{"id":"https://openalex.org/W1978015681","doi":"https://doi.org/10.1172/jci116836","title":"Effects of interleukin-1 on syntheses of alkaline phosphatase, type X collagen, and 1,25-dihydroxyvitamin D3 receptor, and matrix calcification in rabbit chondrocyte cultures.","display_name":"Effects of interleukin-1 on syntheses of alkaline phosphatase, type X collagen, and 1,25-dihydroxyvitamin D3 receptor, and matrix calcification in rabbit chondrocyte cultures.","publication_year":1993,"publication_date":"1993-11-01","ids":{"openalex":"https://openalex.org/W1978015681","doi":"https://doi.org/10.1172/jci116836","mag":"1978015681","pmid":"https://pubmed.ncbi.nlm.nih.gov/8227347","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/288413"},"language":"en","primary_location":{"id":"doi:10.1172/jci116836","doi":"https://doi.org/10.1172/jci116836","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci116836","pdf_url":"http://www.jci.org/articles/view/116836/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/116836/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078475231","display_name":"Yukio Kato","orcid":"https://orcid.org/0000-0003-0192-9324","observed_orcids":["https://orcid.org/0000-0003-0192-9324"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Kato","raw_affiliation_strings":["Department of Biochemistry, School of Dentistry, Hiroshima University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, School of Dentistry, Hiroshima University, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081454261","display_name":"Kazuhisa Nakashima","orcid":"https://orcid.org/0000-0003-0491-2149","observed_orcids":["https://orcid.org/0000-0003-0491-2149"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]},{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Nakashima","raw_affiliation_strings":["Department ofBiochemistry , School ofDentistry , Hiroshima University , Hiroshima 734 , Japan;","Department ofBiochemistry, School ofDentistry, Hiroshima University, Hiroshima 734, Japan; Departments oftRadiology and 4Biochemistry, Faculty ofDentistry,","Osaka City University, Osaka 545, Japan; and","Osaka University, Suita, Osaka 565, Japan; I1Department ofPediatrics, Medical School,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofBiochemistry , School ofDentistry , Hiroshima University , Hiroshima 734 , Japan;","institution_ids":["https://openalex.org/I113306721"]},{"raw_affiliation_string":"Department ofBiochemistry, School ofDentistry, Hiroshima University, Hiroshima 734, Japan; Departments oftRadiology and 4Biochemistry, Faculty ofDentistry,","institution_ids":["https://openalex.org/I113306721"]},{"raw_affiliation_string":"Osaka City University, Osaka 545, Japan; and","institution_ids":["https://openalex.org/I317356780"]},{"raw_affiliation_string":"Osaka University, Suita, Osaka 565, Japan; I1Department ofPediatrics, Medical School,","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101831835","display_name":"Masahiro Iwamoto","orcid":"https://orcid.org/0000-0001-5045-9352","observed_orcids":["https://orcid.org/0000-0001-5045-9352"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Iwamoto","raw_affiliation_strings":["Faculty ofDentistry , Osaka University , Suita , Osaka 565 , Japan","Department of Biochemistry,","School of Dentistry, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima City, 734, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty ofDentistry , Osaka University , Suita , Osaka 565 , Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Biochemistry,","institution_ids":[]},{"raw_affiliation_string":"School of Dentistry, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima City, 734, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084689060","display_name":"Hiroshi Murakami","orcid":"https://orcid.org/0000-0002-5482-8095","observed_orcids":["https://orcid.org/0000-0002-5482-8095"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Murakami","raw_affiliation_strings":["Departments oftRadiology and 4Biochemistry ,","Department of Biochemistry,","School of Dentistry, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima City, 734, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments oftRadiology and 4Biochemistry ,","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry,","institution_ids":[]},{"raw_affiliation_string":"School of Dentistry, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima City, 734, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079774591","display_name":"Hiroko Hiranuma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]},{"id":"https://openalex.org/I31784960","display_name":"Fukuoka