{"id":"https://openalex.org/W1978228601","doi":"https://doi.org/10.1056/nejmoa011807","title":"Intravenous Zoledronic Acid in Postmenopausal Women with Low Bone Mineral Density","display_name":"Intravenous Zoledronic Acid in Postmenopausal Women with Low Bone Mineral Density","publication_year":2002,"publication_date":"2002-02-28","ids":{"openalex":"https://openalex.org/W1978228601","doi":"https://doi.org/10.1056/nejmoa011807","mag":"1978228601","pmid":"https://pubmed.ncbi.nlm.nih.gov/11870242"},"language":"en","primary_location":{"id":"doi:10.1056/nejmoa011807","doi":"https://doi.org/10.1056/nejmoa011807","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa011807","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa011807?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa011807?articleTools=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058399747","display_name":"Ian R. Reid","orcid":"https://orcid.org/0000-0001-6021-5458","observed_orcids":["https://orcid.org/0000-0001-6021-5458"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Ian R. Reid","raw_affiliation_strings":["Department of Medicine, University of Auckland, Auckland, New Zealand. i.reid@auckland.ac.nz","Department of Medicine, University of Auckland, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Auckland, Auckland, New Zealand. i.reid@auckland.ac.nz","institution_ids":["https://openalex.org/I154130895"]},{"raw_affiliation_string":"Department of Medicine, University of Auckland, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032907896","display_name":"Jacques P. Brown","orcid":"https://orcid.org/0000-0003-1910-788X","observed_orcids":["https://orcid.org/0000-0003-1910-788X"]},"institutions":[{"id":"https://openalex.org/I4210139308","display_name":"Centre hospitalier de l'Universit\u00e9 Laval","ror":"https://ror.org/041v96n47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210139308","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]},{"id":"https://openalex.org/I4405256986","display_name":"Centre de recherche du CHU de Qu\u00e9bec-Universit\u00e9 Laval","ror":"https://ror.org/04rgqcd02","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256986","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jacques P. Brown","raw_affiliation_strings":["Centre de Recherche du Centre Hospitalier del Universit\u00e9 Laval, Quebec, Que., Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche du Centre Hospitalier del Universit\u00e9 Laval, Quebec, Que., Canada","institution_ids":["https://openalex.org/I4210139308","https://openalex.org/I43406934","https://openalex.org/I4405256986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011404558","display_name":"P. Burckhardt","orcid":"https://orcid.org/0000-0001-8857-8664","observed_orcids":["https://orcid.org/0000-0001-8857-8664"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Peter Burckhardt","raw_affiliation_strings":["Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080377347","display_name":"Zebulun D. Horowitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117619","display_name":"Novartis (United States)","ror":"https://ror.org/028fhxy95","country_code":"US","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zebulun Horowitz","raw_affiliation_strings":["Novartis Pharmaceuticals, East Hanover, N.J"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharmaceuticals, East Hanover, N.J","institution_ids":["https://openalex.org/I4210117619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040502547","display_name":"Peter A. Richardson","orcid":"https://orcid.org/0000-0002-6810-0249","observed_orcids":["https://orcid.org/0000-0002-6810-0249"]},"institutions":[{"id":"https://openalex.org/I4210117619","display_name":"Novartis (United States)","ror":"https://ror.org/028fhxy95","country_code":"US","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Richardson","raw_affiliation_strings":["Novartis Pharmaceuticals, East Hanover, N.J"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharmaceuticals, East Hanover, N.J","institution_ids":["https://openalex.org/I4210117619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080569065","display_name":"U. Trechsel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Ulrich Trechsel","raw_affiliation_strings":["Novartis Pharma, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079356358","display_name":"Albert Widmer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Albert Widmer","raw_affiliation_strings":["Novartis Pharma, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112425783","display_name":"J.