{"id":"https://openalex.org/W1978220671","doi":"https://doi.org/10.1055/s-2004-830501","title":"Hypothermia-Induced Platelet Aggregation: No Effect of Aprotinin (Trasylol\u00ae) but Inhibition by Eptifibatide (Integrilin\u00ae)","display_name":"Hypothermia-Induced Platelet Aggregation: No Effect of Aprotinin (Trasylol\u00ae) but Inhibition by Eptifibatide (Integrilin\u00ae)","publication_year":2005,"publication_date":"2005-03-23","ids":{"openalex":"https://openalex.org/W1978220671","doi":"https://doi.org/10.1055/s-2004-830501","mag":"1978220671","pmid":"https://pubmed.ncbi.nlm.nih.gov/15786005"},"language":"en","primary_location":{"id":"doi:10.1055/s-2004-830501","doi":"https://doi.org/10.1055/s-2004-830501","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2004-830501","pdf_url":null,"source":{"id":"https://openalex.org/S81394012","display_name":"The Thoracic and Cardiovascular Surgeon","issn_l":"0171-6425","issn":["0171-6425","1439-1902"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Thoracic and Cardiovascular Surgeon","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042374620","display_name":"Andreas Straub","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. Straub","raw_affiliation_strings":["Department of Thoracic, Cardiac and Vascular Surgery, University of T\u00fcbingen, T\u00fcbingen, Germany. anstraub@nexgo.de","Department of Thoracic, Cardiac and Vascular Surgery, University of T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic, Cardiac and Vascular Surgery, University of T\u00fcbingen, T\u00fcbingen, Germany. anstraub@nexgo.de","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Department of Thoracic, Cardiac and Vascular Surgery, University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":null,"display_name":"R. Azevedo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R. Azevedo","raw_affiliation_strings":["Department of Thoracic, Cardiac and Vascular Surgery, University of T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic, Cardiac and Vascular Surgery, University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040834512","display_name":"W Beierlein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"W. Beierlein","raw_affiliation_strings":["Department of Thoracic, Cardiac and Vascular Surgery, University of T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic, Cardiac and Vascular Surgery, University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110073496","display_name":"H.P. Wendel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H. P. Wendel","raw_affiliation_strings":["Department of Thoracic, Cardiac and Vascular Surgery, University of T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic, Cardiac and Vascular Surgery, University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110884561","display_name":"AM Scheule","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. M. Scheule","raw_affiliation_strings":["Department of Thoracic, Cardiac and Vascular Surgery, University of T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic, Cardiac and Vascular Surgery, University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041842032","display_name":"Gerhard Ziemer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G. Ziemer","raw_affiliation_strings":["Department of Thoracic, Cardiac and Vascular Surgery, University of T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic, Cardiac and Vascular Surgery, University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I8087733"],"apc_list":null,"apc_paid":null,"fwci":0.5851,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.65349603,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"53","issue":"2","first_page":"80","last_page":"84"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.4957999885082245,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.4957999885082245,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.2870999872684479,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.11800000071525574,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypothermia","display_name":"hypothermia","score":0.7200000286102295},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/aprotinin","display_name":"aprotinin","score":0.9789999723434448},{"id":"https://openalex.org/keywords/eptifibatide","display_name":"eptifibatide","score":0.9980000257492065},{"id":"https://openalex.org/keywords/deep-hypothermic-circulatory-arrest","display_name":"deep hypothermic circulatory arrest","score":0.9890000224113464},{"id":"https://openalex.org/keywords/gp-iib-iiia","display_name":"GPIIb/IIIa","score":0.7400000095367432},{"id":"https://openalex.org/keywords/platelet-function","display_name":"platelet function","score":0.6909999847412109},{"id":"https://openalex.org/keywords/cardiopulmonary-bypass","display_name":"cardiopulmonary bypass","score":0.8880000114440918},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.734000027179718},{"id":"https://openalex.org/keywords/adp-induced-platelet-aggregation","display_name":"ADP-induced aggregation","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C2781056559","wikidata":"https://www.wikidata.org/wiki/Q2295855","display_name":"Eptifibatide","level":4,"score":0.9102638959884644},{"id":"https://openalex.org/C2780799893","wikidata":"https://www.wikidata.org/wiki/Q418625","display_name":"Aprotinin","level":2,"score":0.8474193811416626},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.6844452619552612},{"id":"https://openalex.org/C2778881276","wikidata":"https://www.wikidata.org/wiki/Q552304","display_name":"Cardiopulmonary