{"id":"https://openalex.org/W1978216074","doi":"https://doi.org/10.1271/bbb.64.1153","title":"Protection Against the Diabetogenic Effect of Feedingtert-Butylhydroquinone to Rats Prior to the Administration of Streptozotocin","display_name":"Protection Against the Diabetogenic Effect of Feedingtert-Butylhydroquinone to Rats Prior to the Administration of Streptozotocin","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W1978216074","doi":"https://doi.org/10.1271/bbb.64.1153","mag":"1978216074","pmid":"https://pubmed.ncbi.nlm.nih.gov/10923784"},"language":"en","primary_location":{"id":"doi:10.1271/bbb.64.1153","doi":"https://doi.org/10.1271/bbb.64.1153","is_oa":false,"landing_page_url":"https://doi.org/10.1271/bbb.64.1153","pdf_url":null,"source":{"id":"https://openalex.org/S94095188","display_name":"Bioscience Biotechnology and Biochemistry","issn_l":"0916-8451","issn":["0916-8451","1347-6947"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, Biotechnology, and Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088341226","display_name":"Shoko Nishizono","orcid":"https://orcid.org/0000-0001-9927-7664","observed_orcids":["https://orcid.org/0000-0001-9927-7664"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shoko NISHIZONO","raw_affiliation_strings":["Division of Bioresource and Bioenvironmental Sciences, Graduate School, Kyushu University, Fukuoka, Japan","Laboratory of Nutrition Chemistry, Division of Bioresource and Bioenvironmental Sciences, Graduate School, Kyushu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Bioresource and Bioenvironmental Sciences, Graduate School, Kyushu University, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"Laboratory of Nutrition Chemistry, Division of Bioresource and Bioenvironmental Sciences, Graduate School, Kyushu University","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031957941","display_name":"Tadao HAYAMI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadao HAYAMI","raw_affiliation_strings":["Laboratory of Nutrition Chemistry, Division of Bioresource and Bioenvironmental Sciences, Graduate School, Kyushu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Nutrition Chemistry, Division of Bioresource and Bioenvironmental Sciences, Graduate School, Kyushu University","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025469685","display_name":"Ikuo Ikeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ikuo IKEDA","raw_affiliation_strings":["Laboratory of Nutrition Chemistry, Division of Bioresource and Bioenvironmental Sciences, Graduate School, Kyushu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Nutrition Chemistry, Division of Bioresource and Bioenvironmental Sciences, Graduate School, Kyushu University","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111667141","display_name":"Katsumi Imaizumi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsumi IMAIZUMI","raw_affiliation_strings":["Laboratory of Nutrition Chemistry, Division of Bioresource and Bioenvironmental Sciences, Graduate School, Kyushu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Nutrition Chemistry, Division of Bioresource and Bioenvironmental Sciences, Graduate School, Kyushu University","institution_ids":["https://openalex.org/I135598925"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I135598925"],"apc_list":{"value":3272,"currency":"USD","value_usd":3272},"apc_paid":null,"fwci":0.8415,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.72563728,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"64","issue":"6","first_page":"1153","last_page":"1158"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.7973999977111816,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.7973999977111816,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.07919999957084656,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.06310000270605087,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tert-butylhydroquinone","display_name":"tert-butylhydroquinone","score":0.9959999918937683},{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":0.9279999732971191},{"id":"https://openalex.org/keywords/streptozotocin","display_name":"streptozotocin","score":0.9160000085830688},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.8460000157356262},{"id":"https://openalex.org/keywords/diabetes-prevention","display_name":"diabetes prevention","score":0.7649999856948853},{"id":"https://openalex.org/keywords/glucose-stimulated-insulin-secretion","display_name":"glucose-stimulated insulin secretion","score":0.8600000143051147},{"id":"https://openalex.org/keywords/pancreatic-islets","display_name":"pancreatic islets","score":0.9269999861717224},{"id":"https://openalex.org/keywords/free-radicals","display_name":"free radicals","score":0.6710000038146973},{"id":"https://openalex.org/keywords/lipoxygenase-inhibition","display_name":"lipoxygenase