{"id":"https://openalex.org/W1978101875","doi":"https://doi.org/10.1371/journal.pgen.1002716","title":"DNA Demethylation and USF Regulate the Meiosis-Specific Expression of the Mouse Miwi","display_name":"DNA Demethylation and USF Regulate the Meiosis-Specific Expression of the Mouse Miwi","publication_year":2012,"publication_date":"2012-05-17","ids":{"openalex":"https://openalex.org/W1978101875","doi":"https://doi.org/10.1371/journal.pgen.1002716","mag":"1978101875","pmid":"https://pubmed.ncbi.nlm.nih.gov/22661915","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3355075"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pgen.1002716","doi":"https://doi.org/10.1371/journal.pgen.1002716","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1002716","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002716&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002716&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086183173","display_name":"Yu Hou","orcid":"https://orcid.org/0000-0002-3896-5321","observed_orcids":["https://orcid.org/0000-0002-3896-5321"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Hou","raw_affiliation_strings":["Department of Genetics, College of Life Sciences, Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, College of Life Sciences, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101934690","display_name":"Jia Yuan","orcid":"https://orcid.org/0000-0001-5544-1768","observed_orcids":["https://orcid.org/0000-0001-5544-1768"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Yuan","raw_affiliation_strings":["Department of Genetics, College of Life Sciences, Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, College of Life Sciences, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029478416","display_name":"Xiang Yu Zhou","orcid":"https://orcid.org/0000-0002-1172-7948","observed_orcids":["https://orcid.org/0000-0002-1172-7948"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang Zhou","raw_affiliation_strings":["Department of Genetics, College of Life Sciences, Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, College of Life Sciences, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059295035","display_name":"Xiazhou Fu","orcid":"https://orcid.org/0000-0002-2738-5233","observed_orcids":["https://orcid.org/0000-0002-2738-5233"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Xiazhou Fu","raw_affiliation_strings":["Department of Genetics, College of Life Sciences, Wuhan University, Wuhan, China","Stanford University School of Medicine, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, College of Life Sciences, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]},{"raw_affiliation_string":"Stanford University School of Medicine, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068112588","display_name":"Hanhua Cheng","orcid":"https://orcid.org/0000-0002-3479-1598","observed_orcids":["https://orcid.org/0000-0002-3479-1598"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hanhua Cheng","raw_affiliation_strings":["Department of Genetics, College of Life Sciences, Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, College of Life Sciences, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006280673","display_name":"Rongjia Zhou","orcid":"https://orcid.org/0000-0002-9701-8009","observed_orcids":["https://orcid.org/0000-0002-9701-8009"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Rongjia Zhou","raw_affiliation_strings":["Department of Genetics, College of Life Sciences, Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, College of Life Sciences, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5006280673","https://openalex.org/A5068112588"],"corresponding_institution_ids":["https://openalex.org/I37461747"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":1.9453,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.86105754,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"8","issue":"5","first_page":"e1002716","last_page":"e1002716"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.7348999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.7348999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.22789999842643738,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.023800000548362732,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/miwi","display_name":"MIWI","score":0.9929999709129333},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8410000205039978},{"id":"https://openalex.org/keywords/usf","display_name":"USF","score":0.8759999871253967},{"id":"https://openalex.org/keywords/nf-y","display_name":"NF-Y","score":0.8019999861717224},{"id":"https://openalex.org/keywords/spermatogenesis","display_name":"spermatogenesis","score":0.7770000100135803},{"id":"https://openalex.org/keywords/argonaute-proteins","display_name":"Argonaute proteins","score":0.6320000290870667},{"id":"https://openalex.org/keywords/cpg-islands","display_name":"CpG islands","score":0.8569999933242798},{"id":"https://openalex.org/keywords/promoter-regulation","display_name":"promoter regulation","score":0.699999988079071},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/germ-cells","display_name":"germ cells","score":0.7260000109672546},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.3149999976158142}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7982138395309448},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.547198474407196},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5179125666618347},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.5119136571884155},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5039677023887634},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.4964306950569153},{"id":"https://openalex.org/C2776053789","wikidata":"https://www.wikidata.org/wiki/Q3486515","display_name":"Spermatocyte","level":4,"score":0.4231113791465759},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.4126535654067993},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4094834327697754},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4088789224624634},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3806285262107849},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35096776485443115},{"id":"https://openalex.org/C148196450","wikidata":"https://www.wikidata.org/wiki/Q21100485","display_name":"Meiosis","level":3,"score":0.17949023842811584}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005854","descriptor_name":"Germ Cells","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D005854","descriptor_name":"Germ Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008540","descriptor_name":"Meiosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013087","descriptor_name":"Spermatids","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D013087","descriptor_name":"Spermatids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013090","descriptor_name":"Spermatocytes","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D013090","descriptor_name":"Spermatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013091","descriptor_name":"Spermatogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023081","descriptor_name":"CCAAT-Binding Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023081","descriptor_name":"CCAAT-Binding Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051720","descriptor_name":"Upstream