University","ror":"https://ror.org/04nt8b154","country_code":"JP","type":"education","lineage":["https://openalex.org/I31784960"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Hiranuma","raw_affiliation_strings":["'Department ofBiochemistry , Fukuoka University , School ofMedicine , Fukuoka 814-01 , Japan","Department of Biochemistry,","School of Dentistry, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima City, 734, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"'Department ofBiochemistry , Fukuoka University , School ofMedicine , Fukuoka 814-01 , Japan","institution_ids":["https://openalex.org/I31784960"]},{"raw_affiliation_string":"Department of Biochemistry,","institution_ids":[]},{"raw_affiliation_string":"School of Dentistry, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima City, 734, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074923100","display_name":"Tatsuya Koike","orcid":"https://orcid.org/0000-0002-1522-8740","observed_orcids":["https://orcid.org/0000-0002-1522-8740"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]},{"id":"https://openalex.org/I31784960","display_name":"Fukuoka University","ror":"https://ror.org/04nt8b154","country_code":"JP","type":"education","lineage":["https://openalex.org/I31784960"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Koike","raw_affiliation_strings":["'Department ofBiochemistry , Fukuoka University , School ofMedicine , Fukuoka 814-01 , Japan","Department of Biochemistry,","School of Dentistry, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima City, 734, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"'Department ofBiochemistry , Fukuoka University , School ofMedicine , Fukuoka 814-01 , Japan","institution_ids":["https://openalex.org/I31784960"]},{"raw_affiliation_string":"Department of Biochemistry,","institution_ids":[]},{"raw_affiliation_string":"School of Dentistry, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima City, 734, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084214689","display_name":"Fumihiko Suzuki","orcid":"https://orcid.org/0000-0002-5156-9729","observed_orcids":["https://orcid.org/0000-0002-5156-9729"]},"institutions":[{"id":"https://openalex.org/I31784960","display_name":"Fukuoka University","ror":"https://ror.org/04nt8b154","country_code":"JP","type":"education","lineage":["https://openalex.org/I31784960"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"F Suzuki","raw_affiliation_strings":["Faculty ofDentistry , Osaka University , Suita , Osaka 565 , Japan","Department ofBiochemistry, Fukuoka University, School ofMedicine, Fukuoka 814-01, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty ofDentistry , Osaka University , Suita , Osaka 565 , Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department ofBiochemistry, Fukuoka University, School ofMedicine, Fukuoka 814-01, Japan","institution_ids":["https://openalex.org/I31784960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077441494","display_name":"Hajime Fuchihata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Fuchihata","raw_affiliation_strings":["Faculty ofDentistry , Osaka University , Suita , Osaka 565 , Japan","School of Dentistry, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima City, 734, Japan","Department of Biochemistry,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty ofDentistry , Osaka University , Suita , Osaka 565 , Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"School of Dentistry, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima City, 734, Japan","institution_ids":["https://openalex.org/I113306721"]},{"raw_affiliation_string":"Department of Biochemistry,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014499294","display_name":"Yuzuru Ikehara","orcid":"https://orcid.org/0000-0002-1915-9172","observed_orcids":["https://orcid.org/0000-0002-1915-9172"]},"institutions":[{"id":"https://openalex.org/I31784960","display_name":"Fukuoka University","ror":"https://ror.org/04nt8b154","country_code":"JP","type":"education","lineage":["https://openalex.org/I31784960"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Ikehara","raw_affiliation_strings":["Faculty ofDentistry , Osaka University , Suita , Osaka 565 , Japan","Department ofBiochemistry, Fukuoka University, School ofMedicine, Fukuoka 814-01, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty ofDentistry , Osaka University , Suita , Osaka 565 , Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department ofBiochemistry, Fukuoka University, School ofMedicine, Fukuoka 814-01, Japan","institution_ids":["https://openalex.org/I31784960"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111601691","display_name":"M. Noshiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]},{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Noshiro","raw_affiliation_strings":["Department