{"id":"https://openalex.org/W1978111954","doi":"https://doi.org/10.1161/strokeaha.111.622225","title":"Can Genes Modify Stroke Outcome and By What Mechanisms?","display_name":"Can Genes Modify Stroke Outcome and By What Mechanisms?","publication_year":2011,"publication_date":"2011-12-09","ids":{"openalex":"https://openalex.org/W1978111954","doi":"https://doi.org/10.1161/strokeaha.111.622225","mag":"1978111954","pmid":"https://pubmed.ncbi.nlm.nih.gov/22156698","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3282466"},"language":"en","primary_location":{"id":"doi:10.1161/strokeaha.111.622225","doi":"https://doi.org/10.1161/strokeaha.111.622225","is_oa":true,"landing_page_url":"https://doi.org/10.1161/strokeaha.111.622225","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/STROKEAHA.111.622225","source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/STROKEAHA.111.622225","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069808116","display_name":"Roger Pancoast Simon","orcid":"https://orcid.org/0000-0001-7287-6915","observed_orcids":["https://orcid.org/0000-0001-7287-6915"]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]},{"id":"https://openalex.org/I6332465","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64","country_code":"US","type":"education","lineage":["https://openalex.org/I6332465"]}],"countries":["IE","US"],"is_corresponding":false,"raw_author_name":"Roger P. Simon","raw_affiliation_strings":["From the Morehouse School of Medicine (R.P.S., R.M., A.Z.), the Neuroscience Institute, Atlanta, GA; Royal College of Surgeons in Ireland (D.H.), Dublin, Ireland","Royal College of Surgeons in Ireland (D.H.), Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Morehouse School of Medicine (R.P.S., R.M., A.Z.), the Neuroscience Institute, Atlanta, GA; Royal College of Surgeons in Ireland (D.H.), Dublin, Ireland","institution_ids":["https://openalex.org/I142762351","https://openalex.org/I6332465"]},{"raw_affiliation_string":"Royal College of Surgeons in Ireland (D.H.), Dublin, Ireland","institution_ids":["https://openalex.org/I142762351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070403963","display_name":"Robert Meller","orcid":"https://orcid.org/0000-0003-3528-8019","observed_orcids":["https://orcid.org/0000-0003-3528-8019"]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]},{"id":"https://openalex.org/I6332465","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64","country_code":"US","type":"education","lineage":["https://openalex.org/I6332465"]}],"countries":["IE","US"],"is_corresponding":false,"raw_author_name":"Robert Meller","raw_affiliation_strings":["From the Morehouse School of Medicine (R.P.S., R.M., A.Z.), the Neuroscience Institute, Atlanta, GA; Royal College of Surgeons in Ireland (D.H.), Dublin, Ireland","Royal College of Surgeons in Ireland (D.H.), Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Morehouse School of Medicine (R.P.S., R.M., A.Z.), the Neuroscience Institute, Atlanta, GA; Royal College of Surgeons in Ireland (D.H.), Dublin, Ireland","institution_ids":["https://openalex.org/I142762351","https://openalex.org/I6332465"]},{"raw_affiliation_string":"Royal College of Surgeons in Ireland (D.H.), Dublin, Ireland","institution_ids":["https://openalex.org/I142762351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090960111","display_name":"An Zhou","orcid":"https://orcid.org/0000-0002-9358-8012","observed_orcids":["https://orcid.org/0000-0002-9358-8012","https://orcid.org/0000-0001-6649-5606"]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]},{"id":"https://openalex.org/I6332465","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64","country_code":"US","type":"education","lineage":["https://openalex.org/I6332465"]}],"countries":["IE","US"],"is_corresponding":false,"raw_author_name":"An Zhou","raw_affiliation_strings":["From the Morehouse School of Medicine (R.P.S., R.M., A.Z.), the Neuroscience Institute, Atlanta, GA; Royal College of Surgeons in Ireland (D.H.), Dublin, Ireland","Royal College of Surgeons in Ireland (D.H.), Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Morehouse School of Medicine (R.P.S., R.M., A.Z.), the Neuroscience Institute, Atlanta, GA; Royal College of Surgeons in Ireland (D.H.), Dublin, Ireland","institution_ids":["https://openalex.org/I142762351","https://openalex.org/I6332465"]},{"raw_affiliation_string":"Royal College of Surgeons in Ireland (D.H.), Dublin, Ireland","institution_ids":["https://openalex.org/I142762351"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002978004","display_name":"David Clifford Henshall","orcid":"https://orcid.org/0000-0001-6237-9632","observed_orcids":["https://orcid.org/0000-0001-6237-9632"]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]},{"id":"https://openalex.org/I6332465","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64","country_code":"US","type":"education","lineage":["https://openalex.org/I6332465"]}],"countries":["IE","US"],"is_corresponding":false,"raw_author_name":"David Henshall","raw_affiliation_strings":["From the Morehouse School of Medicine (R.P.S., R.M., A.Z.), the Neuroscience Institute, Atlanta, GA; Royal College of Surgeons in Ireland (D.H.), Dublin, Ireland","Royal College of Surgeons in Ireland (D.H.), Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Morehouse