{"id":"https://openalex.org/W1978007043","doi":"https://doi.org/10.1073/pnas.96.11.6261","title":"Converting enzyme-independent release of tumor necrosis factor \u03b1 and IL-1\u03b2 from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3","display_name":"Converting enzyme-independent release of tumor necrosis factor \u03b1 and IL-1\u03b2 from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3","publication_year":1999,"publication_date":"1999-05-25","ids":{"openalex":"https://openalex.org/W1978007043","doi":"https://doi.org/10.1073/pnas.96.11.6261","mag":"1978007043","pmid":"https://pubmed.ncbi.nlm.nih.gov/10339575","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/26869"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.96.11.6261","doi":"https://doi.org/10.1073/pnas.96.11.6261","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.96.11.6261","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/26869","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089717033","display_name":"Claire M. Coeshott","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claire Coeshott","raw_affiliation_strings":["Cortech, Inc., 6850 North Broadway, Denver, CO 80221","Cortech, Inc., 6850 North Broadway, Denver, CO 80221, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cortech, Inc., 6850 North Broadway, Denver, CO 80221","institution_ids":[]},{"raw_affiliation_string":"Cortech, Inc., 6850 North Broadway, Denver, CO 80221, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068454618","display_name":"Christie Ohnemus","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christie Ohnemus","raw_affiliation_strings":["Cortech, Inc., 6850 North Broadway, Denver, CO 80221"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cortech, Inc., 6850 North Broadway, Denver, CO 80221","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047767118","display_name":"Anna Pilyavskaya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Pilyavskaya","raw_affiliation_strings":["Cortech, Inc., 6850 North Broadway, Denver, CO 80221"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cortech, Inc., 6850 North Broadway, Denver, CO 80221","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sherman Ross","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sherman Ross","raw_affiliation_strings":["Cortech, Inc., 6850 North Broadway, Denver, CO 80221"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cortech, Inc., 6850 North Broadway, Denver, CO 80221","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074594600","display_name":"Maciej Wieczorek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maciej Wieczorek","raw_affiliation_strings":["Cortech, Inc., 6850 North Broadway, Denver, CO 80221"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cortech, Inc., 6850 North Broadway, Denver, CO 80221","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011932531","display_name":"Heather Kroona","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heather Kroona","raw_affiliation_strings":["Cortech, Inc., 6850 North Broadway, Denver, CO 80221"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cortech, Inc., 6850 North Broadway, Denver, CO 80221","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085171956","display_name":"Axel H. Leimer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Axel H. Leimer","raw_affiliation_strings":["Cortech, Inc., 6850 North Broadway, Denver, CO 80221"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cortech, Inc., 6850 North Broadway, Denver, CO 80221","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075795213","display_name":"John C. Cheronis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Cheronis","raw_affiliation_strings":["Cortech, Inc., 6850 North Broadway, Denver, CO 80221"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cortech, Inc., 6850 North Broadway, Denver, CO 80221","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.4725,"has_fulltext":false,"cited_by_count":373,"citation_normalized_percentile":{"value":0.95567223,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"96","issue":"11","first_page":"6261","last_page":"6266"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.5996000170707703,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.5996000170707703,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.2224999964237213,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.06669999659061432,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cytokine-processing","display_name":"cytokine