{"id":"https://openalex.org/W1978094794","doi":"https://doi.org/10.1371/journal.pone.0035736","title":"Differential Effects of Short Term Feeding of a Soy Protein Isolate Diet and Estrogen Treatment on Bone in the Pre-Pubertal Rat","display_name":"Differential Effects of Short Term Feeding of a Soy Protein Isolate Diet and Estrogen Treatment on Bone in the Pre-Pubertal Rat","publication_year":2012,"publication_date":"2012-04-20","ids":{"openalex":"https://openalex.org/W1978094794","doi":"https://doi.org/10.1371/journal.pone.0035736","mag":"1978094794","pmid":"https://pubmed.ncbi.nlm.nih.gov/22536432","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3335011"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0035736","doi":"https://doi.org/10.1371/journal.pone.0035736","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0035736","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0035736&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0035736&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103400283","display_name":"Jian Zhang","orcid":"https://orcid.org/0009-0001-0623-2422","observed_orcids":["https://orcid.org/0009-0001-0623-2422"]},"institutions":[{"id":"https://openalex.org/I4210146069","display_name":"Arkansas Children's Nutrition Center","ror":"https://ror.org/03vvhya80","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210122704","https://openalex.org/I4210146069"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian Zhang","raw_affiliation_strings":["Arkansas Children's Nutrition Center, Little Rock, Arkansas, United States of America","Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Nutrition Center, Little Rock, Arkansas, United States of America","institution_ids":["https://openalex.org/I4210146069"]},{"raw_affiliation_string":"Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015737319","display_name":"Oxana P. Lazarenko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146069","display_name":"Arkansas Children's Nutrition Center","ror":"https://ror.org/03vvhya80","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210122704","https://openalex.org/I4210146069"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oxana P. Lazarenko","raw_affiliation_strings":["Arkansas Children's Nutrition Center, Little Rock, Arkansas, United States of America","Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Nutrition Center, Little Rock, Arkansas, United States of America","institution_ids":["https://openalex.org/I4210146069"]},{"raw_affiliation_string":"Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023588495","display_name":"Xianli Wu","orcid":"https://orcid.org/0000-0002-0094-3258","observed_orcids":["https://orcid.org/0000-0002-0094-3258"]},"institutions":[{"id":"https://openalex.org/I4210146069","display_name":"Arkansas Children's Nutrition Center","ror":"https://ror.org/03vvhya80","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210122704","https://openalex.org/I4210146069"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xianli Wu","raw_affiliation_strings":["Arkansas Children's Nutrition Center, Little Rock, Arkansas, United States of America","Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Nutrition Center, Little Rock, Arkansas, United States of America","institution_ids":["https://openalex.org/I4210146069"]},{"raw_affiliation_string":"Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100884976","display_name":"Yudong Tong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146069","display_name":"Arkansas Children's Nutrition Center","ror":"https://ror.org/03vvhya80","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210122704","https://openalex.org/I4210146069"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yudong Tong","raw_affiliation_strings":["Arkansas Children's Nutrition Center, Little Rock, Arkansas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Nutrition Center, Little Rock, Arkansas, United States of America","institution_ids":["https://openalex.org/I4210146069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064881126","display_name":"Michael L. Blackburn","orcid":"https://orcid.org/0000-0002-4126-3750","observed_orcids":["https://orcid.org/0000-0002-4126-3750"]},"institutions":[{"id":"https://openalex.org/I4210146069","display_name":"Arkansas Children's Nutrition Center","ror":"https://ror.org/03vvhya80","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210122704","https://openalex.org/I4210146069"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael L. Blackburn","raw_affiliation_strings":["Arkansas Children's Nutrition Center, Little Rock, Arkansas, United States of America","Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Nutrition Center, Little Rock, Arkansas, United States of America","institution_ids":["https://openalex.org/I4210146069"]},{"raw_affiliation_string":"Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089951262","display_name":"Horatio Gomez-Acevedo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146069","display_name":"Arkansas Children's Nutrition