{"id":"https://openalex.org/W1978210778","doi":"https://doi.org/10.1021/jm100057h","title":"Development of a New Generation of 4-Aminoquinoline Antimalarial Compounds Using Predictive Pharmacokinetic and Toxicology Models","display_name":"Development of a New Generation of 4-Aminoquinoline Antimalarial Compounds Using Predictive Pharmacokinetic and Toxicology Models","publication_year":2010,"publication_date":"2010-04-05","ids":{"openalex":"https://openalex.org/W1978210778","doi":"https://doi.org/10.1021/jm100057h","mag":"1978210778","pmid":"https://pubmed.ncbi.nlm.nih.gov/20361799","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2866084"},"language":"en","primary_location":{"id":"doi:10.1021/jm100057h","doi":"https://doi.org/10.1021/jm100057h","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm100057h","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2866084","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071395268","display_name":"Sunetra Ray","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298353152","display_name":"SRI International","ror":"https://ror.org/05s570m15","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298353152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunetra Ray","raw_affiliation_strings":["SRI International, 333 Ravenswood Avenue, Menlo Park, California 94025","SRI International , 333 Ravenswood Avenue, Menlo Park, California, 94025, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SRI International, 333 Ravenswood Avenue, Menlo Park, California 94025","institution_ids":["https://openalex.org/I1298353152"]},{"raw_affiliation_string":"SRI International , 333 Ravenswood Avenue, Menlo Park, California, 94025, USA","institution_ids":["https://openalex.org/I1298353152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025984430","display_name":"Peter B. Madrid","orcid":"https://orcid.org/0000-0002-4895-5610","observed_orcids":["https://orcid.org/0000-0002-4895-5610"]},"institutions":[{"id":"https://openalex.org/I1298353152","display_name":"SRI International","ror":"https://ror.org/05s570m15","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298353152"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter B. Madrid","raw_affiliation_strings":["SRI International, 333 Ravenswood Avenue, Menlo Park, California 94025","SRI International, 333 Ravenswood Avenue, Menlo Park, California, 94025#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SRI International, 333 Ravenswood Avenue, Menlo Park, California 94025","institution_ids":["https://openalex.org/I1298353152"]},{"raw_affiliation_string":"SRI International, 333 Ravenswood Avenue, Menlo Park, California, 94025#TAB#","institution_ids":["https://openalex.org/I1298353152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007469626","display_name":"Paul Catz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298353152","display_name":"SRI International","ror":"https://ror.org/05s570m15","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298353152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Catz","raw_affiliation_strings":["SRI International, 333 Ravenswood Avenue, Menlo Park, California 94025","SRI International, 333 Ravenswood Avenue, Menlo Park, California, 94025#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SRI International, 333 Ravenswood Avenue, Menlo Park, California 94025","institution_ids":["https://openalex.org/I1298353152"]},{"raw_affiliation_string":"SRI International, 333 Ravenswood Avenue, Menlo Park, California, 94025#TAB#","institution_ids":["https://openalex.org/I1298353152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112484978","display_name":"Susanna E. LeValley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298353152","display_name":"SRI International","ror":"https://ror.org/05s570m15","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298353152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susanna E. LeValley","raw_affiliation_strings":["SRI International, 333 Ravenswood Avenue, Menlo Park, California 94025","SRI International, 333 Ravenswood Avenue, Menlo Park, California, 94025#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SRI International, 333 Ravenswood Avenue, Menlo Park, California 94025","institution_ids":["https://openalex.org/I1298353152"]},{"raw_affiliation_string":"SRI International, 333 Ravenswood Avenue, Menlo Park, California, 94025#TAB#","institution_ids":["https://openalex.org/I1298353152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080876963","display_name":"Michael J. Furniss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298353152","display_name":"SRI International","ror":"https://ror.org/05s570m15","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298353152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Furniss","raw_affiliation_strings":["SRI International, 333 Ravenswood Avenue, Menlo Park, California 94025","SRI International, 333 Ravenswood Avenue, Menlo Park, California, 94025#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SRI International, 333 Ravenswood Avenue, Menlo Park, California 94025","institution_ids":["https://openalex.org/I1298353152"]},{"raw_affiliation_string":"SRI International, 333 Ravenswood Avenue, Menlo Park, California, 94025#TAB#","institution_ids":["https://openalex.org/I1298353152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064974850","display_name":"Linda L. Rausch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298353152","display_name":"SRI International","ror":"https://ror.org/05s570m15","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298353152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda L. Rausch","raw_affiliation_strings":["SRI International, 333 Ravenswood Avenue, Menlo Park, California 94025","SRI International, 333 Ravenswood Avenue, Menlo Park, California, 94025#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SRI International, 