{"id":"https://openalex.org/W1978214088","doi":"https://doi.org/10.1189/jlb.0406237","title":"Differential involvement of RelB in morphine-induced modulation of chemotaxis, NO, and cytokine production in murine macrophages and lymphocytes","display_name":"Differential involvement of RelB in morphine-induced modulation of chemotaxis, NO, and cytokine production in murine macrophages and lymphocytes","publication_year":2006,"publication_date":"2006-10-05","ids":{"openalex":"https://openalex.org/W1978214088","doi":"https://doi.org/10.1189/jlb.0406237","mag":"1978214088","pmid":"https://pubmed.ncbi.nlm.nih.gov/17023558"},"language":"en","primary_location":{"id":"doi:10.1189/jlb.0406237","doi":"https://doi.org/10.1189/jlb.0406237","is_oa":false,"landing_page_url":"https://doi.org/10.1189/jlb.0406237","pdf_url":null,"source":{"id":"https://openalex.org/S199011235","display_name":"Journal of Leukocyte Biology","issn_l":"0741-5400","issn":["0741-5400","1938-3673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Leukocyte Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002391875","display_name":"Cataldo Martucci","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cataldo Martucci","raw_affiliation_strings":["Department of Pharmacology, University of Milan , Milan , Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Milan , Milan , Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028449400","display_name":"Silvia Franchi","orcid":"https://orcid.org/0000-0002-0933-1522","observed_orcids":["https://orcid.org/0000-0002-0933-1522"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Franchi","raw_affiliation_strings":["Department of Pharmacology, University of Milan , Milan , Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Milan , Milan , Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112297690","display_name":"Donatella Lattuada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Donatella Lattuada","raw_affiliation_strings":["Department of Pharmacology, University of Milan , Milan , Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Milan , Milan , Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082929777","display_name":"Alberto Emilio Panerai","orcid":"https://orcid.org/0000-0002-8896-2516","observed_orcids":["https://orcid.org/0000-0002-8896-2516"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alberto E Panerai","raw_affiliation_strings":["Department of Pharmacology, University of Milan , Milan , Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Milan , Milan , Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067038903","display_name":"Paola Sacerdote","orcid":"https://orcid.org/0000-0003-4577-511X","observed_orcids":["https://orcid.org/0000-0003-4577-511X"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Paola Sacerdote","raw_affiliation_strings":["Department of Pharmacology, University of Milan , Milan , Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Milan , Milan , Italy","institution_ids":["https://openalex.org/I189158943"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5067038903"],"corresponding_institution_ids":["https://openalex.org/I189158943"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":1.0991,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.7682963,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"81","issue":"1","first_page":"344","last_page":"354"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.5098000168800354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.5098000168800354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.30790001153945923,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.12549999356269836,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/morphine","display_name":"morphine","score":0.8880000114440918},{"id":"https://openalex.org/keywords/relb","display_name":"RelB","score":0.9210000038146973},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9470000267028809},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.9319999814033508},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.906000018119812},{"id":"https://openalex.org/keywords/lymphocytes","display_name":"lymphocytes","score":0.9290000200271606},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.8450000286102295},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8009999990463257},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"chemotaxis","score":0.8700000047683716},{"id":"https://openalex.org/keywords/th1-cytokines","display_name":"Th1 cytokines","score":0.8560000061988831},{"id":"https://openalex.org/keywords/th2-cytokines","display_name":"Th2 cytokines","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7409999966621399},{"id":"https://openalex.org/keywords/anti-inflammatory-cytokines","display_name":"anti-inflammatory cytokines","score":0.8529999852180481}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7242470979690552},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.7152550220489502},{"id":"https://openalex.org/C2777453290","wikidata":"https://www.wikidata.org/wiki/Q18031090","display_name":"RELB","level":5,"score":0.6968486905097961},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6422727108001709},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.48433125019073486},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46169909834861755},{"id":"https://openalex.org/C93226319","wikidata":"https://www.wikidata.org/wiki/Q193137","display_name":"Differential (mechanical