{"id":"https://openalex.org/W1978129474","doi":"https://doi.org/10.1021/bi026293l","title":"Role of Entropy in Protein Thermostability: Folding Kinetics of a Hyperthermophilic Cold Shock Protein at High Temperatures Using 19F NMR","display_name":"Role of Entropy in Protein Thermostability: Folding Kinetics of a Hyperthermophilic Cold Shock Protein at High Temperatures Using 19F NMR","publication_year":2002,"publication_date":"2002-08-17","ids":{"openalex":"https://openalex.org/W1978129474","doi":"https://doi.org/10.1021/bi026293l","mag":"1978129474","pmid":"https://pubmed.ncbi.nlm.nih.gov/12269809"},"language":"en","primary_location":{"id":"doi:10.1021/bi026293l","doi":"https://doi.org/10.1021/bi026293l","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi026293l","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055791638","display_name":"Benjamin Schuler","orcid":"https://orcid.org/0000-0002-5970-4251","observed_orcids":["https://orcid.org/0000-0002-5970-4251"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Benjamin Schuler","raw_affiliation_strings":["Institut f\u00fcr Biophysik und Physikalische Biochemie, Universit\u00e4t Regensburg, Universit\u00e4tsstrasse 31, 93040 Regensburg, Germany, and Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0520"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Biophysik und Physikalische Biochemie, Universit\u00e4t Regensburg, Universit\u00e4tsstrasse 31, 93040 Regensburg, Germany, and Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0520","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091497117","display_name":"Werner Kremer","orcid":"https://orcid.org/0000-0001-6398-1596","observed_orcids":["https://orcid.org/0000-0001-6398-1596"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Werner Kremer","raw_affiliation_strings":["Institut f\u00fcr Biophysik und Physikalische Biochemie, Universit\u00e4t Regensburg, Universit\u00e4tsstrasse 31, 93040 Regensburg, Germany, and Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0520"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Biophysik und Physikalische Biochemie, Universit\u00e4t Regensburg, Universit\u00e4tsstrasse 31, 93040 Regensburg, Germany, and Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0520","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042870599","display_name":"Hans Robert Kalbitzer","orcid":"https://orcid.org/0000-0002-6514-2355","observed_orcids":["https://orcid.org/0000-0002-6514-2355"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Hans Robert Kalbitzer","raw_affiliation_strings":["Institut f\u00fcr Biophysik und Physikalische Biochemie, Universit\u00e4t Regensburg, Universit\u00e4tsstrasse 31, 93040 Regensburg, Germany, and Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0520"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Biophysik und Physikalische Biochemie, Universit\u00e4t Regensburg, Universit\u00e4tsstrasse 31, 93040 Regensburg, Germany, and Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0520","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567","https://openalex.org/I60668342"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023088787","display_name":"Rainer Jaenicke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Rainer Jaenicke","raw_affiliation_strings":["Institut f\u00fcr Biophysik und Physikalische Biochemie, Universit\u00e4t Regensburg, Universit\u00e4tsstrasse 31, 93040 Regensburg, Germany, and Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0520"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Biophysik und Physikalische Biochemie, Universit\u00e4t Regensburg, Universit\u00e4tsstrasse 31, 93040 Regensburg, Germany, and Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0520","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567","https://openalex.org/I60668342"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5055791638"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567","https://openalex.org/I60668342"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.3057,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.77914657,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"41","issue":"39","first_page":"11670","last_page":"11680"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-thermostability","display_name":"protein thermal stability","score":0.9330000281333923},{"id":"https://openalex.org/keywords/cold-shock-proteins","display_name":"cold shock proteins","score":0.7850000262260437},{"id":"https://openalex.org/keywords/thermotoga-maritima","display_name":"Thermotoga maritima","score":0.9440000057220459},{"id":"https://openalex.org/keywords/19f-nmr","display_name":"19F