{"id":"https://openalex.org/W1978145676","doi":"https://doi.org/10.1093/jnci/85.24.1994","title":"Cigarette Smoking and Risk of Acute Leukemia: Associations With Morphology and Cytogenetic Abnormalities in Bone Marrow","display_name":"Cigarette Smoking and Risk of Acute Leukemia: Associations With Morphology and Cytogenetic Abnormalities in Bone Marrow","publication_year":1993,"publication_date":"1993-12-01","ids":{"openalex":"https://openalex.org/W1978145676","doi":"https://doi.org/10.1093/jnci/85.24.1994","mag":"1978145676","pmid":"https://pubmed.ncbi.nlm.nih.gov/8246285"},"language":"en","primary_location":{"id":"doi:10.1093/jnci/85.24.1994","doi":"https://doi.org/10.1093/jnci/85.24.1994","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnci/85.24.1994","pdf_url":null,"source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI Journal of the National Cancer Institute","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058634982","display_name":"Dale P. Sandler","orcid":"https://orcid.org/0000-0002-6776-0018","observed_orcids":["https://orcid.org/0000-0002-6776-0018"]},"institutions":[{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"D. P. Sandler","raw_affiliation_strings":["Environmental and Molecular Epidemiology Section, National Institute of Environmental Health Sciences, Research Triangle Park, N.C","Environmental and Molecular Epidemiology Section. Epidemiology Branch, National Institute of Environmental Health SciencesResearch Triangel Park, N.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental and Molecular Epidemiology Section, National Institute of Environmental Health Sciences, Research Triangle Park, N.C","institution_ids":["https://openalex.org/I4210095140"]},{"raw_affiliation_string":"Environmental and Molecular Epidemiology Section. Epidemiology Branch, National Institute of Environmental Health SciencesResearch Triangel Park, N.C","institution_ids":["https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113231213","display_name":"D Shore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1333523220","display_name":"Westat (United States)","ror":"https://ror.org/00wt7xg39","country_code":"US","type":"company","lineage":["https://openalex.org/I1333523220"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. L. Shore","raw_affiliation_strings":["Westat, Inc. Durham. N.C","Westat, Inc.Durham. N.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Westat, Inc. Durham. N.C","institution_ids":[]},{"raw_affiliation_string":"Westat, Inc.Durham. N.C","institution_ids":["https://openalex.org/I1333523220"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103400343","display_name":"J R Anderson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307117695","display_name":"Nebraska Medical Center","ror":"https://ror.org/03azxga02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1307117695"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. R. Anderson","raw_affiliation_strings":["Department of Preventive adn Societal meidicine, Nebraska Medical Center Omaha","Department of Preventive adn Societal meidicine, Nebraska Medical CenterOmaha"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive adn Societal meidicine, Nebraska Medical Center Omaha","institution_ids":["https://openalex.org/I1307117695"]},{"raw_affiliation_string":"Department of Preventive adn Societal meidicine, Nebraska Medical CenterOmaha","institution_ids":["https://openalex.org/I1307117695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110055768","display_name":"Frederick R. Davey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. R. Davey","raw_affiliation_strings":["Depaertmetn of Pathology, State University of New York Health Science Center Syracuse","Depaertmetn of Pathology, State University of New York Health Science CenterSyracuse"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depaertmetn of Pathology, State University of New York Health Science Center Syracuse","institution_ids":["https://openalex.org/I1327163397"]},{"raw_affiliation_string":"Depaertmetn of Pathology, State University of New York Health Science CenterSyracuse","institution_ids":["https://openalex.org/I1327163397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109945973","display_name":"D Arthur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Arthur","raw_affiliation_strings":["Departmetn of Laboratory Medicine and Pathology, University of Minnesota Minneapolis","Departmetn of Laboratory Medicine and Pathology, University of MinnesotaMinneapolis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departmetn of Laboratory Medicine and Pathology, University of Minnesota Minneapolis","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Departmetn of Laboratory Medicine and Pathology, University of MinnesotaMinneapolis","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055389521","display_name":"Robert James Mayer","orcid":"https://orcid.org/0000-0002-0484-2876","observed_orcids":["https://orcid.org/0000-0002-0484-2876"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. J. Mayer","raw_affiliation_strings":["Dana-Farber Cancer Insitiute Bostobn, Mass","Dana-Farber Cancer InsitiuteBostobn, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Insitiute Bostobn, Mass","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Dana-Farber Cancer