{"id":"https://openalex.org/W1978199820","doi":"https://doi.org/10.1084/jem.105.3.195","title":"CYTOLOGICAL AND CYTOCHEMICAL STUDIES OF H E L A CELLS INFECTED WITH ADENOVIRUSES","display_name":"CYTOLOGICAL AND CYTOCHEMICAL STUDIES OF H E L A CELLS INFECTED WITH ADENOVIRUSES","publication_year":1957,"publication_date":"1957-03-01","ids":{"openalex":"https://openalex.org/W1978199820","doi":"https://doi.org/10.1084/jem.105.3.195","mag":"1978199820","pmid":"https://pubmed.ncbi.nlm.nih.gov/13406179","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2136693"},"language":"en","primary_location":{"id":"doi:10.1084/jem.105.3.195","doi":"https://doi.org/10.1084/jem.105.3.195","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.105.3.195","pdf_url":"https://rupress.org/jem/article-pdf/105/3/195/1078967/195.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://rupress.org/jem/article-pdf/105/3/195/1078967/195.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111495019","display_name":"Georgiana S. Boyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Georgiana S. Boyer","raw_affiliation_strings":["From the Departments of Preventive Medicine and Medicine, School of Medicine and the Institute of Pathology, Western Reserve University, and the University Hospitals, Cleveland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Preventive Medicine and Medicine, School of Medicine and the Institute of Pathology, Western Reserve University, and the University Hospitals, Cleveland","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112159177","display_name":"Cecilie Leuchtenberger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cecilie Leuchtenberger","raw_affiliation_strings":["From the Departments of Preventive Medicine and Medicine, School of Medicine and the Institute of Pathology, Western Reserve University, and the University Hospitals, Cleveland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Preventive Medicine and Medicine, School of Medicine and the Institute of Pathology, Western Reserve University, and the University Hospitals, Cleveland","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109554812","display_name":"Harold S. Ginsberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harold S. Ginsberg","raw_affiliation_strings":["From the Departments of Preventive Medicine and Medicine, School of Medicine and the Institute of Pathology, Western Reserve University, and the University Hospitals, Cleveland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Preventive Medicine and Medicine, School of Medicine and the Institute of Pathology, Western Reserve University, and the University Hospitals, Cleveland","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":13.2928,"has_fulltext":true,"cited_by_count":124,"citation_normalized_percentile":{"value":0.99366472,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"105","issue":"3","first_page":"195","last_page":"216"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.4043000042438507,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.4043000042438507,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.13899999856948853,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.09279999881982803,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenovirus-infection","display_name":"adenovirus infection","score":0.8220000267028809},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/intranuclear-inclusions","display_name":"intranuclear inclusions","score":0.8059999942779541},{"id":"https://openalex.org/keywords/nuclear-dna-content","display_name":"nuclear DNA content","score":0.4830000102519989},{"id":"https://openalex.org/keywords/feulgen-staining","display_name":"Feulgen staining","score":0.7900000214576721},{"id":"https://openalex.org/keywords/cytochemistry","display_name":"cytochemistry","score":0.5440000295639038},{"id":"https://openalex.org/keywords/cytopathic-effect","display_name":"cytopathic effect","score":0.7009999752044678},{"id":"https://openalex.org/keywords/nuclear-morphology","display_name":"nuclear morphology","score":0.34700000286102295}],"concepts":[{"id":"https://openalex.org/C19210678","wikidata":"https://www.wikidata.org/wiki/Q672718","display_name":"Basophilic","level":2,"score":0.9563460350036621},{"id":"https://openalex.org/C62649737","wikidata":"https://www.wikidata.org/wiki/Q902526","display_name":"Feulgen stain","level":3,"score":0.7775821685791016},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.715157151222229},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6989318132400513},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.4274079203605652},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4268166124820709},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.4108169972896576},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.36926156282424927},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2801797688007355},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2135452926158905},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1061519980430603},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014780","descriptor_name":"Viruses","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1084/jem.105.3.195","doi":"https://doi.org/10.1084/jem.105.3.195","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.105.3.195","pdf_url":"https://rupress.org/jem/article-pdf/105/3/195/1078967/195.