Center","ror":"https://ror.org/03vvhya80","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210122704","https://openalex.org/I4210146069"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Horatio Gomez-Acevedo","raw_affiliation_strings":["Arkansas Children's Nutrition Center, Little Rock, Arkansas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Nutrition Center, Little Rock, Arkansas, United States of America","institution_ids":["https://openalex.org/I4210146069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035081477","display_name":"Kartik Shankar","orcid":"https://orcid.org/0000-0002-7964-9026","observed_orcids":["https://orcid.org/0000-0002-7964-9026"]},"institutions":[{"id":"https://openalex.org/I4210146069","display_name":"Arkansas Children's Nutrition Center","ror":"https://ror.org/03vvhya80","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210122704","https://openalex.org/I4210146069"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kartik Shankar","raw_affiliation_strings":["Arkansas Children's Nutrition Center, Little Rock, Arkansas, United States of America","Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Nutrition Center, Little Rock, Arkansas, United States of America","institution_ids":["https://openalex.org/I4210146069"]},{"raw_affiliation_string":"Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076259954","display_name":"Thomas M. Badger","orcid":"https://orcid.org/0000-0003-1159-7191","observed_orcids":["https://orcid.org/0000-0003-1159-7191"]},"institutions":[{"id":"https://openalex.org/I4210146069","display_name":"Arkansas Children's Nutrition Center","ror":"https://ror.org/03vvhya80","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210122704","https://openalex.org/I4210146069"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas M. Badger","raw_affiliation_strings":["Arkansas Children's Nutrition Center, Little Rock, Arkansas, United States of America","Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America","Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Nutrition Center, Little Rock, Arkansas, United States of America","institution_ids":["https://openalex.org/I4210146069"]},{"raw_affiliation_string":"Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041753848","display_name":"Martin J. J. Ronis","orcid":"https://orcid.org/0000-0002-0116-3771","observed_orcids":["https://orcid.org/0000-0002-0116-3771"]},"institutions":[{"id":"https://openalex.org/I4210146069","display_name":"Arkansas Children's Nutrition Center","ror":"https://ror.org/03vvhya80","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210122704","https://openalex.org/I4210146069"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin J. J. Ronis","raw_affiliation_strings":["Arkansas Children's Nutrition Center, Little Rock, Arkansas, United States of America","Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America","Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Nutrition Center, Little Rock, Arkansas, United States of America","institution_ids":["https://openalex.org/I4210146069"]},{"raw_affiliation_string":"Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000727397","display_name":"Jin\u2010Ran Chen","orcid":"https://orcid.org/0000-0001-6984-5878","observed_orcids":["https://orcid.org/0000-0001-6984-5878"]},"institutions":[{"id":"https://openalex.org/I4210146069","display_name":"Arkansas Children's Nutrition Center","ror":"https://ror.org/03vvhya80","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210122704","https://openalex.org/I4210146069"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jin-Ran Chen","raw_affiliation_strings":["Arkansas Children's Nutrition Center, Little Rock, Arkansas, United States of America","Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Nutrition Center, Little Rock, Arkansas, United States of America","institution_ids":["https://openalex.org/I4210146069"]},{"raw_affiliation_string":"Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America","institution_ids":["https://openalex.org/I79620101"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5000727397"],"corresponding_institution_ids":["https://openalex.org/I4210146069","https://openalex.org/I79620101"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.3023,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.86966583,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"7","issue":"4","first_page":"e35736","last_page":"e35736"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.02070000022649765,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/soy-protein-isolate","display_name":"soy protein isolate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9169999957084656},{"id":"https://openalex.org/keywords/estrogen","display_name":"estrogen","score":0.49399998784065247},{"id":"https://openalex.org/keywords/bone-turnover","display_name":"bone