{"id":"https://openalex.org/W1978119458","doi":"https://doi.org/10.1371/journal.pone.0036003","title":"Sphingomyelinase D Activity in Model Membranes: Structural Effects of in situ Generation of Ceramide-1-Phosphate","display_name":"Sphingomyelinase D Activity in Model Membranes: Structural Effects of in situ Generation of Ceramide-1-Phosphate","publication_year":2012,"publication_date":"2012-04-25","ids":{"openalex":"https://openalex.org/W1978119458","doi":"https://doi.org/10.1371/journal.pone.0036003","mag":"1978119458","pmid":"https://pubmed.ncbi.nlm.nih.gov/22558302","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3338491"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0036003","doi":"https://doi.org/10.1371/journal.pone.0036003","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0036003","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0036003&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0036003&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089241562","display_name":"Roberto Pablo Stock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]},{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["DK","MX"],"is_corresponding":false,"raw_author_name":"Roberto P. Stock","raw_affiliation_strings":["Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Cuernavaca, Morelos, Mexico","Membrane Biophysics and Biophotonics Group/MEMPHYS, Department of Biochemistry and Molecular Biology, Center for Biomembrane Physics, University of Southern Denmark, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Cuernavaca, Morelos, Mexico","institution_ids":["https://openalex.org/I8961855"]},{"raw_affiliation_string":"Membrane Biophysics and Biophotonics Group/MEMPHYS, Department of Biochemistry and Molecular Biology, Center for Biomembrane Physics, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017975271","display_name":"Jonathan Richard Brewer","orcid":"https://orcid.org/0000-0002-3444-1715","observed_orcids":["https://orcid.org/0000-0002-3444-1715"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jonathan Brewer","raw_affiliation_strings":["Membrane Biophysics and Biophotonics Group/MEMPHYS, Department of Biochemistry and Molecular Biology, Center for Biomembrane Physics, University of Southern Denmark, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Membrane Biophysics and Biophotonics Group/MEMPHYS, Department of Biochemistry and Molecular Biology, Center for Biomembrane Physics, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109946711","display_name":"Kerstin Wagner","orcid":"https://orcid.org/0000-0002-6182-2142","observed_orcids":["https://orcid.org/0000-0002-6182-2142"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Kerstin Wagner","raw_affiliation_strings":["Membrane Biophysics and Biophotonics Group/MEMPHYS, Department of Biochemistry and Molecular Biology, Center for Biomembrane Physics, University of Southern Denmark, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Membrane Biophysics and Biophotonics Group/MEMPHYS, Department of Biochemistry and Molecular Biology, Center for Biomembrane Physics, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067055123","display_name":"Blanca Ramos\u2010Cerrillo","orcid":"https://orcid.org/0000-0002-4155-4873","observed_orcids":["https://orcid.org/0000-0002-4155-4873"]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Blanca Ramos-Cerrillo","raw_affiliation_strings":["Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Cuernavaca, Morelos, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Cuernavaca, Morelos, Mexico","institution_ids":["https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003486286","display_name":"Lars Duelund","orcid":"https://orcid.org/0000-0002-3786-2822","observed_orcids":["https://orcid.org/0000-0002-3786-2822"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Lars Duelund","raw_affiliation_strings":["MEMPHYS, Department of Physics, Chemistry and Pharmacy, Center for Biomembrane Physics, University of Southern Denmark, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MEMPHYS, Department of Physics, Chemistry and Pharmacy, Center for Biomembrane Physics, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083022870","display_name":"Kit Drescher Jernsh\u00f8j","orcid":"https://orcid.org/0000-0003-3697-2170","observed_orcids":["https://orcid.org/0000-0003-3697-2170"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Kit Drescher Jernsh\u00f8j","raw_affiliation_strings":["Cellular Complexity Group (CelCom), Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Complexity Group (CelCom), Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068328382","display_name":"Lars Folke Olsen","orcid":"https://orcid.org/0000-0001-7391-2340","observed_orcids":["https://orcid.org/0000-0001-7391-2340"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Lars Folke Olsen","raw_affiliation_strings":["Cellular Complexity Group (CelCom), Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Complexity Group (CelCom), Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002764364","display_name":"Lu\u00eds A. Bagatolli","orcid":"https://orcid.org/0000-0002-4727-8611","observed_orcids":["https://orcid.org/0000-0002-4727-8611"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Luis A. Bagatolli","raw_affiliation_strings":["Membrane Biophysics and Biophotonics Group/MEMPHYS, Department of Biochemistry and Molecular Biology, Center for Biomembrane Physics, University of Southern Denmark, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Membrane Biophysics and Biophotonics Group/MEMPHYS, Department of Biochemistry and Molecular Biology, Center for Biomembrane