{"id":"https://openalex.org/W1978170853","doi":"https://doi.org/10.1159/000115174","title":"Predictability of Phenytoin Serum Levels by Nomograms and Clinicians","display_name":"Predictability of Phenytoin Serum Levels by Nomograms and Clinicians","publication_year":2008,"publication_date":"2008-01-29","ids":{"openalex":"https://openalex.org/W1978170853","doi":"https://doi.org/10.1159/000115174","mag":"1978170853","pmid":"https://pubmed.ncbi.nlm.nih.gov/7439207"},"language":"en","primary_location":{"id":"doi:10.1159/000115174","doi":"https://doi.org/10.1159/000115174","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000115174","pdf_url":null,"source":{"id":"https://openalex.org/S162735375","display_name":"European Neurology","issn_l":"0014-3022","issn":["0014-3022","1421-9913"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110397807","display_name":"S. Vo\u017eeh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Vozeh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005355198","display_name":"A. Koelz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Koelz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"E. Martin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Martin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081843818","display_name":"H. Magun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Magun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065347559","display_name":"Giuseppe Scollo\u2010Lavizzari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Scollo-Lavizzari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5034932372","display_name":"Ferenc Foll\u00e1th","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. Follath","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"6","first_page":"345","last_page":"352"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.8999000191688538,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.8999000191688538,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.04089999943971634,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenytoin","display_name":"phenytoin","score":1.0},{"id":"https://openalex.org/keywords/serum-drug-levels","display_name":"serum drug concentration","score":0.699999988079071},{"id":"https://openalex.org/keywords/nomogram","display_name":"nomogram","score":0.7480000257492065},{"id":"https://openalex.org/keywords/prediction-error","display_name":"prediction error","score":0.7300000190734863},{"id":"https://openalex.org/keywords/clinical-judgment","display_name":"clinical judgment","score":0.550000011920929},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.6740000247955322},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.7450000047683716},{"id":"https://openalex.org/keywords/therapeutic-drug-monitoring","display_name":"therapeutic drug monitoring","score":0.7590000033378601},{"id":"https://openalex.org/keywords/forecast-uncertainty","display_name":"forecast uncertainty","score":0.3569999933242798}],"concepts":[{"id":"https://openalex.org/C34626388","wikidata":"https://www.wikidata.org/wiki/Q721129","display_name":"Nomogram","level":2,"score":0.9511962532997131},{"id":"https://openalex.org/C2778337148","wikidata":"https://www.wikidata.org/wiki/Q410400","display_name":"Phenytoin","level":3,"score":0.9285730123519897},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.7204201221466064},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5551757216453552},{"id":"https://openalex.org/C3020081911","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Serum concentration","level":2,"score":0.47039589285850525},{"id":"https://openalex.org/C19831878","wikidata":"https://www.wikidata.org/wiki/Q659446","display_name":"Therapeutic index","level":3,"score":0.41534504294395447},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36988505721092224},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.27629753947257996},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.1603933572769165},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.15733030438423157},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010672","descriptor_name":"Phenytoin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010672","descriptor_name":"Phenytoin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010672","descriptor_name":"Phenytoin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1159/000115174","doi":"https://doi.org/10.1159/000115174","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000115174","pdf_url":null,"source":{"id":"https://openalex.org/S162735375","display_name":"European Neurology","issn_l":"0014-3022","issn":["0014-3022","1421-9913"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Neurology","raw_type":"journal-article"},{"id":"pmid:7439207","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7439207","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European neurology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2423577119","https://openalex.org/W2002964701","https://openalex.org/W2035346637","https://openalex.org/W48994847","https://openalex.org/W2050060252","https://openalex.org/W2138701962","https://openalex.org/W2022311270","https://openalex.org/W1993952552","https://openalex.org/W2414839062","https://openalex.org/W2042000224"],"abstract_inverted_index":{"On":[0],"the":[1,15,52,55,59,79,98,113,120,129,131,137,148,152],"basis":[2],"of":[3,78,119,136,151,156],"a":[4,19,125,189],"reliable":[5],"steady":[6,191],"state":[7,192],"phenytoin":[8,43,157],"serum":[9,16,56,87,158,163],"concentration":[10,17,57,164],"on":[11,18,51,58,161],"one":[12,162],"(lower)":[13],"dose,":[14],"second":[20],"(higher)":[21],"dose":[22,179],"was":[23,68,124,143,166],"predicted":[24,84],"in":[25,128,169],"28":[26],"patients":[27],"(32":[28],"levels)":[29],"by":[30],"two":[31,99],"previously":[32],"reported":[33],"nomograms":[34,46,100],"and":[35,47,76,85,93,101,108],"3":[36,49,114],"physicians":[37,50],"who":[38],"had":[39,180],"clinical":[40],"experience":[41],"with":[42],"therapy.":[44],"Both":[45],"all":[48],"average":[53],"underestimated":[54],"higher":[60],"dose.":[61],"Except":[62],"for":[63,97,112],"1":[64],"physician,":[65],"this":[66,170],"bias":[67],"statistically":[69],"significant":[70],"(p":[71],"<":[72],"0.05).":[73],"The":[74],"mean":[75],"SD":[77],"prediction":[80,138,155],"errors":[81],"(difference":[82],"between":[83],"measured":[86],"concentration)":[88],"were":[89],"-2.2":[90],"+/-":[91,95,103,106,110,141],"4.2":[92,111],"-3.1":[94],"3.6":[96],"-1.0":[102],"4.0,":[104],"-2.1":[105],"4.1":[107],"-1.8":[109],"physicians,":[115],"respectively.":[116],"Thus,":[117],"independent":[118],"method":[121],"used,":[122],"there":[123],"large":[126,146],"uncertainty":[127],"prediction;":[130],"approximate":[132],"68%":[133],"confidence":[134],"interval":[135],"error":[139],"(mean":[140],"SD)":[142],"almost":[144],"as":[145,147],"therapeutic":[149],"range":[150],"drug.":[153],"Because":[154],"levels":[159],"based":[160],"measurement":[165],"found":[167],"unreliable":[168],"study,":[171],"it":[172],"is":[173],"proposed":[174],"that":[175],"every":[176],"patient":[177],"whose":[178],"been":[181,194],"increased":[182],"should":[183],"be":[184],"under":[185],"close":[186],"observation":[187],"until":[188],"new":[190],"has":[193],"confirmed.":[195]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