inhibition","score":0.824999988079071}],"concepts":[{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.8363616466522217},{"id":"https://openalex.org/C2780765947","wikidata":"https://www.wikidata.org/wiki/Q12033531","display_name":"Administration (probate law)","level":2,"score":0.6219228506088257},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40257927775382996},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4005686938762665},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37662583589553833},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33940839767456055},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.26160919666290283},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.09956324100494385},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.06717631220817566}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006873","descriptor_name":"Hydroquinones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013311","descriptor_name":"Streptozocin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013311","descriptor_name":"Streptozocin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016859","descriptor_name":"Lipoxygenase Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1271/bbb.64.1153","doi":"https://doi.org/10.1271/bbb.64.1153","is_oa":false,"landing_page_url":"https://doi.org/10.1271/bbb.64.1153","pdf_url":null,"source":{"id":"https://openalex.org/S94095188","display_name":"Bioscience Biotechnology and Biochemistry","issn_l":"0916-8451","issn":["0916-8451","1347-6947"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, Biotechnology, and Biochemistry","raw_type":"journal-article"},{"id":"pmid:10923784","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10923784","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, biotechnology, and biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1499834471","https://openalex.org/W1558965215","https://openalex.org/W1831301545","https://openalex.org/W1964448491","https://openalex.org/W1985483697","https://openalex.org/W1988315325","https://openalex.org/W1988540419","https://openalex.org/W1989683994","https://openalex.org/W1997010909","https://openalex.org/W2005833772","https://openalex.org/W2021568006","https://openalex.org/W2023150880","https://openalex.org/W2031328816","https://openalex.org/W2040923416","https://openalex.org/W2047069988","https://openalex.org/W2058568014","https://openalex.org/W2059353746","https://openalex.org/W2068330507","https://openalex.org/W2073071131","https://openalex.org/W2079517314","https://openalex.org/W2080745163","https://openalex.org/W2099023764","https://openalex.org/W2110741515","https://openalex.org/W2183817340","https://openalex.org/W4231523688"],"related_works":["https://openalex.org/W2073056431","https://openalex.org/W2317522064","https://openalex.org/W7218905715","https://openalex.org/W1829131178","https://openalex.org/W7144022808","https://openalex.org/W1966935537","https://openalex.org/W1964096868","https://openalex.org/W2013994229","https://openalex.org/W2086361674","https://openalex.org/W7218877951"],"abstract_inverted_index":{"We":[0],"determined":[1],"whether":[2],"an":[3,37,149],"oral":[4],"administration":[5,53],"of":[6,28,54,58,148,160],"the":[7,13,25,46,73,84,88,107,111,122,143,157],"synthetic":[8],"antioxidant,":[9],"tert-butylhydroquinone":[10],"(TBHQ),":[11],"or":[12,44],"naturally":[14],"occurring":[15],"lipoxygenase":[16],"inhibitor,":[17],"curcumin,":[18],"to":[19,78],"rats":[20,33,70,85,112,126],"would":[21],"provide":[22,139],"protection":[23],"against":[24],"diabetogenic":[26,158],"effect":[27,132,155],"streptozotocin":[29],"(STZ).":[30],"Male":[31],"Sprague-Dawley":[32],"were":[34,76],"fed":[35,71,86],"on":[36,45,72,87,133,156],"AIN-76-based":[38],"purified":[39,47],"diet":[40,48,75,90],"containing":[41],"0.0028%":[42],"TBHQ":[43,116],"with":[49,83],"a":[50,93,153],"daily":[51],"intragastric":[52],"curcumin":[55,128],"(200":[56],"mg/kg":[57],"body":[59,95],"weight)":[60],"for":[61,142],"one":[62],"week":[63],"while":[64],"receiving":[65,127],"intravenously":[66],"administered":[67],"STZ.":[68],"The":[69,125],"TBHQ-containing":[74],"resistant":[77],"diabetes":[79],"development":[80],"when":[81],"compared":[82],"TBHQ-free":[89],"and":[91,98],"had":[92,114],"higher":[94,118],"weight":[96],"gain":[97],"lower":[99],"serum":[100],"glucose":[101],"concentration.":[102],"Glucose-stimulated":[103],"insulin":[104],"secretion":[105],"from":[106],"pancreatic":[108],"islet":[109],"in":[110,121],"that":[113,120,145],"received":[115],"was":[117],"than":[119],"control":[123],"rats.":[124],"showed":[129],"no":[130],"beneficial":[131],"these":[134],"diabetic":[135],"symptoms.":[136],"These":[137],"findings":[138],"direct":[140],"evidence":[141],"suggestion":[144],"dietary":[146],"supplementation":[147],"antioxidant":[150],"may":[151],"exert":[152],"preventive":[154],"action":[159],"free-radical":[161],"producers.":[162]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}