{"id":"https://openalex.org/W1978212400","doi":"https://doi.org/10.1371/journal.pone.0051641","title":"Wax Ester Synthesis is Required for Mycobacterium tuberculosis to Enter In Vitro Dormancy","display_name":"Wax Ester Synthesis is Required for Mycobacterium tuberculosis to Enter In Vitro Dormancy","publication_year":2012,"publication_date":"2012-12-14","ids":{"openalex":"https://openalex.org/W1978212400","doi":"https://doi.org/10.1371/journal.pone.0051641","mag":"1978212400","pmid":"https://pubmed.ncbi.nlm.nih.gov/23272127","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3522743"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0051641","doi":"https://doi.org/10.1371/journal.pone.0051641","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0051641","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0051641&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0051641&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023274221","display_name":"Tatiana D. Sirakova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tatiana D. Sirakova","raw_affiliation_strings":["Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, United States of America","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018510494","display_name":"Chirajyoti Deb","orcid":"https://orcid.org/0000-0002-9949-4279","observed_orcids":["https://orcid.org/0000-0002-9949-4279"]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chirajyoti Deb","raw_affiliation_strings":["Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, United States of America","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000847733","display_name":"Jaiyanth Daniel","orcid":"https://orcid.org/0000-0002-3605-687X","observed_orcids":["https://orcid.org/0000-0002-3605-687X"]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaiyanth Daniel","raw_affiliation_strings":["Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, United States of America","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082973114","display_name":"Harminder D. Singh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harminder D. Singh","raw_affiliation_strings":["Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, United States of America","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063036150","display_name":"H\u00e9dia Maamar","orcid":"https://orcid.org/0000-0002-0236-177X","observed_orcids":["https://orcid.org/0000-0002-0236-177X"]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hedia Maamar","raw_affiliation_strings":["Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, United States of America","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110084425","display_name":"Vinod Shanker Dubey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vinod S. Dubey","raw_affiliation_strings":["Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, United States of America","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011765239","display_name":"Pappachan E. Kolattukudy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pappachan E. Kolattukudy","raw_affiliation_strings":["Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, United States of America","institution_ids":["https://openalex.org/I106165777"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5011765239"],"corresponding_institution_ids":["https://openalex.org/I106165777"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.4403,"has_fulltext":true,"cited_by_count":56,"citation_normalized_percentile":{"value":0.87705518,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"7","issue":"12","first_page":"e51641","last_page":"e51641"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13736","display_name":"Steroid Chemistry and Biochemistry","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/wax-ester-synthesis","display_name":"wax ester synthesis","score":0.8479999899864197},{"id":"https://openalex.org/keywords/bacterial-dormancy","display_name":"bacterial dormancy","score":0.8399999737739563},{"id":"https://openalex.org/keywords/fatty-acyl-coa-reductase","display_name":"fatty acyl-CoA reductase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/oleoyl-coa","display_name":"oleoyl-CoA","score":0.7770000100135803},{"id":"https://openalex.org/keywords/nadph-dependent-reduction","display_name":"NADPH-dependent reduction","score":0.8100000023841858},{"id":"https://openalex.org/keywords/nitrosative-stress","display_name":"nitrosative stress","score":0.875},{"id":"https://openalex.org/keywords/antibiotic-tolerance","display_name":"antibiotic tolerance","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cell-wall-permeability","display_name":"cell wall permeability","score":0.8199999928474426},{"id":"https://openalex.org/keywords/knockout-mutants","display_name":"knockout mutants","score":0.6200000047683716},{"id":"https://openalex.org/keywords/complementation","display_name":"complementation","score":0.7369999885559082},{"id":"https://openalex.org/keywords/tuberculosis-drug-targets","display_name":"tuberculosis drug targets","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6678882837295532},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6473104357719421},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.6011617183685303},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.5555433034896851},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.531886875629425},{"id":"https://openalex.org/C2776941171","wikidata":"https://www.wikidata.org/wiki/Q900209","display_name":"Fatty acid