999923706055},{"id":"https://openalex.org/keywords/therapeutic-plasma-exchange","display_name":"plasma exchange","score":0.8029999732971191},{"id":"https://openalex.org/keywords/arginine-therapy","display_name":"arginine therapy","score":0.7020000219345093},{"id":"https://openalex.org/keywords/sodium-phenylacetate","display_name":"sodium phenylacetate","score":0.8939999938011169},{"id":"https://openalex.org/keywords/seizures","display_name":"seizures","score":0.4519999921321869},{"id":"https://openalex.org/keywords/hyperbilirubinemia","display_name":"hyperbilirubinemia","score":0.6869999766349792},{"id":"https://openalex.org/keywords/enteral-nutrition","display_name":"enteral nutrition","score":0.7170000076293945},{"id":"https://openalex.org/keywords/neonatal-intensive-care","display_name":"neonatal intensive care","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C2781099255","wikidata":"https://www.wikidata.org/wiki/Q1640868","display_name":"Hyperammonemia","level":2,"score":0.9442132115364075},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8874707221984863},{"id":"https://openalex.org/C77061444","wikidata":"https://www.wikidata.org/wiki/Q595994","display_name":"Urea cycle","level":4,"score":0.8579744100570679},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.5557844042778015},{"id":"https://openalex.org/C2780365088","wikidata":"https://www.wikidata.org/wiki/Q48318","display_name":"Urea","level":2,"score":0.4767416715621948},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38600555062294006},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0702461302280426},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3893/jjaam.21.312","doi":"https://doi.org/10.3893/jjaam.21.312","is_oa":true,"landing_page_url":"https://doi.org/10.3893/jjaam.21.312","pdf_url":"https://www.jstage.jst.go.jp/article/jjaam/21/6/21_6_312/_pdf","source":{"id":"https://openalex.org/S182431383","display_name":"Nihon Kyukyu Igakukai Zasshi Journal of Japanese Association for Acute Medicine","issn_l":"0915-924X","issn":["0915-924X","1883-3772"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4363609399","host_organization_name":"Japanese Association for Acute Medicine","host_organization_lineage":["https://openalex.org/P4363609399"],"host_organization_lineage_names":["Japanese Association for Acute Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon Kyukyu Igakukai Zasshi","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3893/jjaam.21.312","doi":"https://doi.org/10.3893/jjaam.21.312","is_oa":true,"landing_page_url":"https://doi.org/10.3893/jjaam.21.312","pdf_url":"https://www.jstage.jst.go.jp/article/jjaam/21/6/21_6_312/_pdf","source":{"id":"https://openalex.org/S182431383","display_name":"Nihon Kyukyu Igakukai Zasshi Journal of Japanese Association for Acute Medicine","issn_l":"0915-924X","issn":["0915-924X","1883-3772"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4363609399","host_organization_name":"Japanese Association for Acute Medicine","host_organization_lineage":["https://openalex.org/P4363609399"],"host_organization_lineage_names":["Japanese Association for Acute Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon Kyukyu Igakukai Zasshi","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978249679.pdf","grobid_xml":"https://content.openalex.org/works/W1978249679.