{"id":"https://openalex.org/W1978121836","doi":"https://doi.org/10.1371/journal.pone.0099214","title":"A TRIP230-Retinoblastoma Protein Complex Regulates Hypoxia-Inducible Factor-1\u03b1-Mediated Transcription and Cancer Cell Invasion","display_name":"A TRIP230-Retinoblastoma Protein Complex Regulates Hypoxia-Inducible Factor-1\u03b1-Mediated Transcription and Cancer Cell Invasion","publication_year":2014,"publication_date":"2014-06-11","ids":{"openalex":"https://openalex.org/W1978121836","doi":"https://doi.org/10.1371/journal.pone.0099214","mag":"1978121836","pmid":"https://pubmed.ncbi.nlm.nih.gov/24919196","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4053355"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0099214","doi":"https://doi.org/10.1371/journal.pone.0099214","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0099214","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0099214&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0099214&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068120375","display_name":"Mark P. Labrecque","orcid":"https://orcid.org/0000-0001-7887-7599","observed_orcids":["https://orcid.org/0000-0001-7887-7599"]},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mark P. Labrecque","raw_affiliation_strings":["Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada","Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, #N#Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada","institution_ids":["https://openalex.org/I18014758"]},{"raw_affiliation_string":"Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, #N#Canada","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069536069","display_name":"Mandeep Takhar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mandeep K. Takhar","raw_affiliation_strings":["Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada","Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, #N#Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada","institution_ids":["https://openalex.org/I18014758"]},{"raw_affiliation_string":"Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, #N#Canada","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063706392","display_name":"Julienne M. Jagdeo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Julienne M. Jagdeo","raw_affiliation_strings":["Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada","Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, #N#Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada","institution_ids":["https://openalex.org/I18014758"]},{"raw_affiliation_string":"Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, #N#Canada","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033148309","display_name":"Kevin J. Tam","orcid":"https://orcid.org/0000-0003-2871-8738","observed_orcids":["https://orcid.org/0000-0003-2871-8738"]},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kevin J. Tam","raw_affiliation_strings":["Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada","Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, #N#Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada","institution_ids":["https://openalex.org/I18014758"]},{"raw_affiliation_string":"Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, #N#Canada","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Christina Chiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Christina Chiu","raw_affiliation_strings":["Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada","Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, #N#Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada","institution_ids":["https://openalex.org/I18014758"]},{"raw_affiliation_string":"Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, #N#Canada","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018940203","display_name":"Te-Yu Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Te-Yu Wang","raw_affiliation_strings":["Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada","Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, #N#Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada","institution_ids":["https://openalex.org/I18014758"]},{"raw_affiliation_string":"Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, #N#Canada","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037431244","display_name":"Gratien G. Pr\u00e9fontaine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gratien G. Prefontaine","raw_affiliation_strings":["Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada","Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, #N#Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada","institution_ids":["https://openalex.org/I18014758"]},{"raw_affiliation_string":"Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, #N#Canada","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101825863","display_name":"Michael Cox","orcid":"https://orcid.org/0000-0001-6468-6046","observed_orcids":["https://orcid.org/0000-0001-6468-6046"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4405261103","display_name":"Vancouver Prostate Centre","ror":"https://ror.org/04skhpe58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405261103"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michael E. Cox","raw_affiliation_strings":["Department of Urologic Sciences, The Vancouver Prostate Center, University of British Columbia, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urologic Sciences, The Vancouver Prostate Center, University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405261103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059735937","display_name":"Timothy V. Beischlag","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Timothy