{"id":"https://openalex.org/W1978206460","doi":"https://doi.org/10.1093/mutage/1.4.261","title":"Mutagenicity to Salmonella of four derivatives of the azo mutagen 5I: some implications for structure\u2014activity databases and the evaluation of combinations of mutagens","display_name":"Mutagenicity to Salmonella of four derivatives of the azo mutagen 5I: some implications for structure\u2014activity databases and the evaluation of combinations of mutagens","publication_year":1986,"publication_date":"1986-01-01","ids":{"openalex":"https://openalex.org/W1978206460","doi":"https://doi.org/10.1093/mutage/1.4.261","mag":"1978206460","pmid":"https://pubmed.ncbi.nlm.nih.gov/3137411"},"language":"en","primary_location":{"id":"doi:10.1093/mutage/1.4.261","doi":"https://doi.org/10.1093/mutage/1.4.261","is_oa":false,"landing_page_url":"https://doi.org/10.1093/mutage/1.4.261","pdf_url":null,"source":{"id":"https://openalex.org/S101337917","display_name":"Mutagenesis","issn_l":"0267-8357","issn":["0267-8357","1464-3804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutagenesis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082820494","display_name":"Roderick H. Dashwood","orcid":"https://orcid.org/0000-0003-0351-4034","observed_orcids":["https://orcid.org/0000-0003-0351-4034"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R.H. Dashwood","raw_affiliation_strings":["School of Biological Sciences, Portsmouth Polytechnic, Hants, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Portsmouth Polytechnic, Hants, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081082286","display_name":"Robert D. Combes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R.D. Combes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"D. Paton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Paton","raw_affiliation_strings":["ICI PLC, Central Toxicology Laboratory Alderley Park, Nr Macclesfield, Cheshire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICI PLC, Central Toxicology Laboratory Alderley Park, Nr Macclesfield, Cheshire, UK","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113714844","display_name":"John Ashby","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Ashby","raw_affiliation_strings":["ICI PLC, Central Toxicology Laboratory Alderley Park, Nr Macclesfield, Cheshire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICI PLC, Central Toxicology Laboratory Alderley Park, Nr Macclesfield, Cheshire, UK","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3162,"currency":"GBP","value_usd":4170},"apc_paid":null,"fwci":0.2575,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.46989122,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"1","issue":"4","first_page":"261","last_page":"265"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11493","display_name":"Water Treatment and Disinfection","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salmonella-mutagenicity","display_name":"Salmonella mutagenicity","score":0.9290000200271606},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.9670000076293945},{"id":"https://openalex.org/keywords/dimethylation","display_name":"dimethylation","score":0.5400000214576721},{"id":"https://openalex.org/keywords/n-methyl-substitution","display_name":"N-methyl substitution","score":0.5860000252723694},{"id":"https://openalex.org/keywords/2-acetylaminofluorene","display_name":"2-acetylaminofluorene","score":0.8930000066757202},{"id":"https://openalex.org/keywords/bacterial-mutagenicity","display_name":"bacterial mutagenicity","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C2781065037","wikidata":"https://www.wikidata.org/wiki/Q150839","display_name":"Salmonella","level":3,"score":0.6569716930389404},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.6236788630485535},{"id":"https://openalex.org/C2776639595","wikidata":"https://www.wikidata.org/wiki/Q221696","display_name":"Mutagen","level":3,"score":0.603485107421875},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.42923545837402344},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.40491020679473877},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.37025031447410583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3361320495605469},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.24179908633232117},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2376771867275238},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21923008561134338},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08288216590881348},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.07129478454589844},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001391","descriptor_name":"Azo Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D003628","descriptor_name":"Database Management Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004124","descriptor_name":"p-Dimethylaminoazobenzene","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004124","descriptor_name":"p-Dimethylaminoazobenzene","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007191","descriptor_name":"Indazoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D009152","descriptor_name":"Mutagenicity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009153","descriptor_name":"Mutagens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/mutage/1.4.261","doi":"https://doi.org/10.1093/mutage/1.4.261","is_oa":false,"landing_page_url":"https://doi.org/10.1093/mutage/1.4.261","pdf_url":null,"source":{"id":"https://openalex.org/S101337917","display_name":"Mutagenesis","issn_l":"0267-8357","issn":["0267-8357","1464-3804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutagenesis","raw_type":"journal-article"},{"id":"pmid:3137411","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3137411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutagenesis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.46810001134872437,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2022696497","https://openalex.org/W2028570525","https://openalex.org/W2073716264","https://openalex.org/W1970073999","https://openalex.org/W2091111181","https://openalex.org/W2076961787","https://openalex.org/W2032508997","https://openalex.org/W2025500168","https://openalex.org/W2059617663","https://openalex.org/W2029360629"],"abstract_inverted_index":{"A":[0],"structure--activity":[1,123],"study":[2],"is":[3],"described":[4],"in":[5,77,125],"which":[6,70],"four":[7],"new":[8],"derivatives":[9],"of":[10,27,31,39,50,94,100,110,120,128],"the":[11,28,40,51,78,91,101,111,126],"potent":[12],"bacterial":[13],"mutagen":[14,103],"5-dimethylaminophenylazoindazole":[15],"(5I)":[16],"have":[17],"been":[18],"evaluated":[19],"for":[20,117],"mutagenicity":[21,118],"to":[22],"Salmonella.":[23],"As":[24],"expected,":[25],"monodemethylation":[26],"-NMe2":[29,41],"group":[30,55,61],"5I":[32,95],"increased":[33],"its":[34],"mutagenic":[35,66,92],"potency":[36,93],"while":[37],"replacement":[38,49],"with":[42,114],"a":[43,68],"cyclic":[44],"amine":[45],"reduced":[46],"it.":[47],"However,":[48],"aromatic":[52],"indazole":[53],"-NH":[54],"(of":[56],"5I)":[57],"by":[58],"an":[59,87],"-NMe":[60],"(yielding":[62],"NMe5I)":[63],"dramatically":[64],"attenuated":[65],"potency,":[67],"reduction":[69],"was":[71],"both":[72],"unexpected":[73],"and":[74,97,119],"not":[75],"reversed":[76],"monomethyl":[79],"analogue":[80],"(NMeMA5I).":[81],"In":[82],"competition":[83],"experiments":[84],"NMe5I":[85],"had":[86],"inhibitory":[88],"effect":[89],"on":[90,98],"itself":[96],"that":[99],"nonazo":[102],"2-acetylaminofluorene":[104],"2AAF.":[105],"The":[106],"results":[107],"illustrate":[108],"some":[109],"problems":[112],"associated":[113],"evaluating":[115],"mixtures":[116],"assuming":[121],"simple":[122],"relationships":[124],"absence":[127],"relevant":[129],"experimental":[130],"data.":[131]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