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W50060077","https://openalex.org/W2020160805","https://openalex.org/W2024666413","https://openalex.org/W2036985418","https://openalex.org/W2049159033","https://openalex.org/W2065713403","https://openalex.org/W2090960562","https://openalex.org/W2098366405","https://openalex.org/W2148973700","https://openalex.org/W2156525673","https://openalex.org/W2207346807","https://openalex.org/W4211046086"],"related_works":["https://openalex.org/W3118667329","https://openalex.org/W2615737394","https://openalex.org/W629042672","https://openalex.org/W2528525454","https://openalex.org/W2090218710","https://openalex.org/W2336717048","https://openalex.org/W2900178139","https://openalex.org/W3032608165","https://openalex.org/W4402137888","https://openalex.org/W2048801986"],"abstract_inverted_index":{"\u9ad8\u30a2\u30f3\u30e2\u30cb\u30a2\u8840\u75c7\u306b\u3088\u308b\u610f\u8b58\u969c\u5bb3\u3067\u767a\u75c7\u3057\uff0c\u30b7\u30e7\u30c3\u30af\u72b6\u614b\u3067\u642c\u9001\u3055\u308c\uff0c\u6301\u7d9a\u7684\u8840\u6db2\u6d44\u5316\u306b\u3088\u308a\u6551\u547d\u3057\u5f97\u305f\u65b0\u751f\u5150\u75c7\u4f8b\u3092\u7d4c\u9a13\u3057\u305f\u306e\u3067\u5831\u544a\u3059\u308b\u3002\u75c7\u4f8b\u306f\u65e5\u9f625\u306e\u5973\u5150\u3002\u547c\u5438\u304c\u4e0d\u5b89\u5b9a\u3068\u306a\u308a\u8fd1\u533b\u3092\u53d7\u8a3a\u3057\u305f\u3002\u7121\u547c\u5438\u306e\u305f\u3081\uff0c\u6c17\u7ba1\u633f\u7ba1\u3055\u308c\u5f53\u30bb\u30f3\u30bf\u30fc\u306b\u642c\u9001\u3055\u308c\u305f\u3002\u6765\u9662\u6642\uff0c\u81ea\u767a\u958b\u773c\u306a\u304f\uff0c\u308f\u305a\u304b\u306b\u4f53\u52d5\u304c\u8a8d\u3081\u3089\u308c\u308b\u306e\u307f\u3067\u3042\u3063\u305f\u3002\u5fc3\u62cd\u6570166/min\uff0c\u8840\u5727\u306f\u6e2c\u5b9a\u3067\u304d\u305a\uff0c\u5168\u8eab\u5f37\u76f4\u9593\u4ee3\u6027\u75d9\u6523\u304c\u51fa\u73fe\u3057\u305f\u3002\u5165\u9662\u6642\u306e\u8840\u6db2\u691c\u67fb\u306e\u7d50\u679c\uff0c\u8840\u4e2d\u30a2\u30f3\u30e2\u30cb\u30a2\u6fc3\u5ea6\u304c1,175\u03bcg/dl\u3068\u8457\u660e\u306b\u4e0a\u6607\u3057\u3066\u304a\u308a\uff0c\u9ad8\u30a2\u30f3\u30e2\u30cb\u30a2\u8840\u75c7\u306b\u3088\u308b\u610f\u8b58\u969c\u5bb3\u3068\u8a3a\u65ad\u3057\u305f\u3002\u76f4\u3061\u306bICU\u5165\u5ba4\u3068\u306a\u308a\uff0c\u4eba\u5de5\u547c\u5438\u7ba1\u7406\u4e0b\u306b\u8840\u6db2\u6d44\u5316\uff08\u6301\u7d9a\u8840\u6db2\u6ffe\u904e\uff0c\u6301\u7d9a\u8840\u6db2\u900f\u6790\uff0c\u6301\u7d9a\u8840\u6db2\u6ffe\