-P. Devogelaer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jean-Pierre Devogelaer","raw_affiliation_strings":["Department of Rheumatology, Universit\u00e9 Catholique de Louvain, St. Luc, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Universit\u00e9 Catholique de Louvain, St. Luc, Brussels, Belgium","institution_ids":["https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082779954","display_name":"Jean\u2010Marc Kaufman","orcid":"https://orcid.org/0000-0002-1400-6812","observed_orcids":["https://orcid.org/0000-0002-1400-6812"]},"institutions":[{"id":"https://openalex.org/I2801227569","display_name":"Ghent University Hospital","ror":"https://ror.org/00xmkp704","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801227569"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jean-Marc Kaufman","raw_affiliation_strings":["Department of Endocrinology, University Hospital of Ghent, Ghent, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, University Hospital of Ghent, Ghent, Belgium","institution_ids":["https://openalex.org/I2801227569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112043769","display_name":"Philippe Jaeger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Philippe Jaeger","raw_affiliation_strings":["Medizinische Universit\u00e4tspoliklinik, Inselspital Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Universit\u00e4tspoliklinik, Inselspital Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111382378","display_name":"Jean-Jacques Body","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jean-Jacques Body","raw_affiliation_strings":["Endocrinology and Supportive Care Clinic, Institut J. Bordet, Free University of Brussels, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrinology and Supportive Care Clinic, Institut J. Bordet, Free University of Brussels, Brussels, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2801838318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055069129","display_name":"Maria Luisa Brandi","orcid":"https://orcid.org/0000-0002-8741-0592","observed_orcids":["https://orcid.org/0000-0002-8741-0592"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Luisa Brandi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011347495","display_name":"Johann Broell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johann Broell","raw_affiliation_strings":["(J.-M.K.) ; the","Centro di Fi- siopatologia della Menopausa , Ospedale Maggiore La Maternit\u00e0 , Bologna , Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(J.-M.K.) ; the","institution_ids":[]},{"raw_affiliation_string":"Centro di Fi- siopatologia della Menopausa , Ospedale Maggiore La Maternit\u00e0 , Bologna , Italy;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083794612","display_name":"Raffaele Di Micco","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raffaele Di Micco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103400428","display_name":"Andrea Riccardo Genazzani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122765","display_name":"Kaiser-Franz-Josef-Spital","ror":"https://ror.org/02p47pe37","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210117134","https://openalex.org/I4210122765"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Andrea Riccardo Genazzani","raw_affiliation_strings":["Medizinische Abteilung mit Rheumatologie und Osteologie , Kaiser-Franz-Josef-Spital der Stadt Wien , Vienna , Austria;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Abteilung mit Rheumatologie und Osteologie , Kaiser-Franz-Josef-Spital der Stadt Wien , Vienna , Austria;","institution_ids":["https://openalex.org/I4210122765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071132796","display_name":"Dieter Felsenberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dieter Felsenberg","raw_affiliation_strings":["Frankfurt , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frankfurt , Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061603572","display_name":"J. Happ","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joachim Happ","raw_affiliation_strings":["Pisa , Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pisa , Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054962330","display_name":"Michael James Hooper","orcid":"https://orcid.org/0000-0002-4161-8961","observed_orcids":["https://orcid.org/0000-0002-4161-8961"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael J. Hooper","raw_affiliation_strings":["Universit\u00e4tsklinikum Benjamin Franklin , Strahlenklinik und Poliklinik , Berlin , Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum Benjamin Franklin , Strahlenklinik und Poliklinik , Berlin , Germany;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048636730","display_name":"Jochen R Ittner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jochen Ittner","raw_affiliation_strings":["Universit\u00e4tsklinikum Benjamin Franklin , Strahlenklinik und Poliklinik , Berlin , Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum Benjamin Franklin , Strahlenklinik und Poliklinik , Berlin , Germany;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038809176","display_name":"G. Leb","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Georg Leb","raw_affiliation_strings":["s Hospital , Toronto ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"s Hospital , Toronto ;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013083863","display_name":"Hans Mallmin","orcid":"https://orcid.org/0000-0002-0074-7484","observed_orcids":["https://orcid.org/0000-0002-0074-7484"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hans Mallmin","raw_affiliation_strings":["Uppsala , Sweden;","s Hospital , Toronto ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uppsala , Sweden;","institution_ids":[]},{"raw_affiliation_string":"s Hospital , Toronto ;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110895002","display_name":"Timothy M. Murray","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134201","display_name":"IRCCS Istituto Auxologico