333 Ravenswood Avenue, Menlo Park, California 94025","institution_ids":["https://openalex.org/I1298353152"]},{"raw_affiliation_string":"SRI International, 333 Ravenswood Avenue, Menlo Park, California, 94025#TAB#","institution_ids":["https://openalex.org/I1298353152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052097118","display_name":"Rodney Kiplin Guy","orcid":"https://orcid.org/0000-0002-9638-2060","observed_orcids":["https://orcid.org/0000-0002-9638-2060"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Kiplin Guy","raw_affiliation_strings":["Department of Chemical Biology and Therapeutics, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Biology and Therapeutics, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039824565","display_name":"Joseph L. DeRisi","orcid":"https://orcid.org/0000-0002-4611-9205","observed_orcids":["https://orcid.org/0000-0002-4611-9205"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph L. DeRisi","raw_affiliation_strings":["Department of Biochemistry and Biophysics, University of California\u2014San Francisco, San Francisco, California","Howard Hughes Medical Institute, University of California\u2014San Francisco, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, University of California\u2014San Francisco, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, University of California\u2014San Francisco, San Francisco, California","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032438481","display_name":"Lalitha Iyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298353152","display_name":"SRI International","ror":"https://ror.org/05s570m15","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298353152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lalitha V. Iyer","raw_affiliation_strings":["SRI International, 333 Ravenswood Avenue, Menlo Park, California 94025","SRI International, 333 Ravenswood Avenue, Menlo Park, California, 94025#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SRI International, 333 Ravenswood Avenue, Menlo Park, California 94025","institution_ids":["https://openalex.org/I1298353152"]},{"raw_affiliation_string":"SRI International, 333 Ravenswood Avenue, Menlo Park, California, 94025#TAB#","institution_ids":["https://openalex.org/I1298353152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030813448","display_name":"Carol E. Green","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298353152","display_name":"SRI International","ror":"https://ror.org/05s570m15","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298353152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol E. Green","raw_affiliation_strings":["SRI International, 333 Ravenswood Avenue, Menlo Park, California 94025","SRI International, 333 Ravenswood Avenue, Menlo Park, California, 94025#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SRI International, 333 Ravenswood Avenue, Menlo Park, California 94025","institution_ids":["https://openalex.org/I1298353152"]},{"raw_affiliation_string":"SRI International, 333 Ravenswood Avenue, Menlo Park, California, 94025#TAB#","institution_ids":["https://openalex.org/I1298353152"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062741465","display_name":"Jon C. Mirsalis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298353152","display_name":"SRI International","ror":"https://ror.org/05s570m15","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298353152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon C. Mirsalis","raw_affiliation_strings":["SRI International, 333 Ravenswood Avenue, Menlo Park, California 94025","SRI International, 333 Ravenswood Avenue, Menlo Park, California, 94025#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SRI International, 333 Ravenswood Avenue, Menlo Park, California 94025","institution_ids":["https://openalex.org/I1298353152"]},{"raw_affiliation_string":"SRI International, 333 Ravenswood Avenue, Menlo Park, California, 94025#TAB#","institution_ids":["https://openalex.org/I1298353152"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5025984430"],"corresponding_institution_ids":["https://openalex.org/I1298353152"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":6.6626,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.966838,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"53","issue":"9","first_page":"3685","last_page":"3695"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.04320000112056732,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/4-aminoquinolines","display_name":"4-aminoquinolines","score":0.972000002861023},{"id":"https://openalex.org/keywords/antimalarial-drugs","display_name":"antimalarial drugs","score":0.9150000214576721},{"id":"https://openalex.org/keywords/chloroquine-resistance","display_name":"chloroquine resistance","score":0.9089999794960022},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9779999852180481},{"id":"https://openalex.org/keywords/admet-prediction","display_name":"ADMET prediction","score":0.9459999799728394},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.828000009059906},{"id":"https://openalex.org/keywords/toxicology","display_name":"toxicology","score":0.5910000205039978},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.734000027179718},{"id":"https://openalex.org/keywords/lead-identification","display_name":"lead compound identification","score":0.593999981880188},{"id":"https://openalex.org/keywords/in-vitro-antimalarial-activity","display_name":"in vitro antimalarial