synthesis","level":3,"score":0.47401222586631775},{"id":"https://openalex.org/C3527866","wikidata":"https://www.wikidata.org/wiki/Q162267","display_name":"Dormancy","level":3,"score":0.4724215269088745},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.4183492660522461},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3255773186683655},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16814368963241577},{"id":"https://openalex.org/C100701293","wikidata":"https://www.wikidata.org/wiki/Q193838","display_name":"Germination","level":2,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000214","descriptor_name":"Acyl Coenzyme A","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000214","descriptor_name":"Acyl Coenzyme A","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000214","descriptor_name":"Acyl Coenzyme A","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000214","descriptor_name":"Acyl Coenzyme A","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000447","descriptor_name":"Aldehydes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000447","descriptor_name":"Aldehydes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000447","descriptor_name":"Aldehydes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000447","descriptor_name":"Aldehydes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000449","descriptor_name":"Aldehyde Reductase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000449","descriptor_name":"Aldehyde Reductase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000449","descriptor_name":"Aldehyde Reductase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000449","descriptor_name":"Aldehyde Reductase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004952","descriptor_name":"Esters","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004952","descriptor_name":"Esters","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004952","descriptor_name":"Esters","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004952","descriptor_name":"Esters","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005233","descriptor_name":"Fatty Alcohols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005233","descriptor_name":"Fatty Alcohols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005233","descriptor_name":"Fatty Alcohols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005233","descriptor_name":"Fatty Alcohols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005816","descriptor_name":"Genetic Complementation Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005816","descriptor_name":"Genetic Complementation Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005816","descriptor_name":"Genetic Complementation Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005816","descriptor_name":"Genetic Complementation Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005990","descriptor_name":"Glycerol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005990","descriptor_name":"Glycerol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005990","descriptor_name":"Glycerol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005990","descriptor_name":"Glycerol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016366","descriptor_name":"Open Reading Frames","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016366","descriptor_name":"Open Reading Frames","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016366","descriptor_name":"Open Reading Frames","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016366","descriptor_name":"Open Reading Frames","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0051641","doi":"https://doi.org/10.1371/journal.pone.0051641","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0051641","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0051641&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2527314","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3522743","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3522743","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3522743","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:23272127","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23272127","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.802.1529","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.802.1529","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/58/99/pone.0051641.PMC3522743.pdf","raw_type":"text"},{"id":"pmh:oai:stars.library.ucf.edu:facultybib2010-4314","doi":null,"is_oa":true,"landing_page_url":"https://stars.library.ucf.edu/facultybib2010/3315","pdf_url":null,"source":{"id":"https://openalex.org/S4210172555","display_name":"Journal of International Crisis and Risk Communication Research","issn_l":"2576-0017","issn":["2576-0017","2576-0025"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Bibliography 2010s","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:1b159b0d90014439beae394c46d77a4b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1b159b0d90014439beae394c46d77a4b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 12, p e51641 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0051641","doi":"https://doi.org/10.1371/journal.pone.0051641","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0051641","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0051641&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Affordable and clean energy","id":"https://metadata.un.org/sdg/7","score":0.4399999976158142}],"study_designs":[],"awards":[{"id":"https://openalex.org/G203290395","display_name":null,"funder_award_id":"AI 35272","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3788876014","display_name":"Search for novel TB Drug Targets in Lipid Metabolism","funder_award_id":"R01AI046582","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4139608193","display_name":"Lipid storage and mobilization in M. tuberculosis as antilatency drugs targets","funder_award_id":"R01AI035272","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G63530767","display_name":null,"funder_award_id":"AI-46582","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978212400.pdf","grobid_xml":"https://content.openalex.org/works/W1978212400.