turnover","score":0.9900000095367432},{"id":"https://openalex.org/keywords/sclerostin","display_name":"sclerostin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/caveolin-1","display_name":"caveolin-1","score":0.8740000128746033},{"id":"https://openalex.org/keywords/bmp-2","display_name":"BMP-2","score":0.9470000267028809},{"id":"https://openalex.org/keywords/smad","display_name":"Smad","score":0.9200000166893005},{"id":"https://openalex.org/keywords/runx2","display_name":"Runx2","score":0.996999979019165},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.9020000100135803},{"id":"https://openalex.org/keywords/bone-gene-expression","display_name":"bone gene expression","score":0.7070000171661377},{"id":"https://openalex.org/keywords/isoflavones","display_name":"isoflavones","score":0.8220000267028809},{"id":"https://openalex.org/keywords/casein-diet","display_name":"casein diet","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C2777014122","wikidata":"https://www.wikidata.org/wiki/Q7571993","display_name":"Soy protein","level":2,"score":0.7672320604324341},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7607917785644531},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7568656206130981},{"id":"https://openalex.org/C2779277721","wikidata":"https://www.wikidata.org/wiki/Q14887295","display_name":"Sclerostin","level":4,"score":0.641308069229126},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.618824303150177},{"id":"https://openalex.org/C131075544","wikidata":"https://www.wikidata.org/wiki/Q415863","display_name":"Osteocalcin","level":4,"score":0.49808382987976074},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.479030042886734},{"id":"https://openalex.org/C2776142715","wikidata":"https://www.wikidata.org/wiki/Q193970","display_name":"Casein","level":2,"score":0.46100494265556335},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.46026092767715454},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45282846689224243},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35721468925476074},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.3525933027267456},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.27318626642227173},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22403094172477722},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.17326593399047852},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16473576426506042},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14362585544586182},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.07185101509094238},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06879588961601257}],"mesh":[{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001862","descriptor_name":"Bone Resorption","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002116","descriptor_name":"Calcitonin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002116","descriptor_name":"Calcitonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004044","descriptor_name":"Dietary Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012741","descriptor_name":"Sexual Maturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015675","descriptor_name":"Osteocalcin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030262","descriptor_name":"Soybean Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D050659","descriptor_name":"Core Binding Factor Alpha 1 Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050659","descriptor_name":"Core Binding Factor Alpha 1 Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051242","descriptor_name":"Caveolin 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051242","descriptor_name":"Caveolin 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051700","descriptor_name":"Activating Transcription Factor 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051700","descriptor_name":"Activating Transcription Factor 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055396","descriptor_name":"Bone Morphogenetic Protein 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055396","descriptor_name":"Bone Morphogenetic Protein 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0035736","doi":"https://doi.org/10.1371/journal.pone.0035736","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0035736","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0035736&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2340778","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3335011","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3335011","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3335011","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:22536432","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22536432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.270.7124","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.270.7124","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/90/08/PLoS_One_2012_Apr_20_7(4)_e35736.