InsitiuteBostobn, Mass","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111555397","display_name":"R. T. Sliver","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405272987","display_name":"Weill Cornell Medical Center","ror":"https://ror.org/052v90092","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. T. Sliver","raw_affiliation_strings":["Section of Clinical Oncology, New York Hospital-cornell Medical Center New York","Section of Clinical Oncology, New York Hospital-cornell Medical CenterNew York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Clinical Oncology, New York Hospital-cornell Medical Center New York","institution_ids":["https://openalex.org/I4405272987"]},{"raw_affiliation_string":"Section of Clinical Oncology, New York Hospital-cornell Medical CenterNew York","institution_ids":["https://openalex.org/I4405272987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110127607","display_name":"R B Weiss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800363604","display_name":"Walter Reed National Military Medical Center","ror":"https://ror.org/025cem651","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330347796","https://openalex.org/I2800250139","https://openalex.org/I2800363604","https://openalex.org/I2800386880"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. B. Weiss","raw_affiliation_strings":["Section of Medicdal Oncology, Walter Reed Army Medical Center Washington, D.C","Section of Medicdal Oncology, Walter Reed Army Medical CenterWashington, D.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Medicdal Oncology, Walter Reed Army Medical Center Washington, D.C","institution_ids":["https://openalex.org/I2800363604"]},{"raw_affiliation_string":"Section of Medicdal Oncology, Walter Reed Army Medical CenterWashington, D.C","institution_ids":["https://openalex.org/I2800363604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109247403","display_name":"Joseph O. Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. O. Moore","raw_affiliation_strings":["Department of Hematology/Oncology, Duke University medical Center Durham, N.C","Department of Hematology/Oncology, Duke University medical CenterDurham, N.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology/Oncology, Duke University medical Center Durham, N.C","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Hematology/Oncology, Duke University medical CenterDurham, N.C","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021092277","display_name":"Charles Alan Schiffer","orcid":"https://orcid.org/0000-0003-4188-7886","observed_orcids":["https://orcid.org/0000-0003-4188-7886"]},"institutions":[{"id":"https://openalex.org/I1315496137","display_name":"University of Maryland Medical Center","ror":"https://ror.org/00sde4n60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315496137","https://openalex.org/I14285509"]},{"id":"https://openalex.org/I4390039317","display_name":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center","ror":"https://ror.org/01vft3j45","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I14285509","https://openalex.org/I4390039317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. A. Schiffer","raw_affiliation_strings":["University of Maryland Cancer Center, and Department of Medicine, University of Maryland Medical Center Baltimore","University of Maryland Cancer Center, and Department of Medicine, University of Maryland Medical CenterBaltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland Cancer Center, and Department of Medicine, University of Maryland Medical Center Baltimore","institution_ids":["https://openalex.org/I1315496137","https://openalex.org/I4390039317"]},{"raw_affiliation_string":"University of Maryland Cancer Center, and Department of Medicine, University of Maryland Medical CenterBaltimore","institution_ids":["https://openalex.org/I1315496137","https://openalex.org/I4390039317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024714738","display_name":"Doris H. Wurster\u2010Hill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289422878","display_name":"Dartmouth\u2013Hitchcock Medical Center","ror":"https://ror.org/00d1dhh09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I1289422878","https://openalex.org/I4390039337"]},{"id":"https://openalex.org/I4390039337","display_name":"Dartmouth Health","ror":"https://ror.org/01pa9ed26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I4390039337"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. H. Wurster-Hill","raw_affiliation_strings":["Department of Pathology, Dartmouth-Hitchcock Medical Center Hanover, N.H","Department of Pathology, Dartmouth-Hitchcock Medical CenterHanover, N.H"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Dartmouth-Hitchcock Medical Center Hanover, N.H","institution_ids":["https://openalex.org/I1289422878","https://openalex.org/I4390039337"]},{"raw_affiliation_string":"Department of Pathology, Dartmouth-Hitchcock Medical CenterHanover, N.H","institution_ids":["https://openalex.org/I1289422878","https://openalex.org/I4390039337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031875226","display_name":"O. Ross McIntyre","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289422878","display_name":"Dartmouth\u2013Hitchcock Medical Center","ror":"https://ror.org/00d1dhh09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I1289422878","https://openalex.org/I4390039337"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"O. R. McIntyre","raw_affiliation_strings":["Cancer