{"id":"https://openalex.org/W1978128757","doi":"https://doi.org/10.1097/00007890-199102000-00047","title":"MIXED LYMPHOCYTE REACTION-INDUCED RELEASE OF SOLUBLE IL-2 RECEPTOR","display_name":"MIXED LYMPHOCYTE REACTION-INDUCED RELEASE OF SOLUBLE IL-2 RECEPTOR","publication_year":1991,"publication_date":"1991-02-01","ids":{"openalex":"https://openalex.org/W1978128757","doi":"https://doi.org/10.1097/00007890-199102000-00047","mag":"1978128757","pmid":"https://pubmed.ncbi.nlm.nih.gov/1825248"},"language":"en","primary_location":{"id":"doi:10.1097/00007890-199102000-00047","doi":"https://doi.org/10.1097/00007890-199102000-00047","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199102000-00047","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006110354","display_name":"Dimitrios Degiannis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"DIMITRIOS DEGIANNIS","raw_affiliation_strings":["Department of Pathology, UMDNJ-Robert Wood Johnson Medical School, Piscataway 08854","07103","08854"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, UMDNJ-Robert Wood Johnson Medical School, Piscataway 08854","institution_ids":[]},{"raw_affiliation_string":"07103","institution_ids":[]},{"raw_affiliation_string":"08854","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047718858","display_name":"Margaret Czarnecki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MARGARET CZARNECKI","raw_affiliation_strings":["The Department of Pathology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854","and The Department of Laboratory Medicine and Pathology, UMDNJ-New Jersey Medical School, Newark, New Jersey 07103","07103","08854"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Pathology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854","institution_ids":[]},{"raw_affiliation_string":"and The Department of Laboratory Medicine and Pathology, UMDNJ-New Jersey Medical School, Newark, New Jersey 07103","institution_ids":["https://openalex.org/I4402554120"]},{"raw_affiliation_string":"07103","institution_ids":[]},{"raw_affiliation_string":"08854","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028896915","display_name":"Nete Hornung","orcid":"https://orcid.org/0000-0002-2462-9490","observed_orcids":["https://orcid.org/0000-0002-2462-9490"]},"institutions":[{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"NETE HORNUNG","raw_affiliation_strings":["The Department of Pathology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854","and The Department of Laboratory Medicine and Pathology, UMDNJ-New Jersey Medical School, Newark, New Jersey 07103","07103","08854"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Pathology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854","institution_ids":[]},{"raw_affiliation_string":"and The Department of Laboratory Medicine and Pathology, UMDNJ-New Jersey Medical School, Newark, New Jersey 07103","institution_ids":["https://openalex.org/I4402554120"]},{"raw_affiliation_string":"07103","institution_ids":[]},{"raw_affiliation_string":"08854","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110170256","display_name":"Jana Ra\u0161kov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JANA RASKOVA","raw_affiliation_strings":["The Department of Pathology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854","and The Department of Laboratory Medicine and Pathology, UMDNJ-New Jersey Medical School, Newark, New Jersey 07103","07103","08854"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Pathology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854","institution_ids":[]},{"raw_affiliation_string":"and The Department of Laboratory Medicine and Pathology, UMDNJ-New Jersey Medical School, Newark, New Jersey 07103","institution_ids":["https://openalex.org/I4402554120"]},{"raw_affiliation_string":"07103","institution_ids":[]},{"raw_affiliation_string":"08854","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003081720","display_name":"Karel Raska Jr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"RASKA KAREL","raw_affiliation_strings":["The Department of Pathology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854","and The Department of Laboratory Medicine and Pathology, UMDNJ-New Jersey Medical School, Newark, New Jersey 07103","07103","08854"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Pathology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854","institution_ids":[]},{"raw_affiliation_string":"and The Department of Laboratory Medicine and Pathology, UMDNJ-New Jersey Medical School, Newark, New Jersey 07103","institution_ids":["https://openalex.org/I4402554120"]},{"raw_affiliation_string":"07103","institution_ids":[]},{"raw_affiliation_string":"08854","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9579,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.7383363,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"51","issue":"2","first_page":"518","last_page":"523"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7235999703407288,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7235999703407288,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.16110000014305115,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.04179999977350235,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/soluble-il-2-receptor","display_name":"soluble interleukin-2 receptor","score":0.9629999995231628},{"id":"https://openalex.org/keywords/mixed-lymphocyte-reaction","display_name":"mixed lymphocyte reaction","score":0.9909999966621399},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.8349999785423279},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.8199999928474426},{"id":"https://openalex.org/keywords/prednisolone","display_name":"prednisolone","score":1.0},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7549999952316284},{"id":"https://openalex.org/keywords/alloantigen-response","display_name":"alloantigen response","score":0.878000020980835},{"id":"https://openalex.org/keywords/graft-rejection","display_name":"graft