{"id":"https://openalex.org/W1978187692","doi":"https://doi.org/10.1016/j.neuron.2013.02.012","title":"Pax6 Exerts Regional Control of Cortical Progenitor Proliferation via Direct Repression of Cdk6 and Hypophosphorylation of pRb","display_name":"Pax6 Exerts Regional Control of Cortical Progenitor Proliferation via Direct Repression of Cdk6 and Hypophosphorylation of pRb","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W1978187692","doi":"https://doi.org/10.1016/j.neuron.2013.02.012","mag":"1978187692","pmid":"https://pubmed.ncbi.nlm.nih.gov/23622063","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3898967"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuron.2013.02.012","doi":"https://doi.org/10.1016/j.neuron.2013.02.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuron.2013.02.012","pdf_url":"http://www.cell.com/article/S0896627313001700/pdf","source":{"id":"https://openalex.org/S45757444","display_name":"Neuron","issn_l":"0896-6273","issn":["0896-6273","1097-4199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuron","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.cell.com/article/S0896627313001700/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015584850","display_name":"Da Mi","orcid":"https://orcid.org/0000-0002-7829-1923","observed_orcids":["https://orcid.org/0000-0002-7829-1923"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Da Mi","raw_affiliation_strings":["Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019161818","display_name":"Catherine B. Carr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Catherine\u00a0B. Carr","raw_affiliation_strings":["Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048589331","display_name":"Petrina A. Georgala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Petrina\u00a0A. Georgala","raw_affiliation_strings":["Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104029689","display_name":"Yu-Ting Huang","orcid":"https://orcid.org/0000-0002-7056-5686","observed_orcids":["https://orcid.org/0000-0002-7056-5686"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yu-Ting Huang","raw_affiliation_strings":["Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031703434","display_name":"Martine N. Manuel","orcid":"https://orcid.org/0000-0001-7674-8785","observed_orcids":["https://orcid.org/0000-0001-7674-8785"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Martine\u00a0N. Manuel","raw_affiliation_strings":["Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060861344","display_name":"Emily C. Jeanes","orcid":"https://orcid.org/0000-0003-0806-5442","observed_orcids":["https://orcid.org/0000-0003-0806-5442"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Emily Jeanes","raw_affiliation_strings":["Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020301257","display_name":"Emi Niisato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Emi Niisato","raw_affiliation_strings":["Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087953869","display_name":"Stephen Nicholas Sansom","orcid":"https://orcid.org/0000-0003-4569-8513","observed_orcids":["https://orcid.org/0000-0003-4569-8513"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2801782436","display_name":"The Gurdon Institute","ror":"https://ror.org/00fp3ce15","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I2801782436","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stephen\u00a0N. Sansom","raw_affiliation_strings":["The Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801782436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086843415","display_name":"Frederick J. Livesey","orcid":"https://orcid.org/0000-0001-6128-3372","observed_orcids":["https://orcid.org/0000-0001-6128-3372"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2801782436","display_name":"The Gurdon Institute","ror":"https://ror.org/00fp3ce15","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I2801782436","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Frederick\u00a0J. Livesey","raw_affiliation_strings":["The Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801782436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059513122","display_name":"Thomas Theil","orcid":"https://orcid.org/0000-0001-6590-8309","observed_orcids":["https://orcid.org/0000-0001-6590-8309"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Thomas Theil","raw_affiliation_strings":["Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047333780","display_name":"Kerstin Hasenpusch\u2010Theil","orcid":"https://orcid.org/0000-0002-8463-892X","observed_orcids":["https://orcid.org/0000-0002-8463-892X"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kerstin Hasenpusch-Theil","raw_affiliation_strings":["Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084953972","display_name":"T. Ian Simpson","orcid":"https://orcid.org/0000-0003-0495-7187","observed_orcids":["https://orcid.org/0000-0003-0495-7187"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"T.