{"id":"https://openalex.org/W1978115234","doi":"https://doi.org/10.1021/ol049942p","title":"An Approach to Pancratistatins via Ring-Closing Metathesis: Efficient Synthesis of Novel 1-Aryl-1-deoxyconduritols F","display_name":"An Approach to Pancratistatins via Ring-Closing Metathesis: Efficient Synthesis of Novel 1-Aryl-1-deoxyconduritols F","publication_year":2004,"publication_date":"2004-01-31","ids":{"openalex":"https://openalex.org/W1978115234","doi":"https://doi.org/10.1021/ol049942p","mag":"1978115234","pmid":"https://pubmed.ncbi.nlm.nih.gov/14986986"},"language":"en","primary_location":{"id":"doi:10.1021/ol049942p","doi":"https://doi.org/10.1021/ol049942p","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ol049942p","pdf_url":null,"source":{"id":"https://openalex.org/S201989124","display_name":"Organic Letters","issn_l":"1523-7052","issn":["1523-7052","1523-7060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066264938","display_name":"\u041e\u043b\u0435\u0433 \u041d. \u041d\u0430\u0434\u0435\u0438\u043d","orcid":"https://orcid.org/0000-0003-4461-1674","observed_orcids":["https://orcid.org/0000-0003-4461-1674"]},"institutions":[{"id":"https://openalex.org/I207123951","display_name":"New Mexico Institute of Mining and Technology","ror":"https://ror.org/005p9kw61","country_code":"US","type":"education","lineage":["https://openalex.org/I207123951"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oleg N. Nadein","raw_affiliation_strings":["Department of Chemistry, New Mexico Institute of Mining and Technology, Socorro, New Mexico 87801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, New Mexico Institute of Mining and Technology, Socorro, New Mexico 87801","institution_ids":["https://openalex.org/I207123951"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009000319","display_name":"Alexander Kornienko","orcid":"https://orcid.org/0000-0003-2041-7367","observed_orcids":["https://orcid.org/0000-0003-2041-7367"]},"institutions":[{"id":"https://openalex.org/I207123951","display_name":"New Mexico Institute of Mining and Technology","ror":"https://ror.org/005p9kw61","country_code":"US","type":"education","lineage":["https://openalex.org/I207123951"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Kornienko","raw_affiliation_strings":["Department of Chemistry, New Mexico Institute of Mining and Technology, Socorro, New Mexico 87801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, New Mexico Institute of Mining and Technology, Socorro, New Mexico 87801","institution_ids":["https://openalex.org/I207123951"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I207123951"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.7883,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.93615941,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"6","issue":"5","first_page":"831","last_page":"834"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11549","display_name":"Synthetic Organic Chemistry Methods","score":0.4120999872684479,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11549","display_name":"Synthetic Organic Chemistry Methods","score":0.4120999872684479,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.34200000762939453,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13124","display_name":"Chemical synthesis and alkaloids","score":0.06669999659061432,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancratistatin","display_name":"pancratistatin","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cyclitols","display_name":"cyclitols","score":0.9340000152587891},{"id":"https://openalex.org/keywords/ring-closing-metathesis","display_name":"ring-closing metathesis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/d-xylose","display_name":"D-xylose","score":0.8820000290870667},{"id":"https://openalex.org/keywords/total-synthesis","display_name":"total synthesis","score":0.6159999966621399},{"id":"https://openalex.org/keywords/anticancer-alkaloids","display_name":"antitumor alkaloids","score":0.9470000267028809},{"id":"https://openalex.org/keywords/stereocontrol","display_name":"stereocontrol","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8342381715774536},{"id":"https://openalex.org/C2778523565","wikidata":"https://www.wikidata.org/wiki/Q3008453","display_name":"Cyclitol","level":4,"score":0.7062418460845947},{"id":"https://openalex.org/C2781076698","wikidata":"https://www.wikidata.org/wiki/Q718074","display_name":"Aryl","level":3,"score":0.6729778051376343},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.552703320980072},{"id":"https://openalex.org/C35753019","wikidata":"https://www.wikidata.org/wiki/Q644785","display_name":"Total