u904e\u900f\u6790\uff09\u3092\u958b\u59cb\u3057\u305f\u3002\u7fcc\u65e5\u306b\u30a2\u30f3\u30e2\u30cb\u30a2\u6fc3\u5ea6\u306f\u534a\u6e1b\u3057\u305f\u304c\u6b63\u5e38\u7bc4\u56f2\u307e\u3067\u306f\u4f4e\u4e0b\u3092\u8a8d\u3081\u306a\u304b\u3063\u305f\u3002\u30a2\u30df\u30ce\u9178\u5206\u6790\u306e\u7d50\u679c\u3088\u308a\u9ad8\u30b7\u30c8\u30eb\u30ea\u30f3\u8840\u75c7\u306b\u3088\u308b\u9ad8\u30a2\u30f3\u30e2\u30cb\u30a2\u8840\u75c7\u3068\u8a3a\u65ad\u3057\u30a2\u30eb\u30ae\u30cb\u30f3\uff0c\u5b89\u606f\u9999\u9178\u30ca\u30c8\u30ea\u30a6\u30e0\u306e\u6295\u4e0e\u3092\u958b\u59cb\u3057\u305f\u3002ICU\u5165\u5ba4\u5f8c9\u65e5\u76ee\u306b\u30a2\u30f3\u30e2\u30cb\u30a2\u5024\u304c\u5b89\u5b9a\u3057\u305f\u305f\u3081\u8840\u6db2\u6d44\u5316\u6cd5\u3092\u4e2d\u6b62\u3057\u305f\u3002\u4e2d\u6b62\u5f8c2\u65e5\u76ee\u306b\u30d3\u30ea\u30eb\u30d3\u30f3\u306e\u4e0a\u6607\u3092\u4f34\u3046\u30a2\u30f3\u30e2\u30cb\u30a2\u306e\u6025\u6fc0\u306a\u4e0a\u6607\u3092\u8a8d\u3081\uff0c\u8840\u6f3f\u4ea4\u63db\u3092\u65bd\u884c\u3059\u308b\u3082\u52b9\u679c\u304c\u4e00\u6642\u7684\u3067\u3042\u3063\u305f\u305f\u3081\uff0c\u6301\u7d9a\u8840\u6db2\u900f\u6790\u3092\u518d\u958b\u3057\u305f\u3002\u305d\u306e\u5f8c3\u56de\u306e\u8840\u6f3f\u4ea4\u63db\u3068\u6301\u7d9a\u8840\u6db2\u900f\u6790\u3092\u4f75\u7528\u3057\uff0c\u7279\u6b8a\u30df\u30eb\u30af\u306b\u3088\u308b\u7d4c\u8178\u6804\u990a\u3092\u958b\u59cb\u3057\u305f\u3002\u5165\u5ba4\u5f8c19\u65e5\u4ee5\u964d\u306f\u8840\u6db2\u6d44\u5316\u3092\u4e2d\u6b62\u3057\u305f\u304c\uff0c\u30a2\u30f3\u30e2\u30cb\u30a2\u306e\u518d\u4e0a\u6607\u306f\u8a8d\u3081\u306a\u304b\u3063\u305f\u3002\u767a\u75c7\u6642\u306b\u75d9\u6523\u3092\u8a8d\u3081\u305f\u306e\u3067\u30d5\u30a7\u30ce\u30d0\u30eb\u30d3\u30bf\u30fc\u30eb\u3092\u5185\u670d\u3057\u3066\u3044\u308b\u304c\uff0c\u4ee5\u964d\uff0c\u75d9\u6523\u306e\u518d\u767a\u306f\u8a8d\u3081\u306a\u304b\u3063\u305f\u3002\u4f53\u683c\u306e\u5c0f\u3055\u3044\u5c0f\u5150\uff0c\u3068\u304f\u306b\u65b0\u751f\u5150\u306b\u304a\u3044\u3066\u306f\uff0c\u8840\u6db2\u6d44\u5316\u6cd5\u306e\u65bd\u884c\u306b\u969b\u3057\u3066vascular":[0],"access\u306e\u78ba\u4fdd\u56f0\u96e3\uff0c\u5faa\u74b0\u52d5\u614b\u306b\u4e0e\u3048\u308b\u5f71\u97ff\uff0c\u4f4e\u4f53\u6e29\u306a\u3069\u5c0f\u5150\u7279\u6709\u306e\u554f\u984c\u304c\u3042\u308b\u3002\u9ad8\u30a2\u30f3\u30e2\u30cb\u30a2\u8840\u75c7\u306f\u9ad8\u6fc3\u5ea6\u306e\u30a2\u30f3\u30e2\u30cb\u30a2\u304a\u3088\u3073\u305d\u306e\u9ad8\u6fc3\u5ea6\u306b\u66b4\u9732\u3055\u308c\u305f\u6642\u9593\u304c\u795e\u7d4c\u5b66\u7684\u4e88\u5f8c\u306b\u5bc6\u63a5\u306b\u95a2\u4fc2\u3057\u3066\u3044\u308b\u305f\u3081\uff0c\u5c0f\u5150\u3068\u304f\u306b\u65b0\u751f\u5150\u306b\u304a\u3044\u3066\u3082\u7a4d\u6975\u7684\u306a\u8840\u6db2\u6d44\u5316\u306e\u5c0e\u5165\u3092\u884c\u3046\u5fc5\u8981\u304c\u3042\u308b\u3002":[1]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}