\u00a0Ian Simpson","raw_affiliation_strings":["Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087074605","display_name":"John O. Mason","orcid":"https://orcid.org/0000-0002-0489-2400","observed_orcids":["https://orcid.org/0000-0002-0489-2400"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"John\u00a0O. Mason","raw_affiliation_strings":["Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057027392","display_name":"David Jonathan Price","orcid":"https://orcid.org/0000-0002-5318-307X","observed_orcids":["https://orcid.org/0000-0002-5318-307X"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"David\u00a0J. Price","raw_affiliation_strings":["Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK","institution_ids":["https://openalex.org/I98677209"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5057027392","https://openalex.org/A5087074605"],"corresponding_institution_ids":["https://openalex.org/I98677209"],"apc_list":{"value":10400,"currency":"USD","value_usd":10400},"apc_paid":{"value":10400,"currency":"USD","value_usd":10400},"fwci":2.6565,"has_fulltext":true,"cited_by_count":80,"citation_normalized_percentile":{"value":0.89877905,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"78","issue":"2","first_page":"269","last_page":"284"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pax6","display_name":"Pax6","score":1.0},{"id":"https://openalex.org/keywords/retinoblastoma-protein","display_name":"retinoblastoma protein","score":0.8579999804496765},{"id":"https://openalex.org/keywords/prb-hypophosphorylation","display_name":"pRb hypophosphorylation","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cell-cycle-genes","display_name":"cell cycle genes","score":0.5590000152587891},{"id":"https://openalex.org/keywords/cyclins","display_name":"cyclins","score":0.7049999833106995},{"id":"https://openalex.org/keywords/dna-replication","display_name":"DNA replication","score":0.8619999885559082},{"id":"https://openalex.org/keywords/cortical-development","display_name":"cortical development","score":0.9359999895095825},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.7390000224113464}],"concepts":[{"id":"https://openalex.org/C51816534","wikidata":"https://www.wikidata.org/wiki/Q14916213","display_name":"PAX6","level":4,"score":0.9015010595321655},{"id":"https://openalex.org/C124320809","wikidata":"https://www.wikidata.org/wiki/Q46292","display_name":"Cyclin-dependent kinase","level":4,"score":0.693261444568634},{"id":"https://openalex.org/C108619961","wikidata":"https://www.wikidata.org/wiki/Q5173281","display_name":"Corticogenesis","level":4,"score":0.6514975428581238},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6124753355979919},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.592418372631073},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5898383855819702},{"id":"https://openalex.org/C2776062698","wikidata":"https://www.wikidata.org/wiki/Q21111463","display_name":"Retinoblastoma protein","level":4,"score":0.5770640969276428},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.5466161966323853},{"id":"https://openalex.org/C120089663","wikidata":"https://www.wikidata.org/wiki/Q59250999","display_name":"Cyclin","level":4,"score":0.5324802398681641},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5295370817184448},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5254087448120117},{"id":"https://openalex.org/C199649820","wikidata":"https://www.wikidata.org/wiki/Q14911762","display_name":"Cyclin-dependent kinase 6","level":5,"score":0.49733808636665344},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.4692855775356293},{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.4547620415687561},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.29611271619796753},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2494138777256012},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21238863468170166},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.16029927134513855}],"mesh":[{"descriptor_ui":"D000071841","descriptor_name":"PAX6 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099260","descriptor_name":"Empty Spiracles Homeobox Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001973","descriptor_name":"Bromodeoxyuridine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008164","descriptor_name":"Luminescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008164","descriptor_name":"Luminescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016160","descriptor_name":"Retinoblastoma Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016160","descriptor_name":"Retinoblastoma Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051361","descriptor_name":"Cyclin-Dependent Kinase 6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051361","descriptor_name":"Cyclin-Dependent Kinase 6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051761","descriptor_name":"Paired Box Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051761","descriptor_name":"Paired Box Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051763","descriptor_name":"PAX7 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.neuron.2013.02.012","doi":"https://doi.org/10.1016/j.neuron.2013.02.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuron.2013.02.012","pdf_url":"http://www.cell.com/article/S0896627313001700/pdf","source":{"id":"https://openalex.org/S45757444","display_name":"Neuron","issn_l":"0896-6273","issn":["0896-6273","1097-4199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuron","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2885442","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3898967","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3898967","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3898967","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuron","raw_type":"Text"},{"id":"pmid:23622063","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23622063","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuron","raw_type":"Journal Article"},{"id":"pmh:oai:pure.ed.ac.uk:openaire/c141c029-d53e-49ae-8a72-d2342d932412","doi":null,"is_oa":true,"landing_page_url":"https://www.research.ed.ac.uk/en/publications/c141c029-d53e-49ae-8a72-d2342d932412","pdf_url":null,"source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mi, D, Carr, C B, Georgala, P A, Huang, Y-T, Manuel, M N, Jeanes, E, Niisato, E, Sansom, S N, Livesey, F J, Theil, T, Hasenpusch-Theil, K, Simpson, T I, Mason, J O & Price, D J 2013, 'Pax6 Exerts Regional Control of Cortical Progenitor Proliferation via Direct Repression of Cdk6 and Hypophosphorylation of pRb', Neuron, vol. 78, no. 2, pp. 269-284. https://doi.org/10.1016/j.neuron.2013.02.012","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.neuron.2013.02.012","doi":"https://doi.org/10.1016/j.neuron.2013.02.