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W98450836","https://openalex.org/W419562888","https://openalex.org/W640826481","https://openalex.org/W1496157310","https://openalex.org/W1522861351","https://openalex.org/W1537333064","https://openalex.org/W1597808424","https://openalex.org/W1634027312","https://openalex.org/W1932641935","https://openalex.org/W1934542416","https://openalex.org/W1967981179","https://openalex.org/W1971337268","https://openalex.org/W1972851920","https://openalex.org/W1975401101","https://openalex.org/W1979690999","https://openalex.org/W1982032244","https://openalex.org/W1996953184","https://openalex.org/W2019486445","https://openalex.org/W2019835759","https://openalex.org/W2033541022","https://openalex.org/W2036032145","https://openalex.org/W2038914630","https://openalex.org/W2040616409","https://openalex.org/W2053867514","https://openalex.org/W2056199232","https://openalex.org/W2066912280","https://openalex.org/W2077464081","https://openalex.org/W2078663039","https://openalex.org/W2082507312","https://openalex.org/W2086788604","https://openalex.org/W2086815042","https://openalex.org/W2092030365","https://openalex.org/W2111090688","https://openalex.org/W2111771826","https://openalex.org/W2117936351","https://openalex.org/W2119733261","https://openalex.org/W2125112523","https://openalex.org/W2133119080","https://openalex.org/W2134345572","https://openalex.org/W2149717582","https://openalex.org/W2155158924","https://openalex.org/W2158023121","https://openalex.org/W2278661400","https://openalex.org/W2414580923","https://openalex.org/W4211104832"],"related_works":["https://openalex.org/W7098413683","https://openalex.org/W1963873819","https://openalex.org/W2612974321","https://openalex.org/W2117936351","https://openalex.org/W1982032244","https://openalex.org/W2144825193","https://openalex.org/W4224437636","https://openalex.org/W2000248841","https://openalex.org/W7100786684","https://openalex.org/W2086105177"],"abstract_inverted_index":{"Mycobacterium":[0],"tuberculosis":[1],"(Mtb)":[2],"is":[3,16],"known":[4,17],"to":[5,12,53,116,219,243,288,298],"produce":[6],"wax":[7],"esters":[8],"(WE)":[9],"when":[10,143],"subjected":[11],"stress.":[13],"However,":[14],"nothing":[15],"about":[18],"the":[19,70,107,120,123,134,146,151,156,162,189,209,214,238,241,250,281,306],"enzymes":[20,60],"involved":[21,231,257],"in":[22,29,44,106,122,130,155,161,169,232,258,262,273],"biosynthesis":[23],"of":[24,50,133,183,188,208,216,224,229,240,296,305],"WE":[25,102,165,259,268],"and":[26,56,62,80,101,159,196,235,252,266,292],"their":[27],"role":[28,272],"mycobacterial":[30],"dormancy.":[31],"We":[32,86],"report":[33],"that":[34,113,249,267],"two":[35],"putative":[36],"Mtb":[37,88,282,297],"fatty":[38,51,54,57,78,99,126],"acyl-CoA":[39,52,79,127],"reductase":[40,128],"genes":[41,230],"(fcr)":[42],"expressed":[43],"E.":[45],"coli":[46],"display":[47],"catalytic":[48],"reduction":[49],"aldehyde":[55],"alcohol.":[58],"Both":[59],"(FCR1/Rv3391)":[61],"FCR2/Rv1543)":[63],"showed":[64,227],"a":[65,72,270,275],"requirement":[66],"for":[67,74,91],"NADPH":[68],"as":[69],"reductant,":[71],"preference":[73],"oleoyl-CoA":[75],"over":[76],"saturated":[77],"were":[81],"inhibited":[82,168],"by":[83,119],"thiol-directed":[84],"reagents.":[85],"generated":[87],"gene-knockout":[89],"mutants":[90,108,135,175,210,226,242],"each":[92],"reductase.":[93],"Metabolic":[94],"incorporation":[95],"of(":[96],"14)C-oleate":[97],"into":[98,290],"alcohols":[100],"was":[103,140,167],"severely":[104],"diminished":[105],"under":[109,136,201,261],"dormancy-inducing":[110,202,264],"stress":[111,139,205],"conditions":[112,265],"are":[114,256],"thought":[115],"be":[117],"encountered":[118],"pathogen":[121,307],"host.":[124],"The":[125,173],"activity":[129,153,194],"cell":[131,190],"lysates":[132],"nitric":[137],"oxide":[138],"significantly":[141],"reduced":[142],"compared":[144],"with":[145],"wild":[147],"type.":[148],"Complementation":[149,207],"restored":[150],"lost":[152],"completely":[154],"\u0394fcr1":[157],"mutant":[158],"partially":[160],"\u0394fcr2":[163],"mutant.":[164],"synthesis":[166,260],"both":[170],"\u0394fcr":[171,174,225],"mutants.":[172],"exhibited":[176],"faster":[177],"growth":[178],"rates,":[179],"an":[180],"increased":[181,186,192],"uptake":[182],"(14)C-glycerol":[184],"suggesting":[185],"permeability":[187],"wall,":[191],"metabolic":[193],"levels":[195],"impaired":[197],"phenotypic":[198],"antibiotic":[199,217],"tolerance":[200,218],"combined":[203],"multiple":[204],"conditions.":[206],"did":[211],"not":[212],"restore":[213],"development":[215],"wild-type":[220],"levels.":[221],"Transcript":[222],"analysis":[223],"upregulation":[228],"energy":[233],"generation":[234],"transcription,":[236],"indicating":[237],"inability":[239],"become":[244],"dormant.":[245],"Our":[246],"results":[247],"indicate":[248],"fcr1":[251],"fcr2":[253],"gene":[254],"products":[255],"vitro":[263],"play":[269],"critical":[271],"reaching":[274],"dormant":[276],"state.":[277],"Drugs":[278],"targeted":[279],"against":[280],"reductases":[283],"may":[284],"inhibit":[285],"its":[286],"ability":[287],"go":[289],"dormancy":[291],"therefore":[293],"increase":[294],"susceptibility":[295],"currently":[299],"used":[300],"antibiotics":[301],"thereby":[302],"enhancing":[303],"clearance":[304],"from":[308],"patients.":[309]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}