NMR","score":0.8610000014305115},{"id":"https://openalex.org/keywords/folding-kinetics","display_name":"folding kinetics","score":0.7889999747276306},{"id":"https://openalex.org/keywords/unfolding-kinetics","display_name":"unfolding kinetics","score":0.6729999780654907},{"id":"https://openalex.org/keywords/two-state-folding","display_name":"two-state folding","score":0.7519999742507935},{"id":"https://openalex.org/keywords/entropy-stabilization","display_name":"entropic stabilization","score":0.49399998784065247},{"id":"https://openalex.org/keywords/hyperthermophilic-proteins","display_name":"hyperthermophilic proteins","score":0.8190000057220459},{"id":"https://openalex.org/keywords/guanidine-hydrochloride","display_name":"guanidine hydrochloride","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C2781216036","wikidata":"https://www.wikidata.org/wiki/Q902494","display_name":"Thermostability","level":3,"score":0.9096083641052246},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.7193684577941895},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.6655568480491638},{"id":"https://openalex.org/C199677211","wikidata":"https://www.wikidata.org/wiki/Q24780964","display_name":"Cold-shock domain","level":4,"score":0.592632532119751},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5180411338806152},{"id":"https://openalex.org/C106301342","wikidata":"https://www.wikidata.org/wiki/Q4117933","display_name":"Entropy (arrow of time)","level":2,"score":0.4580698013305664},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.4378267824649811},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.41616925597190857},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.39129167795181274},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.33584505319595337},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3215203285217285},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2876281142234802},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.21361851692199707},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1527053713798523},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.12838208675384521},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06610614061355591},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002152","descriptor_name":"Calorimetry, Differential Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002152","descriptor_name":"Calorimetry, Differential Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002152","descriptor_name":"Calorimetry, Differential Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005461","descriptor_name":"Fluorine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005461","descriptor_name":"Fluorine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005461","descriptor_name":"Fluorine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011489","descriptor_name":"Protein Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011489","descriptor_name":"Protein Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011489","descriptor_name":"Protein Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013053","descriptor_name":"Spectrophotometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013053","descriptor_name":"Spectrophotometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013053","descriptor_name":"Spectrophotometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019791","descriptor_name":"Guanidine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019791","descriptor_name":"Guanidine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019791","descriptor_name":"Guanidine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020124","descriptor_name":"Thermotoga maritima","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020124","descriptor_name":"Thermotoga maritima","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020124","descriptor_name":"Thermotoga maritima","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/bi026293l","doi":"https://doi.org/10.1021/bi026293l","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi026293l","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:12269809","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12269809","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:epub.uni-regensburg.de:72704","doi":null,"is_oa":false,"landing_page_url":"http://orcid.org/0000-0002-5970-4251>,","pdf_url":null,"source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.557.9077","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.557.9077","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.bioc.uzh.ch/schuler/Schuler02b.