ofBiochemistry, School ofDentistry, Hiroshima University, Hiroshima 734, Japan; Departments oftRadiology and 4Biochemistry, Faculty ofDentistry,","Osaka City University, Osaka 545, Japan; and","Osaka University, Suita, Osaka 565, Japan; I1Department ofPediatrics, Medical School,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofBiochemistry, School ofDentistry, Hiroshima University, Hiroshima 734, Japan; Departments oftRadiology and 4Biochemistry, Faculty ofDentistry,","institution_ids":["https://openalex.org/I113306721"]},{"raw_affiliation_string":"Osaka City University, Osaka 545, Japan; and","institution_ids":["https://openalex.org/I317356780"]},{"raw_affiliation_string":"Osaka University, Suita, Osaka 565, Japan; I1Department ofPediatrics, Medical School,","institution_ids":["https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":1.9361,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.82967515,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"92","issue":"5","first_page":"2323","last_page":"2330"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9679999947547913},{"id":"https://openalex.org/keywords/chondrocyte-hypertrophy","display_name":"chondrocyte hypertrophy","score":0.9440000057220459},{"id":"https://openalex.org/keywords/matrix-calcification","display_name":"matrix calcification","score":0.7429999709129333},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.9610000252723694},{"id":"https://openalex.org/keywords/type-x-collagen","display_name":"type X collagen","score":0.996999979019165},{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d3-receptor","display_name":"1,25-dihydroxyvitamin D3 receptor","score":0.9959999918937683},{"id":"https://openalex.org/keywords/growth-plate-cartilage","display_name":"growth plate cartilage","score":0.7940000295639038},{"id":"https://openalex.org/keywords/ossification","display_name":"ossification","score":0.699999988079071},{"id":"https://openalex.org/keywords/calcium-incorporation","display_name":"calcium incorporation","score":0.6359999775886536},{"id":"https://openalex.org/keywords/type-ii-collagen","display_name":"type II collagen","score":0.7440000176429749}],"concepts":[{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.8553566336631775},{"id":"https://openalex.org/C2780309369","wikidata":"https://www.wikidata.org/wiki/Q933382","display_name":"Calcification","level":2,"score":0.830162525177002},{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.796455442905426},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7354210615158081},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.721685528755188},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.578686535358429},{"id":"https://openalex.org/C111696902","wikidata":"https://www.wikidata.org/wiki/Q6864413","display_name":"Mineralization (soil science)","level":3,"score":0.5751028656959534},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4924999177455902},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.47988784313201904},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.45610952377319336},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32464906573295593},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2362453043460846},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.19471678137779236},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13180524110794067},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.12656909227371216},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10571405291557312},{"id":"https://openalex.org/C537208039","wikidata":"https://www.wikidata.org/wiki/Q627","display_name":"Nitrogen","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002113","descriptor_name":"Calcification, Physiologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006132","descriptor_name":"Growth Plate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006132","descriptor_name":"Growth Plate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010281","descriptor_name":"Parathyroid Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014574","descriptor_name":"Uronic Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018167","descriptor_name":"Receptors, Calcitriol","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1172/jci116836","doi":"https://doi.org/10.1172/jci116836","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci116836","pdf_url":"http://www.jci.org/articles/view/116836/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmid:8227347","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8227347","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:288413","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC288413/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.852.8145","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.852.8145","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://dm5migu4zj3pb.cloudfront.net/manuscripts/116000/116836/JCI93116836.