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuron.2013.02.012","pdf_url":"http://www.cell.com/article/S0896627313001700/pdf","source":{"id":"https://openalex.org/S45757444","display_name":"Neuron","issn_l":"0896-6273","issn":["0896-6273","1097-4199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuron","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5654005620","display_name":"Regulation of gene expression in developing cortex by the transcription factor Pax6","funder_award_id":"MR/J003662/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G8015038321","display_name":"Core support for the Wellcome Trust Cancer Research UK Gurdon Institute.","funder_award_id":"092096","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978187692.pdf","grobid_xml":"https://content.openalex.org/works/W1978187692.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W31572314","https://openalex.org/W1501165471","https://openalex.org/W1885235228","https://openalex.org/W1933799138","https://openalex.org/W1964784784","https://openalex.org/W1967679856","https://openalex.org/W1967890615","https://openalex.org/W1972618720","https://openalex.org/W1973030969","https://openalex.org/W1978281222","https://openalex.org/W1980462590","https://openalex.org/W1986166279","https://openalex.org/W1989723706","https://openalex.org/W1989830594","https://openalex.org/W1992366122","https://openalex.org/W2007897399","https://openalex.org/W2010852678","https://openalex.org/W2011978143","https://openalex.org/W2017806952","https://openalex.org/W2031482377","https://openalex.org/W2035477213","https://openalex.org/W2041513882","https://openalex.org/W2049176011","https://openalex.org/W2055614532","https://openalex.org/W2066699807","https://openalex.org/W2075152619","https://openalex.org/W2077613098","https://openalex.org/W2080264636","https://openalex.org/W2084414513","https://openalex.org/W2089350180","https://openalex.org/W2090046686","https://openalex.org/W2091841926","https://openalex.org/W2096474420","https://openalex.org/W2098203835","https://openalex.org/W2099046541","https://openalex.org/W2107557980","https://openalex.org/W2108221620","https://openalex.org/W2108796882","https://openalex.org/W2109627278","https://openalex.org/W2110065044","https://openalex.org/W2113377982","https://openalex.org/W2113787496","https://openalex.org/W2117719082","https://openalex.org/W2120272758","https://openalex.org/W2122739666","https://openalex.org/W2129975913","https://openalex.org/W2132627208","https://openalex.org/W2134413846","https://openalex.org/W2139103260","https://openalex.org/W2139230560","https://openalex.org/W2147746178","https://openalex.org/W2147977861","https://openalex.org/W2154165535","https://openalex.org/W2154589085","https://openalex.org/W2155103945","https://openalex.org/W2155609574","https://openalex.org/W2157832282","https://openalex.org/W2158546099","https://openalex.org/W2165376655","https://openalex.org/W2165936853","https://openalex.org/W2169696276","https://openalex.org/W2171852242","https://openalex.org/W4323238746"],"related_works":["https://openalex.org/W2901896055","https://openalex.org/W2621511215","https://openalex.org/W2131169075","https://openalex.org/W1548061724","https://openalex.org/W2165376655","https://openalex.org/W2801467336","https://openalex.org/W2066699807","https://openalex.org/W1979925962","https://openalex.org/W2132416045","https://openalex.org/W164376625"],"abstract_inverted_index":{"The":[0],"mechanisms":[1],"by":[2,53],"which":[3],"early":[4],"spatiotemporal":[5],"expression":[6,66],"patterns":[7],"of":[8,47,68,109,116,141],"transcription":[9,108],"factors":[10],"such":[11],"as":[12],"Pax6":[13,24,48,60,93,124],"regulate":[14],"cortical":[15,50,142],"progenitors":[16,71],"in":[17,27,132],"a":[18,28],"region-specific":[19],"manner":[20],"are":[21],"poorly":[22],"understood.":[23],"is":[25,35,146],"expressed":[26],"gradient":[29],"across":[30],"the":[31,64,107,114,117],"developing":[32],"cortex":[33],"and":[34,75,78,87,120,128,148],"essential":[36],"for":[37],"normal":[38,59],"corticogenesis.":[39],"We":[40,62],"found":[41,122],"that":[42,55,92,111,123,138],"constitutive":[43],"or":[44],"conditional":[45],"loss":[46],"increases":[49],"progenitor":[51,143],"proliferation":[52],"amounts":[54],"vary":[56],"regionally":[57],"with":[58],"levels.":[61],"compared":[63],"gene":[65],"profiles":[67],"equivalent":[69],"Pax6-expressing":[70],"isolated":[72],"from":[73],"Pax6\u207a/\u207a":[74],"Pax6\u207b/\u207b":[76],"cortices":[77],"identified":[79],"many":[80],"negatively":[81],"regulated":[82],"cell-cycle":[83],"genes,":[84],"including":[85],"Cyclins":[86],"Cdks.":[88],"Biochemical":[89],"assays":[90],"indicated":[91],"directly":[94,112],"represses":[95,129],"Cdk6":[96],"expression.":[97],"Cyclin/Cdk":[98],"repression":[99],"inhibits":[100,125],"retinoblastoma":[101],"protein":[102],"(pRb)":[103],"phosphorylation,":[104],"thereby":[105],"limiting":[106],"genes":[110,130],"promote":[113],"mechanics":[115],"cell":[118,144],"cycle,":[119],"we":[121],"pRb":[126],"phosphorylation":[127],"involved":[131],"DNA":[133],"replication.":[134],"Our":[135],"results":[136],"indicate":[137],"Pax6's":[139],"modulation":[140],"cycles":[145],"regional":[147],"direct.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
