{"id":"https://openalex.org/W1977913554","doi":"https://doi.org/10.1089/10430349950017103","title":"Combination of CD80 and Granulocyte-Macrophage Colony-Stimulating Factor Coexpression by a Leukemia Cell Vaccine: Preclinical Studies in a Murine Model Recapitulating Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia","display_name":"Combination of CD80 and Granulocyte-Macrophage Colony-Stimulating Factor Coexpression by a Leukemia Cell Vaccine: Preclinical Studies in a Murine Model Recapitulating Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia","publication_year":1999,"publication_date":"1999-09-01","ids":{"openalex":"https://openalex.org/W1977913554","doi":"https://doi.org/10.1089/10430349950017103","mag":"1977913554","pmid":"https://pubmed.ncbi.nlm.nih.gov/10498243"},"language":"en","primary_location":{"id":"doi:10.1089/10430349950017103","doi":"https://doi.org/10.1089/10430349950017103","is_oa":false,"landing_page_url":"https://doi.org/10.1089/10430349950017103","pdf_url":null,"source":{"id":"https://openalex.org/S39730559","display_name":"Human Gene Therapy","issn_l":"1043-0342","issn":["1043-0342","1557-7422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Gene Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007570262","display_name":"Renata Stripecke","orcid":"https://orcid.org/0000-0001-7756-8460","observed_orcids":["https://orcid.org/0000-0001-7756-8460"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Stripecke","raw_affiliation_strings":["Division of Research Immunology/BMT, Childrens Hospital Los Angeles, CA 90027, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Research Immunology/BMT, Childrens Hospital Los Angeles, CA 90027, USA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111426650","display_name":"Dianne C. Skelton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D.C. Skelton","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112379045","display_name":"P K Pattengale","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P.K. Pattengale","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008628156","display_name":"Hiroyuki Shimada","orcid":"https://orcid.org/0000-0001-5025-7507","observed_orcids":["https://orcid.org/0000-0001-5025-7507","https://orcid.org/0000-0001-9024-7792"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Shimada","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050971129","display_name":"Donald B. Kohn","orcid":"https://orcid.org/0000-0003-1840-6087","observed_orcids":["https://orcid.org/0000-0003-1840-6087"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D.B. Kohn","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4181,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.80427992,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"10","issue":"13","first_page":"2109","last_page":"2122"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/philadelphia-chromosome-positive-acute-lymphoblastic-leukemia","display_name":"Philadelphia chromosome-positive acute lymphoblastic leukemia","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cd80","display_name":"CD80","score":0.9459999799728394},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9779999852180481},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.7900000214576721},{"id":"https://openalex.org/keywords/genetically-modified-cells","display_name":"genetically modified cells","score":0.753000020980835},{"id":"https://openalex.org/keywords/bcr-abl","display_name":"BCR-ABL","score":0.6880000233650208},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.7929999828338623},{"id":"https://openalex.org/keywords/adoptive-immunotherapy","display_name":"adoptive immunotherapy","score":0.7390000224113464},{"id":"https://openalex.org/keywords/tumor-rejection","display_name":"tumor rejection","score":0.4480000138282776},{"id":"https://openalex.org/keywords/transgene-expression","display_name":"transgene expression","score":0.47999998927116394}],"concepts":[{"id":"https://openalex.org/C2778297628","wikidata":"https://www.wikidata.org/wiki/Q5009843","display_name":"CD80","level":5,"score":0.7302831411361694},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.6811483502388},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5661527514457703},{"id":"https://openalex.org/C147969180","wikidata":"https://www.wikidata.org/wiki/Q5014579","display_name":"CTL*","level":4,"score":0.5170212984085083},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5005013942718506},{"id":"https://openalex.org/C2778904597","wikidata":"https://www.wikidata.org/wiki/Q1129111","display_name":"Philadelphia chromosome","level":4,"score":0.4983360767364502},{"id":"https://openalex.org/C2777478134","wikidata":"https://www.wikidata.org/wiki/Q423660","display_name":"Granulocyte macrophage colony-stimulating factor","level":3,"score":0.4354912042617798},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4209596514701843},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41076159477233887},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4049568772315979},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39656534790992737},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.29708606004714966},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.22177553176879883},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.18308228254318237},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.11520197987556458},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.10217878222465515},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000938","descriptor_name":"Antigen-Presenting Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018122","descriptor_name":"B7-1 