{"id":"https://openalex.org/W1978218804","doi":"https://doi.org/10.1016/0014-4827(91)90500-t","title":"Characterization of trans-immortalized hepatic cell lines established from transgenic mice","display_name":"Characterization of trans-immortalized hepatic cell lines established from transgenic mice","publication_year":1991,"publication_date":"1991-07-01","ids":{"openalex":"https://openalex.org/W1978218804","doi":"https://doi.org/10.1016/0014-4827(91)90500-t","mag":"1978218804","pmid":"https://pubmed.ncbi.nlm.nih.gov/1711473"},"language":"en","primary_location":{"id":"doi:10.1016/0014-4827(91)90500-t","doi":"https://doi.org/10.1016/0014-4827(91)90500-t","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-4827(91)90500-t","pdf_url":null,"source":{"id":"https://openalex.org/S132505712","display_name":"Experimental Cell Research","issn_l":"0014-4827","issn":["0014-4827","1090-2422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Cell Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113611222","display_name":"Fr\u00e9d\u00e9ric Perraud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152238723","display_name":"Transgene (France)","ror":"https://ror.org/02d4qpq05","country_code":"FR","type":"company","lineage":["https://openalex.org/I152238723"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fr\u00e9d\u00e9ric Perraud","raw_affiliation_strings":["Transgene S.A., Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transgene S.A., Strasbourg, France","institution_ids":["https://openalex.org/I152238723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053330687","display_name":"Wilfried Dalemans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152238723","display_name":"Transgene (France)","ror":"https://ror.org/02d4qpq05","country_code":"FR","type":"company","lineage":["https://openalex.org/I152238723"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Wilfried Dalemans","raw_affiliation_strings":["Transgene S. A., 11, rue de Molsheim 67082 Strasbourg Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transgene S. A., 11, rue de Molsheim 67082 Strasbourg Cedex, France","institution_ids":["https://openalex.org/I152238723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113555510","display_name":"Jean\u2010Louis Gendrault","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152238723","display_name":"Transgene (France)","ror":"https://ror.org/02d4qpq05","country_code":"FR","type":"company","lineage":["https://openalex.org/I152238723"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Louis Gendrault","raw_affiliation_strings":["Transgene S. A., 11, rue de Molsheim 67082 Strasbourg Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transgene S. A., 11, rue de Molsheim 67082 Strasbourg Cedex, France","institution_ids":["https://openalex.org/I152238723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034071020","display_name":"Dominique Dreyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152238723","display_name":"Transgene (France)","ror":"https://ror.org/02d4qpq05","country_code":"FR","type":"company","lineage":["https://openalex.org/I152238723"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Dominique Dreyer","raw_affiliation_strings":["Transgene S. A., 11, rue de Molsheim 67082 Strasbourg Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transgene S. A., 11, rue de Molsheim 67082 Strasbourg Cedex, France","institution_ids":["https://openalex.org/I152238723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052814621","display_name":"Dalila Ali-Hadji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152238723","display_name":"Transgene (France)","ror":"https://ror.org/02d4qpq05","country_code":"FR","type":"company","lineage":["https://openalex.org/I152238723"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Dalila Ali-Hadji","raw_affiliation_strings":["Transgene S. A., 11, rue de Molsheim 67082 Strasbourg Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transgene S. A., 11, rue de Molsheim 67082 Strasbourg Cedex, France","institution_ids":["https://openalex.org/I152238723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039533513","display_name":"T. Faure","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152238723","display_name":"Transgene (France)","ror":"https://ror.org/02d4qpq05","country_code":"FR","type":"company","lineage":["https://openalex.org/I152238723"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Th\u00e9r\u00e8se Faure","raw_affiliation_strings":["Transgene S. A., 11, rue de Molsheim 67082 Strasbourg Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transgene S. A., 11, rue de Molsheim 67082 Strasbourg Cedex, France","institution_ids":["https://openalex.org/I152238723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111962738","display_name":"Andr\u00e9a Pavirani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152238723","display_name":"Transgene (France)","ror":"https://ror.org/02d4qpq05","country_code":"FR","type":"company","lineage":["https://openalex.org/I152238723"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Andrea Pavirani","raw_affiliation_strings":["Transgene S. A., 11, rue de Molsheim 67082 Strasbourg Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transgene