{"id":"https://openalex.org/W1978001038","doi":"https://doi.org/10.1172/jci40567","title":"KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine","display_name":"KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W1978001038","doi":"https://doi.org/10.1172/jci40567","mag":"1978001038","pmid":"https://pubmed.ncbi.nlm.nih.gov/20364091","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2847423"},"language":"en","primary_location":{"id":"doi:10.1172/jci40567","doi":"https://doi.org/10.1172/jci40567","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci40567","pdf_url":"http://www.jci.org/articles/view/40567/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1978001038"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jci.org/articles/view/40567/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000505153","display_name":"Don Ganem","orcid":"https://orcid.org/0009-0002-0250-2314","observed_orcids":["https://orcid.org/0009-0002-0250-2314"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Don Ganem","raw_affiliation_strings":["Department of Medicine and Microbiology, University of California, 513 Parnassus Ave., San Francisco, CA 91413, USA. ganem@cgl.ucsf.edu","Department of Medicine and Microbiology, University of California, 513 Parnassus Ave., San Francisco, CA 91413, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Microbiology, University of California, 513 Parnassus Ave., San Francisco, CA 91413, USA. ganem@cgl.ucsf.edu","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Medicine and Microbiology, University of California, 513 Parnassus Ave., San Francisco, CA 91413, USA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000505153"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":{"value":5200,"currency":"USD","value_usd":5200},"fwci":4.0226,"has_fulltext":true,"cited_by_count":384,"citation_normalized_percentile":{"value":0.96828753,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"120","issue":"4","first_page":"939","last_page":"949"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kaposi-sarcoma","display_name":"Kaposi's sarcoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/kaposi-s-sarcoma-associated-herpesvirus","display_name":"Kaposi's sarcoma-associated herpesvirus","score":0.9950000047683716},{"id":"https://openalex.org/keywords/viral-carcinogenesis","display_name":"viral oncogenesis","score":0.6570000052452087},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.6600000262260437},{"id":"https://openalex.org/keywords/oncogenic-viruses","display_name":"oncogenic viruses","score":0.7070000171661377},{"id":"https://openalex.org/keywords/tumor-biology","display_name":"tumor biology","score":0.38199999928474426}],"concepts":[{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.5891846418380737},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.566429615020752},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5503378510475159},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5338778495788574},{"id":"https://openalex.org/C2779236070","wikidata":"https://www.wikidata.org/wiki/Q725345","display_name":"Kaposi's sarcoma","level":4,"score":0.4665503203868866},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.42193859815597534},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3977718651294708},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3348366618156433},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3317156732082367},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24108228087425232},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.22269585728645325},{"id":"https://openalex.org/C3018958071","wikidata":"https://www.wikidata.org/wiki/Q149348","display_name":"Human herpesvirus","level":3,"score":0.21770289540290833},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19317945837974548}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012514","descriptor_name":"Sarcoma, Kaposi","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D012514","descriptor_name":"Sarcoma, Kaposi","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019288","descriptor_name":"Herpesvirus 8, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019288","descriptor_name":"Herpesvirus 8, Human","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D019288","descriptor_name":"Herpesvirus 8, Human","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D056189","descriptor_name":"Viral