{"id":"https://openalex.org/W197809359","doi":"https://doi.org/10.1007/bf01875506","title":"Natural IFN-\u03b1 therapy in hairy-cell leukaemia (namalva-type IFN \u2014 wellferon)","display_name":"Natural IFN-\u03b1 therapy in hairy-cell leukaemia (namalva-type IFN \u2014 wellferon)","publication_year":1987,"publication_date":"1987-07-01","ids":{"openalex":"https://openalex.org/W197809359","doi":"https://doi.org/10.1007/bf01875506","mag":"197809359","pmid":"https://pubmed.ncbi.nlm.nih.gov/3306138"},"language":"de","primary_location":{"id":"doi:10.1007/bf01875506","doi":"https://doi.org/10.1007/bf01875506","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf01875506","pdf_url":null,"source":{"id":"https://openalex.org/S114689480","display_name":"Journal of Molecular Medicine","issn_l":"0946-2716","issn":["0946-2716","1432-1440"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Klinische Wochenschrift","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111840018","display_name":"Colin P. Worman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289784979","display_name":"University College Hospital","ror":"https://ror.org/00wrevg56","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1289784979","https://openalex.org/I1340918713"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C. P. Worman","raw_affiliation_strings":["Department of Haematology, University College Hospital, London, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, University College Hospital, London, England","institution_ids":["https://openalex.org/I1289784979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009754802","display_name":"A.B.W. Nethersell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. B. W. Nethersell","raw_affiliation_strings":["Wellcome Research Laboratories, Beckenham, Kent, England","Wellcome Research Laboratories, Beckenham, (England)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Research Laboratories, Beckenham, Kent, England","institution_ids":["https://openalex.org/I87048295"]},{"raw_affiliation_string":"Wellcome Research Laboratories, Beckenham, (England)","institution_ids":["https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108221608","display_name":"Juliana Bottomley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. M. Bottomley","raw_affiliation_strings":["Wellcome Research Laboratories, Beckenham, Kent, England","Wellcome Research Laboratories, Beckenham, (England)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Research Laboratories, Beckenham, Kent, England","institution_ids":["https://openalex.org/I87048295"]},{"raw_affiliation_string":"Wellcome Research Laboratories, Beckenham, (England)","institution_ids":["https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109867533","display_name":"Konstantin Apostolov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K. Apostolov","raw_affiliation_strings":["Department of Virology, Royal Postgraduate Medical School, Hammersmith Hospital, London, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Virology, Royal Postgraduate Medical School, Hammersmith Hospital, London, England","institution_ids":["https://openalex.org/I2801748203"]}]},{"author_position":"middle","author":{"id":null,"display_name":"W. Barker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"W. Barker","raw_affiliation_strings":["Department of Virology, Royal Postgraduate Medical School, Hammersmith Hospital, London, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Virology, Royal Postgraduate Medical School, Hammersmith Hospital, London, England","institution_ids":["https://openalex.org/I2801748203"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103431417","display_name":"John C. Cawley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802775644","display_name":"Royal Liverpool University Hospital","ror":"https://ror.org/01ycr6b80","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802729160","https://openalex.org/I2802775644"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. C. Cawley","raw_affiliation_strings":["University Department of Haematology, Royal Liverpool Hospital, Liverpool, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Department of Haematology, Royal Liverpool Hospital, Liverpool, England","institution_ids":["https://openalex.org/I2802775644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.5492,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.6299639,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"65","issue":"14","first_page":"685","last_page":"687"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hairy-cell-leukemia","display_name":"hairy cell leukemia","score":0.9900000095367432},{"id":"https://openalex.org/keywords/interferon-alpha-therapy","display_name":"interferon-alpha therapy","score":0.7379999756813049},{"id":"https://openalex.org/keywords/natural-interferon","display_name":"natural interferon","score":0.6389999985694885},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.6940000057220459},{"id":"https://openalex.org/keywords/bone-marrow-response","display_name":"bone marrow response","score":0.8569999933242798},{"id":"https://openalex.org/keywords/t-cell-subsets","display_name":"T cell subsets","score":0.5609999895095825},{"id":"https://openalex.org/keywords/helper-suppressor-ratio","display_name":"helper/suppressor ratio","score":0.828000009059906},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.8600000143051147},{"id":"https://openalex.org/keywords/erythrocyte-fatty-acids","display_name":"erythrocyte fatty acids","score":0.7400000095367432},{"id":"https://openalex.org/keywords/treatment-side-effects","display_name":"treatment side effects","score":0.5120000243186951},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C2776608160","wikidata":"https://www.wikidata.org/wiki/Q4785462","display_name":"Natural (archaeology)","level":2,"score":0.5072876811027527},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.438480406999588},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.382572740316391},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3642977476119995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22269272804260254},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007370","descriptor_name":"Interferon Type I","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007370","descriptor_name":"Interferon Type I","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007943","descriptor_name":"Leukemia, Hairy Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008563","descriptor_name":"Membrane Lipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf01875506","doi":"https://doi.org/10.1007/bf01875506","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf01875506","pdf_url":null,"source":{"id":"https://openalex.org/S114689480","display_name":"Journal of Molecular Medicine","issn_l":"0946-2716","issn":["0946-2716","1432-1440"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Klinische Wochenschrift","raw_type":"journal-article"},{"id":"pmid:3306138","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3306138","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Klinische Wochenschrift","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1629391151","https://openalex.org/W1995628336","https://openalex.org/W2009826794","https://openalex.org/W2063769432","https://openalex.org/W2289779332"],"related_works":["https://openalex.org/W7217764894","https://openalex.org/W7217640172","https://openalex.org/W2047087912","https://openalex.org/W54319851","https://openalex.org/W1979970259","https://openalex.org/W1990523340","https://openalex.org/W2411224204","https://openalex.org/W2063769432","https://openalex.org/W2342063919","https://openalex.org/W2426202002"],"abstract_inverted_index":null,"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}