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1089/10430349950017103","doi":"https://doi.org/10.1089/10430349950017103","is_oa":false,"landing_page_url":"https://doi.org/10.1089/10430349950017103","pdf_url":null,"source":{"id":"https://openalex.org/S39730559","display_name":"Human Gene Therapy","issn_l":"1043-0342","issn":["1043-0342","1557-7422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Gene Therapy","raw_type":"journal-article"},{"id":"pmid:10498243","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10498243","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human gene therapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320317194","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W841691","https://openalex.org/W5946015","https://openalex.org/W68691347","https://openalex.org/W97760204","https://openalex.org/W105534366","https://openalex.org/W185283559","https://openalex.org/W231759835","https://openalex.org/W267564600","https://openalex.org/W319578897","https://openalex.org/W1501664116","https://openalex.org/W1505556619","https://openalex.org/W1549471106","https://openalex.org/W1750539994","https://openalex.org/W1889360239","https://openalex.org/W1909132577","https://openalex.org/W1914820210","https://openalex.org/W1981686597","https://openalex.org/W1989383189","https://openalex.org/W1990668606","https://openalex.org/W1991148746","https://openalex.org/W1993301801","https://openalex.org/W2005037046","https://openalex.org/W2010350911","https://openalex.org/W2011913856","https://openalex.org/W2014183131","https://openalex.org/W2016667073","https://openalex.org/W2019546595","https://openalex.org/W2024209547","https://openalex.org/W2031172299","https://openalex.org/W2039613763","https://openalex.org/W2054161891","https://openalex.org/W2055814218","https://openalex.org/W2060799642","https://openalex.org/W2063495860","https://openalex.org/W2068595389","https://openalex.org/W2077739104","https://openalex.org/W2090073469","https://openalex.org/W2098725133","https://openalex.org/W2100117872","https://openalex.org/W2110340781","https://openalex.org/W2118561802","https://openalex.org/W2129779913","https://openalex.org/W2130901389","https://openalex.org/W2131761283","https://openalex.org/W2135272173","https://openalex.org/W2150290224","https://openalex.org/W2158528246","https://openalex.org/W2207680991","https://openalex.org/W2261215219","https://openalex.org/W2276344482","https://openalex.org/W2346631764","https://openalex.org/W2405695350","https://openalex.org/W2418882667"],"related_works":["https://openalex.org/W2016667073","https://openalex.org/W1860254846","https://openalex.org/W2597041708","https://openalex.org/W2979784686","https://openalex.org/W2014315961","https://openalex.org/W2073633978","https://openalex.org/W2587132900","https://openalex.org/W1587791254","https://openalex.org/W2031695807","https://openalex.org/W267564600"],"abstract_inverted_index":{"Philadelphia":[0],"chromosome-positive":[1],"acute":[2],"lymphoblastic":[3],"leukemia":[4,34,59,71,123,136,169],"(Ph+":[5],"ALL)":[6],"is":[7],"a":[8,84,101],"highly":[9],"aggressive":[10],"malignancy":[11],"caused":[12,119,132],"by":[13],"the":[14,31,38,69,97,109,146,155,160],"bcr-abl":[15],"translocation":[16],"oncogene.":[17],"To":[18],"explore":[19],"alternative":[20],"treatments":[21],"for":[22,180],"Ph+":[23,183],"ALL":[24,184],"we":[25],"tested":[26],"gene-modified":[27],"cell":[28,42,111,149,170],"vaccines":[29,75,171],"in":[30,48,182],"BALB/c-derived":[32],"BM185":[33,41,58,130],"model.":[35],"We":[36],"compared":[37],"efficacy":[39,144],"of":[40,77,96,104,108,122,135,145,157],"vaccine":[43,112,150],"expressing":[44,159],"CD80":[45,64,173],"alone":[46],"or":[47,52],"combination":[49],"with":[50,56,116,129,154],"IL-2":[51],"GM-CSF.":[53],"Mice":[54],"injected":[55],"viable":[57],"cells":[60,80,118,131,158],"modified":[61],"to":[62],"express":[63],"and":[65,174],"GM-CSF":[66,148,175],"(BM185/CD80+GM-CSF)":[67],"showed":[68,100],"highest":[70],"rejection":[72],"rates.":[73,141],"Cell":[74],"consisting":[76],"irradiated":[78],"BM185/CD80+GM-CSF":[79,110],"administered":[81],"subcutaneously":[82],"stimulated":[83],"potent":[85],"cytotoxic":[86],"T":[87],"lymphocyte":[88],"(CTL)":[89],"response":[90],"against":[91],"parental":[92,117],"BM185.":[93],"Histological":[94],"examination":[95],"vaccination":[98],"site":[99],"large":[102],"concentration":[103],"immune":[105],"cells.":[106],"Administration":[107],"before":[113],"intravenous":[114],"challenge":[115,128],"strong":[120],"inhibition":[121],"development.":[124],"Vaccination":[125],"after":[126],"subcutaneous":[127],"efficient":[133],"elimination":[134],"promoting":[137],"40-60%":[138],"long-term":[139],"survival":[140],"The":[142],"immunization":[143],"BM185/CD80+":[147],"was":[151],"directly":[152],"correlated":[153],"percentage":[156],"transgenes.":[161],"In":[162],"all,":[163],"this":[164],"preclinical":[165],"study":[166],"shows":[167],"that":[168],"coexpressing":[172],"can":[176],"potentially":[177],"be":[178],"explored":[179],"immunotherapy":[181],"patients.":[185]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
