{"id":"https://openalex.org/W1978044086","doi":"https://doi.org/10.1021/bi015649a","title":"Thermodynamic Model for the Stabilization of Trigonal Thiolato Mercury(II) in Designed Three-Stranded Coiled Coils","display_name":"Thermodynamic Model for the Stabilization of Trigonal Thiolato Mercury(II) in Designed Three-Stranded Coiled Coils","publication_year":2001,"publication_date":"2001-11-07","ids":{"openalex":"https://openalex.org/W1978044086","doi":"https://doi.org/10.1021/bi015649a","mag":"1978044086","pmid":"https://pubmed.ncbi.nlm.nih.gov/11724584"},"language":"en","primary_location":{"id":"doi:10.1021/bi015649a","doi":"https://doi.org/10.1021/bi015649a","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi015649a","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075155514","display_name":"Brian T. Farrer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian T. Farrer","raw_affiliation_strings":["Department of Chemistry, The University of Michigan, Ann Arbor, Michigan 48109-1055"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The University of Michigan, Ann Arbor, Michigan 48109-1055","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062617491","display_name":"Nzingha P. Harris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nzingha P. Harris","raw_affiliation_strings":["Department of Chemistry, The University of Michigan, Ann Arbor, Michigan 48109-1055"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The University of Michigan, Ann Arbor, Michigan 48109-1055","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007384336","display_name":"Kristen E. Balchus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristen E. Balchus","raw_affiliation_strings":["Department of Chemistry, The University of Michigan, Ann Arbor, Michigan 48109-1055"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The University of Michigan, Ann Arbor, Michigan 48109-1055","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084987684","display_name":"Vincent L. Pecoraro","orcid":"https://orcid.org/0000-0002-1540-5735","observed_orcids":["https://orcid.org/0000-0002-1540-5735","https://orcid.org/0000-0002-1800-0936"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent L. Pecoraro","raw_affiliation_strings":["Department of Chemistry, The University of Michigan, Ann Arbor, Michigan 48109-1055"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The University of Michigan, Ann Arbor, Michigan 48109-1055","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.6982,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.65591925,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"40","issue":"48","first_page":"14696","last_page":"14705"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.7407000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.7407000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.09969999641180038,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10578","display_name":"Supramolecular Chemistry and Complexes","score":0.031599998474121094,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mercury-ii-binding","display_name":"mercury(II) binding","score":0.8320000171661377},{"id":"https://openalex.org/keywords/de-novo-peptide-design","display_name":"de novo peptide design","score":0.7590000033378601},{"id":"https://openalex.org/keywords/binding-constant","display_name":"binding constant","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C55988834","wikidata":"https://www.wikidata.org/wiki/Q903650","display_name":"Coiled coil","level":2,"score":0.7053842544555664},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.703793466091156},{"id":"https://openalex.org/C122146531","wikidata":"https://www.wikidata.org/wiki/Q16920125","display_name":"Heptad repeat","level":4,"score":0.6693937182426453},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.627568781375885},{"id":"https://openalex.org/C184866935","wikidata":"https://www.wikidata.org/wiki/Q191010","display_name":"Titration","level":2,"score":0.6100836992263794},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.6092510223388672},{"id":"https://openalex.org/C194185919","wikidata":"https://www.wikidata.org/wiki/Q663314","display_name":"Trigonal crystal system","level":3,"score":0.5946199893951416},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3346376419067383},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.29345235228538513},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.16362988948822021},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16063141822814941},{"id":"https://openalex.org/C115624301","wikidata":"https://www.wikidata.org/wiki/Q895901","display_name":"Crystal