{"id":"https://openalex.org/W1978152500","doi":"https://doi.org/10.1016/s1091-255x(99)80072-9","title":"Gadolinium chloride inhibits lipopolysaccharide-induced mortality and in vivo prostaglandin E2 release by splenic macrophages","display_name":"Gadolinium chloride inhibits lipopolysaccharide-induced mortality and in vivo prostaglandin E2 release by splenic macrophages","publication_year":1999,"publication_date":"1999-05-01","ids":{"openalex":"https://openalex.org/W1978152500","doi":"https://doi.org/10.1016/s1091-255x(99)80072-9","mag":"1978152500","pmid":"https://pubmed.ncbi.nlm.nih.gov/10481123"},"language":"en","primary_location":{"id":"doi:10.1016/s1091-255x(99)80072-9","doi":"https://doi.org/10.1016/s1091-255x(99)80072-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1091-255x(99)80072-9","pdf_url":null,"source":{"id":"https://openalex.org/S78051145","display_name":"Journal of Gastrointestinal Surgery","issn_l":"1091-255X","issn":["1091-255X","1873-4626"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastrointestinal Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111807375","display_name":"Claude R. Roland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claude R. Roland","raw_affiliation_strings":["Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA","Department of Surgery, Washington University School of Medicine, One Barnes Hospital Plaza, St. Louis,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Surgery, Washington University School of Medicine, One Barnes Hospital Plaza, St. Louis,","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110016012","display_name":"Yuji Nakafusa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuji Nakafusa","raw_affiliation_strings":["Department of Surgery, Washington University School of Medicine, St. Louis, Mo. U.S.A","Department of Surgery, Washington University School of Medicine, One Barnes Hospital Plaza, St. Louis,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Washington University School of Medicine, St. Louis, Mo. U.S.A","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Surgery, Washington University School of Medicine, One Barnes Hospital Plaza, St. Louis,","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108561279","display_name":"M. Wayne Flye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M. Wayne Flye","raw_affiliation_strings":["Department of Surgery, Washington University School of Medicine, St. Louis, Mo. U.S.A","Department of Surgery, Washington University School of Medicine, One Barnes Hospital Plaza, St. Louis,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Washington University School of Medicine, St. Louis, Mo. U.S.A","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Surgery, Washington University School of Medicine, One Barnes Hospital Plaza, St. Louis,","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108561279"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":3950,"currency":"USD","value_usd":3950},"apc_paid":null,"fwci":0.2281,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.48900871,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"3","issue":"3","first_page":"301","last_page":"307"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.33500000834465027,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.33500000834465027,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.16429999470710754,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.15150000154972076,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gadolinium-chloride","display_name":"gadolinium chloride","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9089999794960022},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.8029999732971191},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9390000104904175},{"id":"https://openalex.org/keywords/splenic-macrophages","display_name":"splenic macrophages","score":0.9810000061988831},{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":0.8510000109672546},{"id":"https://openalex.org/keywords/endotoxemia","display_name":"endotoxemia","score":0.746999979019165},{"id":"https://openalex.org/keywords/portal-vein","display_name":"portal vein","score":0.3580000102519989},{"id":"https://openalex.org/keywords/alanine","display_name":"alanine","score":0.6930000185966492},{"id":"https://openalex.org/keywords/macrophage-phagocytosis","display_name":"macrophage phagocytosis","score":0.7160000205039978},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.37599998712539673},{"id":"https://openalex.org/keywords/macrophage-secretion","display_name":"macrophage secretion","score":0.43799999356269836},{"id":"https://openalex.org/keywords/portal-hypertension","display_name":"portal hypertension","score":0.40400001406669617},{"id":"https://openalex.org/keywords/liver-macrophages","display_name":"hepatic macrophages","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7634417414665222},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.7578561305999756},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6977671980857849},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.6610917448997498},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.6013880372047424},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5635325312614441},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.5485334396362305},{"id":"https://openalex.org/C2777956040","wikidata":"https://www.wikidata.org/wiki/Q416554","display_name":"Prostaglandin E2","level":2,"score":0.5233530402183533},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5223463773727417},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4944877624511719},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4881663918495178},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3892635703086853},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18949675559997559},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.17659419775009155},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14550870656967163},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.06468844413757324},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005682","descriptor_name":"Gadolinium","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005682","descriptor_name":"Gadolinium","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006503","descriptor_name":"Hepatic Veins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011169","descriptor_name":"Portal Vein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019446","descriptor_name":"Endotoxemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019610","descriptor_name":"Cytoprotection","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s1091-255x(99)80072-9","doi":"https://doi.org/10.1016/s1091-255x(99)80072-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1091-255x(99)80072-9","pdf_url":null,"source":{"id":"https://openalex.org/S78051145","display_name":"Journal of Gastrointestinal Surgery","issn_l":"1091-255X","issn":["1091-255X","1873-4626"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastrointestinal Surgery","raw_type":"journal-article"},{"id":"pmid:10481123","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10481123","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8167858695","display_name":null,"funder_award_id":"R01 28480","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W237380194","https://openalex.org/W292944800","https://openalex.org/W1419207898","https://openalex.org/W1566128266","https://openalex.org/W1604713777","https://openalex.org/W1661850314","https://openalex.org/W1822094726","https://openalex.org/W1944330918","https://openalex.org/W1965168337","https://openalex.org/W1972793829","https://openalex.org/W1994303699","https://openalex.org/W2011951102","https://openalex.org/W2015088732","https://openalex.org/W2019451160","https://openalex.org/W2025975662","https://openalex.org/W2035678219","https://openalex.org/W2036800888","https://openalex.org/W2046945073","https://openalex.org/W2060043509","https://openalex.org/W2061756277","https://openalex.org/W2068358887","https://openalex.org/W2081642488","https://openalex.org/W2085279940","https://openalex.org/W2089407657","https://openalex.org/W2113333095","https://openalex.org/W2128325715","https://openalex.org/W2128454894","https://openalex.org/W2141493942","https://openalex.org/W2144363851","https://openalex.org/W2147751374","https://openalex.org/W2159936534","https://openalex.org/W2160820460","https://openalex.org/W2169940712","https://openalex.org/W2171908596","https://openalex.org/W2178289462","https://openalex.org/W2313982762","https://openalex.org/W2344165305","https://openalex.org/W2403214817","https://openalex.org/W2411233224","https://openalex.org/W2414794348","https://openalex.org/W2425490862","https://openalex.org/W6641870496"],"related_works":["https://openalex.org/W2158347788","https://openalex.org/W2070787926","https://openalex.org/W2159936534","https://openalex.org/W2061651706","https://openalex.org/W1994923510","https://openalex.org/W2030023685","https://openalex.org/W2048466985","https://openalex.org/W1964648236","https://openalex.org/W1515185458","https://openalex.org/W2294124108"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