School of Medicine (R.P.S., R.M., A.Z.), the Neuroscience Institute, Atlanta, GA; Royal College of Surgeons in Ireland (D.H.), Dublin, Ireland","institution_ids":["https://openalex.org/I142762351","https://openalex.org/I6332465"]},{"raw_affiliation_string":"Royal College of Surgeons in Ireland (D.H.), Dublin, Ireland","institution_ids":["https://openalex.org/I142762351"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1766,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.76795217,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"43","issue":"1","first_page":"286","last_page":"291"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.6265000104904175,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.6265000104904175,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.19099999964237213,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.029100000858306885,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.7860000133514404},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8169999718666077},{"id":"https://openalex.org/keywords/ischemic-tolerance","display_name":"ischemic tolerance","score":0.7519999742507935},{"id":"https://openalex.org/keywords/preconditioning","display_name":"preconditioning","score":0.7689999938011169},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6940000057220459},{"id":"https://openalex.org/keywords/ischemic-brain-injury","display_name":"ischemic brain injury","score":0.8080000281333923},{"id":"https://openalex.org/keywords/transient-ischemic-attack","display_name":"transient ischemic attack","score":0.8169999718666077},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.4169999957084656}],"concepts":[{"id":"https://openalex.org/C2778037673","wikidata":"https://www.wikidata.org/wiki/Q4034536","display_name":"Atlanta","level":3,"score":0.7884702682495117},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7122575640678406},{"id":"https://openalex.org/C74916050","wikidata":"https://www.wikidata.org/wiki/Q841090","display_name":"Classics","level":1,"score":0.3887462913990021},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.34787821769714355},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.12970316410064697},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10849785804748535},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C158739034","wikidata":"https://www.wikidata.org/wiki/Q1907114","display_name":"Metropolitan area","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1161/strokeaha.111.622225","doi":"https://doi.org/10.1161/strokeaha.111.622225","is_oa":true,"landing_page_url":"https://doi.org/10.1161/strokeaha.111.622225","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/STROKEAHA.111.622225","source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},{"id":"pmid:22156698","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22156698","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2531547","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3282466","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3282466","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3282466","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Stroke","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1161/strokeaha.111.622225","doi":"https://doi.org/10.1161/strokeaha.111.622225","is_oa":true,"landing_page_url":"https://doi.org/10.1161/strokeaha.111.622225","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/STROKEAHA.111.622225","source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1430487935","display_name":"Rapid ischemic tolerance: Synaptic re-organization and reduced excitotoxicity","funder_award_id":"R01NS059588","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G1673703941","display_name":"Morehouse School of Medicine Center of Excellence Research Endowment Program","funder_award_id":"S21MD000101","funder_id":"https://openalex.org/F4320337534","funder_display_name":"National Institute on Minority Health and Health Disparities"},{"id":"https://openalex.org/G4341343528","display_name":"Molecular mechanisms of seizure induced brain injury","funder_award_id":"R01NS039016","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4658142325","display_name":"Morehouse School of Medicine G12 Multidisciplinary Biomedical Research Center","funder_award_id":"G12RR003034","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G557927960","display_name":"Molecular Mechanisms of Ischemia","funder_award_id":"P01NS035965","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6832070455","display_name":"Brain ischemia attenuates neuropeptide biosynthesis","funder_award_id":"R01NS046560","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7549037155","display_name":"RCMI Infrastructure for Clinical and Translational Research (RCTR) (U54)","funder_award_id":"U54MD007588","funder_id":"https://openalex.org/F4320337534","funder_display_name":"National Institute on Minority Health and Health Disparities"},{"id":"https://openalex.org/G7883401512","display_name":"RCMI Infrastructure for Clinical and Translational Research (RCTR) (U54)","funder_award_id":"U54RR026137","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337534","display_name":"National Institute on Minority Health and Health Disparities","ror":"https://ror.org/0493hgw16"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978111954.pdf","grobid_xml":"https://content.openalex.org/works/W1978111954.