{"id":"https://openalex.org/W1978068134","doi":"https://doi.org/10.1046/j.1365-2249.1999.00750.x","title":"Anti-inflammatory effects of a new tumour necrosis factor-alpha (TNF-\u03b1) inhibitor (CNI-1493) in collagen-induced arthritis (CIA) in rats","display_name":"Anti-inflammatory effects of a new tumour necrosis factor-alpha (TNF-\u03b1) inhibitor (CNI-1493) in collagen-induced arthritis (CIA) in rats","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W1978068134","doi":"https://doi.org/10.1046/j.1365-2249.1999.00750.x","mag":"1978068134","pmid":"https://pubmed.ncbi.nlm.nih.gov/9933418","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1905187"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2249.1999.00750.x","doi":"https://doi.org/10.1046/j.1365-2249.1999.00750.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2249.1999.00750.x","pdf_url":null,"source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1905187","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050423614","display_name":"Karin \u00c5kerlund","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"K \u00c5KERLUND","raw_affiliation_strings":["Department of Rheumatology, Astrid Lindgren's Children's Hospital, Karolinska Hospital, Stockholm, Sweden","Department of Rheumatology, Centre of Molecular Medicine, Karolinska"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Astrid Lindgren's Children's Hospital, Karolinska Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Department of Rheumatology, Centre of Molecular Medicine, Karolinska","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052851685","display_name":"Helena Erlandsson Harris","orcid":"https://orcid.org/0000-0002-7951-7509","observed_orcids":["https://orcid.org/0000-0002-7951-7509"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"H ERLANDSSON HARRIS","raw_affiliation_strings":["Department of Rheumatology, Centre of Molecular Medicine, Karolinska"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Centre of Molecular Medicine, Karolinska","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030646863","display_name":"Kevin J. Tracey","orcid":"https://orcid.org/0000-0003-1884-6314","observed_orcids":["https://orcid.org/0000-0003-1884-6314"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K J TRACEY","raw_affiliation_strings":["Laboratory of Biomedical Science, Picower Institute for Medical Research, Manhasset, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biomedical Science, Picower Institute for Medical Research, Manhasset, NY, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100452906","display_name":"Haichao Wang","orcid":"https://orcid.org/0000-0002-0211-9000","observed_orcids":["https://orcid.org/0000-0002-0211-9000"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H WANG","raw_affiliation_strings":["Laboratory of Biomedical Science, Picower Institute for Medical Research, Manhasset, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biomedical Science, Picower Institute for Medical Research, Manhasset, NY, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016323798","display_name":"Todd A. Fehniger","orcid":"https://orcid.org/0000-0002-8705-2887","observed_orcids":["https://orcid.org/0000-0002-8705-2887"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"T FEHNIGER","raw_affiliation_strings":["Department of Infectious Diseases, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071491614","display_name":"Lars Klareskog","orcid":"https://orcid.org/0000-0001-9601-6186","observed_orcids":["https://orcid.org/0000-0001-9601-6186"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"L KLARESKOG","raw_affiliation_strings":["Department of Rheumatology, Centre of Molecular Medicine, Karolinska"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Centre of Molecular Medicine, Karolinska","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078542779","display_name":"Jan Andersson","orcid":"https://orcid.org/0000-0003-0316-3860","observed_orcids":["https://orcid.org/0000-0003-0316-3860","https://orcid.org/0009-0005-7276-8056"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"J ANDERSSON","raw_affiliation_strings":["Department of Infectious Diseases, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078542779","display_name":"Jan Andersson","orcid":"https://orcid.org/0000-0003-0316-3860","observed_orcids":["https://orcid.org/0000-0003-0316-3860","https://orcid.org/0009-0005-7276-8056"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"U ANDERSSON","raw_affiliation_strings":["Department of Rheumatology, Centre of Molecular Medicine, Karolinska"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Centre of Molecular Medicine, Karolinska","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5050423614"],"corresponding_institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"],"apc_list":{"value":2894,"currency":"GBP","value_usd":3816},"apc_paid":null,"fwci":2.4949,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.8827244,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"115","issue":"1","first_page":"32","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cni-1493","display_name":"CNI-1493","score":0.996999979019165},{"id":"https://openalex.org/keywords/collagen-induced-arthritis","display_name":"collagen-induced arthritis","score":0.9300000071525574},{"id":"https://openalex.org/keywords/guanylhydrazones","display_name":"guanylhydrazones","score":0.8939999938011169},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.6819999814033508},{"id":"https://openalex.org/keywords/prophylaxis","display_name":"prophylaxis","score":0.8080000281333923},{"id":"https://openalex.org/keywords/therapeutic-interventions","display_name":"therapeutic interventions","score":0.6340000033378601},{"id":"https://openalex.org/keywords/tnf-alpha-expression","display_name":"TNF-\u03b1 