device)","level":2,"score":0.4426004886627197},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1742447316646576},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10060596466064453},{"id":"https://openalex.org/C123298856","wikidata":"https://www.wikidata.org/wiki/Q15317427","display_name":"NFKB1","level":4,"score":0.0810309648513794},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07256266474723816},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.06871446967124939},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009020","descriptor_name":"Morphine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D010537","descriptor_name":"Peritoneum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010537","descriptor_name":"Peritoneum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051841","descriptor_name":"Transcription Factor RelB","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051841","descriptor_name":"Transcription Factor RelB","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1189/jlb.0406237","doi":"https://doi.org/10.1189/jlb.0406237","is_oa":false,"landing_page_url":"https://doi.org/10.1189/jlb.0406237","pdf_url":null,"source":{"id":"https://openalex.org/S199011235","display_name":"Journal of Leukocyte Biology","issn_l":"0741-5400","issn":["0741-5400","1938-3673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Leukocyte Biology","raw_type":"journal-article"},{"id":"pmid:17023558","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17023558","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of leukocyte biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W122953857","https://openalex.org/W1524549627","https://openalex.org/W1566443283","https://openalex.org/W1588586944","https://openalex.org/W1609862856","https://openalex.org/W1933774151","https://openalex.org/W1961542776","https://openalex.org/W1972922050","https://openalex.org/W1996752594","https://openalex.org/W1997285460","https://openalex.org/W2016987788","https://openalex.org/W2018718597","https://openalex.org/W2020969008","https://openalex.org/W2022075056","https://openalex.org/W2031507820","https://openalex.org/W2033810895","https://openalex.org/W2035646853","https://openalex.org/W2037029897","https://openalex.org/W2041912408","https://openalex.org/W2044936430","https://openalex.org/W2046271033","https://openalex.org/W2047879558","https://openalex.org/W2051433588","https://openalex.org/W2051998790","https://openalex.org/W2057794769","https://openalex.org/W2060555846","https://openalex.org/W2063649408","https://openalex.org/W2067317344","https://openalex.org/W2069638092","https://openalex.org/W2074150439","https://openalex.org/W2075584722","https://openalex.org/W2078303207","https://openalex.org/W2084900761","https://openalex.org/W2101127404","https://openalex.org/W2106877484","https://openalex.org/W2108473659","https://openalex.org/W2115374585","https://openalex.org/W2130261183","https://openalex.org/W2162665387","https://openalex.org/W2162725795","https://openalex.org/W2219562258","https://openalex.org/W4231581694","https://openalex.org/W4312244634","https://openalex.org/W4313347838"],"related_works":["https://openalex.org/W2006746280","https://openalex.org/W2022075056","https://openalex.org/W2057794769","https://openalex.org/W2135074653","https://openalex.org/W155108226","https://openalex.org/W2115374585","https://openalex.org/W4312244634","https://openalex.org/W4320729102","https://openalex.org/W2084520505","https://openalex.org/W2401906626"],"abstract_inverted_index":{"Acute":[0],"morphine":[1,72,133,139,204,222,233],"impairs":[2],"innate":[3],"and":[4,28,64,75,94,99,138,155,168,195,207,226],"acquired":[5],"immunity.":[6],"The":[7,18],"mechanisms":[8],"involved":[9,36],"in":[10,37,43,52,55,96,110,123,134,144,148,182,205],"immunosuppression":[11,54],"have":[12],"not":[13],"been":[14],"well":[15],"defined":[16],"yet.":[17],"transcription":[19],"factor":[20],"NF-kappaB":[21,31],"is":[22,34,217],"a":[23,162],"central":[24],"regulator":[25],"of":[26,29,40,50,88,107,151,166,177,190,224],"immunity,":[27],"the":[30,38,48,59,89,100,105,111,116,124,145,149,178,186,188,191,200],"family,":[32],"RelB":[33,51,60,216],"particularly":[35],"expression":[39],"genes":[41],"important":[42,219],"immune":[44,79],"responses.":[45],"We":[46],"investigated":[47],"involvement":[49],"morphine-induced":[53,164],"mice":[56,63],"deficient":[57],"for":[58,221],"factor.":[61],"RelB-/-":[62,112,183,208],"wild-type":[65],"(WT)":[66],"controls":[67],"were":[68,81,158],"injected":[69],"s.c.":[70],"with":[71],"20":[73],"mg/Kg,":[74],"1":[76],"h":[77],"later,":[78],"parameters":[80],"evaluated.":[82],"Morphine":[83],"significantly":[84],"reduced":[85],"macrophage":[86,142],"production":[87,106,129,170,189],"proinflammatory":[90,225],"cytokines":[91,109,157,193],"IL-1beta,":[92],"TNF-alpha,":[93],"IL-12":[95],"WT":[97,135,172,206],"animals,":[98],"drug":[101,179],"failed":[102],"to":[103,199,238],"diminish":[104],"these":[108],"mice.":[113,184,209],"In":[114,210],"contrast,":[115],"anti-inflammatory":[117],"cytokine":[118],"IL-10":[119,196],"was":[120,130,180,197],"similarly":[121,140],"affected":[122],"two":[125],"strains.":[126],"Macrophage":[127],"NO":[128],"modulated":[131],"by":[132,171,203],"animals":[136],"only,":[137],"decreased":[141],"chemotaxis":[143],"presence":[146],"or":[147],"absence":[150],"RelB.":[152],"When":[153],"Th1":[154,227],"Th2":[156,192],"evaluated,":[159],"we":[160],"observed":[161,181],"clear":[163],"reduction":[165],"IL-2":[167],"IFN-gamma":[169],"splenocytes,":[173],"whereas":[174],"no":[175],"effect":[176],"On":[185],"contrary,":[187],"IL-4":[194],"lessened":[198],"same":[201],"degree":[202],"conclusion,":[211],"our":[212],"data":[213],"suggest":[214],"that":[215,232],"an":[218],"target":[220],"modulation":[223],"cytokines.":[228],"They":[229],"also":[230],"indicate":[231],"uses":[234],"multiple":[235],"intracellular":[236],"pathways":[237],"exert":[239],"its":[240],"generalized":[241],"immunosuppression.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}