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:c84c8e1118ec48fcb835dfda4eea2475","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c84c8e1118ec48fcb835dfda4eea2475","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 4, p e35736 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0035736","doi":"https://doi.org/10.1371/journal.pone.0035736","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0035736","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0035736&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243},{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.4359000027179718}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306114","display_name":"U.S. Department of Agriculture","ror":"https://ror.org/01na82s61"},{"id":"https://openalex.org/F4320332605","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978094794.pdf","grobid_xml":"https://content.openalex.org/works/W1978094794.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1831301545","https://openalex.org/W1873938148","https://openalex.org/W1898962100","https://openalex.org/W1971930482","https://openalex.org/W1975914690","https://openalex.org/W1983889476","https://openalex.org/W1984574341","https://openalex.org/W2012192649","https://openalex.org/W2015839100","https://openalex.org/W2049970571","https://openalex.org/W2059113657","https://openalex.org/W2061881547","https://openalex.org/W2064282853","https://openalex.org/W2067458274","https://openalex.org/W2082429467","https://openalex.org/W2083188840","https://openalex.org/W2091909438","https://openalex.org/W2092437783","https://openalex.org/W2096588215","https://openalex.org/W2102483861","https://openalex.org/W2109555266","https://openalex.org/W2116195377","https://openalex.org/W2117990011","https://openalex.org/W2125272276","https://openalex.org/W2131212741","https://openalex.org/W2143116600","https://openalex.org/W2158228609","https://openalex.org/W2164637108","https://openalex.org/W2168202609","https://openalex.org/W2995395594","https://openalex.org/W4232934018"],"related_works":["https://openalex.org/W3172597653","https://openalex.org/W2267710408","https://openalex.org/W2131212741","https://openalex.org/W2532085122","https://openalex.org/W1527063362","https://openalex.org/W2133197996","https://openalex.org/W2046723447","https://openalex.org/W1965947180","https://openalex.org/W2117633768","https://openalex.org/W2400132635"],"abstract_inverted_index":{"BACKGROUND:":[0],"Previous":[1],"reports":[2],"suggest":[3,223],"that":[4],"beneficial":[5],"effects":[6,30,52,68,229,258],"of":[7,18,31,53,57,69,81,145,176,202,238,279],"soy":[8,32,58],"on":[9,36,62,121,230],"bone":[10,63,130,149,216,231,280],"quality":[11],"are":[12,43,241,269],"due":[13],"to":[14,66,79,133,172,197,234,277],"the":[15,23,29,51,67,182,239,244,256,261],"estrogenic":[16],"actions":[17],"isoflavone":[19],"phytochemicals":[20],"associated":[21,207],"with":[22,92,106,112,208],"protein.":[24],"However,":[25],"mechanistic":[26],"studies":[27],"comparing":[28],"diet":[33,88,101,168],"and":[34,161,169,212,217,225,259,272],"estrogens":[35],"bone,":[37],"particularly":[38],"in":[39,64,72,181,188,215,243,252],"rapidly":[40],"growing":[41],"animals":[42],"lacking.":[44],"METHODOLOGY":[45],"AND":[46],"PRINCIPAL":[47],"FINDINGS:":[48],"We":[49],"studied":[50],"short":[54],"term":[55],"feeding":[56],"protein":[59,179],"isolate":[60],"(SPI)":[61,109],"comparison":[65],"17\u03b2-estradiol":[70],"(E2)":[71],"pre-pubertal":[73],"rats.":[74],"Female":[75],"rats":[76,189,198],"were":[77],"weaned":[78],"one":[80],"4":[82],"treatments:":[83],"1)":[84],"a":[85,99,178],"control":[86,264],"casein-based":[87],"(CAS);":[89],"2)":[90],"CAS":[91],"subcutaneous":[93,107],"E2":[94,108,115,128,170,195,226,248,270],"(10":[95],"\u00b5g/kg/d)":[96],"(CAS+E2);":[97],"3)":[98],"SPI-containing":[100],"(SPI);":[102],"or":[103,110,249],"4)":[104],"SPI":[105,111,125,167,205,224,254],"10":[113],"\u00b5g/kg/d":[114],"(SPI+E2)":[116],"for":[117],"14":[118],"days":[119],"beginning":[120],"postnatal":[122],"day":[123],"20.":[124],"increased":[126,209],"while":[127],"decreased":[129,139],"turnover":[131,232],"compared":[132,171,196],"CAS.":[134,173],"In":[135,266],"contrast,":[136],"both":[137,166],"treatments":[138],"serum":[140],"sclerostin":[141],"levels.":[142,265],"Microarray":[143],"analysis":[144],"RNA":[146],"isolated":[147],"from":[148],"revealed":[150],"652":[151],"genes":[152,157,163,240],"regulated":[153,158,164,242],"by":[154,159,165,194,204,247],"SPI,":[155,191,250],"491":[156],"E2,":[160],"266":[162],"The":[174],"expression":[175,214],"caveolin-1,":[177],"localized":[180],"cell":[183],"membrane,":[184],"was":[185,206],"down-regulated":[186],"(p<0.05)":[187],"fed":[190,199],"but":[192,251],"not":[193],"casein.":[200],"Down-regulation":[201],"caveolin-1":[203],"BMP2,":[210],"Smad":[211],"Runx2":[213],"osteoblasts":[218],"(p<0.05).":[219],"CONCLUSIONS/SIGNIFICANCE:":[220],"These":[221],"results":[222],"have":[227],"different":[228],"prior":[233],"puberty.":[235],"Approximately":[236],"half":[237],"same":[245],"direction":[246],"combination,":[253],"blocks":[255],"estrogen":[257],"returns":[260],"profile":[262],"towards":[263],"addition,":[267],"there":[268],"specific":[271],"SPI-specific":[273],"gene":[274],"changes":[275],"related":[276],"regulation":[278],"formation.":[281]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
