{"id":"https://openalex.org/W1978077421","doi":"https://doi.org/10.1111/j.1365-2885.2007.00922.x","title":"Role of intracellular kinases in the regulation of equine eosinophil migration and actin polymerization","display_name":"Role of intracellular kinases in the regulation of equine eosinophil migration and actin polymerization","publication_year":2007,"publication_date":"2007-11-20","ids":{"openalex":"https://openalex.org/W1978077421","doi":"https://doi.org/10.1111/j.1365-2885.2007.00922.x","mag":"1978077421","pmid":"https://pubmed.ncbi.nlm.nih.gov/18177316"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2885.2007.00922.x","doi":"https://doi.org/10.1111/j.1365-2885.2007.00922.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2885.2007.00922.x","pdf_url":null,"source":{"id":"https://openalex.org/S23625584","display_name":"Journal of Veterinary Pharmacology and Therapeutics","issn_l":"0140-7783","issn":["0140-7783","1365-2885"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Pharmacology and Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://researchonline.rvc.ac.uk/id/eprint/4959/1/4959.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061622933","display_name":"Marie C. Weston","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133836048","display_name":"Royal Veterinary College","ror":"https://ror.org/01wka8n18","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I133836048"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"M. C. WESTON","raw_affiliation_strings":["Department of Veterinary Basic Sciences and Pathology and Infectious Diseases, The Royal Veterinary College, Hertfordshire, UK. marie.weston@piramed.com","Department of Veterinary Basic Sciences and Pathology and Infectious Diseases, The Royal Veterinary College, Hertfordshire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Basic Sciences and Pathology and Infectious Diseases, The Royal Veterinary College, Hertfordshire, UK. marie.weston@piramed.com","institution_ids":["https://openalex.org/I133836048"]},{"raw_affiliation_string":"Department of Veterinary Basic Sciences and Pathology and Infectious Diseases, The Royal Veterinary College, Hertfordshire, UK","institution_ids":["https://openalex.org/I133836048"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057408519","display_name":"Margaret E. Collins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133836048","display_name":"Royal Veterinary College","ror":"https://ror.org/01wka8n18","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I133836048"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. E. COLLINS","raw_affiliation_strings":["Department of Veterinary Basic Sciences and Pathology and Infectious Diseases, The Royal Veterinary College, Hertfordshire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Basic Sciences and Pathology and Infectious Diseases, The Royal Veterinary College, Hertfordshire, UK","institution_ids":["https://openalex.org/I133836048"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007575726","display_name":"Fiona M Cunningham","orcid":"https://orcid.org/0000-0002-7445-2419","observed_orcids":["https://orcid.org/0000-0002-7445-2419"]},"institutions":[{"id":"https://openalex.org/I133836048","display_name":"Royal Veterinary College","ror":"https://ror.org/01wka8n18","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I133836048"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"F. M. CUNNINGHAM","raw_affiliation_strings":["Department of Veterinary Basic Sciences and Pathology and Infectious Diseases, The Royal Veterinary College, Hertfordshire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Basic Sciences and Pathology and Infectious Diseases, The Royal Veterinary College, Hertfordshire, UK","institution_ids":["https://openalex.org/I133836048"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5061622933"],"corresponding_institution_ids":["https://openalex.org/I133836048"],"apc_list":{"value":4520,"currency":"USD","value_usd":4520},"apc_paid":null,"fwci":0.4223,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.65922005,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"31","issue":"1","first_page":"31","last_page":"38"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.7875999808311462,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.7875999808311462,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.13609999418258667,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12600","display_name":"Eosinophilic Disorders and