{"id":"https://openalex.org/W1977950418","doi":"https://doi.org/10.1038/325268a0","title":"A transcription factor which binds to the enhancers of SV40, immunoglobulin heavy chain and U2 snRNA genes","display_name":"A transcription factor which binds to the enhancers of SV40, immunoglobulin heavy chain and U2 snRNA genes","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W1977950418","doi":"https://doi.org/10.1038/325268a0","mag":"1977950418","pmid":"https://pubmed.ncbi.nlm.nih.gov/3027566"},"language":"en","primary_location":{"id":"doi:10.1038/325268a0","doi":"https://doi.org/10.1038/325268a0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/325268a0","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044917668","display_name":"Dirk Bohmann","orcid":"https://orcid.org/0000-0003-2362-9461","observed_orcids":["https://orcid.org/0000-0003-2362-9461"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dirk Bohmann","raw_affiliation_strings":["Division of Molecular Biology, Institute of Cell and Tumor Biology, German Cancer Research Center, D-6900, Heidelberg, FRG","Division of Molecular Biology, Institute of Cell and Tumor Biology, German Cancer Research Center, Heidelberg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Biology, Institute of Cell and Tumor Biology, German Cancer Research Center, D-6900, Heidelberg, FRG","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"Division of Molecular Biology, Institute of Cell and Tumor Biology, German Cancer Research Center, Heidelberg","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Walter Keller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Walter Keller","raw_affiliation_strings":["Division of Molecular Biology, Institute of Cell and Tumor Biology, German Cancer Research Center, D-6900, Heidelberg, FRG","Division of Molecular Biology, Institute of Cell and Tumor Biology, German Cancer Research Center, Heidelberg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Biology, Institute of Cell and Tumor Biology, German Cancer Research Center, D-6900, Heidelberg, FRG","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"Division of Molecular Biology, Institute of Cell and Tumor Biology, German Cancer Research Center, Heidelberg","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003639137","display_name":"Trevor C. Dale","orcid":"https://orcid.org/0000-0002-4880-9963","observed_orcids":["https://orcid.org/0000-0002-4880-9963"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Trevor Dale","raw_affiliation_strings":["Division of Molecular Biology, Institute of Cell and Tumor Biology, German Cancer Research Center, D-6900, Heidelberg, FRG","Division of Molecular Biology, Institute of Cell and Tumor Biology, German Cancer Research Center, Heidelberg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Biology, Institute of Cell and Tumor Biology, German Cancer Research Center, D-6900, Heidelberg, FRG","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"Division of Molecular Biology, Institute of Cell and Tumor Biology, German Cancer Research Center, Heidelberg","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078962332","display_name":"Hans Robert Sch\u00f6ler","orcid":"https://orcid.org/0000-0003-2643-5136","observed_orcids":["https://orcid.org/0000-0003-2643-5136","https://orcid.org/0000-0002-7422-8847"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans R. Sch\u00f6ler","raw_affiliation_strings":["Division of Molecular Biology, Institute of Cell and Tumor Biology, German Cancer Research Center, D-6900, Heidelberg, FRG","Division of Molecular Biology, Institute of Cell and Tumor Biology, German Cancer Research Center, Heidelberg","Zentrum f\u00fcr Molekulare Biologic, University of Heidelberg, Heidleberg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Biology, Institute of Cell and Tumor Biology, German Cancer Research Center, D-6900, Heidelberg, FRG","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"Division of Molecular Biology, Institute of Cell and Tumor Biology, German Cancer Research Center, Heidelberg","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"Zentrum f\u00fcr Molekulare Biologic, University of Heidelberg, Heidleberg","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088975878","display_name":"Graham Tebb","orcid":"https://orcid.org/0000-0002-1294-2025","observed_orcids":["https://orcid.org/0000-0002-1294-2025"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Graham Tebb","raw_affiliation_strings":["Division of Molecular Biology, Institute of Cell and Tumor Biology, German Cancer Research Center, D-6900, Heidelberg, FRG","Division of Molecular Biology, Institute of Cell and Tumor Biology, German Cancer Research Center, Heidelberg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Biology, Institute of Cell and Tumor Biology, German Cancer Research Center, D-6900, Heidelberg, FRG","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"Division of Molecular Biology, Institute of Cell and Tumor Biology, German Cancer Research Center, Heidelberg","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080948421","display_name":"Iain W. Mattaj","orcid":"https://orcid.org/0000-0002-5537-8284","observed_orcids":["https://orcid.org/0000-0002-5537-8284"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Iain W. Mattaj","raw_affiliation_strings":["Division of Molecular Biology, Institute of Cell and Tumor Biology, German