Tropism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci40567","doi":"https://doi.org/10.1172/jci40567","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci40567","pdf_url":"http://www.jci.org/articles/view/40567/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmid:20364091","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20364091","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2847423","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2847423/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1172/jci40567","doi":"https://doi.org/10.1172/jci40567","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci40567","pdf_url":"http://www.jci.org/articles/view/40567/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978001038.pdf","grobid_xml":"https://content.openalex.org/works/W1978001038.grobid-xml"},"referenced_works_count":197,"referenced_works":["https://openalex.org/W46541548","https://openalex.org/W134197049","https://openalex.org/W149983562","https://openalex.org/W160739290","https://openalex.org/W165618002","https://openalex.org/W174734164","https://openalex.org/W1496154938","https://openalex.org/W1521064197","https://openalex.org/W1566845420","https://openalex.org/W1567236637","https://openalex.org/W1604210388","https://openalex.org/W1673584566","https://openalex.org/W1673837423","https://openalex.org/W1946172505","https://openalex.org/W1963854942","https://openalex.org/W1965549777","https://openalex.org/W1966758687","https://openalex.org/W1970339166","https://openalex.org/W1972008542","https://openalex.org/W1972120717","https://openalex.org/W1975794017","https://openalex.org/W1977500292","https://openalex.org/W1978855492","https://openalex.org/W1979733640","https://openalex.org/W1981194870","https://openalex.org/W1982047106","https://openalex.org/W1982209692","https://openalex.org/W1982904957","https://openalex.org/W1984661089","https://openalex.org/W1985804036","https://openalex.org/W1986097409","https://openalex.org/W1988760901","https://openalex.org/W1989237080","https://openalex.org/W1990386824","https://openalex.org/W1991952124","https://openalex.org/W1993756299","https://openalex.org/W1995782808","https://openalex.org/W1996633580","https://openalex.org/W2001135991","https://openalex.org/W2002155325","https://openalex.org/W2003117397","https://openalex.org/W2004263085","https://openalex.org/W2005608244","https://openalex.org/W2006224384","https://openalex.org/W2008403396","https://openalex.org/W2011574439","https://openalex.org/W2013191622","https://openalex.org/W2017985723","https://openalex.org/W2018091905","https://openalex.org/W2019237849","https://openalex.org/W2019745410","https://openalex.org/W2019982289","https://openalex.org/W2021360464","https://openalex.org/W2021522625","https://openalex.org/W2022660931","https://openalex.org/W2027338293","https://openalex.org/W2028318125","https://openalex.org/W2028613979","https://openalex.org/W2028953187","https://openalex.org/W2030085084","https://openalex.org/W2030277142","https://openalex.org/W2032201575","https://openalex.org/W2032438721","https://openalex.org/W2032458366","https://openalex.org/W2033474859","https://openalex.org/W2035092384","https://openalex.org/W2036279650","https://openalex.org/W2036830225","https://openalex.org/W2037163036","https://openalex.org/W2037836140","https://openalex.org/W2040250369","https://openalex.org/W2040675530","https://openalex.org/W2040998346","https://openalex.org/W2043436845","https://openalex.org/W2043905557","https://openalex.org/W2044627970","https://openalex.org/W2047235352","https://openalex.org/W2048158327","https://openalex.org/W2049306580","https://openalex.org/W2050029927","https://openalex.org/W2050461547","https://openalex.org/W2051260092","https://openalex.org/W2053494754","https://openalex.org/W2053543225","https://openalex.org/W2055412399","https://openalex.org/W2058069863","https://openalex.org/W2058562532","https://openalex.org/W2059136727","https://openalex.org/W2061789335","https://openalex.org/W2062110139","https://openalex.org/W2062826371","https://openalex.org/W2062999927","https://openalex.org/W2063979760","https://openalex.org/W2064640692","https://openalex.org/W2065537276","https://openalex.org/W2066371413","https://openalex.org/W2066410692","https://openalex.org/W2066502941","https://openalex.org/W2067444184","https://openalex.org/W2068854499","https://openalex.org/W2068877639","https://openalex.org/W2069786905","https://openalex.org/W2069800741","https://openalex.org/W2070053830","https://openalex.org/W2070204121","https://openalex.org/W2070335382","https://openalex.org/W2072459627","https://openalex.org/W2073825815","https://openalex.org/W2073952283","https://openalex.org/W2077416276","https://openalex.org/W2079473945","https://openalex.org/W2079626135","https://openalex.org/W2081651119","https://openalex.org/W2082267123","https://openalex.org/W2085622884","https://openalex.org/W2088063759","https://openalex.org/W2089097621","https://openalex.org/W2089470376","https://openalex.org/W2089906148","https://openalex.