Italiano","ror":"https://ror.org/033qpss18","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210134201","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Timothy Murray","raw_affiliation_strings":["Centro Studi Metabolis- mo Osseo , Istituto Auxologico Italiano , Milan , Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Studi Metabolis- mo Osseo , Istituto Auxologico Italiano , Milan , Italy;","institution_ids":["https://openalex.org/I4210134201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014247680","display_name":"S. Ortolani","orcid":"https://orcid.org/0000-0001-7939-5348","observed_orcids":["https://orcid.org/0000-0001-7939-5348"]},"institutions":[{"id":"https://openalex.org/I4210134201","display_name":"IRCCS Istituto Auxologico Italiano","ror":"https://ror.org/033qpss18","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210134201","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sergio Ortolani","raw_affiliation_strings":["Centro Studi Metabolis- mo Osseo , Istituto Auxologico Italiano , Milan , Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Studi Metabolis- mo Osseo , Istituto Auxologico Italiano , Milan , Italy;","institution_ids":["https://openalex.org/I4210134201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056725317","display_name":"Alessandro Rubinacci","orcid":"https://orcid.org/0000-0003-1736-0531","observed_orcids":["https://orcid.org/0000-0003-1736-0531"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Alessandro Rubinacci","raw_affiliation_strings":["Univer- sitetskliniken , Lund , Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univer- sitetskliniken , Lund , Sweden","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I4210137844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081939530","display_name":"Maria S\u00e4\u00e4f","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria S\u00e4\u00e4f","raw_affiliation_strings":["s Hospital , Toronto ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"s Hospital , Toronto ;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087556944","display_name":"G\u00f6ran Samsioe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Goran Samsioe","raw_affiliation_strings":["Depart- ment of Rheumatology , Academic Hospital , Brussels Free University , Brus- sels , Belgium","Endokrinologiska Kliniken , Karolinska Sjukhuset , Stockholm , Sweden;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depart- ment of Rheumatology , Academic Hospital , Brussels Free University , Brus- sels , Belgium","institution_ids":[]},{"raw_affiliation_string":"Endokrinologiska Kliniken , Karolinska Sjukhuset , Stockholm , Sweden;","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051812055","display_name":"Leon Verbruggen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Leon Verbruggen","raw_affiliation_strings":["Unit\u00e0 Metabolica dell'Osso , Ospedale S. Raffaele , Milan , Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e0 Metabolica dell'Osso , Ospedale S. Raffaele , Milan , Italy;","institution_ids":["https://openalex.org/I4210133214"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108070349","display_name":"Pierre Jean Meunier","orcid":"https://orcid.org/0000-0002-5836-2771","observed_orcids":["https://orcid.org/0000-0002-5836-2771"]},"institutions":[{"id":"https://openalex.org/I4210123600","display_name":"H\u00f4pital Edouard Herriot","ror":"https://ror.org/02qt1p572","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210123600"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre J. Meunier","raw_affiliation_strings":["Department of Rheumatology and Bone Diseases, H\u00f4pital Edouard Herriot, Lyons, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Bone Diseases, H\u00f4pital Edouard Herriot, Lyons, France","institution_ids":["https://openalex.org/I4210123600"]}]}],"institutions":[],"countries_distinct_count":9,"institutions_distinct_count":19,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":95.8861,"has_fulltext":true,"cited_by_count":870,"citation_normalized_percentile":{"value":0.99992724,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"346","issue":"9","first_page":"653","last_page":"661"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.8734999895095825,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.8734999895095825,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.12549999356269836,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zoledronic-acid","display_name":"zoledronic acid","score":0.9980000257492065},{"id":"https://openalex.org/keywords/intravenous-bisphosphonates","display_name":"intravenous bisphosphonates","score":0.9470000267028809},{"id":"https://openalex.org/keywords/postmenopausal-osteoporosis","display_name":"postmenopausal osteoporosis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/osteopenia","display_name":"osteopenia","score":0.9869999885559082},{"id":"https://openalex.org/keywords/dosing-regimen","display_name":"dosing regimen","score":0.5559999942779541},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.7409999966621399},{"id":"https://openalex.org/keywords/bone-turnover-markers","display_name":"bone turnover markers","score":0.7390000224113464},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.7360000014305115},{"id":"https://openalex.org/keywords/lumbar-spine","display_name":"lumbar