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2136693","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2136693","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},{"id":"pmid:13406179","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13406179","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1084/jem.105.3.195","doi":"https://doi.org/10.1084/jem.105.3.195","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.105.3.195","pdf_url":"https://rupress.org/jem/article-pdf/105/3/195/1078967/195.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978199820.pdf","grobid_xml":"https://content.openalex.org/works/W1978199820.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W162187343","https://openalex.org/W625946490","https://openalex.org/W1620408678","https://openalex.org/W1819437971","https://openalex.org/W1967006453","https://openalex.org/W1978834567","https://openalex.org/W1990369141","https://openalex.org/W2004862744","https://openalex.org/W2018322908","https://openalex.org/W2018491495","https://openalex.org/W2020304700","https://openalex.org/W2030768555","https://openalex.org/W2033367850","https://openalex.org/W2044625790","https://openalex.org/W2045452082","https://openalex.org/W2087510109","https://openalex.org/W2115430692","https://openalex.org/W2318904093","https://openalex.org/W2328476123","https://openalex.org/W2334093679","https://openalex.org/W2405173501","https://openalex.org/W2407120512","https://openalex.org/W2418772141","https://openalex.org/W2436785674","https://openalex.org/W4285719527","https://openalex.org/W4313389436"],"related_works":["https://openalex.org/W7096727314","https://openalex.org/W2134542664","https://openalex.org/W9687812","https://openalex.org/W7100516582","https://openalex.org/W2018322908","https://openalex.org/W2061659982","https://openalex.org/W7099755892","https://openalex.org/W2415474792","https://openalex.org/W2167656279","https://openalex.org/W2424194775"],"abstract_inverted_index":{"The":[0],"sequential":[1],"morphological":[2],"and":[3,27,42,83,87,115,150,156,159],"cytochemical":[4],"alterations":[5],"in":[6,33,45,52,61,122,167,178],"HeLa":[7],"cells":[8,68,180],"infected":[9,49,69,101,179],"with":[10,70,90,102],"adenovirus":[11,107],"types":[12,148,157],"1":[13,72,149],"to":[14,25,85,129,181],"4":[15,106,160],"are":[16],"described.":[17],"Each":[18],"of":[19,48,65,111,133,165,172,187],"the":[20,46,53,62,138,153,162,176,185,188],"four":[21,38,139],"viruses":[22],"studied":[23],"led":[24],"consistent":[26],"reproducible":[28],"cytological":[29,135],"changes":[30,44],"not":[31],"observed":[32],"uninfected":[34,189],"control":[35],"cultures.":[36],"All":[37],"agents":[39,140],"produced":[40],"striking":[41],"characteristic":[43],"nuclei":[47,169],"cells.":[50],"Alterations":[51],"cytoplasm,":[54],"though":[55],"present,":[56],"were":[57,97],"less":[58],"marked,":[59],"particularly":[60],"early":[63],"stages":[64],"infection.":[66],"In":[67,131],"type":[71,103],"or":[73,105],"2":[74,151],"adenovirus,":[75],"rounded":[76],"intranuclear":[77,121],"inclusions":[78],"which":[79,124],"progressed":[80],"from":[81,127],"eosinophilic":[82],"Feulgen-negative":[84,128],"basophilic":[86,112],"Feulgen-positive,":[88],"together":[89],"a":[91],"homogeneous":[92],"glassy,":[93],"Feulgen-positive":[94],"nuclear":[95,113],"background,":[96],"prominent":[98],"features.":[99],"Cells":[100],"3":[104,158],"exhibited":[108],"marked":[109],"rearrangement":[110],"material":[114],"sharply":[116],"defined":[117],"crystal-like":[118],"inclusions,":[119],"predominantly":[120],"location,":[123],"also":[125],"varied":[126],"positive.":[130],"terms":[132],"detailed":[134],"effects,":[136],"therefore,":[137],"could":[141],"be":[142,182],"divided":[143],"into":[144],"two":[145],"subgroups,":[146],"viz.,":[147],"on":[152,161],"one":[154],"hand":[155],"other.":[163],"Measurement":[164],"DNA":[166],"individual":[168],"by":[170],"means":[171],"Feulgen":[173],"microspectrophotometry":[174],"revealed":[175],"values":[177],"increased":[183],"above":[184],"levels":[186],"controls.":[190]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}