org/W2092908191","https://openalex.org/W2093208208","https://openalex.org/W2093340006","https://openalex.org/W2094614562","https://openalex.org/W2095700994","https://openalex.org/W2095733423","https://openalex.org/W2096437190","https://openalex.org/W2097681908","https://openalex.org/W2097851380","https://openalex.org/W2099031313","https://openalex.org/W2099904968","https://openalex.org/W2100921826","https://openalex.org/W2101934364","https://openalex.org/W2102274616","https://openalex.org/W2102853282","https://openalex.org/W2104340222","https://openalex.org/W2105863246","https://openalex.org/W2107943733","https://openalex.org/W2108233169","https://openalex.org/W2108408806","https://openalex.org/W2109745177","https://openalex.org/W2109948993","https://openalex.org/W2110599787","https://openalex.org/W2110863828","https://openalex.org/W2111316211","https://openalex.org/W2113694619","https://openalex.org/W2114778798","https://openalex.org/W2115522441","https://openalex.org/W2119979880","https://openalex.org/W2121918395","https://openalex.org/W2121964400","https://openalex.org/W2123045210","https://openalex.org/W2123685397","https://openalex.org/W2125479948","https://openalex.org/W2126615745","https://openalex.org/W2127432085","https://openalex.org/W2127798219","https://openalex.org/W2129585918","https://openalex.org/W2130399704","https://openalex.org/W2130993320","https://openalex.org/W2132014894","https://openalex.org/W2132451996","https://openalex.org/W2132927652","https://openalex.org/W2133443287","https://openalex.org/W2136278403","https://openalex.org/W2136620152","https://openalex.org/W2138046727","https://openalex.org/W2140398904","https://openalex.org/W2140611891","https://openalex.org/W2141574972","https://openalex.org/W2141797212","https://openalex.org/W2142798790","https://openalex.org/W2143090686","https://openalex.org/W2143795959","https://openalex.org/W2145561586","https://openalex.org/W2145989568","https://openalex.org/W2146632710","https://openalex.org/W2149346514","https://openalex.org/W2150745385","https://openalex.org/W2152736091","https://openalex.org/W2155587524","https://openalex.org/W2159163386","https://openalex.org/W2160976310","https://openalex.org/W2166187451","https://openalex.org/W2167977613","https://openalex.org/W2168968799","https://openalex.org/W2169557810","https://openalex.org/W2312580646","https://openalex.org/W2325680067","https://openalex.org/W2337331768","https://openalex.org/W2340640662","https://openalex.org/W2399708443","https://openalex.org/W2414072355","https://openalex.org/W2415108344","https://openalex.org/W2415919700","https://openalex.org/W2594615440","https://openalex.org/W3142246247","https://openalex.org/W4250337588"],"related_works":["https://openalex.org/W2120246830","https://openalex.org/W2041811554","https://openalex.org/W2021557527","https://openalex.org/W1516052726","https://openalex.org/W1986965478","https://openalex.org/W2765680130","https://openalex.org/W2365139511","https://openalex.org/W1869953429","https://openalex.org/W35259288","https://openalex.org/W2136990658"],"abstract_inverted_index":{"The":[0],"linkage":[1],"of":[2,19,23,43],"Kaposi":[3],"sarcoma":[4],"(KS)":[5],"to":[6,50,60,63],"infection":[7,58],"by":[8,30,39,55,67,100],"a":[9,36,40],"novel":[10],"human":[11],"herpesvirus":[12,15],"(Kaposi":[13],"sarcoma-associated":[14],"[KSHV])":[16],"is":[17],"one":[18],"the":[20,52,71,92],"great":[21],"successes":[22],"contemporary":[24],"biomedical":[25],"research":[26],"and":[27,45,87,98],"was":[28],"achieved":[29],"using":[31],"advanced":[32],"genomic":[33],"technologies":[34],"in":[35,76],"manner":[37],"informed":[38],"nuanced":[41],"understanding":[42],"epidemiology":[44],"clinical":[46],"investigation.":[47],"Ongoing":[48],"efforts":[49],"understand":[51],"molecular":[53,88],"mechanisms":[54],"which":[56],"KSHV":[57],"predisposes":[59],"KS":[61,77],"continue":[62],"be":[64],"powerfully":[65],"influenced":[66],"insights":[68],"emanating":[69],"from":[70],"clinic.":[72],"Here,":[73],"recent":[74],"developments":[75],"pathogenesis":[78],"are":[79],"reviewed,":[80],"with":[81],"particular":[82],"emphasis":[83],"on":[84],"clinical,":[85],"pathologic,":[86],"observations":[89],"that":[90],"highlight":[91],"many":[93],"differences":[94],"between":[95],"this":[96],"process":[97],"tumorigenesis":[99],"other":[101],"oncogenic":[102],"viruses.":[103]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":26},{"year":2020,"cited_by_count":20},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":28},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":35},{"year":2014,"cited_by_count":40},{"year":2013,"cited_by_count":39},{"year":2012,"cited_by_count":31}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}