{"id":"https://openalex.org/W1978159715","doi":"https://doi.org/10.1016/0024-3205(81)90080-1","title":"The effect of phencyclidine on dopamine metabolism in the mouse brain","display_name":"The effect of phencyclidine on dopamine metabolism in the mouse brain","publication_year":1981,"publication_date":"1981-01-01","ids":{"openalex":"https://openalex.org/W1978159715","doi":"https://doi.org/10.1016/0024-3205(81)90080-1","mag":"1978159715","pmid":"https://pubmed.ncbi.nlm.nih.gov/7194409"},"language":"en","primary_location":{"id":"doi:10.1016/0024-3205(81)90080-1","doi":"https://doi.org/10.1016/0024-3205(81)90080-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0024-3205(81)90080-1","pdf_url":null,"source":{"id":"https://openalex.org/S175775512","display_name":"Life Sciences","issn_l":"0024-3205","issn":["0024-3205","1879-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090421340","display_name":"Kenneth M. Johnson","orcid":"https://orcid.org/0000-0001-5621-0312","observed_orcids":["https://orcid.org/0000-0001-5621-0312"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth M. Johnson","raw_affiliation_strings":["Department of Pharmacology and Toxicology The University of Texas Medical Branch Galveston, TX 77550, USA","Pharmacology & Toxicology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology The University of Texas Medical Branch Galveston, TX 77550, USA","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Pharmacology & Toxicology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078465445","display_name":"Kevin Charles Oeffinger","orcid":"https://orcid.org/0000-0003-0806-7894","observed_orcids":["https://orcid.org/0000-0003-0806-7894"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin C. Oeffinger","raw_affiliation_strings":["Department of Pharmacology and Toxicology The University of Texas Medical Branch Galveston, TX 77550, USA","University of Texas Medical Branch at Galveston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology The University of Texas Medical Branch Galveston, TX 77550, USA","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"University of Texas Medical Branch at Galveston","institution_ids":["https://openalex.org/I55302922"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I55302922"],"apc_list":{"value":3810,"currency":"USD","value_usd":3810},"apc_paid":null,"fwci":1.6917,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.81703508,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"4","first_page":"361","last_page":"369"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9214000105857849,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9214000105857849,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.07129999995231628,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phencyclidine","display_name":"phencyclidine","score":1.0},{"id":"https://openalex.org/keywords/dopamine-metabolism","display_name":"dopamine metabolism","score":0.8970000147819519},{"id":"https://openalex.org/keywords/homovanillic-acid","display_name":"homovanillic acid","score":0.8550000190734863},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.8619999885559082},{"id":"https://openalex.org/keywords/tyrosine","display_name":"tyrosine","score":0.9390000104904175},{"id":"https://openalex.org/keywords/alpha-methyl-p-tyrosine","display_name":"alpha-methyl-p-tyrosine","score":0.9110000133514404},{"id":"https://openalex.org/keywords/haloperidol","display_name":"haloperidol","score":0.9169999957084656},{"id":"https://openalex.org/keywords/baclofen","display_name":"baclofen","score":0.9779999852180481},{"id":"https://openalex.org/keywords/presynaptic-dopamine-receptors","display_name":"presynaptic dopamine receptors","score":0.8769999742507935},{"id":"https://openalex.org/keywords/probenecid","display_name":"probenecid","score":0.734000027179718},{"id":"https://openalex.org/keywords/plasma-tyrosine","display_name":"plasma tyrosine","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C2778851735","wikidata":"https://www.wikidata.org/wiki/Q407324","display_name":"Phencyclidine","level":4,"score":0.9099788665771484},{"id":"https://openalex.org/C2775841634","wikidata":"https://www.wikidata.org/wiki/Q903566","display_name":"Homovanillic acid","level":4,"score":0.779965877532959},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6586928367614746},{"id":"https://openalex.org/C2780948584","wikidata":"https://www.wikidata.org/wiki/Q251347","display_name":"Haloperidol","level":3,"score":0.6454811692237854},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.5919420719146729},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5686754584312439},{"id":"https://openalex.org/C2777193897","wikidata":"https://www.wikidata.org/wiki/Q179452","display_name":"Amphetamine","level":3,"score":0.5498221516609192},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4925885796546936},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4697183668613434},{"id":"https://openalex.org/C2780250439","wikidata":"https://www.wikidata.org/wiki/Q423288","display_name":"Desipramine","level":4,"score":0.44063568115234375},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.3819419741630554},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3139004111289978},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.22300288081169128},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17322880029678345},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10830861330032349},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.0},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006220","descriptor_name":"Haloperidol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006719","descriptor_name":"Homovanillic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008124","descriptor_name":"Locomotion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008781","descriptor_name":"Methyltyrosines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010622","descriptor_name":"Phencyclidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013239","descriptor_name":"Stereotyped Behavior","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015107","descriptor_name":"4-Butyrolactone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0024-3205(81)90080-1","doi":"https://doi.org/10.1016/0024-3205(81)90080-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0024-3205(81)90080-1","pdf_url":null,"source":{"id":"https://openalex.org/S175775512","display_name":"Life Sciences","issn_l":"0024-3205","issn":["0024-3205","1879-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences","raw_type":"journal-article"},{"id":"pmid:7194409","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7194409","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1534748687","https://openalex.org/W1840994181","https://openalex.org/W1967143599","https://openalex.org/W1971248803","https://openalex.org/W1972817694","https://openalex.org/W1974605349","https://openalex.org/W1976036133","https://openalex.org/W1978442412","https://openalex.org/W1983349481","https://openalex.org/W1991771532","https://openalex.org/W1994037589","https://openalex.org/W1994395762","https://openalex.org/W1995837298","https://openalex.org/W1999084893","https://openalex.org/W2004156074","https://openalex.org/W2022100528","https://openalex.org/W2026043391","https://openalex.org/W2028181575","https://openalex.org/W2039869680","https://openalex.org/W2040808064","https://openalex.org/W2043036183","https://openalex.org/W2045448963","https://openalex.org/W2051664368","https://openalex.org/W2052852412","https://openalex.org/W2053596442","https://openalex.org/W2053702099","https://openalex.org/W2057894499","https://openalex.org/W2064593710","https://openalex.org/W2064865304","https://openalex.org/W2067021261","https://openalex.org/W2078047234","https://openalex.org/W2078420177","https://openalex.org/W2080796104","https://openalex.org/W2083089551","https://openalex.org/W2083596927","https://openalex.org/W2087978136","https://openalex.org/W2088815651","https://openalex.org/W2092543962","https://openalex.org/W2123557698","https://openalex.org/W2143008707","https://openalex.org/W2202180915","https://openalex.org/W2274283551","https://openalex.org/W2403916375","https://openalex.org/W2432237959","https://openalex.org/W2605039511"],"related_works":["https://openalex.org/W1999084893","https://openalex.org/W2005830584","https://openalex.org/W2417801574","https://openalex.org/W2977888758","https://openalex.org/W1942054656","https://openalex.org/W1970141813","https://openalex.org/W2023946617","https://openalex.org/W1988870167","https://openalex.org/W1964189718","https://openalex.org/W2147761349"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}