Cancer Research Center, D-6900, Heidelberg, FRG","Division of Molecular Biology, Institute of Cell and Tumor Biology, German Cancer Research Center, Heidelberg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Biology, Institute of Cell and Tumor Biology, German Cancer Research Center, D-6900, Heidelberg, FRG","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"Division of Molecular Biology, Institute of Cell and Tumor Biology, German Cancer Research Center, Heidelberg","institution_ids":["https://openalex.org/I17937529"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":15.4255,"has_fulltext":false,"cited_by_count":151,"citation_normalized_percentile":{"value":0.99509305,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"325","issue":"6101","first_page":"268","last_page":"272"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.8339999914169312},{"id":"https://openalex.org/keywords/octamer-motif","display_name":"octamer motif","score":0.8629999756813049},{"id":"https://openalex.org/keywords/enhancers","display_name":"enhancers","score":0.5130000114440918},{"id":"https://openalex.org/keywords/immunoglobulin-heavy-chain-genes","display_name":"immunoglobulin heavy chain genes","score":0.9570000171661377},{"id":"https://openalex.org/keywords/rna-polymerase-ii","display_name":"RNA polymerase II","score":0.7289999723434448},{"id":"https://openalex.org/keywords/cis-regulatory-elements","display_name":"cis-regulatory elements","score":0.902999997138977},{"id":"https://openalex.org/keywords/protein-dna-interactions","display_name":"protein-DNA interactions","score":0.8709999918937683},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.6489999890327454},{"id":"https://openalex.org/keywords/xenopus-laevis","display_name":"Xenopus laevis","score":0.9620000123977661}],"concepts":[{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.714460551738739},{"id":"https://openalex.org/C96007430","wikidata":"https://www.wikidata.org/wiki/Q3776943","display_name":"Immunoglobulin heavy chain","level":3,"score":0.6608136892318726},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5940994024276733},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5205248594284058},{"id":"https://openalex.org/C84613547","wikidata":"https://www.wikidata.org/wiki/Q17037912","display_name":"Heavy chain","level":3,"score":0.43951451778411865},{"id":"https://openalex.org/C36394416","wikidata":"https://www.wikidata.org/wiki/Q949267","display_name":"Immunoglobulin light chain","level":3,"score":0.4361409544944763},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4287719428539276},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4198026657104492},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3755425214767456},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3603901267051697},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36003363132476807}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007143","descriptor_name":"Immunoglobulin Heavy Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012091","descriptor_name":"Repetitive Sequences, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012319","descriptor_name":"RNA Polymerase II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012342","descriptor_name":"RNA, Small Nuclear","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013539","descriptor_name":"Simian virus 40","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/325268a0","doi":"https://doi.org/10.1038/325268a0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/325268a0","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:3027566","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3027566","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W18949849","https://openalex.org/W126863029","https://openalex.org/W164839272","https://openalex.org/W183830646","https://openalex.org/W1513288881","https://openalex.org/W1547231703","https://openalex.org/W1558516755","https://openalex.org/W1784243624","https://openalex.org/W1801817680","https://openalex.org/W1857597002","https://openalex.org/W1924979116","https://openalex.org/W1968244375","https://openalex.org/W1989080074","https://openalex.org/W1993243592","https://openalex.org/W2001187632","https://openalex.org/W2002499610","https://openalex.org/W2004563262","https://openalex.org/W2013545053","https://openalex.org/W2027469396","https://openalex.org/W2032069520","https://openalex.org/W2038218774","https://openalex.org/W2043070717","https://openalex.org/W2057893650","https://openalex.org/W2079396488","https://openalex.org/W2079578031","https://openalex.org/W2080301359","https://openalex.org/W2080567269","https://openalex.org/W2086498983","https://openalex.org/W2088094960","https://openalex.org/W2088272992","https://openalex.org/W2089593395","https://openalex.org/W2091206046","https://openalex.org/W2094571268","https://openalex.org/W2097330186","https://openalex.org/W2296218749","https://openalex.org/W2428905324"],"related_works":["https://openalex.org/W2005777655","https://openalex.org/W2054618390","https://openalex.org/W2010353576","https://openalex.org/W1801817680","https://openalex.org/W1978372522","https://openalex.org/W1474595909","https://openalex.org/W65818879","https://openalex.org/W2040880324","https://openalex.org/W183830646","https://openalex.org/W2072467553"],"abstract_inverted_index":null,"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}