Physics, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5002764364"],"corresponding_institution_ids":["https://openalex.org/I177969490"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.2288,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.75999258,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"7","issue":"4","first_page":"e36003","last_page":"e36003"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.03720000013709068,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sphingomyelinase-d","display_name":"sphingomyelinase D","score":1.0},{"id":"https://openalex.org/keywords/ceramide-1-phosphate","display_name":"ceramide-1-phosphate","score":0.9160000085830688},{"id":"https://openalex.org/keywords/sphingomyelin","display_name":"sphingomyelin","score":0.8130000233650208},{"id":"https://openalex.org/keywords/model-membranes","display_name":"model membranes","score":0.734000027179718},{"id":"https://openalex.org/keywords/lipid-rafts","display_name":"lipid rafts","score":0.7900000214576721},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.7210000157356262},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.5619999766349792},{"id":"https://openalex.org/keywords/giant-unilamellar-vesicles","display_name":"giant unilamellar vesicles","score":0.8379999995231628},{"id":"https://openalex.org/keywords/dermonecrosis","display_name":"dermonecrosis","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C61322309","wikidata":"https://www.wikidata.org/wiki/Q423143","display_name":"Sphingomyelin","level":3,"score":0.963067889213562},{"id":"https://openalex.org/C2777851122","wikidata":"https://www.wikidata.org/wiki/Q424213","display_name":"Ceramide","level":3,"score":0.8979998826980591},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.6395318508148193},{"id":"https://openalex.org/C2781070647","wikidata":"https://www.wikidata.org/wiki/Q413230","display_name":"Sphingomyelin phosphodiesterase","level":4,"score":0.5917881727218628},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.5756837725639343},{"id":"https://openalex.org/C61705674","wikidata":"https://www.wikidata.org/wiki/Q410395","display_name":"Sphingolipid","level":2,"score":0.5395260453224182},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.49852895736694336},{"id":"https://openalex.org/C180899940","wikidata":"https://www.wikidata.org/wiki/Q117982","display_name":"Lipid signaling","level":3,"score":0.44944408535957336},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43587854504585266},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4099493622779846},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.36602967977523804},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3312099575996399},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002152","descriptor_name":"Calorimetry, Differential Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002518","descriptor_name":"Ceramides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002518","descriptor_name":"Ceramides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007848","descriptor_name":"Laurates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008567","descriptor_name":"Membranes, Artificial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010713","descriptor_name":"Phosphatidylcholines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010727","descriptor_name":"Phosphoric Diester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012542","descriptor_name":"Scattering, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013109","descriptor_name":"Sphingomyelins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013112","descriptor_name":"Spiders","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015081","descriptor_name":"2-Naphthylamine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D015081","descriptor_name":"2-Naphthylamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D031541","descriptor_name":"Fluorescence Resonance Energy Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053835","descriptor_name":"Unilamellar Liposomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0036003","doi":"https://doi.org/10.1371/journal.pone.0036003","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0036003","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0036003&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmid:22558302","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22558302","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3338491","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3338491/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.788.4746","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.788.4746","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/46/a5/pone.0036003.PMC3338491.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:3a9b101bb0504fa5824254d616616222","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3a9b101bb0504fa5824254d616616222","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 4, p e36003 (2012)","raw_type":"article"},{"id":"pmh:oai:sdu.dk:openaire_cris_publications/5abbface-8aff-429a-9021-06cc64375ffb","doi":null,"is_oa":false,"landing_page_url":"https://portal.findresearcher.sdu.dk/da/publications/5abbface-8aff-429a-9021-06cc64375ffb","pdf_url":null,"source":{"id":"https://openalex.org/S4306400423","display_name":"University of Southern Denmark Research Portal (University of Southern Denmark)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177969490","host_organization_name":"University of Southern Denmark","host_organization_lineage":["https://openalex.org/I177969490"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Stock, R, Brewer, J R, Wagner, K, Ramos-Cerrillo, B, Duelund, L, Jernsh\u00f8j, K D, Olsen, L F & Bagatolli, L 2012, 'Sphingomyelinase D activity in model membranes: structural effects of in situ generation of ceramide-1-phosphate', PLOS ONE, vol. 7, no. 4, pp. 1-15 (e-36003). < http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0036003 >","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0036003","doi":"https://doi.org/10.1371/journal.pone.0036003","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0036003","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0036003&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4158202031","display_name":"The study of membrane phenomena caused by sphingomyelinase D from spider venoms","funder_award_id":"236688","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320320943","display_name":"Danmarks Grundforskningsfond","ror":"https://ror.org/00znyv691"},{"id":"https://openalex.org/F4320323799","display_name":"Syddansk Universitet","ror":"https://ror.org/03yrrjy16"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978119458.pdf","grobid_xml":"https://content.openalex.org/works/W1978119458.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W1229372959","https://openalex.org/W1484830982","https://openalex.org/W1510210099","https://openalex.org/W1513897103","https://openalex.org/W1529759862","https://openalex.org/W1586833407","https://openalex.org/W1964305754","https://openalex.org/W1965704337","https://openalex.org/W1971852751","https://openalex.org/W1972701314","https://openalex.org/W1973892869","https://openalex.org/W1974092461","https://openalex.org/W1974772611","https://openalex.org/W1974913746","https://openalex.org/W1978996581","https://openalex.org/W1981984118","https://openalex.org/W1982533264","https://openalex.org/W1988952795","https://openalex.org/W1989184602","https://openalex.org/W1992032029","https://openalex.org/W1993395883","https://openalex.org/W2000472852","https://openalex.org/W2001642480","https://openalex.org/W2007279705","https://openalex.org/W2008242531","https://openalex.org/W2011093544","https://openalex.org/W2018622490","https://openalex.org/W2022092745","https://openalex.org/W2022793196","https://openalex.org/W2026330708","https://openalex.org/W2030765885","https://openalex.org/W2031291372","https://openalex.org/W2032315776","https://openalex.org/W2035640598","https://openalex.org/W2049656197","https://openalex.org/W2051264547","https://openalex.org/W2054071979","https://openalex.org/W2056848910","https://openalex.org/W2061631057","https://openalex.org/W2068038495","https://openalex.org/W2068592796","https://openalex.org/W2068672794","https://openalex.org/W2072677086","https://openalex.org/W2073554187","https://openalex.org/W2076723104","https://openalex.org/W2081594405","https://openalex.org/W2082698221","https://openalex.org/W2083243207","https://openalex.org/W2089833507","https://openalex.org/W2090732296","https://openalex.org/W2097790844","https://openalex.org/W2098280274","https://openalex.org/W2099925238","https://openalex.org/W2101040824","https://openalex.org/W2111631843","https://openalex.org/W2115025939","https://openalex.org/W2127202162","https://openalex.org/W2135740694","https://openalex.org/W2146439388","https://openalex.org/W2150087688","https://openalex.org/W2153211631","https://openalex.org/W2153435210","https://openalex.org/W2159301814","https://openalex.org/W2169082359","https://openalex.org/W2237164154","https://openalex.org/W4229712971"],"related_works":["https://openalex.org/W2051535628","https://openalex.org/W2094413806","https://openalex.org/W2079974278","https://openalex.org/W3025860263","https://openalex.org/W2048279611","https://openalex.org/W2081629852","https://openalex.org/W2049926206","https://openalex.org/W1984927266","https://openalex.org/W1964999852","https://openalex.org/W2039298438"],"abstract_inverted_index":{"The":[0,20,69,102,130],"toxicity":[1],"of":[2,22,36,48,71,99,104,111,117,123,152,160,170,191],"Loxosceles":[3,59],"spider":[4,58],"venom":[5],"has":[6],"been":[7],"attributed":[8],"to":[9,18],"a":[10,52,97,146],"rare":[11],"enzyme,":[12],"sphingomyelinase":[13,54,161],"D,":[14],"which":[15],"transforms":[16],"sphingomyelin":[17,66,127,143],"ceramide-1-phosphate.":[19],"bases":[21],"its":[23,171],"inflammatory":[24],"and":[25,61,67,84,88,114,149,189],"dermonecrotic":[26],"activity,":[27],"however,":[28],"remain":[29],"unclear.":[30],"In":[31],"this":[32,49],"work":[33],"the":[34,57,109,115,121,158,167,186,192],"effects":[35],"ceramide-1-phosphate":[37,135,179],"on":[38,108,120],"model":[39],"membranes":[40,125,174],"were":[41,73,128],"studied":[42],"both":[43],"by":[44,62,166,181],"in":[45,145,173,177],"situ":[46,178],"generation":[47,180],"lipid":[50],"using":[51,96],"recombinant":[53],"D":[55,162],"from":[56],"laeta":[60],"pre-mixing":[63],"it":[64],"with":[65],"cholesterol.":[68],"systems":[70],"choice":[72],"large":[74],"unilamellar":[75,90],"vesicles":[76,91],"for":[77,92],"bulk":[78],"studies":[79],"(enzyme":[80],"kinetics,":[81],"fluorescence":[82,93],"spectroscopy":[83],"dynamic":[85],"light":[86],"scattering)":[87],"giant":[89],"microscopy":[94],"examination":[95],"variety":[98],"fluorescent":[100],"probes.":[101],"influence":[103],"membrane":[105],"lateral":[106,187],"structure":[107,122,188],"kinetics":[110],"enzyme":[112,118],"activity":[113,119,159,183],"consequences":[116],"target":[124,193],"containing":[126],"examined.":[129],"findings":[131],"indicate":[132],"that:":[133],"1)":[134],"(particularly":[136],"lauroyl":[137],"ceramide-1-phosphate)":[138],"can":[139],"be":[140],"incorporated":[141],"into":[142],"bilayers":[144],"concentration-dependent":[147],"manner":[148],"generates":[150],"coexistence":[151],"liquid":[153],"disordered/solid":[154],"ordered":[155],"domains,":[156],"2)":[157],"is":[163],"clearly":[164],"influenced":[165],"supramolecular":[168],"organization":[169],"substrate":[172],"and,":[175],"3)":[176],"enzymatic":[182],"profoundly":[184],"alters":[185],"morphology":[190],"membranes.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}