processing","score":0.6790000200271606},{"id":"https://openalex.org/keywords/proteinase-3","display_name":"proteinase 3","score":0.8840000033378601},{"id":"https://openalex.org/keywords/neutrophil-elastase","display_name":"neutrophil elastase","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cathepsin-g","display_name":"cathepsin G","score":0.9940000176429749},{"id":"https://openalex.org/keywords/secretory-leukocyte-protease-inhibitor","display_name":"secretory leukocyte protease inhibitor","score":0.7860000133514404},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.6179999709129333},{"id":"https://openalex.org/keywords/thp-1-cells","display_name":"THP-1 cells","score":0.8529999852180481},{"id":"https://openalex.org/keywords/lipopolysaccharide-stimulation","display_name":"lipopolysaccharide stimulation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/local-inflammation","display_name":"local inflammation","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.7213952541351318},{"id":"https://openalex.org/C2781044401","wikidata":"https://www.wikidata.org/wiki/Q418897","display_name":"Elastase","level":3,"score":0.6799987554550171},{"id":"https://openalex.org/C2777132095","wikidata":"https://www.wikidata.org/wiki/Q14906548","display_name":"Cathepsin G","level":4,"score":0.6561766862869263},{"id":"https://openalex.org/C21194631","wikidata":"https://www.wikidata.org/wiki/Q2113501","display_name":"Proteinase 3","level":4,"score":0.5396997332572937},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5250344276428223},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.5196903347969055},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5155289173126221},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4711393713951111},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4393719434738159},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.43481704592704773},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4121502637863159},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39128464460372925},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3557438552379608},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34422922134399414},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3078123927116394},{"id":"https://openalex.org/C203565725","wikidata":"https://www.wikidata.org/wiki/Q420012","display_name":"Myeloperoxidase","level":3,"score":0.1590401530265808},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002403","descriptor_name":"Cathepsins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015842","descriptor_name":"Serine Proteinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019272","descriptor_name":"Leukocyte Elastase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053146","descriptor_name":"Myeloblastin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053491","descriptor_name":"Proteinase Inhibitory Proteins, Secretory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056649","descriptor_name":"Cathepsin G","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.96.11.6261","doi":"https://doi.org/10.1073/pnas.96.11.6261","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.96.11.6261","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:191713","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/26869","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:26869","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/26869","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:10339575","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10339575","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"mag:2188334610","doi":null,"is_oa":false,"landing_page_url":"https://www.pnas.org/content/96/11/6261.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:191713","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/26869","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G130274786","display_name":"SALINAS STRYVE FOR A SAFE COMMUNITY","funder_award_id":"U81CE002072","funder_id":"https://openalex.org/F4320332162","funder_display_name":"Centers for Disease Control and