S. A., 11, rue de Molsheim 67082 Strasbourg Cedex, France","institution_ids":["https://openalex.org/I152238723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111962738"],"corresponding_institution_ids":["https://openalex.org/I152238723"],"apc_list":{"value":3270,"currency":"USD","value_usd":3270},"apc_paid":null,"fwci":1.0027,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.80777538,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"195","issue":"1","first_page":"59","last_page":"65"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.5648999810218811,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.5648999810218811,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.12200000137090683,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.09019999951124191,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.7139999866485596},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9409999847412109},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.7289999723434448},{"id":"https://openalex.org/keywords/sv40-t-antigen","display_name":"SV40 T antigen","score":0.972000002861023},{"id":"https://openalex.org/keywords/oncogene-expression","display_name":"oncogene expression","score":0.6740000247955322},{"id":"https://openalex.org/keywords/hepatoma-cell-lines","display_name":"hepatoma cell lines","score":0.5580000281333923},{"id":"https://openalex.org/keywords/alpha-1-antitrypsin","display_name":"alpha-1-antitrypsin","score":0.9279999732971191},{"id":"https://openalex.org/keywords/recombinant-protein-expression","display_name":"recombinant protein expression","score":0.777999997138977}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9254034757614136},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.7253325581550598},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6592748761177063},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.6570512056350708},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.6565251350402832},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.556471586227417},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5517732501029968},{"id":"https://openalex.org/C6045943","wikidata":"https://www.wikidata.org/wiki/Q21014462","display_name":"Immortalised cell line","level":3,"score":0.500521183013916},{"id":"https://openalex.org/C2775971809","wikidata":"https://www.wikidata.org/wiki/Q7395063","display_name":"SV40 large T antigen","level":4,"score":0.49199721217155457},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4845249056816101},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4690784811973572},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.45703282952308655},{"id":"https://openalex.org/C21592294","wikidata":"https://www.wikidata.org/wiki/Q3238407","display_name":"Regulatory sequence","level":4,"score":0.414179265499115},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34079450368881226},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.29894131422042847},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18844178318977356}],"mesh":[{"descriptor_ui":"D000209","descriptor_name":"Acute-Phase Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000509","descriptor_name":"alpha-Fetoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000515","descriptor_name":"alpha 1-Antitrypsin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000952","descriptor_name":"Antigens, Polyomavirus Transforming","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0014-4827(91)90500-t","doi":"https://doi.org/10.1016/0014-4827(91)90500-t","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-4827(91)90500-t","pdf_url":null,"source":{"id":"https://openalex.org/S132505712","display_name":"Experimental Cell Research","issn_l":"0014-4827","issn":["0014-4827","1090-2422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Cell Research","raw_type":"journal-article"},{"id":"pmid:1711473","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1711473","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental cell research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1600331093","https://openalex.org/W1965614395","https://openalex.org/W1969838031","https://openalex.org/W1970037534","https://openalex.org/W1987375895","https://openalex.org/W1988652821","https://openalex.org/W1994543006","https://openalex.org/W2027857612","https://openalex.org/W2031896298","https://openalex.org/W2041349540","https://openalex.org/W2044772898","https://openalex.org/W2048536123","https://openalex.org/W2059623464","https://openalex.org/W2085489324","https://openalex.org/W2090962290","https://openalex.org/W2091400806","https://openalex.org/W2139190596","https://openalex.org/W2155585300","https://openalex.org/W2169425069","https://openalex.org/W2332151196"],"related_works":["https://openalex.org/W2048536123","https://openalex.org/W147170243","https://openalex.org/W2312322540","https://openalex.org/W2512365528","https://openalex.org/W1995289527","https://openalex.org/W1970010452","https://openalex.org/W2118937594","https://openalex.org/W2206490814","https://openalex.org/W2292084209","https://openalex.org/W1892608609"],"abstract_inverted_index":null,"counts_by_year":[{"year":2017,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}