{"id":"https://openalex.org/W1978210963","doi":"https://doi.org/10.1016/0042-6822(83)90224-6","title":"2\u20135A synthetase activity does not increase in interferon-resistant friend leukemia cell variants treated with \u03b1/\u03b2 interferon despite the presence of high-affinity interferon receptor sites","display_name":"2\u20135A synthetase activity does not increase in interferon-resistant friend leukemia cell variants treated with \u03b1/\u03b2 interferon despite the presence of high-affinity interferon receptor sites","publication_year":1983,"publication_date":"1983-03-01","ids":{"openalex":"https://openalex.org/W1978210963","doi":"https://doi.org/10.1016/0042-6822(83)90224-6","mag":"1978210963","pmid":"https://pubmed.ncbi.nlm.nih.gov/6301152"},"language":"en","primary_location":{"id":"doi:10.1016/0042-6822(83)90224-6","doi":"https://doi.org/10.1016/0042-6822(83)90224-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0042-6822(83)90224-6","pdf_url":null,"source":{"id":"https://openalex.org/S6147291","display_name":"Virology","issn_l":"0042-6822","issn":["0042-6822","1089-862X","1096-0341"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021764629","display_name":"Elisabetta Affabris","orcid":"https://orcid.org/0000-0001-5142-8144","observed_orcids":["https://orcid.org/0000-0001-5142-8144"]},"institutions":[{"id":"https://openalex.org/I27897274","display_name":"Istituto Superiore di Sanit\u00e0","ror":"https://ror.org/02hssy432","country_code":"IT","type":"government","lineage":["https://openalex.org/I27897274"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E. Affabris","raw_affiliation_strings":["Laboratorio di Virologia, Istituto Superiore di Sanitd, Rome and Gruppo di Microbiologia e Patologia Generale, Universit\u00e0 degli Studi di Roma, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio di Virologia, Istituto Superiore di Sanitd, Rome and Gruppo di Microbiologia e Patologia Generale, Universit\u00e0 degli Studi di Roma, Rome, Italy","institution_ids":["https://openalex.org/I27897274","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101479056","display_name":"G. Romeo","orcid":"https://orcid.org/0000-0002-7638-1001","observed_orcids":["https://orcid.org/0000-0002-7638-1001"]},"institutions":[{"id":"https://openalex.org/I27897274","display_name":"Istituto Superiore di Sanit\u00e0","ror":"https://ror.org/02hssy432","country_code":"IT","type":"government","lineage":["https://openalex.org/I27897274"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Romeo","raw_affiliation_strings":["Laboratorio di Virologia, Istituto Superiore di Sanitd, Rome and Gruppo di Microbiologia e Patologia Generale, Universit\u00e0 degli Studi di Roma, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio di Virologia, Istituto Superiore di Sanitd, Rome and Gruppo di Microbiologia e Patologia Generale, Universit\u00e0 degli Studi di Roma, Rome, Italy","institution_ids":["https://openalex.org/I27897274","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009678390","display_name":"Filippo Belardelli","orcid":"https://orcid.org/0000-0002-3082-3169","observed_orcids":["https://orcid.org/0000-0002-3082-3169"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. Belardelli","raw_affiliation_strings":["Laboratory of Viral Oncology, Institut de Recherches Scientifiques sur le Cancer, BP 8, 94802 Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Viral Oncology, Institut de Recherches Scientifiques sur le Cancer, BP 8, 94802 Villejuif, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110246932","display_name":"C Jemma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27897274","display_name":"Istituto Superiore di Sanit\u00e0","ror":"https://ror.org/02hssy432","country_code":"IT","type":"government","lineage":["https://openalex.org/I27897274"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C. Jemma","raw_affiliation_strings":["Laboratorio di Virologia, Istituto Superiore di Sanitd, Rome and Gruppo di Microbiologia e Patologia Generale, Universit\u00e0 degli Studi di Roma, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio di Virologia, Istituto Superiore di Sanitd, Rome and Gruppo di Microbiologia e Patologia Generale, Universit\u00e0 degli Studi di Roma, Rome, Italy","institution_ids":["https://openalex.org/I27897274","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113695704","display_name":"Nadir Mechti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387154756","display_name":"Universit\u00e9 Montpellier 2","ror":"https://ror.org/00wh4bp03","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307","https://openalex.org/I4387154756"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"N. Mechti","raw_affiliation_strings":["Laboratorre de Biochimie des Proteines, Universit\u00e9 de Montpellier II, 34060 Montpellier Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorre de Biochimie des Proteines, Universit\u00e9 de Montpellier II, 34060 Montpellier Cedex, France","institution_ids":["https://openalex.org/I4387154756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017775489","display_name":"Ion Gresser","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I. Gresser","raw_affiliation_strings":["Laboratory of Viral Oncology, Institut de Recherches Scientifiques sur le Cancer, BP 8, 94802 Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Viral Oncology, Institut de Recherches Scientifiques sur le Cancer, BP 8, 94802 Villejuif, France","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087874445","display_name":"Giovanni Battista Rossi","orcid":"https://orcid.org/0000-0002-0970-1458","observed_orcids":["https://orcid.org/0000-0002-0970-1458"]},"institutions":[{"id":"https://openalex.org/I27897274","display_name":"Istituto