Syndromes","score":0.013000000268220901,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eosinophil-migration","display_name":"eosinophil migration","score":0.9919999837875366},{"id":"https://openalex.org/keywords/actin-polymerization","display_name":"actin polymerization","score":0.9990000128746033},{"id":"https://openalex.org/keywords/superoxide-production","display_name":"superoxide production","score":0.9089999794960022},{"id":"https://openalex.org/keywords/phospholipase-c","display_name":"phospholipase C","score":0.9279999732971191},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.9340000152587891},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9990000128746033},{"id":"https://openalex.org/keywords/erk1-2","display_name":"ERK1/2","score":0.9620000123977661},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9850000143051147},{"id":"https://openalex.org/keywords/tyrosine-kinase","display_name":"tyrosine kinase","score":0.8970000147819519},{"id":"https://openalex.org/keywords/histamine","display_name":"histamine","score":0.9929999709129333},{"id":"https://openalex.org/keywords/eotaxin","display_name":"eotaxin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/intracellular-signaling","display_name":"intracellular signaling","score":0.796999990940094},{"id":"https://openalex.org/keywords/kinase-inhibitors","display_name":"kinase inhibitors","score":0.7250000238418579},{"id":"https://openalex.org/keywords/horses","display_name":"horses","score":0.8820000290870667}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.643963634967804},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.5362832546234131},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5255081653594971},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.5088944435119629},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49849963188171387},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.4616173207759857},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3321273922920227},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3034023642539978},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.14165854454040527}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004963","descriptor_name":"Estrenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006632","descriptor_name":"Histamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006736","descriptor_name":"Horses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010738","descriptor_name":"Type C Phospholipases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D010738","descriptor_name":"Type C Phospholipases","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D011760","descriptor_name":"Pyrrolidinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D054413","descriptor_name":"Chemokine CCL11","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-2885.2007.00922.x","doi":"https://doi.org/10.1111/j.1365-2885.2007.00922.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2885.2007.00922.x","pdf_url":null,"source":{"id":"https://openalex.org/S23625584","display_name":"Journal of Veterinary Pharmacology and Therapeutics","issn_l":"0140-7783","issn":["0140-7783","1365-2885"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Pharmacology and Therapeutics","raw_type":"journal-article"},{"id":"pmid:18177316","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18177316","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of veterinary pharmacology and therapeutics","raw_type":"Journal Article"},{"id":"pmh:oai:researchonline.rvc.ac.uk:4959","doi":null,"is_oa":true,"landing_page_url":"https://researchonline.rvc.ac.uk/id/eprint/4959/1/4959.pdf","pdf_url":"https://researchonline.rvc.ac.uk/id/eprint/4959/1/4959.pdf","source":{"id":"https://openalex.org/S4306402069","display_name":"RVC Research Online (Royal Veterinary College)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I133836048","host_organization_name":"Royal Veterinary College","host_organization_lineage":["https://openalex.org/I133836048"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:researchonline.rvc.ac.uk:4959","doi":null,"is_oa":true,"landing_page_url":"https://researchonline.rvc.ac.uk/id/eprint/4959/1/4959.pdf","pdf_url":"https://researchonline.rvc.ac.uk/id/eprint/4959/1/4959.pdf","source":{"id":"https://openalex.org/S4306402069","display_name":"RVC Research Online (Royal Veterinary College)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I133836048","host_organization_name":"Royal Veterinary