and Leukemia Group B, Dartmouth-Hitchcock Medical Center Buffalo, N.Y","Cancer and Leukemia Group B, Dartmouth-Hitchcock Medical CenterBuffalo, N.Y"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer and Leukemia Group B, Dartmouth-Hitchcock Medical Center Buffalo, N.Y","institution_ids":["https://openalex.org/I1289422878"]},{"raw_affiliation_string":"Cancer and Leukemia Group B, Dartmouth-Hitchcock Medical CenterBuffalo, N.Y","institution_ids":["https://openalex.org/I1289422878"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062108544","display_name":"Clara Derber Bloomfield","orcid":"https://orcid.org/0000-0001-5465-7591","observed_orcids":["https://orcid.org/0000-0001-5465-7591"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. D. Bloomfield","raw_affiliation_strings":["Department of Medicine, Roswell park Cancer Institute Buffalo, N.Y","Department of Medicine, Roswell Park Cancer InstituteBuffalo, N.Y"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Roswell park Cancer Institute Buffalo, N.Y","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Medicine, Roswell Park Cancer InstituteBuffalo, N.Y","institution_ids":["https://openalex.org/I1292894508"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":15,"corresponding_author_ids":["https://openalex.org/A5058634982"],"corresponding_institution_ids":["https://openalex.org/I4210095140"],"apc_list":{"value":5436,"currency":"USD","value_usd":5436},"apc_paid":null,"fwci":1.0846,"has_fulltext":false,"cited_by_count":121,"citation_normalized_percentile":{"value":0.7517807,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"85","issue":"24","first_page":"1994","last_page":"2003"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.7685999870300293,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.7685999870300293,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.12070000171661377,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.03739999979734421,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cigarette-smoking","display_name":"cigarette smoking","score":0.9940000176429749},{"id":"https://openalex.org/keywords/acute-leukemia","display_name":"acute leukemia","score":0.9890000224113464},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9800000190734863},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9309999942779541},{"id":"https://openalex.org/keywords/fab-classification","display_name":"FAB classification","score":0.6669999957084656},{"id":"https://openalex.org/keywords/leukocyte-morphology","display_name":"leukocyte morphology","score":0.675000011920929},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.6830000281333923},{"id":"https://openalex.org/keywords/leukemia-risk-factors","display_name":"leukemia risk factors","score":0.8149999976158142},{"id":"https://openalex.org/keywords/smoking-cessation","display_name":"smoking cessation","score":0.3529999852180481},{"id":"https://openalex.org/keywords/smoking-cessation-counseling","display_name":"smoking cessation counseling","score":0.37299999594688416},{"id":"https://openalex.org/keywords/smoking-cessation-pharmacotherapy","display_name":"smoking cessation pharmacotherapy","score":0.5339999794960022},{"id":"https://openalex.org/keywords/smoking-cessation-support-groups","display_name":"smoking cessation support groups","score":0.375}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7943329215049744},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.7563793659210205},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.7081214785575867},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.6796441674232483},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5974959135055542},{"id":"https://openalex.org/C2776863199","wikidata":"https://www.wikidata.org/wiki/Q976388","display_name":"Acute leukemia","level":3,"score":0.5719113349914551},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4872933626174927},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.46741294860839844},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.4453125596046448},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43758267164230347},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.4196142852306366},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4165787696838379},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4042292833328247},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33113792538642883},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.05774885416030884}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/jnci/85.24.1994","doi":"https://doi.org/10.1093/jnci/85.24.1994","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnci/85.24.1994","pdf_url":null,"source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI Journal of the National Cancer Institute","raw_type":"journal-article"},{"id":"pmid:8246285","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8246285","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the National Cancer Institute","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:jnci:85/24/1994","doi":null,"is_oa":false,"landing_page_url":"http://jnci.oxfordjournals.org/cgi/content/short/85/24/1994","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1047634001","display_name":"CANCER AND LEUKEMIA GROUP B--CORRELATIVE