V. Beischlag","raw_affiliation_strings":["Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada","Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, #N#Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada","institution_ids":["https://openalex.org/I18014758"]},{"raw_affiliation_string":"Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, #N#Canada","institution_ids":["https://openalex.org/I18014758"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5059735937"],"corresponding_institution_ids":["https://openalex.org/I18014758"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.7148,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.65912726,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"9","issue":"6","first_page":"e99214","last_page":"e99214"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13426","display_name":"Kruppel-like factors research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinoblastoma-protein","display_name":"retinoblastoma protein","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hypoxia-inducible-factor-1alpha","display_name":"hypoxia-inducible factor-1\u03b1","score":0.8619999885559082},{"id":"https://openalex.org/keywords/aryl-hydrocarbon-receptor-nuclear-translocator","display_name":"ARNT","score":0.8130000233650208},{"id":"https://openalex.org/keywords/hypoxia-response","display_name":"hypoxia response","score":0.6570000052452087},{"id":"https://openalex.org/keywords/transcriptional-coactivation","display_name":"transcriptional coactivation","score":0.7789999842643738},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.7910000085830688},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8539999723434448},{"id":"https://openalex.org/keywords/tumor-hypoxia","display_name":"tumor hypoxia","score":0.7269999980926514},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.8870000243186951},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.40700000524520874}],"concepts":[{"id":"https://openalex.org/C2776577112","wikidata":"https://www.wikidata.org/wiki/Q500695","display_name":"Retinoblastoma","level":3,"score":0.6554667353630066},{"id":"https://openalex.org/C2776062698","wikidata":"https://www.wikidata.org/wiki/Q21111463","display_name":"Retinoblastoma protein","level":4,"score":0.6290571689605713},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6248874664306641},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5929490327835083},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.5627766251564026},{"id":"https://openalex.org/C45815257","wikidata":"https://www.wikidata.org/wiki/Q109984923","display_name":"Aryl hydrocarbon receptor nuclear translocator","level":5,"score":0.5449823141098022},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5137237310409546},{"id":"https://openalex.org/C2779081379","wikidata":"https://www.wikidata.org/wiki/Q7852677","display_name":"Tumor hypoxia","level":3,"score":0.47717514634132385},{"id":"https://openalex.org/C156902634","wikidata":"https://www.wikidata.org/wiki/Q5058346","display_name":"Cellular adaptation","level":3,"score":0.4310312271118164},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33647775650024414},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33371078968048096},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.24344074726104736},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.24222734570503235},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18545934557914734},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16162589192390442},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07373872399330139},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06944549083709717},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.0},{"id":"https://openalex.org/C33594762","wikidata":"https://www.wikidata.org/wiki/Q155750","display_name":"Aryl hydrocarbon receptor","level":4,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016160","descriptor_name":"Retinoblastoma Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016160","descriptor_name":"Retinoblastoma Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pone.0099214","doi":"https://doi.org/10.1371/journal.pone.0099214","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0099214","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0099214&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4053355","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4053355","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:24919196","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24919196","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:summit.sfu.ca:node-14985","doi":null,"is_oa":true,"landing_page_url":"https://summit.sfu.ca/_flysystem/fedora/sfu_migrate/14985/6.pdf","pdf_url":"https://summit.sfu.ca/_flysystem/fedora/sfu_migrate/14985/6.pdf","source":{"id":"https://openalex.org/S4306400490","display_name":"Summit (Simon Fraser University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I18014758","host_organization_name":"Simon Fraser University","host_organization_lineage":["https://openalex.org/I18014758"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.853.2608","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.853.2608","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.plosone.org/article/fetchObject.action?representation%3DPDF%26uri%3Dinfo%3Adoi/10.1371/journal.pone.0099214","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:e276625e12064928ae0b5aed567d1aed","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e276625e12064928ae0b5aed567d1aed","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 6, p e99214 (2014)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1053765","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_A_TRIP230_Retinoblastoma_Protein_Complex_Regulates_Hypoxia_Inducible_Factor_1_945_Mediated_Transcription_and_Cancer_Cell_Invasion_/1053765","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:summit.sfu.ca:14985","doi":null,"is_oa":true,"landing_page_url":"http://summit.sfu.ca/item/14985","pdf_url":null,"source":{"id":"https://openalex.org/S4306400490","display_name":"Summit (Simon Fraser University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I18014758","host_organization_name":"Simon Fraser University","host_organization_lineage":["https://openalex.org/I18014758"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0099214","doi":"https://doi.org/10.1371/journal.pone.0099214","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0099214","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0099214&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978121836.pdf","grobid_xml":"https://content.openalex.org/works/W1978121836.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1489168351","https://openalex.org/W1497143324","https://openalex.org/W1879346051","https://openalex.org/W1894737223","https://openalex.org/W1967600348","https://openalex.org/W1974258814","https://openalex.org/W1975545468","https://openalex.org/W1980475208","https://openalex.org/W1980790180","https://openalex.org/W1986960362","https://openalex.org/W1989006299","https://openalex.org/W1990234723","https://openalex.org/W1993624611","https://openalex.org/W1994743649","https://openalex.org/W1998329265","https://openalex.org/W2000650776","https://openalex.org/W2006579483","https://openalex.org/W2010802250","https://openalex.org/W2021334422","https://openalex.org/W2021863683","https://openalex.org/W2023338540","https://openalex.org/W2025395658","https://openalex.org/W2029425171","https://openalex.org/W2029644449","https://openalex.org/W2030869361","https://openalex.org/W2035159808","https://openalex.org/W2037082819","https://openalex.org/W2040951753","https://openalex.org/W2040960639","https://openalex.org/W2041360808","https://openalex.org/W2043858835","https://openalex.org/W2051531582","https://openalex.org/W2075811361","https://openalex.org/W2077848026","https://openalex.org/W2085658235","https://openalex.org/W2094249595","https://openalex.org/W2094897541","https://openalex.org/W2099742439","https://openalex.org/W2101911974","https://openalex.org/W2112425896","https://openalex.org/W2121548063","https://openalex.org/W2122068837","https://openalex.org/W2132251976","https://openalex.org/W2138412834","https://openalex.org/W2139593382","https://openalex.org/W2140607197","https://openalex.org/W2141631089","https://openalex.org/W2142013281","https://openalex.org/W2149706478","https://openalex.org/W2159963557","https://openalex.org/W2163214811","https://openalex.org/W2170432991","https://openalex.org/W2322582008","https://openalex.org/W2525832560"],"related_works":["https://openalex.org/W7097521708","https://openalex.org/W2491027990","https://openalex.org/W1743471075","https://openalex.org/W19381053","https://openalex.org/W2303686061","https://openalex.org/W2499543174","https://openalex.org/W2810724976","https://openalex.org/W3025678943","https://openalex.org/W1937657909","https://openalex.org/W7100134656"],"abstract_inverted_index":{"Localized":[0],"hypoxia":[1,73,113],"in":[2,34,101,121,132,142,191],"solid":[3],"tumors":[4],"activates":[5],"transcriptional":[6,144,196],"programs":[7],"that":[8,55,105,125,160],"promote":[9,126],"the":[10,20,42,62,68,72,79,90,108,176,182,186],"metastatic":[11,36,48],"transformation":[12],"of":[13,19,31,44,61,71,87,94,118,128,166,171,189],"cells.":[14,136],"Like":[15],"hypoxia-inducible":[16],"hyper-vascularization,":[17],"loss":[18,86,117],"retinoblastoma":[21],"protein":[22,83],"(Rb)":[23],"is":[24,57,140,162],"a":[25,58,163],"trait":[26],"common":[27],"to":[28,112],"advanced":[29],"stages":[30],"tumor":[32,192],"progression":[33],"many":[35],"cancers.":[37],"However,":[38],"no":[39],"link":[40,184],"between":[41,185],"role":[43],"Rb":[45,56,88,106,119,139,161,190],"and":[46,75,154,194,198],"hypoxia-driven":[47],"processes":[49],"has":[50],"been":[51],"established.":[52],"We":[53],"demonstrated":[54],"key":[59],"mediator":[60],"hypoxic":[63],"response":[64,111],"mediated":[65],"by":[66,114,151,169],"HIF1\u03b1/\u03b2,":[67],"master":[69],"regulator":[70],"response,":[74],"its":[76,172],"essential":[77],"co-activator,":[78],"thyroid":[80],"hormone":[81],"receptor/retinoblastoma-interacting":[82],"(TRIP230).":[84],"Furthermore,":[85],"unmasks":[89],"full":[91],"co-activation":[92],"potential":[93],"TRIP230.":[95],"Using":[96],"small":[97],"inhibitory":[98],"RNA":[99],"approaches":[100],"vivo,":[102],"we":[103],"established":[104],"attenuates":[107],"normal":[109],"physiological":[110],"HIF1\u03b1.":[115],"Notably,":[116],"results":[120,158],"hypoxia-dependent":[122],"biochemical":[123],"changes":[124],"acquisition":[127],"an":[129],"invasive":[130],"phenotype":[131],"MCF7":[133],"breast":[134],"cancer":[135],"In":[137],"addition,":[138],"present":[141],"HIF1\u03b1-ARNT/HIF1\u03b2":[143],"complexes":[145],"associated":[146],"with":[147],"TRIP230":[148],"as":[149],"determined":[150],"co-immuno-precipitation,":[152],"GST-pull-down":[153],"ChIP":[155],"assays.":[156],"These":[157],"demonstrate":[159],"negative":[164],"modulator":[165],"hypoxia-regulated":[167],"transcription":[168],"virtue":[170],"direct":[173],"effects":[174],"on":[175],"HIF1":[177],"complex.":[178],"This":[179],"work":[180],"represents":[181],"first":[183],"functional":[187],"ablation":[188],"cells":[193],"HIF1\u03b1-dependent":[195],"activation":[197],"invasion.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