College","host_organization_lineage":["https://openalex.org/I133836048"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1499539705","https://openalex.org/W1499870879","https://openalex.org/W1516430041","https://openalex.org/W1531804698","https://openalex.org/W1568965788","https://openalex.org/W1584157616","https://openalex.org/W1924345866","https://openalex.org/W1938206116","https://openalex.org/W1963908972","https://openalex.org/W1968518622","https://openalex.org/W1969828432","https://openalex.org/W1973193956","https://openalex.org/W1979270883","https://openalex.org/W2000649989","https://openalex.org/W2003193157","https://openalex.org/W2004371804","https://openalex.org/W2004632384","https://openalex.org/W2006714934","https://openalex.org/W2009756576","https://openalex.org/W2014984654","https://openalex.org/W2016340859","https://openalex.org/W2025788012","https://openalex.org/W2026188379","https://openalex.org/W2027259173","https://openalex.org/W2033559302","https://openalex.org/W2052750950","https://openalex.org/W2052916446","https://openalex.org/W2053305914","https://openalex.org/W2057561125","https://openalex.org/W2059526312","https://openalex.org/W2061440101","https://openalex.org/W2061898655","https://openalex.org/W2062489355","https://openalex.org/W2073860070","https://openalex.org/W2074808191","https://openalex.org/W2077230452","https://openalex.org/W2080916020","https://openalex.org/W2085668133","https://openalex.org/W2086524338","https://openalex.org/W2089207360","https://openalex.org/W2090427349","https://openalex.org/W2099699040","https://openalex.org/W2109283410","https://openalex.org/W2115338907","https://openalex.org/W2141730865","https://openalex.org/W2146869201","https://openalex.org/W2146989813","https://openalex.org/W2151519283","https://openalex.org/W2172068213","https://openalex.org/W4391201110"],"related_works":["https://openalex.org/W1969828432","https://openalex.org/W2006714934","https://openalex.org/W1938922647","https://openalex.org/W2118471454","https://openalex.org/W2084289218","https://openalex.org/W2138999730","https://openalex.org/W2132445477","https://openalex.org/W1992298219","https://openalex.org/W2048838012","https://openalex.org/W2140036853"],"abstract_inverted_index":{"Inappropriately":[0],"activated":[1],"eosinophils":[2,29,68],"can":[3],"contribute":[4],"to":[5,48,153],"disease":[6],"pathogenesis":[7],"and":[8,30,40,50,64,77,104,147,171,185,195],"intracellular":[9,25],"signalling":[10,26],"pathways":[11],"that":[12,165],"regulate":[13],"functional":[14],"responses":[15,47,160],"may":[16,189],"represent":[17,199],"a":[18,41],"therapeutic":[19],"target.":[20],"Little":[21],"is":[22,173,180],"known":[23],"about":[24],"in":[27,74,92,109,158],"equine":[28,166],"this":[31],"study":[32],"examined":[33],"the":[34,75,90,113,127,159],"role":[35,157],"of":[36,43,79,84,99,129,143],"phospholipase":[37],"C":[38,122],"(PLC)":[39],"range":[42],"protein":[44,120],"kinases":[45,198],"on":[46],"histamine":[49,170],"CCL11.":[51],"Histamine":[52],"(10(-4)":[53],"M)":[54],"or":[55],"CCL11":[56,172],"(5.6":[57],"x":[58],"10(-9)":[59],"M)-induced":[60],"actin":[61,102,183],"polymerization,":[62],"migration":[63,110,188],"superoxide":[65,105,186],"production":[66],"by":[67,136,169,193,206],"from":[69],"healthy":[70],"horses":[71],"were":[72],"compared":[73],"presence":[76],"absence":[78],"selective":[80],"kinase":[81,86,121,140,149],"inhibitors.":[82],"Inhibition":[83],"phosphatidylinositol-3":[85],"(PI3K)":[87],"significantly":[88,134],"reduced":[89,135],"response":[91],"each":[93],"assay.":[94],"In":[95],"contrast,":[96],"whilst":[97],"inhibition":[98],"PLC":[100,178,194],"decreased":[101],"polymerization":[103,184],"production,":[106,187],"an":[107,155],"increase":[108],"was":[111,116,124,133],"observed;":[112],"latter":[114],"effect":[115],"also":[117],"seen":[118],"when":[119],"(PKC)":[123],"inhibited.":[125],"With":[126],"exception":[128],"histamine-induced":[130],"migration,":[131],"which":[132],"blocking":[137],"extracellular":[138],"regulated":[139,192],"(ERK)1/2,":[141],"activation":[142,168,179,205],"ERK1/2,":[144],"p38":[145],"MAPK":[146],"tyrosine":[148],"did":[150],"not":[151],"appear":[152],"play":[154],"important":[156],"studied.":[161],"These":[162,197],"results":[163],"suggest":[164],"eosinophil":[167,204],"mediated":[174],"through":[175],"PI3K.":[176],"Whilst":[177],"required":[181],"for":[182,202],"be":[190],"negatively":[191],"PKC.":[196],"potential":[200],"targets":[201],"modulating":[203],"multiple":[207],"stimuli.":[208]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}