Superiore di Sanit\u00e0","ror":"https://ror.org/02hssy432","country_code":"IT","type":"government","lineage":["https://openalex.org/I27897274"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"G.B. Rossi","raw_affiliation_strings":["Laboratorio di Virologia, Istituto Superiore di Sanitd, Rome and Gruppo di Microbiologia e Patologia Generale, Universit\u00e0 degli Studi di Roma, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio di Virologia, Istituto Superiore di Sanitd, Rome and Gruppo di Microbiologia e Patologia Generale, Universit\u00e0 degli Studi di Roma, Rome, Italy","institution_ids":["https://openalex.org/I27897274","https://openalex.org/I861853513"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5087874445"],"corresponding_institution_ids":["https://openalex.org/I27897274","https://openalex.org/I861853513"],"apc_list":{"value":3160,"currency":"USD","value_usd":3160},"apc_paid":null,"fwci":2.2951,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.88861325,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"125","issue":"2","first_page":"508","last_page":"512"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-resistance","display_name":"interferon resistance","score":0.8479999899864197},{"id":"https://openalex.org/keywords/friend-leukemia-cells","display_name":"Friend leukemia cells","score":0.7900000214576721},{"id":"https://openalex.org/keywords/2-5-oligoadenylate-synthetase","display_name":"2',5'-oligoadenylate synthetase","score":0.8980000019073486},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.8920000195503235},{"id":"https://openalex.org/keywords/interferon-receptor","display_name":"interferon receptor","score":0.8759999871253967},{"id":"https://openalex.org/keywords/receptor-binding","display_name":"receptor binding","score":0.6480000019073486},{"id":"https://openalex.org/keywords/double-stranded-rna","display_name":"double-stranded RNA","score":0.8709999918937683}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8718040585517883},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.8210914731025696},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.632339358329773},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5441639423370361},{"id":"https://openalex.org/C2909179924","wikidata":"https://www.wikidata.org/wiki/Q6046488","display_name":"Alpha interferon","level":3,"score":0.4846087396144867},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.47283607721328735},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.45668283104896545},{"id":"https://openalex.org/C2778278966","wikidata":"https://www.wikidata.org/wiki/Q6046488","display_name":"Interferon type I","level":3,"score":0.44720733165740967},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.29752615094184875},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2735444903373718},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14161422848701477}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005622","descriptor_name":"Friend murine leukemia virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007370","descriptor_name":"Interferon Type I","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007942","descriptor_name":"Leukemia, Experimental","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015088","descriptor_name":"2',5'-Oligoadenylate Synthetase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017471","descriptor_name":"Receptors, Interferon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/0042-6822(83)90224-6","doi":"https://doi.org/10.1016/0042-6822(83)90224-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0042-6822(83)90224-6","pdf_url":null,"source":{"id":"https://openalex.org/S6147291","display_name":"Virology","issn_l":"0042-6822","issn":["0042-6822","1089-862X","1096-0341"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virology","raw_type":"journal-article"},{"id":"pmid:6301152","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6301152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virology","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-02361168v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-02361168","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Virology, 1983, 125 (2), pp.508-512. ⟨10.1016/0042-6822(83)90224-6⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.uniroma1.it:11573/142982","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/142982","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.uniroma3.it:11590/119019","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11590/119019","pdf_url":null,"source":{"id":"https://openalex.org/S4377196120","display_name":"Iris (Roma Tre University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I119003972","host_organization_name":"Roma Tre University","host_organization_lineage":["https://openalex.org/I119003972"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1671413742","https://openalex.org/W1977305595","https://openalex.org/W1999867700","https://openalex.org/W2024893223","https://openalex.org/W2030131332","https://openalex.org/W2040551140","https://openalex.org/W2061925892","https://openalex.org/W2063322107","https://openalex.org/W2073701455","https://openalex.org/W2080207655","https://openalex.org/W2083934011","https://openalex.org/W2122994357","https://openalex.org/W2126736790"],"related_works":["https://openalex.org/W7008024375","https://openalex.org/W7036140858","https://openalex.org/W2320389329","https://openalex.org/W2127725661","https://openalex.org/W7009593913","https://openalex.org/W1790781756","https://openalex.org/W2040551140","https://openalex.org/W1958540797","https://openalex.org/W7061640229","https://openalex.org/W7007698192"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}