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W572794845","https://openalex.org/W939781334","https://openalex.org/W1004469317","https://openalex.org/W1482701468","https://openalex.org/W1487346929","https://openalex.org/W1496368635","https://openalex.org/W1508559184","https://openalex.org/W1517145530","https://openalex.org/W1530704185","https://openalex.org/W1533569014","https://openalex.org/W1552774315","https://openalex.org/W1824051645","https://openalex.org/W1973706355","https://openalex.org/W1974956783","https://openalex.org/W1978503507","https://openalex.org/W1982006129","https://openalex.org/W1983839347","https://openalex.org/W1995730663","https://openalex.org/W1996408394","https://openalex.org/W2002195659","https://openalex.org/W2002447487","https://openalex.org/W2005986251","https://openalex.org/W2014381517","https://openalex.org/W2015501310","https://openalex.org/W2025336895","https://openalex.org/W2030934305","https://openalex.org/W2037021218","https://openalex.org/W2038263678","https://openalex.org/W2043517319","https://openalex.org/W2049043767","https://openalex.org/W2049864329","https://openalex.org/W2051920745","https://openalex.org/W2058629823","https://openalex.org/W2067249528","https://openalex.org/W2067293617","https://openalex.org/W2069479024","https://openalex.org/W2076686101","https://openalex.org/W2077270147","https://openalex.org/W2080656389","https://openalex.org/W2082176608","https://openalex.org/W2086951107","https://openalex.org/W2099156330","https://openalex.org/W2104017463","https://openalex.org/W2108107378","https://openalex.org/W2116076986","https://openalex.org/W2117747873","https://openalex.org/W2119586900","https://openalex.org/W2147601655","https://openalex.org/W2153195964","https://openalex.org/W2159422614","https://openalex.org/W2394538741","https://openalex.org/W2405066143","https://openalex.org/W2994423374","https://openalex.org/W4248623180"],"related_works":["https://openalex.org/W1608094563","https://openalex.org/W2366986171","https://openalex.org/W1952548524","https://openalex.org/W4239727325","https://openalex.org/W2018641097","https://openalex.org/W3004688699","https://openalex.org/W2566200359","https://openalex.org/W4311611414","https://openalex.org/W2117300107","https://openalex.org/W2072744250"],"abstract_inverted_index":{"We":[0],"used":[1],"(19)F":[2,73,107],"NMR":[3,74,108],"to":[4,10,111,190,204,217],"extend":[5],"the":[6,25,31,50,57,78,89,106,112,135,157,170,178,184,191,212],"temperature":[7,143,172,198],"range":[8,173],"accessible":[9],"detailed":[11],"kinetic":[12,59],"and":[13,65,83,96,141],"equilibrium":[14,68],"studies":[15],"of":[16,88,93,114,139,148,161,166,208,214],"a":[17,46,85,196],"hyperthermophilic":[18],"protein.":[19],"Employing":[20],"an":[21,205],"optimized":[22],"incorporation":[23],"strategy,":[24],"small":[26],"cold":[27],"shock":[28],"protein":[29],"from":[30,80,105,126,152],"bacterium":[32],"Thermotoga":[33],"maritima":[34],"(TmCsp)":[35],"was":[36,175],"labeled":[37],"with":[38,77,124],"5-fluorotryptophan.":[39],"Although":[40],"chaotropically":[41],"induced":[42],"unfolding":[43,69,97,116,158,192],"transitions":[44,70],"revealed":[45],"significant":[47],"decrease":[48],"in":[49,180,211],"stabilization":[51,213],"free":[52],"energy":[53],"upon":[54],"fluorine":[55],"labeling,":[56],"protein's":[58],"folding":[60,91,136],"mechanism":[61],"is":[62,163,187],"conserved.":[63],"Temperature-":[64],"guanidinium":[66],"chloride-dependent":[67],"monitored":[71],"by":[72,117],"agree":[75],"well":[76],"results":[79,125],"optical":[81],"spectroscopy,":[82],"provide":[84],"stringent":[86],"test":[87],"two-state":[90],"character":[92],"TmCsp.":[94],"Folding":[95],"rate":[98,137,159,193],"constants":[99],"at":[100,129],"high":[101],"temperatures":[102],"were":[103],"determined":[104],"spectra":[109],"close":[110],"midpoint":[113],"thermal":[115],"global":[118],"line":[119],"shape":[120],"analysis.":[121],"In":[122],"combination":[123],"stopped-flow":[127],"experiments":[128],"lower":[130,168],"temperatures,":[131],"they":[132],"show":[133],"that":[134,174],"constant":[138,160,194],"TmCsp":[140,162,215],"its":[142,149,218],"dependence":[144],"closely":[145],"resemble":[146],"those":[147],"mesophilic":[150,219],"homologue":[151],"Bacillus":[153],"subtilis,":[154],"BsCspB.":[155],"However,":[156],"two":[164,185],"orders":[165],"magnitude":[167],"over":[169,195],"entire":[171],"investigated.":[176],"Consequently,":[177],"difference":[179],"conformational":[181],"stability":[182],"between":[183],"proteins":[186],"solely":[188],"due":[189],"wide":[197],"range.":[199],"A":[200],"thermodynamic":[201],"analysis":[202],"points":[203],"important":[206],"role":[207],"entropic":[209],"factors":[210],"relative":[216],"homologues.":[220]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2016-06-24T00:00:00"}
