{"id":"https://openalex.org/W1978109649","doi":"https://doi.org/10.3109/00016489109137352","title":"Vestibular-oculomotor, Opto-oculomotor and Visual Function in the Rat after Long-term Inhalation Exposure to Toluene","display_name":"Vestibular-oculomotor, Opto-oculomotor and Visual Function in the Rat after Long-term Inhalation Exposure to Toluene","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W1978109649","doi":"https://doi.org/10.3109/00016489109137352","mag":"1978109649","pmid":"https://pubmed.ncbi.nlm.nih.gov/2014756"},"language":"en","primary_location":{"id":"doi:10.3109/00016489109137352","doi":"https://doi.org/10.3109/00016489109137352","is_oa":false,"landing_page_url":"https://doi.org/10.3109/00016489109137352","pdf_url":null,"source":{"id":"https://openalex.org/S198335345","display_name":"Acta Oto-Laryngologica","issn_l":"0001-6489","issn":["0001-6489","1651-2251","1651-2553"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Oto-Laryngologica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112722091","display_name":"P. Nyl\u00e9n","orcid":"https://orcid.org/0000-0001-7787-5444","observed_orcids":["https://orcid.org/0000-0001-7787-5444"]},"institutions":[{"id":"https://openalex.org/I1332882736","display_name":"National Institute of Occupational Health","ror":"https://ror.org/04g3t6s80","country_code":"NO","type":"government","lineage":["https://openalex.org/I1332882736"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["NO","SE"],"is_corresponding":false,"raw_author_name":"Per Nylen","raw_affiliation_strings":["Department of Neuromedicine, National Institute of Occupational Health, S-17184, Solna","Department of Physiology, Karolinskti Institute, S-10401, Stockholm"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuromedicine, National Institute of Occupational Health, S-17184, Solna","institution_ids":["https://openalex.org/I1332882736"]},{"raw_affiliation_string":"Department of Physiology, Karolinskti Institute, S-10401, Stockholm","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036771982","display_name":"Birgitta Larsby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151885","display_name":"Link\u00f6ping University Hospital","ror":"https://ror.org/05h1aye87","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210151885"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Birgitta Larsby","raw_affiliation_strings":["Department of Otolaryngology, University Hospital, S-58185, Link\u00f6ping, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, University Hospital, S-58185, Link\u00f6ping, Sweden","institution_ids":["https://openalex.org/I4210151885"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103400300","display_name":"Ann\u2010Christin Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1332882736","display_name":"National Institute of Occupational Health","ror":"https://ror.org/04g3t6s80","country_code":"NO","type":"government","lineage":["https://openalex.org/I1332882736"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["NO","SE"],"is_corresponding":false,"raw_author_name":"Ann-Christin Johnson","raw_affiliation_strings":["Department of Neuromedicine, National Institute of Occupational Health, S-17184, Solna","Department of Physiology, Karolinskti Institute, S-10401, Stockholm"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuromedicine, National Institute of Occupational Health, S-17184, Solna","institution_ids":["https://openalex.org/I1332882736"]},{"raw_affiliation_string":"Department of Physiology, Karolinskti Institute, S-10401, Stockholm","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Birgitta Eriksson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151885","display_name":"Link\u00f6ping University Hospital","ror":"https://ror.org/05h1aye87","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210151885"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Birgitta Eriksson","raw_affiliation_strings":["Department of Otolaryngology, University Hospital, S-58185, Link\u00f6ping, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, University Hospital, S-58185, Link\u00f6ping, Sweden","institution_ids":["https://openalex.org/I4210151885"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111695232","display_name":"G. H\u00f6glund","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1332882736","display_name":"National Institute of Occupational Health","ror":"https://ror.org/04g3t6s80","country_code":"NO","type":"government","lineage":["https://openalex.org/I1332882736"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["NO","SE"],"is_corresponding":false,"raw_author_name":"Gunnar H\u00f6glund","raw_affiliation_strings":["Department of Neuromedicine, National Institute of Occupational Health, S-17184, Solna","Department of Physiology, Karolinskti Institute, S-10401, Stockholm"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuromedicine, National Institute of Occupational Health, S-17184, Solna","institution_ids":["https://openalex.org/I1332882736"]},{"raw_affiliation_string":"Department of Physiology, Karolinskti Institute, S-10401, Stockholm","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110154791","display_name":"Richard Tham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151885","display_name":"Link\u00f6ping University Hospital","ror":"https://ror.org/05h1aye87","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210151885"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Richard Tham","raw_affiliation_strings":["Department of Otolaryngology, University Hospital, S-58185, Link\u00f6ping, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, University Hospital, S-58185, Link\u00f6ping, Sweden","institution_ids":["https://openalex.org/I4210151885"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5311,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.60871319,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"111","issue":"1","first_page":"36","last_page":"43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/toluene","display_name":"toluene","score":0.9549999833106995},{"id":"https://openalex.org/keywords/inhalation-exposure","display_name":"inhalation exposure","score":0.8360000252723694},{"id":"https://openalex.org/keywords/optokinetic-after-nystagmus","display_name":"optokinetic