activity","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7826744318008423},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7675280570983887},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.7160883545875549},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6458287239074707},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6287024021148682},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6275119185447693},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.5899863243103027},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.5873380899429321},{"id":"https://openalex.org/C2777425658","wikidata":"https://www.wikidata.org/wiki/Q422438","display_name":"Chloroquine","level":3,"score":0.5713322162628174},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4941313564777374},{"id":"https://openalex.org/C2908859342","wikidata":"https://www.wikidata.org/wiki/Q521616","display_name":"Antimalarial Agent","level":4,"score":0.4631900489330292},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.41751915216445923},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.305065393447876},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17084652185440063},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08813273906707764},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08154475688934326},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.07207545638084412},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000634","descriptor_name":"Aminoquinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000634","descriptor_name":"Aminoquinolines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010599","descriptor_name":"Pharmacokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014116","descriptor_name":"Toxicology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1021/jm100057h","doi":"https://doi.org/10.1021/jm100057h","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm100057h","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:20361799","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20361799","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2099463","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2866084","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2866084","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2866084","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Med Chem","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.296.1247","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.296.1247","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://derisilab.ucsf.edu/pdfs/jm100057h.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2099463","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2866084","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5140811607","display_name":"Novel Anti-Malarials by Combinatorial Pharmacogenomics","funder_award_id":"U01AI053862","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8653800314","display_name":"Development of Antimalarial Preclinical Candidates","funder_award_id":"U01AI075517","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320313598","display_name":"American Lebanese Syrian Associated Charities","ror":"https://ror.org/03rx10x31"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1584569398","https://openalex.org/W1774308757","https://openalex.org/W1969749985","https://openalex.org/W1970081141","https://openalex.org/W1976917904","https://openalex.org/W1987932485","https://openalex.org/W1994343930","https://openalex.org/W2020988879","https://openalex.org/W2043249607","https://openalex.org/W2043911731","https://openalex.org/W2044972479","https://openalex.org/W2047924589","https://openalex.org/W2058343382","https://openalex.org/W2065842554","https://openalex.org/W2083172435","https://openalex.org/W2114918609","https://openalex.org/W2126522177","https://openalex.org/W2134433202","https://openalex.org/W2135732933","https://openalex.org/W2143573410","https://openalex.org/W2169495846","https://openalex.org/W2171517811","https://openalex.org/W2467993478"],"related_works":["https://openalex.org/W7099305781","https://openalex.org/W2081080057","https://openalex.org/W4293568142","https://openalex.org/W7098259538","https://openalex.org/W2588020454","https://openalex.org/W2005296591","https://openalex.org/W2886800207","https://openalex.org/W7127057786","https://openalex.org/W2066928192","https://openalex.org/W4255895602"],"abstract_inverted_index":{"Among":[0],"the":[1,24,45,107],"known":[2],"antimalarial":[3,29,95],"drugs,":[4],"chloroquine":[5],"(CQ)":[6],"and":[7,14,54,68,84,90,102,132],"other":[8],"4-aminoquinolines":[9],"have":[10,129],"shown":[11],"high":[12],"potency":[13],"good":[15],"bioavailability.":[16],"Yet":[17],"complications":[18],"associated":[19],"with":[20,70,97],"drug":[21],"resistance":[22],"necessitate":[23],"discovery":[25],"of":[26,40,48,100,111,142],"effective":[27],"new":[28,41],"agents.":[30],"ADMET":[31,77],"prediction":[32],"studies":[33,58],"were":[34,126],"employed":[35],"to":[36,62,128,137,149],"evaluate":[37],"a":[38],"library":[39],"molecules":[42],"based":[43],"on":[44],"4-aminoquinolone-related":[46],"structure":[47],"CQ.":[49],"Extensive":[50],"in":[51,55,59,72,122,151],"vitro":[52,73],"screening":[53],"vivo":[56],"pharmacokinetic":[57,86],"mice":[60],"helped":[61],"identify":[63],"two":[64],"lead":[65],"molecules,":[66],"18":[67,89],"4,":[69],"promising":[71],"therapeutic":[74],"efficacy,":[75],"improved":[76],"properties,":[78],"low":[79],"risk":[80],"for":[81],"drug-drug":[82],"interactions,":[83],"desirable":[85,147],"profiles.":[87],"Both":[88],"4":[91],"are":[92,145],"highly":[93],"potent":[94],"compounds,":[96],"IC(50)":[98,116],"values":[99,135],"5.6":[101],"17.3":[103],"nM,":[104],"respectively,":[105],"against":[106],"W2":[108],"(CQ-resistant)":[109],"strain":[110],"Plasmodium":[112],"falciparum":[113],"(for":[114],"CQ,":[115],"=":[117],"382":[118],"nM).":[119],"When":[120],"tested":[121],"mice,":[123],"these":[124],"compounds":[125],"found":[127],"biological":[130],"half-lives":[131],"plasma":[133],"exposure":[134],"similar":[136],"or":[138],"higher":[139],"than":[140],"those":[141],"CQ;":[143],"they":[144],"therefore":[146],"candidates":[148],"pursue":[150],"future":[152],"clinical":[153],"trials.":[154]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}