spine","score":0.859000027179718},{"id":"https://openalex.org/keywords/femoral-neck","display_name":"femoral neck","score":0.984000027179718},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.5889999866485596},{"id":"https://openalex.org/keywords/myalgia","display_name":"myalgia","score":0.7279999852180481},{"id":"https://openalex.org/keywords/fever","display_name":"fever","score":0.9610000252723694}],"concepts":[{"id":"https://openalex.org/C2776326535","wikidata":"https://www.wikidata.org/wiki/Q218507","display_name":"Zoledronic acid","level":2,"score":0.9293709993362427},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9019955396652222},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.7450416684150696},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7067445516586304},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.6994013786315918},{"id":"https://openalex.org/C2775854910","wikidata":"https://www.wikidata.org/wiki/Q4844892","display_name":"Femoral neck","level":3,"score":0.6551418900489807},{"id":"https://openalex.org/C2777251235","wikidata":"https://www.wikidata.org/wiki/Q412205","display_name":"Bisphosphonate","level":3,"score":0.6308616995811462},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.5218345522880554},{"id":"https://openalex.org/C2779329777","wikidata":"https://www.wikidata.org/wiki/Q2304401","display_name":"Bone density","level":3,"score":0.4703388810157776},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.41877004504203796},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.39674314856529236},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3913057744503021},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.332261323928833},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077211","descriptor_name":"Zoledronic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015663","descriptor_name":"Osteoporosis, Postmenopausal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015663","descriptor_name":"Osteoporosis, Postmenopausal","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D016723","descriptor_name":"Bone Remodeling","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D024042","descriptor_name":"Collagen Type I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050723","descriptor_name":"Fractures, Bone","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false}],"locations_count":12,"locations":[{"id":"doi:10.1056/nejmoa011807","doi":"https://doi.org/10.1056/nejmoa011807","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa011807","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa011807?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:11870242","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11870242","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Clinical Trial"},{"id":"pmh:oai:archive.ugent.be:164901","doi":null,"is_oa":false,"landing_page_url":"https://biblio.ugent.be/publication/164901","pdf_url":null,"source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0028-4793","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:arpi.unipi.it:11568/75513","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11568/75513","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dial.uclouvain.be:boreal:232572","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2078.1/232572","pdf_url":null,"source":{"id":"https://openalex.org/S4306401974","display_name":"DIAL (Catholic University of Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The New England journal of medicine, Vol. 346, no.9, p. 653-661 (2002)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/177677","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/177677","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The New England journal of medicine, 346 (9","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unil.ch:iris/120654","doi":null,"is_oa":false,"landing_page_url":"https://iris.unil.ch/handle/iris/120654","pdf_url":null,"source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:lup.lub.lu.se:30081f0f-e538-4f26-8195-2498cfcd59dd","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/343129","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0028-4793","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:serval.unil.ch:BIB_25508","doi":null,"is_oa":false,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_25508","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NEJM, vol. 346, pp. 653-661","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:vubissmart:VUBISSMART:2000:76899","doi":null,"is_oa":false,"landing_page_url":"http://www.ncbi.nlm.nih.gov/pubmed/11870242","pdf_url":null,"source":{"id":"https://openalex.org/S4306402573","display_name":"VUBIR (Vrije Universiteit Brussel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I13469542","host_organization_name":"Vrije Universiteit Brussel","host_organization_lineage":["https://openalex.org/I13469542"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:zenodo.org:179950","doi":null,"is_oa":true,"landing_page_url":"https://www.openaccessrepository.it/record/179950","pdf_url":null,"source":{"id":"https://openalex.org/S4306402478","display_name":"INFM-OAR (INFN Catania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210116497","host_organization_name":"Istituto Nazionale di Fisica Nucleare, Sezione di Catania","host_organization_lineage":["https://openalex.org/I4210116497"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:3147602238","doi":null,"is_oa":false,"landing_page_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa011807","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1056/nejmoa011807","doi":"https://doi.org/10.1056/nejmoa011807","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa011807","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa011807?