structure","level":2,"score":0.06746894121170044},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008628","descriptor_name":"Mercury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008628","descriptor_name":"Mercury","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008667","descriptor_name":"Metalloproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008667","descriptor_name":"Metalloproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011489","descriptor_name":"Protein Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013057","descriptor_name":"Spectrum Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019791","descriptor_name":"Guanidine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi015649a","doi":"https://doi.org/10.1021/bi015649a","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi015649a","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:11724584","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11724584","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2209244459","display_name":null,"funder_award_id":"1F32 ES05888-01","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G566439749","display_name":"PROBING ARSENIC TOXICITY USING SYNTHETIC PEPTIDES","funder_award_id":"5f32es005888-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1513861898","https://openalex.org/W1996653292","https://openalex.org/W1999830371","https://openalex.org/W2034561754","https://openalex.org/W2038949562","https://openalex.org/W2047568524","https://openalex.org/W2053390244","https://openalex.org/W2055300232","https://openalex.org/W2066158370","https://openalex.org/W2084376937","https://openalex.org/W2104460080","https://openalex.org/W2136028668"],"related_works":["https://openalex.org/W2157861621","https://openalex.org/W1981901173","https://openalex.org/W2136028668","https://openalex.org/W3015183222","https://openalex.org/W2043821193","https://openalex.org/W2788220583","https://openalex.org/W1969008435","https://openalex.org/W123619347","https://openalex.org/W2114329690","https://openalex.org/W2048688795"],"abstract_inverted_index":{"A":[0],"thermodynamic":[1],"model":[2],"is":[3,99],"presented":[4],"that":[5,182,264],"describes":[6],"the":[7,25,34,79,153,211,221,259,271,305,308,314,324,328,339],"binding":[8,254,267],"of":[9,120,155,193,200,205,213,223,233,241,268,288,307,323,330,341,351],"Hg(II)":[10,209,281,317],"to":[11,41,108,148,252,258,270,295,312],"de":[12],"novo":[13],"designed":[14,107],"peptides,":[15],"Tri":[16,26,29,60,104,126,144,234,352],"L9C":[17,61,86,132,145,162,184,195,235,238,353],"and":[18,38,51,76,82,130,136,236,248],"Baby":[19,85,128,131,161,183,194,237],"L9C,":[20,105,127],"which":[21,90],"were":[22,138,250],"derived":[23],"from":[24],"family.":[27],"The":[28,117,191,202],"peptides":[30,272],"are":[31,39],"based":[32],"on":[33],"parent":[35],"sequence":[36,70],"Ac-NH-G(LKALEEK)(x)()G-CONH(2)":[37],"known":[40],"form":[42,109],"two-stranded":[43,275],"coiled":[44,53,113,121,176,216,276,299,344],"coils":[45,54,114],"at":[46,55,133,157,167,188,229,243,282,318,354],"low":[47],"pH":[48,57,134,158,168,189,244,319,355],"(pH":[49,58],"<4)":[50],"three-stranded":[52,215,298,343],"high":[56],">7).":[59],"(x":[62,87],"=":[63,88],"4)":[64],"contains":[65],"a":[66,81,93,171,186,206,214,224,262,274,289,297,342,349],"four":[67],"heptad":[68,101],"repeat":[69],"with":[71,278],"cysteine":[72,94,310,325],"in":[73,78,95,115,152,210,327,348],"position":[74,96],"9":[75,97,249],"leucines":[77],"other":[80],"d":[83],"positions;":[84],"3),":[89],"also":[91],"has":[92],"but":[98],"one":[100],"shorter":[102],"than":[103],"was":[106,146,185,196,218,336],"less":[110],"stable":[111],"helical":[112,151,165],"solution.":[116],"free":[118],"energies":[119],"coil":[122,217,277,345],"formation":[123,204],"for":[124,333],"Tri,":[125,129],"2.5":[135],"8.5":[137,159],"determined":[139],"by":[140,198,220,286,338,346],"guanidinium":[141],"denaturation":[142],"titrations;":[143],"observed":[147],"be":[149],"highly":[150],"absence":[154],"denaturant":[156],"while":[160],"contained":[163],"<20%":[164],"content":[166],"8.5,":[169],"indicating":[170],"weakly":[172,291],"associated":[173,292],"or":[174],"unassociated":[175],"coil.":[177,300],"Size-exclusion":[178],"chromatography":[179],"(SEC)":[180],"verified":[181,219],"monomer":[187],"8.5.":[190],"helicity":[192],"induced":[197],"addition":[199,287],"HgCl(2).":[201],"subsequent":[203],"trigonal":[207,315],"thiolato":[208,280,316],"interior":[212],"presence":[222,329],"characteristic":[225],"HgS(3)":[226],"UV":[227],"band":[228],"248":[230],"nm.":[231],"Titrations":[232],"into":[239],"solutions":[240],"HgCl(2)":[242],"values":[245],"between":[246],"7":[247],"performed":[251],"extract":[253],"constants.":[255],"Global":[256],"fits":[257],"data":[260],"employed":[261],"mechanism":[263,302,335],"involved":[265],"initial":[266],"mercury":[269],"forming":[273],"linear":[279],"[peptide]/[Hg]":[283],"<2,":[284],"followed":[285],"more":[290],"third":[293,309],"helix":[294],"generate":[296,313],"This":[301],"would":[303],"require":[304],"deprotonation":[306],"thiol":[311,326],">7.5":[320],"[the":[321],"pK(a)":[322],"Hg(II)].":[331],"Support":[332],"this":[334],"given":[337],"observation":[340],"SEC":[347],"solution":[350],"7.0.":[356]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