expression","score":0.7509999871253967},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.829380989074707},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.7042360305786133},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6721602082252502},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.5284856557846069},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.517871618270874},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4457799792289734},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40339195728302},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39110884070396423},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33690178394317627},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.11043724417686462},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000813","descriptor_name":"Anilides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001169","descriptor_name":"Arthritis, Experimental","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D001169","descriptor_name":"Arthritis, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001169","descriptor_name":"Arthritis, Experimental","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006146","descriptor_name":"Guanidines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006835","descriptor_name":"Hydrazones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009573","descriptor_name":"Nitrites","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1046/j.1365-2249.1999.00750.x","doi":"https://doi.org/10.1046/j.1365-2249.1999.00750.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2249.1999.00750.x","pdf_url":null,"source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1905187","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1905187","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},{"id":"pmid:9933418","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9933418","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1905187","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1905187","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G174099042","display_name":"PATHOGENESIS OF WASTING IN AIDS","funder_award_id":"R01DK049283","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W107548672","https://openalex.org/W112216778","https://openalex.org/W132781887","https://openalex.org/W1501833360","https://openalex.org/W1528765374","https://openalex.org/W1964042457","https://openalex.org/W1966761397","https://openalex.org/W1967913927","https://openalex.org/W1976912963","https://openalex.org/W1986957921","https://openalex.org/W1996794055","https://openalex.org/W2002365046","https://openalex.org/W2006831045","https://openalex.org/W2007452858","https://openalex.org/W2008846580","https://openalex.org/W2010463792","https://openalex.org/W2017720269","https://openalex.org/W2026342001","https://openalex.org/W2029085089","https://openalex.org/W2031504111","https://openalex.org/W2032090998","https://openalex.org/W2032731042","https://openalex.org/W2033228977","https://openalex.org/W2058068049","https://openalex.org/W2070786645","https://openalex.org/W2071616525","https://openalex.org/W2085853581","https://openalex.org/W2114298357","https://openalex.org/W2129202470","https://openalex.org/W2133602875","https://openalex.org/W2142273705","https://openalex.org/W2143124583","https://openalex.org/W2145549313","https://openalex.org/W2146922459","https://openalex.org/W2406155508","https://openalex.org/W2417069510"],"related_works":["https://openalex.org/W2114029047","https://openalex.org/W213884132","https://openalex.org/W60170577","https://openalex.org/W2084030755","https://openalex.org/W2409736251","https://openalex.org/W4362575214","https://openalex.org/W2094434507","https://openalex.org/W2035180752","https://openalex.org/W2947459817","https://openalex.org/W2066614216"],"abstract_inverted_index":{"A":[0],"recently":[1],"developed":[2],"compound,":[3],"a":[4,66,80,119,156,162,168],"multivalent":[5],"guanylhydrazone":[6],"(CNI-1493)":[7],"that":[8,115,152],"inhibits":[9],"TNF-alpha":[10,14,123,137],"production":[11],"by":[12],"suppressing":[13],"translational":[15],"efficiency,":[16],"was":[17,32,111],"administered":[18],"in":[19,28,65,73,79,88,142,148,179],"an":[20],"experimental":[21],"model":[22],"of":[23,40,46,63,83,86,122,127,146,155,165,182],"collagen":[24],"type":[25],"II-induced":[26],"arthritis":[27,41,64,87,147],"DA":[29],"rats.":[30],"CNI-1493":[31,52,72,102,116,131,160],"injected":[33],"daily":[34,101],"intraperitoneally":[35],"either":[36],"before":[37],"the":[38,44,57,61,125,144,153,180],"onset":[39,58],"or":[42,55],"after":[43],"establishment":[45],"clinical":[47,84],"disease.":[48],"Prophylactic":[49],"treatment":[50],"with":[51,71,100,132,161],"significantly":[53],"prevented":[54],"delayed":[56],"and":[59,173],"suppressed":[60],"severity":[62],"dose-dependent":[67],"manner.":[68],"Therapeutic":[69],"intervention":[70],"established":[74],"joint":[75],"disease":[76,128],"also":[77],"resulted":[78],"significant":[81],"reduction":[82],"signs":[85],"treated":[89,99],"animals.":[90],"No":[91],"severe":[92],"side-effects":[93],"were":[94,98],"noted":[95],"when":[96],"animals":[97],"doses":[103],"up":[104],"to":[105,118],"5":[106],"mg/kg.":[107],"An":[108],"immunohistochemical":[109],"study":[110],"performed":[112],"which":[113],"demonstrated":[114],"led":[117],"reduced":[120],"expression":[121],"at":[124],"site":[126],"activity.":[129],"Thus,":[130],"documented":[133],"inhibitory":[134],"effects":[135],"on":[136],"synthesis,":[138],"has":[139],"proven":[140],"successful":[141],"ameliorating":[143],"course":[145],"CIA.":[149],"We":[150],"believe":[151],"use":[154],"compound":[157],"such":[158],"as":[159],"defined":[163],"mode":[164],"action":[166],"provides":[167],"useful":[169],"tool":[170],"for":[171],"dissecting":[172],"understanding":[174],"important":[175],"pathogenic":[176],"mechanisms":[177],"operating":[178],"development":[181],"chronic":[183],"arthritis.":[184]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}