Prevention"}],"funders":[{"id":"https://openalex.org/F4320332162","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W966875535","https://openalex.org/W1515994079","https://openalex.org/W1518605826","https://openalex.org/W1522206572","https://openalex.org/W1535477876","https://openalex.org/W1550592241","https://openalex.org/W1613736574","https://openalex.org/W1627442108","https://openalex.org/W1700571599","https://openalex.org/W1751293018","https://openalex.org/W1940973248","https://openalex.org/W1967206899","https://openalex.org/W1971244052","https://openalex.org/W1973689359","https://openalex.org/W1973752319","https://openalex.org/W1976784572","https://openalex.org/W1981106016","https://openalex.org/W1982520095","https://openalex.org/W1983671664","https://openalex.org/W1987852755","https://openalex.org/W1997115286","https://openalex.org/W1998491594","https://openalex.org/W2002491528","https://openalex.org/W2008261126","https://openalex.org/W2031863841","https://openalex.org/W2036691597","https://openalex.org/W2036842448","https://openalex.org/W2038077043","https://openalex.org/W2041233605","https://openalex.org/W2048209972","https://openalex.org/W2051658957","https://openalex.org/W2062784484","https://openalex.org/W2063662866","https://openalex.org/W2071660979","https://openalex.org/W2074881372","https://openalex.org/W2076817337","https://openalex.org/W2092254804","https://openalex.org/W2092671785","https://openalex.org/W2095574154","https://openalex.org/W2101840353","https://openalex.org/W2114948357","https://openalex.org/W2127310510","https://openalex.org/W2143658570","https://openalex.org/W2149943918","https://openalex.org/W2165239282","https://openalex.org/W2335054421","https://openalex.org/W2399067192","https://openalex.org/W2399204792","https://openalex.org/W4313310030"],"related_works":["https://openalex.org/W2188334610","https://openalex.org/W67040485","https://openalex.org/W2043510935","https://openalex.org/W2006105157","https://openalex.org/W2046221052","https://openalex.org/W2091127196","https://openalex.org/W7097927548","https://openalex.org/W2048209972","https://openalex.org/W1969262076","https://openalex.org/W2337567502"],"abstract_inverted_index":{"Two":[0],"important":[1],"cytokines":[2,74,181],"mediating":[3],"inflammation":[4],"are":[5,60,65],"tumor":[6],"necrosis":[7],"factor":[8],"alpha":[9],"(TNFalpha)":[10],"and":[11,29,38,117,138,158,175,192],"IL-1beta,":[12],"both":[13,180],"of":[14,26,35,51,73,90,101,126,129,150,169,173,179,189,202,226,244,253],"which":[15],"require":[16],"conversion":[17],"to":[18,42,83,103,164,217],"soluble":[19],"forms":[20],"by":[21,48,108,133],"converting":[22,53],"enzymes.":[23],"The":[24],"importance":[25],"TNFalpha-converting":[27],"enzyme":[28,31,54],"IL-1beta-converting":[30],"in":[32,40,81,94,147,186,250],"the":[33,49,99,104,124,148,167,187,203,212,242,251],"production":[34,243],"circulating":[36],"TNFalpha":[37,130,137,157],"IL-1beta":[39,132,139,159],"response":[41,82],"systemic":[43,62,85],"challenges":[44],"has":[45],"been":[46],"demonstrated":[47],"use":[50],"specific":[52,171],"inhibitors.":[55],"Many":[56],"inflammatory":[57,255],"responses,":[58],"however,":[59,185],"not":[61,220],"but":[63,219],"instead":[64],"localized.":[66],"In":[67,166],"these":[68,95,155,245],"situations":[69],"release":[70,140,160,178,205,214],"and/or":[71,131],"activation":[72],"may":[75,237],"be":[76,238],"different":[77],"from":[78,141],"that":[79,211,235],"seen":[80],"a":[84,170,190],"stimulus,":[86],"particularly":[87,249],"because":[88],"associations":[89],"various":[91],"cell":[92],"populations":[93],"foci":[96],"allows":[97],"for":[98,241],"exposure":[100],"procytokines":[102],"proteolytic":[105],"enzymes":[106,228],"produced":[107],"activated":[109,151],"neutrophils,":[110],"neutrophil":[111],"elastase":[112],"(NE),":[113],"proteinase":[114,199],"3":[115],"(PR3),":[116],"cathepsin":[118],"G":[119,194],"(Cat":[120],"G).":[121],"To":[122],"investigate":[123],"possibility":[125],"alternative":[127,239],"processing":[128],"neutrophil-derived":[134],"proteinases,":[135],"immunoreactive":[136],"lipopolysaccharide-stimulated":[142],"THP-1":[143],"cells":[144],"was":[145,161,182,206,215],"measured":[146],"presence":[149,168,188],"human":[152],"neutrophils.":[153],"Under":[154],"conditions,":[156],"augmented":[162,213],"2-":[163],"5-fold.":[165],"inhibitor":[172],"NE":[174,191,221],"PR3,":[176],"enhanced":[177,204],"largely":[183],"abolished;":[184],"Cat":[193,223],"selective":[195],"inhibitor,":[196,200],"secretory":[197],"leucocyte":[198],"reduction":[201],"minimal.":[207],"This":[208],"finding":[209],"suggested":[210],"attributable":[216],"PR3":[218],"nor":[222],"G.":[224],"Use":[225],"purified":[227],"confirmed":[229],"this":[230],"conclusion.":[231],"These":[232],"results":[233],"indicate":[234],"there":[236],"pathways":[240],"two":[246],"proinflammatory":[247],"cytokines,":[248],"context":[252],"local":[254],"processes.":[256]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":19},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":23}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}