Stimulatory Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051720","descriptor_name":"Upstream Stimulatory Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060565","descriptor_name":"Argonaute Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pgen.1002716","doi":"https://doi.org/10.1371/journal.pgen.1002716","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1002716","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002716&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2372810","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3355075","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:22661915","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22661915","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS genetics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3355075","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3355075/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genet","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.810.5058","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.810.5058","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/9e/f3/pgen.1002716.PMC3355075.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:ead3175d316d4a38bcf04c47709f0517","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ead3175d316d4a38bcf04c47709f0517","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Genetics, Vol 8, Iss 5, p e1002716 (2012)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/124980","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/DNA_Demethylation_and_USF_Regulate_the_Meiosis_Specific_Expression_of_the_Mouse_Miwi_/124980","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pgen.1002716","doi":"https://doi.org/10.1371/journal.pgen.1002716","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1002716","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002716&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5738210548","display_name":null,"funder_award_id":"B06018","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320327912","display_name":"Higher Education Discipline Innovation Project","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978101875.pdf","grobid_xml":"https://content.openalex.org/works/W1978101875.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1501535278","https://openalex.org/W1538630077","https://openalex.org/W1565144343","https://openalex.org/W1869102274","https://openalex.org/W1970951301","https://openalex.org/W1977681950","https://openalex.org/W1977733607","https://openalex.org/W1981968179","https://openalex.org/W1984070362","https://openalex.org/W1985336724","https://openalex.org/W1987872465","https://openalex.org/W1996782393","https://openalex.org/W2002679485","https://openalex.org/W2012453729","https://openalex.org/W2020767030","https://openalex.org/W2020940277","https://openalex.org/W2027509763","https://openalex.org/W2028267599","https://openalex.org/W2034335556","https://openalex.org/W2035251095","https://openalex.org/W2037272593","https://openalex.org/W2046878942","https://openalex.org/W2047649140","https://openalex.org/W2049503648","https://openalex.org/W2049667466","https://openalex.org/W2049696888","https://openalex.org/W2049918172","https://openalex.org/W2053084007","https://openalex.org/W2058939605","https://openalex.org/W2066118199","https://openalex.org/W2070781219","https://openalex.org/W2073261912","https://openalex.org/W2077249217","https://openalex.org/W2084092102","https://openalex.org/W2092463855","https://openalex.org/W2096723148","https://openalex.org/W2103012554","https://openalex.org/W2107086678","https://openalex.org/W2110341505","https://openalex.org/W2113083989","https://openalex.org/W2124049725","https://openalex.org/W2139102988","https://openalex.org/W2142906190","https://openalex.org/W2143859191","https://openalex.org/W2151741487","https://openalex.org/W2161221810","https://openalex.org/W2165879373","https://openalex.org/W2170767694","https://openalex.org/W2171975928","https://openalex.org/W7098400432"],"related_works":["https://openalex.org/W2344032721","https://openalex.org/W2414135795","https://openalex.org/W2174071221","https://openalex.org/W2075598836","https://openalex.org/W4409283333","https://openalex.org/W4406278659","https://openalex.org/W2904906974","https://openalex.org/W2800727818","https://openalex.org/W4399173908","https://openalex.org/W2165567873"],"abstract_inverted_index":{"Miwi,":[0],"a":[1,33,101,144],"member":[2],"of":[3,19,39,61,92,109,118,136,152,162,171,220],"the":[4,13,17,20,40,58,74,87,97,106,110,123,127,131,134,149,153,158,163,172,217],"Argonaute":[5],"family,":[6],"is":[7,167,180],"required":[8],"for":[9,216],"initiating":[10],"spermiogenesis;":[11],"however,":[12],"mechanisms":[14],"that":[15,79,170,177,195],"regulate":[16],"expression":[18,47,117,199,219],"Miwi":[21,42,88,142,164,174,178,198,222],"gene":[22],"remain":[23],"unknown.":[24],"By":[25],"mutation":[26],"analysis":[27],"and":[28,68,77,85,113,140],"transgenic":[29,155],"models,":[30],"we":[31],"identified":[32],"303":[34],"bp":[35],"proximal":[36,98],"promoter":[37,76,99,132],"region":[38],"mouse":[41,221],"gene,":[43],"which":[44],"controls":[45,197],"specific":[46],"from":[48,200],"midpachytene":[49,201],"spermatocytes":[50,202],"to":[51,84,187,203],"round":[52,204],"spermatids":[53,205],"during":[54,223],"meiosis.":[55],"We":[56],"characterized":[57],"binding":[59,135],"sites":[60],"transcription":[62],"factors":[63,81],"NF-Y":[64],"(Nuclear":[65],"Factor":[66],"Y)":[67],"USF":[69,196],"(Upstream":[70],"Stimulatory":[71],"Factor)":[72],"within":[73,96,126],"core":[75],"found":[78],"both":[80],"specifically":[82],"bind":[83],"activate":[86],"promoter.":[89],"Methylation":[90],"profiling":[91],"three":[93],"CpG":[94,111,120],"islands":[95,112],"reveals":[100],"markedly":[102],"inverse":[103],"correlation":[104],"between":[105],"methylation":[107,121,160,184],"status":[108],"germ":[114,150],"cell":[115],"type-specific":[116],"Miwi.":[119],"at":[122],"USF-binding":[124],"site":[125],"E2":[128],"box":[129],"in":[130,148,185],"inhibits":[133],"USF.":[137],"Transgenic":[138],"Miwi-EGFP":[139,154],"endogenous":[141,173],"reveal":[143],"subcellular":[145],"co-localization":[146],"pattern":[147],"cells":[151],"mouse.":[156],"Furthermore,":[157],"DNA":[159],"profile":[161],"promoter-driven":[165],"transgene":[166,179],"consistent":[168],"with":[169],"promoter,":[175],"indicating":[176],"epigenetically":[181],"modified":[182],"through":[183,206],"vivo":[186],"ensure":[188],"its":[189],"spatio-temporal":[190,218],"expression.":[191],"Our":[192],"findings":[193],"suggest":[194],"methylation-mediated":[207],"regulation.":[208],"This":[209],"work":[210],"identifies":[211],"an":[212],"epigenetic":[213],"regulation":[214],"mechanism":[215],"spermatogenesis.":[224]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}