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1172/jci116836","doi":"https://doi.org/10.1172/jci116836","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci116836","pdf_url":"http://www.jci.org/articles/view/116836/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324177","display_name":"Otsuka Pharmaceutical","ror":"https://ror.org/013k5y296"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978015681.pdf","grobid_xml":"https://content.openalex.org/works/W1978015681.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W158373933","https://openalex.org/W1488147817","https://openalex.org/W1528445946","https://openalex.org/W1540384225","https://openalex.org/W1550447653","https://openalex.org/W1588586232","https://openalex.org/W1608320218","https://openalex.org/W1775897120","https://openalex.org/W1803860857","https://openalex.org/W1848552725","https://openalex.org/W1883653801","https://openalex.org/W1896878812","https://openalex.org/W1964139678","https://openalex.org/W1967357201","https://openalex.org/W1969481354","https://openalex.org/W1969627571","https://openalex.org/W1972800962","https://openalex.org/W1982183335","https://openalex.org/W1989045284","https://openalex.org/W1989260105","https://openalex.org/W1990734433","https://openalex.org/W1991636897","https://openalex.org/W1994175026","https://openalex.org/W1999652145","https://openalex.org/W2015346965","https://openalex.org/W2019840336","https://openalex.org/W2024171962","https://openalex.org/W2028028333","https://openalex.org/W2033686530","https://openalex.org/W2036871530","https://openalex.org/W2041439846","https://openalex.org/W2048539790","https://openalex.org/W2051585460","https://openalex.org/W2053034249","https://openalex.org/W2066978821","https://openalex.org/W2073453630","https://openalex.org/W2073977304","https://openalex.org/W2077077811","https://openalex.org/W2092819862","https://openalex.org/W2096904163","https://openalex.org/W2103896404","https://openalex.org/W2129795201","https://openalex.org/W2147637167","https://openalex.org/W2150876596","https://openalex.org/W2316398848","https://openalex.org/W2413177977","https://openalex.org/W6638801643"],"related_works":["https://openalex.org/W2082837821","https://openalex.org/W2354761786","https://openalex.org/W2071886638","https://openalex.org/W2352706065","https://openalex.org/W2139212391","https://openalex.org/W2355079602","https://openalex.org/W1967357201","https://openalex.org/W1972233883","https://openalex.org/W2046245538","https://openalex.org/W1972800962"],"abstract_inverted_index":{"The":[0,102],"effect":[1,91,129],"of":[2,6,16,39,54,76,86,95,104,118,147],"IL-1":[3,21,55,66,114,120,140],"on":[4,92,130],"expression":[5],"the":[7,37,45,49,74,93,116,123,145],"mineralization-related":[8],"phenotype":[9],"by":[10],"chondrocytes":[11,110],"was":[12,106],"examined.":[13],"In":[14],"cultures":[15],"rabbit":[17],"growth":[18],"plate":[19],"chondrocytes,":[20],"beta":[22,56,67],"at":[23],"0.1":[24],"ng/ml":[25],"caused":[26],"95%":[27],"decreases":[28],"in":[29,62,70,149],"alkaline":[30,33],"phosphatase":[31,34],"activity,":[32],"mRNA":[35],"levels,":[36],"incorporation":[38,132],"45Ca":[40,131],"into":[41,133],"insoluble":[42,134],"material,":[43],"and":[44,59,73,80,144],"calcium":[46],"content":[47],"during":[48],"hypertrophic":[50],"stage.":[51],"These":[52,136],"effects":[53],"were":[57,60,111],"dose-dependent":[58],"observed":[61,107],"24-48":[63],"h.":[64],"Furthermore,":[65],"suppressed":[68],"increase":[69],"cell":[71],"size":[72],"syntheses":[75],"1,25-dihydroxyvitamin":[77],"D3":[78],"receptor":[79],"type":[81,99],"X":[82],"collagen,":[83],"other":[84],"markers":[85],"hypertrophy,":[87],"but":[88],"had":[89,126],"little":[90],"synthesis":[94],"total":[96],"protein":[97],"including":[98],"II":[100],"collagen.":[101],"inhibition":[103],"calcification":[105,148],"only":[108],"when":[109],"exposed":[112],"to":[113],"before":[115],"onset":[117,146],"calcification:":[119],"treatment":[121],"from":[122],"mineralization":[124],"stage":[125],"a":[127],"marginal":[128],"material.":[135],"results":[137],"suggest":[138],"that":[139],"inhibits":[141],"chondrocyte":[142],"hypertrophy":[143],"ossifying":[150],"cartilage.":[151]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
