{"id":"https://openalex.org/W1978143129","doi":"https://doi.org/10.1016/0378-5173(93)90162-9","title":"The estimation of relative water solubility for prodrugs that are unstable in water","display_name":"The estimation of relative water solubility for prodrugs that are unstable in water","publication_year":1993,"publication_date":"1993-05-01","ids":{"openalex":"https://openalex.org/W1978143129","doi":"https://doi.org/10.1016/0378-5173(93)90162-9","mag":"1978143129"},"language":"en","primary_location":{"id":"doi:10.1016/0378-5173(93)90162-9","doi":"https://doi.org/10.1016/0378-5173(93)90162-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0378-5173(93)90162-9","pdf_url":null,"source":{"id":"https://openalex.org/S131016564","display_name":"International Journal of Pharmaceutics","issn_l":"0378-5173","issn":["0378-5173","1873-3476"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064269569","display_name":"Howard D. Beall","orcid":"https://orcid.org/0000-0001-8601-1496","observed_orcids":["https://orcid.org/0000-0001-8601-1496"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H.D. Beall","raw_affiliation_strings":["Department of Medicinal Chemistry, P.O. Box 100485, University of Florida, Gainesville, FL 32610 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, P.O. Box 100485, University of Florida, Gainesville, FL 32610 USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023915181","display_name":"J.J. Getz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.J. Getz","raw_affiliation_strings":["Department of Medicinal Chemistry, P.O. Box 100485, University of Florida, Gainesville, FL 32610 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, P.O. Box 100485, University of Florida, Gainesville, FL 32610 USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112449017","display_name":"Kenneth B. Sloan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"K.B. Sloan","raw_affiliation_strings":["Department of Medicinal Chemistry, P.O. Box 100485, University of Florida, Gainesville, FL 32610 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, P.O. Box 100485, University of Florida, Gainesville, FL 32610 USA","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112449017"],"corresponding_institution_ids":["https://openalex.org/I33213144"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":1.7276,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.77857143,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"93","issue":"1-3","first_page":"37","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isopropyl-myristate","display_name":"isopropyl myristate","score":0.800000011920929},{"id":"https://openalex.org/keywords/partition-coefficient","display_name":"partition coefficient","score":0.8309999704360962},{"id":"https://openalex.org/keywords/hydrolytic-stability","display_name":"hydrolytic stability","score":0.7699999809265137},{"id":"https://openalex.org/keywords/melting-point","display_name":"melting point","score":0.5799999833106995},{"id":"https://openalex.org/keywords/solubility-prediction","display_name":"solubility prediction","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C192552737","wikidata":"https://www.wikidata.org/wiki/Q898797","display_name":"Partition coefficient","level":2,"score":0.8128555417060852},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.8002071380615234},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7224099636077881},{"id":"https://openalex.org/C2779783494","wikidata":"https://www.wikidata.org/wiki/Q416222","display_name":"Isopropyl myristate","level":2,"score":0.5564522743225098},{"id":"https://openalex.org/C13530604","wikidata":"https://www.wikidata.org/wiki/Q15318","display_name":"Melting point","level":2,"score":0.5303027629852295},{"id":"https://openalex.org/C143724316","wikidata":"https://www.wikidata.org/wiki/Q312468","display_name":"Series (stratigraphy)","level":2,"score":0.4127030670642853},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.39843183755874634},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.3980887830257416},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.35369324684143066},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.29697632789611816},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/0378-5173(93)90162-9","doi":"https://doi.org/10.1016/0378-5173(93)90162-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0378-5173(93)90162-9","pdf_url":null,"source":{"id":"https://openalex.org/S131016564","display_name":"International Journal of Pharmaceutics","issn_l":"0378-5173","issn":["0378-5173","1873-3476"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1974078109","https://openalex.org/W1974437354","https://openalex.org/W2003088229","https://openalex.org/W2020375551","https://openalex.org/W2027674790","https://openalex.org/W2040866523","https://openalex.org/W2054449983","https://openalex.org/W2062499970","https://openalex.org/W2066483886","https://openalex.org/W2071192175","https://openalex.org/W2071953730","https://openalex.org/W2073361271","https://openalex.org/W2144084595","https://openalex.org/W2171893580","https://openalex.org/W2403020764","https://openalex.org/W4252111711"],"related_works":["https://openalex.org/W2023868949","https://openalex.org/W2163361076","https://openalex.org/W2355453419","https://openalex.org/W2358112872","https://openalex.org/W2022460098","https://openalex.org/W2017111904","https://openalex.org/W2385837582","https://openalex.org/W1971036212","https://openalex.org/W1970761598","https://openalex.org/W2807714543"],"abstract_inverted_index":null,"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}