rejection","score":0.7590000033378601},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.8140000104904175},{"id":"https://openalex.org/keywords/thymidine-incorporation","display_name":"thymidine incorporation","score":0.8859999775886536}],"concepts":[{"id":"https://openalex.org/C2777108182","wikidata":"https://www.wikidata.org/wiki/Q422464","display_name":"Thymidine","level":3,"score":0.8157309889793396},{"id":"https://openalex.org/C2778740727","wikidata":"https://www.wikidata.org/wiki/Q12055129","display_name":"Mixed lymphocyte reaction","level":4,"score":0.7065613269805908},{"id":"https://openalex.org/C2777371288","wikidata":"https://www.wikidata.org/wiki/Q410130","display_name":"Interleukin 2","level":3,"score":0.5790171027183533},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.50811767578125},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.49956440925598145},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4990835189819336},{"id":"https://openalex.org/C49382859","wikidata":"https://www.wikidata.org/wiki/Q286498","display_name":"Lymphokine","level":3,"score":0.4529503881931305},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45205846428871155},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40067607164382935},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3511393964290619},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3349974751472473},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32842087745666504},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3168985843658447},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.263949990272522},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.2600471079349518},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23242953419685364},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1956270933151245}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003524","descriptor_name":"Cyclosporins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007959","descriptor_name":"Lymphocyte Culture Test, Mixed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011239","descriptor_name":"Prednisolone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015375","descriptor_name":"Receptors, Interleukin-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00007890-199102000-00047","doi":"https://doi.org/10.1097/00007890-199102000-00047","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199102000-00047","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},{"id":"pmid:1825248","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1825248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1438083946","display_name":"ADENOVIRUS T AND SURFACE ANTIGENS AND TUMORIGENICITY","funder_award_id":"R01CA021196","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3279003099","display_name":"CENTRAL JERSEY AIDS CLINICAL STUDIES GROUP","funder_award_id":"U01AI025914","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2087994033","https://openalex.org/W1912996344","https://openalex.org/W7097254134","https://openalex.org/W1794873118","https://openalex.org/W2035640378","https://openalex.org/W1898907862","https://openalex.org/W2038505610","https://openalex.org/W1948876423","https://openalex.org/W2011409139","https://openalex.org/W1971770415"],"abstract_inverted_index":{"We":[0,266],"studied":[1],"the":[2,21,43,47,62,73,76,83,94,106,109,127,131,135,155,174,190,213,216,224,228,235,253,256,269,302],"release":[3,84,116,175,191,230,270],"of":[4,23,27,35,46,58,64,75,85,93,108,114,134,144,157,176,192,210,215,227,231,234,239,247,250,255,264,271,283,291,301,304],"soluble":[5],"interleukin":[6],"2":[7],"receptor":[8],"(sIL-2R)":[9],"by":[10,166],"PBMC":[11],"in":[12,17,29,130,273,293,296],"mixed":[13],"lymphocyte":[14],"reaction":[15],"(MLR)":[16],"order":[18],"to":[19,39,81,188,221,261,275],"clarify":[20],"significance":[22],"high":[24],"plasma":[25],"levels":[26,285],"sIL-2R":[28,36,59,115,193,232,251,272],"transplant":[30],"patients":[31],"undergoing":[32],"rejection.":[33],"Levels":[34],"were":[37,70,79,101,122,258],"shown":[38,80,187,220,260],"increase":[40],"progressively":[41],"after":[42,105,126],"first":[44],"day":[45,54,133],"MLR":[48,77,136,158,217,257],"and":[49,67,78,99,233,281,300],"reached":[50],"their":[51],"peak":[52],"on":[53],"5.":[55],"This":[56,87],"pattern":[57],"correlated":[60,89],"with":[61,90,149,171],"incorporation":[63,263],"[3H]thymidine.":[65,265],"CsA":[66,98,151,162,172],"prednisolone":[68],"(PRED)":[69],"added":[71,102,123],"at":[72,195,212,252],"beginning":[74],"inhibit":[82],"sIL-2R.":[86],"inhibition":[88,92,113,226],"an":[91,278],"[3H]thymidine":[95,168,206,236],"incorporation.":[96,169,207,237],"When":[97],"PRED":[100,153,179,225],"24":[103],"hr":[104,125],"initiation":[107,128,156,214,254],"MLR,":[110],"a":[111,181,288],"similar":[112],"was":[117,141,164,186,218],"observed,":[118],"but":[119,199],"when":[120],"they":[121],"48":[124],"or":[129,138,146,152,295],"last":[132],"little":[137],"no":[139],"effect":[140],"observed.":[142],"Incubation":[143],"responder":[145],"stimulator-responder":[147],"cells":[148],"either":[150,292],"before":[154],"showed":[159],"that":[160,268],"only":[161,242],"preincubation":[163],"accompanied":[165],"decreased":[167],"Preincubation":[170],"inhibited":[173],"sIL-2R,":[177],"whereas":[178],"had":[180],"variable":[182],"effect.":[183],"Recombinant":[184],"IL-2":[185],"augment":[189],"even":[194],"very":[196],"low":[197],"doses,":[198],"it":[200],"did":[201],"not":[202,259],"alter":[203],"significantly":[204],"MLR-induced":[205,229],"The":[208],"addition":[209],"rIL-2":[211,240],"also":[219],"reverse":[222],"completely":[223],"Addition":[238,246],"reversed":[241],"partially":[243],"CsA-induced":[244],"inhibition.":[245],"different":[248],"concentrations":[249],"affect":[262],"conclude":[267],"response":[274],"alloantigens":[276],"is":[277],"IL-2-dependent":[279],"phenomenon,":[280],"determination":[282],"its":[284],"might":[286],"be":[287],"useful":[289],"indicator":[290],"vitro":[294],"vivo":[297],"alloantigen":[298],"responses":[299],"effectiveness":[303],"immunosuppressive":[305],"treatment.":[306]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
