{"id":"https://openalex.org/W1978167674","doi":"https://doi.org/10.1111/j.1600-0773.1976.tb03208.x","title":"Pharmacological Effect of Propranolol after a Single Oral Dose","display_name":"Pharmacological Effect of Propranolol after a Single Oral Dose","publication_year":1976,"publication_date":"1976-11-01","ids":{"openalex":"https://openalex.org/W1978167674","doi":"https://doi.org/10.1111/j.1600-0773.1976.tb03208.x","mag":"1978167674","pmid":"https://pubmed.ncbi.nlm.nih.gov/990040"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-0773.1976.tb03208.x","doi":"https://doi.org/10.1111/j.1600-0773.1976.tb03208.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0773.1976.tb03208.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210230610","display_name":"Acta Pharmacologica et Toxicologica","issn_l":"0001-6683","issn":["0001-6683"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharmacologica et Toxicologica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079930945","display_name":"J Kanto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"J. Kanto","raw_affiliation_strings":["From the Pharmaceutical Plant Leiras, Turku, and the Department of Pharmacology, Turku University, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Pharmaceutical Plant Leiras, Turku, and the Department of Pharmacology, Turku University, Turku, Finland","institution_ids":["https://openalex.org/I155660961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018586285","display_name":"T Kleimola","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"T. Kleimola","raw_affiliation_strings":["From the Pharmaceutical Plant Leiras, Turku, and the Department of Pharmacology, Turku University, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Pharmaceutical Plant Leiras, Turku, and the Department of Pharmacology, Turku University, Turku, Finland","institution_ids":["https://openalex.org/I155660961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109956535","display_name":"Raija M\u00e4ntyl\u00e4","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"R. M\u00e4ntyl\u00e4","raw_affiliation_strings":["From the Pharmaceutical Plant Leiras, Turku, and the Department of Pharmacology, Turku University, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Pharmaceutical Plant Leiras, Turku, and the Department of Pharmacology, Turku University, Turku, Finland","institution_ids":["https://openalex.org/I155660961"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108517108","display_name":"Erkka K G Syv\u00e4lahti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"E. Syv\u00e4lahti","raw_affiliation_strings":["From the Pharmaceutical Plant Leiras, Turku, and the Department of Pharmacology, Turku University, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Pharmaceutical Plant Leiras, Turku, and the Department of Pharmacology, Turku University, Turku, Finland","institution_ids":["https://openalex.org/I155660961"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I155660961"],"apc_list":null,"apc_paid":null,"fwci":2.316,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.86771262,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"39","issue":"5","first_page":"573","last_page":"576"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.37040001153945923,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.37040001153945923,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.358599990606308,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.046799998730421066,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":1.0},{"id":"https://openalex.org/keywords/single-oral-dose","display_name":"single oral dose","score":0.9300000071525574},{"id":"https://openalex.org/keywords/pharmacological-activity","display_name":"pharmacological activity","score":0.8500000238418579},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.8159999847412109},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6652156114578247},{"id":"https://openalex.org/C63433958","wikidata":"https://www.wikidata.org/wiki/Q1774688","display_name":"Clinical pharmacology","level":2,"score":0.5953140258789062},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.22181308269500732}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011433","descriptor_name":"Propranolol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011433","descriptor_name":"Propranolol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1600-0773.1976.tb03208.x","doi":"https://doi.org/10.1111/j.1600-0773.1976.tb03208.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0773.1976.tb03208.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210230610","display_name":"Acta Pharmacologica et Toxicologica","issn_l":"0001-6683","issn":["0001-6683"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharmacologica et Toxicologica","raw_type":"journal-article"},{"id":"pmid:990040","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/990040","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmacologica et toxicologica","raw_type":"Letter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W2008826192","https://openalex.org/W2024659136","https://openalex.org/W2027125816","https://openalex.org/W2027829095","https://openalex.org/W2036077696","https://openalex.org/W2336848413","https://openalex.org/W2405992154"],"related_works":["https://openalex.org/W2606694721","https://openalex.org/W2463172093","https://openalex.org/W4391111627","https://openalex.org/W2472500393","https://openalex.org/W2427502428","https://openalex.org/W1966523964","https://openalex.org/W4298085250","https://openalex.org/W2038854882","https://openalex.org/W4299556456","https://openalex.org/W2051914098"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}