SCIENCES","funder_award_id":"5u10ca037027-12","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1990396305","display_name":null,"funder_award_id":"CA37027","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2647518335","display_name":null,"funder_award_id":"CA-33601","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3054160986","display_name":"Cancer and Leukemia Group B Statistical Center","funder_award_id":"5u10ca033601-35","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6593449295","display_name":"Cancer and Leukemia Group B","funder_award_id":"5u10ca031946-32","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G973482110","display_name":null,"funder_award_id":"CA-31946","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2990397977","https://openalex.org/W2357767897","https://openalex.org/W1162258005","https://openalex.org/W2365804799","https://openalex.org/W2364732766","https://openalex.org/W1980883331","https://openalex.org/W2605482055","https://openalex.org/W2393383561","https://openalex.org/W2001525647","https://openalex.org/W4230253767"],"abstract_inverted_index":{"BACKGROUND:":[0],"Cigarette":[1,357],"smoking":[2,59,168,209,358],"may":[3,367,388],"be":[4,93],"a":[5,18,61,89,184,213,231],"risk":[6,55,163,188,217,235,264,363,427],"factor":[7],"for":[8,106,144,162,173,189,218,236,265,283,294,319,330,364],"leukemia.":[9,433],"No":[10],"detailed":[11],"biological":[12],"mechanism":[13],"has":[14],"been":[15,42],"proposed,":[16],"but":[17],"causal":[19],"link":[20],"is":[21,359],"made":[22],"plausible":[23],"by":[24,98,119,130,147],"evidence":[25],"of":[26,29,38,65,132,152,164,257,277,313,371,386,393,404,415,425],"systemic":[27],"effects":[28],"cigarette":[30,36,58],"smoke":[31,37],"and":[32,100,112,127,176,207,230,255,288,298,324,352,366,374,399,401,429],"the":[33,53,138,148,423],"presence":[34,149],"in":[35,60,68,82,187,216,234,345,353,431],"chemicals":[39],"that":[40,412],"have":[41],"associated":[43,56,166,181,211,261,303,360],"with":[44,57,74,109,167,182,212,253,262,275,304,311,341,361,380],"leukemia":[45,54,77,111,165,190,221,239,365,405],"risk.":[46,394],"PURPOSE:":[47],"Our":[48],"purpose":[49],"was":[50,180,210,260,301,336],"to":[51,80,92,137,369,420,422],"investigate":[52],"multicenter":[62],"case-control":[63],"study":[64,85],"acute":[66,110,219,237,432],"leukemias":[67,370],"adults.":[69],"METHODS:":[70],"Adults":[71],"aged":[72,205,296],"18-79":[73],"newly":[75],"diagnosed":[76],"were":[78,117,171,333],"contacted":[79],"participate":[81],"this":[83],"epidemiologic":[84,410],"when":[86],"they":[87],"entered":[88],"clinical":[90],"trial":[91],"treated":[94],"under":[95],"protocols":[96],"sponsored":[97],"Cancer":[99],"Leukemia":[101],"Group":[102],"B.":[103],"Smoking":[104,179,259,300,335],"histories":[105],"610":[107],"patients":[108,129,340,406],"618":[113],"population":[114],"control":[115],"subjects":[116],"obtained":[118],"telephone":[120],"interviews.":[121],"We":[122,157],"examined":[123],"bone":[124],"marrow":[125],"samples":[126],"classified":[128,267],"morphology":[131],"leukocyte":[133],"precursor":[134],"cells":[135],"according":[136],"French-American-British":[139],"(FAB)":[140],"classification":[141,398],"system":[142],"and,":[143],"378":[145],"patients,":[146],"or":[150,348],"absence":[151],"specific":[153,342,372],"clonal":[154],"chromosome":[155,343],"abnormalities.":[156],"calculated":[158],"odds":[159],"ratios":[160],"(ORs)":[161],"cigarettes.":[169],"ORs":[170,276,312],"adjusted":[172],"age,":[174],"race,":[175],"sex.":[177],"RESULTS:":[178],"only":[183],"modest":[185],"increase":[186,215,233],"overall":[191],"(adjusted":[192],"OR":[193],"=":[194,200,224,228,242,246,281,292,317,328],"1.13;":[195],"95%":[196,226,244],"confidence":[197],"interval":[198],"[CI]":[199],"0.89-1.44).":[201],"However,":[202],"among":[203,339],"participants":[204],"60":[206,287,297,323],"older,":[208],"twofold":[214],"myeloid":[220],"(AML)":[222],"(OR":[223,241],"1.96;":[225],"CI":[227,245,280,291,316,327],"1.17-3.28)":[229],"threefold":[232],"lymphocytic":[238],"(ALL)":[240],"3.40;":[243],"0.97-11.9).":[247],"Among":[248],"older":[249],"persons,":[250],"risks":[251],"increased":[252,263,362],"amount":[254],"duration":[256],"smoking.":[258],"AML":[266,346],"as":[268],"FAB":[269],"type":[270,306],"M2":[271],"at":[272,308],"all":[273,309],"ages,":[274,310],"1.70":[278],"(95%":[279,290,315,326],"1.00-2.90)":[282],"those":[284,295,320,331],"younger":[285,321],"than":[286,322],"3.50":[289],"1.53-8.03)":[293],"older.":[299,334],"also":[302],"ALL":[305,354],"L2":[307],"1.72":[314],"0.90-3.27)":[318],"5.34":[325],"1.03-27.6)":[329],"who":[332],"more":[337,390,408],"common":[338],"abnormalities":[344],"[-7":[347],"7q-,":[349],"-Y,":[350],"+13]":[351],"[t(9;22)(q34;q11)].":[355],"CONCLUSIONS:":[356],"lead":[368],"morphologic":[373,397],"chromosomal":[375],"types.":[376],"The":[377],"association":[378],"varies":[379],"age.":[381],"IMPLICATION:":[382],"Examining":[383],"discrete":[384],"subtypes":[385],"disease":[387],"permit":[389],"accurate":[391],"assessment":[392],"As":[395],"standardized":[396],"cytogenetic":[400],"molecular":[402],"evaluation":[403],"becomes":[407],"common,":[409],"studies":[411],"take":[413],"advantage":[414],"these":[416],"advances":[417],"will":[418],"begin":[419],"contribute":[421],"identification":[424],"additional":[426],"factors":[428],"mechanisms":[430]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