bypass","level":2,"score":0.6809403896331787},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5615214705467224},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4674476087093353},{"id":"https://openalex.org/C2777664302","wikidata":"https://www.wikidata.org/wiki/Q4463725","display_name":"Thromboelastography","level":3,"score":0.42917680740356445},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.40703022480010986},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39716365933418274},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2177664339542389},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.06084001064300537},{"id":"https://openalex.org/C45393284","wikidata":"https://www.wikidata.org/wiki/Q191012","display_name":"Conventional PCI","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077542","descriptor_name":"Eptifibatide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001800","descriptor_name":"Blood Specimen Collection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003080","descriptor_name":"Cold Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007035","descriptor_name":"Hypothermia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007611","descriptor_name":"Aprotinin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019039","descriptor_name":"Platelet Glycoprotein GPIIb-IIIa Complex","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-2004-830501","doi":"https://doi.org/10.1055/s-2004-830501","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2004-830501","pdf_url":null,"source":{"id":"https://openalex.org/S81394012","display_name":"The Thoracic and Cardiovascular Surgeon","issn_l":"0171-6425","issn":["0171-6425","1439-1902"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Thoracic and Cardiovascular Surgeon","raw_type":"journal-article"},{"id":"pmid:15786005","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15786005","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Thoracic and cardiovascular surgeon","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2091031005","https://openalex.org/W2332551371","https://openalex.org/W6884543746","https://openalex.org/W2402979770","https://openalex.org/W1998077656","https://openalex.org/W1981928721","https://openalex.org/W2058602505","https://openalex.org/W3021384959","https://openalex.org/W2414551655","https://openalex.org/W2157571881"],"abstract_inverted_index":{"OBJECTIVES:":[0],"The":[1,34,54,107],"serine-protease":[2],"inhibitor":[3,38],"aprotinin":[4,25,65,114,192],"protects":[5],"platelet":[6,35,45,69,210,222],"function":[7,46,70,137,211],"during":[8,16,32,47,212],"cardiopulmonary":[9,48],"bypass.":[10],"However,":[11],"its":[12],"safety":[13],"and":[14,24,66,98,113,134,153,175,226,234],"efficacy":[15],"deep":[17],"hypothermic":[18],"circulatory":[19],"arrest":[20],"(DHCA)":[21],"is":[22,26,215],"controversial,":[23],"suspected":[27],"to":[28,43,60,95,100],"cause":[29],"thrombosis":[30],"especially":[31],"hypothermia.":[33],"GP":[36],"IIb/IIIa":[37],"eptifibatide":[39,67,110,198],"has":[40,205],"been":[41],"assumed":[42],"preserve":[44],"bypass":[49],"without":[50],"increasing":[51],"bleeding":[52],"complications.":[53],"aim":[55],"of":[56,64,73,109,169,179],"this":[57],"study":[58],"was":[59,84,122,138,188],"compare":[61],"the":[62,141,232],"effect":[63,108,187,208],"on":[68,117,209],"under":[71,119],"conditions":[72,121],"DHCA.":[74],"METHODS:":[75],"Heparinized":[76],"blood":[77],"from":[78],"healthy":[79],"volunteers":[80],"(n":[81],"=":[82],"10)":[83],"incubated":[85,102],"in":[86,224,231,239],"stasis":[87],"for":[88],"30":[89],"minutes":[90],"at":[91,103],"18":[92],"degrees":[93,105],"C":[94],"simulate":[96],"DHCA":[97],"compared":[99],"samples":[101],"37":[104],"C.":[106],"(2.5":[111],"microg/ml)":[112],"(300":[115],"KIU/ml)":[116],"platelets":[118],"these":[120],"analyzed":[123],"by":[124,191,197],"flow":[125],"cytometry.":[126],"Platelet":[127],"aggregates":[128,170],"were":[129],"identified":[130],"using":[131],"CD41-antibody":[132],"binding":[133],"size.":[135],"GPIIb/IIIa":[136,180],"evaluated":[139],"with":[140,147],"activation-specific":[142],"antibody":[143,154],"PAC-1":[144],"after":[145],"stimulation":[146],"10":[148],"microM":[149],"ADP.":[150],"Aggregate":[151],"numbers":[152],"mean-fluorescence":[155],"are":[156],"reported":[157],"as":[158],"mean":[159],"+/-":[160],"standard":[161],"deviation.":[162],"RESULTS:":[163],"Hypothermia":[164],"induced":[165],"a":[166,176],"2.5-fold":[167],"increase":[168,178],"(":[171,182,199],"p":[172,183,200],"<":[173,184,201],"0.001)":[174],"2.6-fold":[177],"activation":[181],"0.001).":[185,202],"This":[186],"not":[189,216],"influenced":[190],"but":[193,214],"almost":[194],"completely":[195],"inhibited":[196],"CONCLUSIONS:":[203],"Aprotinin":[204],"no":[206],"procoagulatory":[207],"hypothermia":[213],"protective":[217],"either.":[218],"Eptifibatide":[219],"inhibits":[220],"hypothermia-induced":[221],"aggregation":[223],"vitro":[225],"may":[227],"prevent":[228],"aggregate":[229],"sequestration":[230],"microvasculature":[233],"consecutive":[235],"ischemic":[236],"organ":[237],"damage":[238],"vivo.":[240]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}