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W197659602","https://openalex.org/W1553653089","https://openalex.org/W1964613871","https://openalex.org/W1964965126","https://openalex.org/W1969104747","https://openalex.org/W1973065553","https://openalex.org/W1977836335","https://openalex.org/W1978688347","https://openalex.org/W1980847964","https://openalex.org/W1985098845","https://openalex.org/W1996721095","https://openalex.org/W2005027470","https://openalex.org/W2009076537","https://openalex.org/W2009802273","https://openalex.org/W2014946489","https://openalex.org/W2016079510","https://openalex.org/W2016112105","https://openalex.org/W2021008015","https://openalex.org/W2022508345","https://openalex.org/W2024289624","https://openalex.org/W2034273710","https://openalex.org/W2036427175","https://openalex.org/W2038707186","https://openalex.org/W2039298489","https://openalex.org/W2045830695","https://openalex.org/W2047324209","https://openalex.org/W2049451829","https://openalex.org/W2050381480","https://openalex.org/W2050798868","https://openalex.org/W2059464380","https://openalex.org/W2060699509","https://openalex.org/W2063175209","https://openalex.org/W2064888885","https://openalex.org/W2066170392","https://openalex.org/W2070932938","https://openalex.org/W2075853235","https://openalex.org/W2078016508","https://openalex.org/W2081440091","https://openalex.org/W2082959814","https://openalex.org/W2085199321","https://openalex.org/W2086085458","https://openalex.org/W2087561636","https://openalex.org/W2088388005","https://openalex.org/W2089582877","https://openalex.org/W2103278596","https://openalex.org/W2103724228","https://openalex.org/W2103839002","https://openalex.org/W2108775383","https://openalex.org/W2117349597","https://openalex.org/W2143563339","https://openalex.org/W2144806891","https://openalex.org/W2148250994","https://openalex.org/W2151407865","https://openalex.org/W2153872342","https://openalex.org/W2155891625","https://openalex.org/W2157368934","https://openalex.org/W2160519338","https://openalex.org/W2161456882","https://openalex.org/W2162148277","https://openalex.org/W2166660871","https://openalex.org/W7074230359"],"related_works":["https://openalex.org/W2023756758","https://openalex.org/W2003003100","https://openalex.org/W2085203835","https://openalex.org/W2011666013","https://openalex.org/W2500596872","https://openalex.org/W2143563339","https://openalex.org/W198805067","https://openalex.org/W2154530383","https://openalex.org/W2038707186","https://openalex.org/W7127436677"],"abstract_inverted_index":{"T":[0],"he":[1],"approach":[2,25,56],"to":[3,44,58,113,118],"neuroprotection":[4,138],"in":[5,80,105,144,151,153,161,197,202,205],"stroke":[6,64,73,152],"has":[7,26,141],"relied":[8],"mainly":[9,218],"on":[10,134],"exogenously":[11],"administered":[12],"drugs":[13],"derived":[14],"from":[15,219],"research":[16],"probing":[17],"the":[18,81,93,106,154,207,220],"cellular":[19],"mechanisms":[20,209],"of":[21,95,108,139,183],"ischemic":[22,66,98,109,122,168],"brain":[23,67,83],"injury.This":[24],"had":[27],"limited":[28],"translational":[29],"impact.Over":[30],"1000":[31],"putative":[32],"neuroprotective":[33,61,91,100],"agents":[34,41],"have":[35,42,48,87,170,179],"been":[36,142],"developed,":[37],"and":[38,72,84,132,150,185,204,222],"over":[39],"100":[40],"advanced":[43],"clinical":[45,50,157,177],"trials.None,":[46],"however,":[47],"shown":[49,180],"efficacy.":[51],"1y":[52],"contrast,":[53],"a":[54,119],"gene-based":[55],"seeks":[57],"harness":[59],"endogenous":[60,90],"programs":[62,101],"for":[63],"therapy.Experimentally,":[65],"injury":[68],"can":[69,102],"be":[70,103],"attenuated,":[71],"outcome":[74],"improved,":[75],"by":[76,127],"gene":[77,199],"expression":[78,200],"modification":[79],"brain.The":[82],"other":[85],"organs":[86],"highly":[88],"conserved,":[89],"programs,":[92],"induction":[94],"which":[96],"reduces":[97],"injury.The":[99],"induced":[104,126],"model":[107],"tolerance:":[110],"brief":[111],"exposure":[112],"sublethal":[114],"ischemia":[115],"produces":[116],"tolerance":[117,128,140,203],"subsequent,":[120],"severe":[121],"challenge.3][4][5]":[123],"The":[124],"protection":[125],"is":[129,193,213],"substantial,":[130],"gene-based,":[131],"dependent":[133],"new":[135],"protein":[136],"synthesis.The":[137],"demonstrated":[143],"experimental":[145],"cardiopulmonary":[146],"bypass":[147],"surgery":[148],"6":[149],"primate.":[155],"7A":[156],"counterpart":[158],"likely":[159],"exists":[160],"human":[162],"brain:":[163],"patients":[164],"with":[165],"prodromal":[166],"transient":[167],"attacks":[169],"milder":[171],"strokes.":[172],"8":[173],"-11":[174],"Two":[175],"small":[176],"trials":[178,188],"potential":[181,196],"benefits":[182],"preconditioning,":[184],"5":[186],"additional":[187],"are":[189],"underway.":[190],"12Thus,":[191],"there":[192],"considerable":[194],"therapeutic":[195],"understanding":[198],"changes":[201],"dissecting":[206],"biological":[208],"that":[210],"regulate":[211],"them.This":[212],"an":[214],"evolving":[215],"story":[216],"deriving":[217],"authors'":[221],"our":[223],"collaborators'":[224],"laboratories.":[225]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