afternystagmus","score":0.824999988079071},{"id":"https://openalex.org/keywords/vestibular-nystagmus","display_name":"vestibular nystagmus","score":0.8730000257492065},{"id":"https://openalex.org/keywords/electroretinography","display_name":"electroretinogram","score":0.781000018119812},{"id":"https://openalex.org/keywords/visual-evoked-potentials","display_name":"visual evoked potentials","score":0.996999979019165},{"id":"https://openalex.org/keywords/peripheral-nerve-conduction-velocity","display_name":"peripheral nerve conduction velocity","score":0.968999981880188},{"id":"https://openalex.org/keywords/long-term-neurotoxicity","display_name":"long-term neurotoxicity","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.5236963033676147},{"id":"https://openalex.org/C190041318","wikidata":"https://www.wikidata.org/wiki/Q596832","display_name":"Vestibular system","level":2,"score":0.5215396881103516},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.48082005977630615},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4395514130592346},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.40362608432769775},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.37617790699005127},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3379629850387573},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.31412267684936523},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.26498329639434814},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.11809512972831726},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.048571497201919556}],"mesh":[{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004596","descriptor_name":"Electroretinography","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005074","descriptor_name":"Evoked Potentials, Visual","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005133","descriptor_name":"Eye Movements","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009760","descriptor_name":"Nystagmus, Physiologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009801","descriptor_name":"Oculomotor Muscles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009802","descriptor_name":"Oculomotor Nerve","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012027","descriptor_name":"Reflex, Vestibulo-Ocular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014050","descriptor_name":"Toluene","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014722","descriptor_name":"Vestibule, Labyrinth","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014722","descriptor_name":"Vestibule, Labyrinth","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D014724","descriptor_name":"Vestibular Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/00016489109137352","doi":"https://doi.org/10.3109/00016489109137352","is_oa":false,"landing_page_url":"https://doi.org/10.3109/00016489109137352","pdf_url":null,"source":{"id":"https://openalex.org/S198335345","display_name":"Acta Oto-Laryngologica","issn_l":"0001-6489","issn":["0001-6489","1651-2251","1651-2553"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Oto-Laryngologica","raw_type":"journal-article"},{"id":"pmid:2014756","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2014756","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta oto-laryngologica","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W26484536","https://openalex.org/W172485978","https://openalex.org/W1549231220","https://openalex.org/W1976610597","https://openalex.org/W1997757689","https://openalex.org/W2006896473","https://openalex.org/W2035749558","https://openalex.org/W2042366502","https://openalex.org/W2079145071","https://openalex.org/W2094128426","https://openalex.org/W2097649696","https://openalex.org/W2108270349","https://openalex.org/W2116267752","https://openalex.org/W2151389778","https://openalex.org/W2313973517","https://openalex.org/W2422861789","https://openalex.org/W2431089366"],"related_works":["https://openalex.org/W2097649696","https://openalex.org/W1971596196","https://openalex.org/W2274165653","https://openalex.org/W1556260236","https://openalex.org/W1590098390","https://openalex.org/W2006896473","https://openalex.org/W326510135","https://openalex.org/W7099988829","https://openalex.org/W2411118500","https://openalex.org/W2046982436"],"abstract_inverted_index":{"Pigmented":[0],"rats":[1],"were":[2,46],"exposed":[3,59],"to":[4,64,123],"toluene":[5,85,150,164],"(1000":[6],"ppm,":[7],"21":[8],"h/day)":[9],"for":[10],"6":[11],"or":[12,40,90,96,184],"11":[13],"weeks.":[14],"The":[15,43,54,114,137,157],"function":[16,115],"of":[17,30,35,83,92,110,116,148,163],"the":[18,28,31,58,84,88,108,111,117,130,133,149,172],"vestibulo-":[19],"and":[20,132],"opto-oculomotor":[21],"systems":[22],"was":[23,61,69,100,103,120,143,155],"tested":[24,121],"one":[25],"month":[26],"after":[27,126],"end":[29],"exposure":[32,86,127,151,180],"by":[33,38,48,128],"recording":[34,129],"nystagmus,":[36],"induced":[37],"vestibular":[39,79,183],"optokinetic":[41,55,112],"stimuli.":[42],"eye":[44],"movements":[45],"recorded":[47],"a":[49,65,71,166],"magnetic":[50],"search":[51],"coil":[52],"technique.":[53],"gain":[56,75,89],"in":[57,74,107,140],"animals":[60],"reduced":[62],"compared":[63],"control":[66],"group.":[67],"There":[68],"also":[70,144],"slight":[72],"reduction":[73],"during":[76,94],"sinusoidal":[77],"oscillatory":[78],"stimulation.":[80],"No":[81,146],"effect":[82,147],"on":[87,152],"duration":[91,109],"nystagmus":[93],"acceleratory":[95],"deceleratory":[97],"rotatory":[98],"stimulation":[99],"demonstrated,":[101],"nor":[102],"there":[104],"any":[105],"change":[106],"after-nystagmus.":[113],"visual":[118,134,185],"system":[119],"2":[122],"5":[124],"days":[125],"electroretinogram":[131],"evoked":[135],"response.":[136],"conduction":[138],"velocity":[139],"peripheral":[141,182],"nerve":[142],"measured.":[145],"these":[153],"variables":[154],"seen.":[156],"results":[158],"indicate":[159],"that":[160,178],"long-term":[161],"inhalation":[162],"causes":[165],"long-lasting,":[167],"possibly":[168],"permanent,":[169],"lesion":[170],"within":[171],"vestibulo-cerebellum.":[173],"They":[174],"gave":[175],"no":[176],"evidence":[177],"such":[179],"affects":[181],"function.":[186]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}