synthesis","level":2,"score":0.48870041966438293},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.45930254459381104},{"id":"https://openalex.org/C2778593322","wikidata":"https://www.wikidata.org/wiki/Q7334670","display_name":"Ring-closing metathesis","level":5,"score":0.45468640327453613},{"id":"https://openalex.org/C153914509","wikidata":"https://www.wikidata.org/wiki/Q191090","display_name":"Metathesis","level":4,"score":0.45466911792755127},{"id":"https://openalex.org/C90150868","wikidata":"https://www.wikidata.org/wiki/Q39513","display_name":"Alkoxy group","level":3,"score":0.449749231338501},{"id":"https://openalex.org/C2780378348","wikidata":"https://www.wikidata.org/wiki/Q25351438","display_name":"Ring (chemistry)","level":2,"score":0.4140205383300781},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.208118736743927},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2777427919","wikidata":"https://www.wikidata.org/wiki/Q407997","display_name":"Inositol","level":3,"score":0.0},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.0},{"id":"https://openalex.org/C44228677","wikidata":"https://www.wikidata.org/wiki/Q181898","display_name":"Polymerization","level":3,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D003500","descriptor_name":"Cyclization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005960","descriptor_name":"Glucosides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007546","descriptor_name":"Isoquinolines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014994","descriptor_name":"Xylose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047151","descriptor_name":"Amaryllidaceae Alkaloids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/ol049942p","doi":"https://doi.org/10.1021/ol049942p","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ol049942p","pdf_url":null,"source":{"id":"https://openalex.org/S201989124","display_name":"Organic Letters","issn_l":"1523-7052","issn":["1523-7052","1523-7060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Letters","raw_type":"journal-article"},{"id":"pmid:14986986","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14986986","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1200708010","display_name":null,"funder_award_id":"CA 99957","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1958911861","display_name":"Enantiodivergent Synthesis of (+) and (-) Pancratistatin","funder_award_id":"R15CA099957","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1584780350","https://openalex.org/W1963518452","https://openalex.org/W1964086956","https://openalex.org/W1966704714","https://openalex.org/W1972645496","https://openalex.org/W1997093700","https://openalex.org/W2010732799","https://openalex.org/W2013586137","https://openalex.org/W2027959733","https://openalex.org/W2030236016","https://openalex.org/W2044125881","https://openalex.org/W2076952931","https://openalex.org/W2083247038","https://openalex.org/W2130642047","https://openalex.org/W2169766834","https://openalex.org/W2951748396","https://openalex.org/W2951772309","https://openalex.org/W2952349963","https://openalex.org/W2952452033"],"related_works":["https://openalex.org/W2129821810","https://openalex.org/W2014920481","https://openalex.org/W2044901466","https://openalex.org/W2023539276","https://openalex.org/W1997372088","https://openalex.org/W2950733362","https://openalex.org/W2169766834","https://openalex.org/W1995329915","https://openalex.org/W1999901660","https://openalex.org/W1965587687"],"abstract_inverted_index":{"Structurally":[0],"novel":[1],"cyclitols,":[2],"1-aryl-1-deoxyconduritols":[3],"F,":[4],"were":[5,19],"efficiently":[6],"prepared":[7],"from":[8],"d-xylose,":[9],"utilizing":[10,29],"RCM":[11],"as":[12],"a":[13,30,36,43,47],"key":[14],"step.":[15],"Various":[16],"aromatic":[17],"residues":[18],"incorporated":[20],"in":[21],"the":[22,51],"cyclitol":[23],"skeleton":[24],"with":[25],"total":[26],"stereochemical":[27],"control,":[28],"diastereoselective":[31],"aryl":[32,57],"cuprate":[33],"addition":[34],"to":[35],"gamma-alkoxy":[37],"enoate.":[38],"The":[39],"synthetic":[40],"route":[41],"establishes":[42],"firm":[44],"foundation":[45],"for":[46],"practical":[48],"synthesis":[49],"of":[50],"antitumor":[52],"alkaloid":[53],"pancratistatin":[54],"and":[55],"its":[56],"analogues.":[58],"[structure:":[59],"see":[60],"text]":[61]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}