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332736","display_name":"Novartis Pharma","ror":"https://ror.org/0013shd50"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978228601.pdf","grobid_xml":"https://content.openalex.org/works/W1978228601.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1836348293","https://openalex.org/W1951349736","https://openalex.org/W1968418396","https://openalex.org/W1993952498","https://openalex.org/W1994414479","https://openalex.org/W1999949526","https://openalex.org/W2000939770","https://openalex.org/W2006021879","https://openalex.org/W2016807489","https://openalex.org/W2042568905","https://openalex.org/W2061235833","https://openalex.org/W2070632695","https://openalex.org/W2070815981","https://openalex.org/W2072797307","https://openalex.org/W2073141330","https://openalex.org/W2101280309","https://openalex.org/W2102123887","https://openalex.org/W2120148445","https://openalex.org/W2124527463","https://openalex.org/W2150410663","https://openalex.org/W2153009489","https://openalex.org/W2153088288","https://openalex.org/W2158504684","https://openalex.org/W2170680219","https://openalex.org/W2321227665","https://openalex.org/W2336678594"],"related_works":["https://openalex.org/W2116733803","https://openalex.org/W2010845213","https://openalex.org/W2150247306","https://openalex.org/W2127055638","https://openalex.org/W2488606810","https://openalex.org/W7098130409","https://openalex.org/W7120651763","https://openalex.org/W2092423369","https://openalex.org/W2320907979","https://openalex.org/W2057461358"],"abstract_inverted_index":{"BACKGROUND:":[0],"Bisphosphonates":[1],"are":[2],"effective":[3,283],"agents":[4],"for":[5,160,179,285],"the":[6,39,53,61,139,154,161,173,180,193,206,220,233],"management":[7],"of":[8,55,58,95,115,127,199,243,277],"osteoporosis.":[9,287],"Their":[10],"low":[11,14,75],"bioavailability":[12],"and":[13,42,68,122,177,214,253],"potency":[15],"necessitate":[16],"frequent":[17],"administration":[18],"on":[19,65,250],"an":[20,274,282],"empty":[21],"stomach,":[22],"which":[23],"may":[24],"reduce":[25],"compliance.":[26],"Gastrointestinal":[27],"intolerance":[28],"limits":[29],"maximal":[30],"dosing.":[31],"Although":[32],"intermittent":[33],"intravenous":[34,90],"treatments":[35],"have":[36,45],"been":[37,47],"used,":[38],"optimal":[40],"doses":[41,94,126],"dosing":[43,264],"interval":[44],"not":[46],"systematically":[48],"explored.":[49],"METHODS:":[50],"We":[51],"studied":[52],"effects":[54,249],"five":[56],"regimens":[57],"zoledronic":[59,91,155,210,221,278],"acid,":[60],"most":[62],"potent":[63],"bisphosphonate,":[64],"bone":[66,76,135,149,200,251,254],"turnover":[67,252],"density":[69,78,137,151,255],"in":[70,79,93,148,152,172,192,208,219,232],"351":[71],"postmenopausal":[72,286],"women":[73],"with":[74,261,265,267],"mineral":[77,136,150],"a":[80,111,119],"one-year,":[81],"randomized,":[82],"double-blind,":[83],"placebo-controlled":[84],"trial.":[85],"Women":[86],"received":[87,110,124],"placebo":[88,174,194,234],"or":[89,100],"acid":[92,156,211,222,238,279],"0.25":[96],"mg,":[97,99],"0.5":[98],"1":[101],"mg":[102,117,129],"at":[103,241],"three-month":[104],"intervals.":[105],"In":[106],"addition,":[107],"one":[108,246],"group":[109,175,195],"total":[112],"annual":[113,275],"dose":[114],"4":[116],"as":[118,256,258],"single":[120],"dose,":[121],"another":[123],"two":[125],"2":[128],"each,":[130],"six":[131],"months":[132],"apart.":[133],"Lumbar-spine":[134],"was":[138],"primary":[140],"end":[141],"point.":[142],"RESULTS:":[143],"There":[144],"were":[145,164,184,202,228],"similar":[146,229],"increases":[147],"all":[153,209],"groups":[157],"to":[158,166,186,230,245],"values":[159,178],"spine":[162],"that":[163,183,231,273],"4.3":[165],"5.1":[167],"percent":[168,188],"higher":[169,189],"than":[170,190],"those":[171,191,259],"(P<0.001)":[176],"femoral":[181],"neck":[182],"3.1":[185],"3.5":[187],"(P<0.001).":[196],"Biochemical":[197],"markers":[198],"resorption":[201],"significantly":[203],"suppressed":[204],"throughout":[205],"study":[207],"groups.":[212],"Myalgia":[213],"pyrexia":[215],"occurred":[216],"more":[217],"commonly":[218],"groups,":[223],"but":[224],"treatment-related":[225],"dropout":[226],"rates":[227],"group.":[235],"CONCLUSIONS:":[236],"Zoledronic":[237],"infusions":[239],"given":[240],"intervals":[242],"up":[244],"year":[247],"produce":[248],"great":[257],"achieved":[260],"daily":[262],"oral":[263],"bisphosphonates":[266],"proven":[268],"efficacy":[269],"against":[270],"fractures,":[271],"suggesting":[272],"infusion":[276],"might":[280],"be":[281],"treatment":[284]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":28},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":24},{"year":2012,"cited_by_count":24}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}